2,565 research outputs found
Present and past experiences in GL management and research: A questionnaire survey on Italian participants to GL Events
No full textLibraries carry out a central role in the process of dissemination of scientific information. Particularly regarding grey literature, libraries have played a key role in overcoming obstacles to full access thereby contributing to the full inclusion of grey literature in the scientific communication network. This activity has been carried out with the development of grey literature produced within their organizations through specific collection-development policies and ad hoc bibliographic and editorial strategies. What issues connected with the planning of collections and with management of GL documents have been encountered and solved? Moreover, recently, a number of libraries are promoting or supporting open archives. To what extent do they profit from their experience in GL management in the realization of institutional repositories or of ongoing projects on open access? The aim of the paper is to examine the different approaches and strategies of a number of Italian special libraries, that hold high-quality collections and whose users have a high specialization, basically, towards their: a) management of historical and special GL collections; b) development and management of current GL collections; c) realization of institutional repositories or projects on open access. The survey makes use of a semi-structured questionnaire, which was submitted to a number of managers of Italian special libraries, of governmental institutes or research institutes. The questionnaire consists of fifty questions designed to capture all the information relevant to the above mentioned goals (a), (b), and (c). The questions are grouped into five sections: (1) general questions, and detailed questions on consistence and quality of GL collections; (2) detailed questions about the management and bibliographic description of GL documents, included the cost of the management of GL documents and people dedicated to them; (3) questions about past, current and future projects on GL education and training; (4) questions about current and future initiative regarding institutional repositories or open archives, and their link to the experience of GL management. scienze sociali. Moreover, each part of the questionnaire includes a set of questions on both objective and subjective data, that express value judgements. GL managers are asked to respond in the light of their personal experience as "privileged observers", in the commonly accepted meaning of this term in the social sciences. We close by discussing the "insight" and "feeling" of GL managers towards old and new issues connected with grey literature, through some open questions added at the end of the questionnaire.Includes: Conference preprint, Powerpoint presentation, Abstract and Biographical notes, Pratt student commentaryXAInternationa
Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3γ via gastric STAT3 activation
Full text linkBACKGROUND: Most of what is known about the Helicobacter pylori (H. pylori) cytotoxin, CagA, pertains to a much-vaunted role as a determinant of gastric inflammation and cancer. Little attention has been devoted to potential roles of CagA in the majority of H. pylori infected individuals not showing oncogenic progression, particularly in relation to host tolerance. Regenerating islet-derived (REG)3γ encodes a secreted C-type lectin that exerts direct bactericidal activity against Gram-positive bacteria in the intestine. Here, we extend this paradigm of lectin-mediated innate immunity, showing that REG3γ expression is triggered by CagA in the H. pylori-infected stomach. METHODOLOGY/PRINCIPAL FINDINGS: In human gastric mucosal tissues, REG3γ expression was significantly increased in CagA-positive, compared to CagA-negative H. pylori infected individuals. Using transfected CagA-inducible gastric MKN28 cells, we recapitulated REG3γ induction in vitro, also showing that tyrosine phosphorylated, not unphosphorylated CagA triggers REG3γ transcription. In concert with induced REG3γ, pro-inflammatory signalling downstream of the gp130 cytokine co-receptor via the signal transducer and activator of transcription (STAT)3 and transcription of two cognate ligands, interleukin(IL)-11 and IL-6, were significantly increased. Exogenous IL-11, but not IL-6, directly stimulated STAT3 activation and REG3γ transcription. STAT3 siRNA knockdown or IL-11 receptor blockade respectively abrogated or subdued CagA-dependent REG3γ mRNA induction, thus demonstrating a requirement for uncompromised signalling via the IL-11/STAT3 pathway. Inhibition of the gp130-related SHP2-(Ras)-ERK pathway did not affect CagA-dependent REG3γ induction, but strengthened STAT3 activation as well as augmenting transcription of mucosal innate immune regulators, IL-6, IL-8 and interferon-response factor (IRF)1. CONCLUSIONS/SIGNIFICANCE: Our results support a model of CagA-directed REG3γ expression in gastric epithelial cells via activation of the IL-11/gp130/STAT3 pathway. This response might allow Gram-negative H. pylori to manipulate host immunity to favour its own survival, by reducing the fitness of co-habiting Gram-positive bacteria with which it competes for resources in the gastric mucosal niche
On the GL(2n) eigenvariety: branching laws, Shalika families and p-adic L-functions
Full text linkIn this paper, we prove that a GL(2n)-eigenvariety is étale over the (pure) weight space at non-critical Shalika points, and construct multi-variable p-adic L-functions varying over the resulting Shalika components. Our constructions hold in tame level 1 and Iwahori level at p, and give p-adic variation of L-values (of regular algebraic cuspidal automorphic representations of GL(2n) admitting Shalika models) over the whole pure weight space. In the case of GL(4), these results have been used by Loeffler and Zerbes to prove cases of the Bloch–Kato conjecture for GSp(4).Our main innovations are: (a) the introduction and systematic study of ‘Shalika refinements’ of local representations of GL(2n), and evaluation of their attached local twisted zeta integrals; and (b) the p-adic interpolation of representation-theoretic branching laws for GL(n) × GL(n) inside GL(2n). Using (b), we give a construction of multi-variable p-adic functionals on the overconvergent cohomology groups for GL(2n), interpolating the zeta integrals of (a). We exploit the resulting non-vanishing of these functionals to prove our main arithmetic applications
Globalization of Distinguished Supercuspidal Representations of GL(n)
No full textAn irreducible supercuspidal representation of = GL(n, ), where is a nonarchimedean local field of characteristic zero, is said to be “distinguished” by a subgroup of and a quasicharacter of if Hom(, ) ≠ 0. There is a suitable global analogue of this notion for an irreducible, automorphic, cuspidal representation associated to GL(n). Under certain general hypotheses, it is shown in this paper that every distinguished, irreducible, supercuspidal representation may be realized as a local component of a distinguished, irreducible automorphic, cuspidal representation. Applications to the theory of distinguished supercuspidal representations are provided
Restriction of Representations of GL (n + 1, ℂ) to GL (n, ℂ) and Action of the Lie Overalgebra
No full textConsider a restriction of an irreducible finite dimensional holomorphic representation of GL(n+1,C) to the subgroup GL(n,C). We write explicitly formulas for generators of the Lie algebra gl(n+1) in the direct sum of representations of GL(n,C). Nontrivial generators act as differential-difference operators, the differential part has order n − 1, the difference part acts on the space of parameters (highest weights) of representations. We also formulate a conjecture about unitary principal series of GL(n,C).© The Author(s) 201
The Balanced Voronoi Formulas for
No full textAbstract
In this article, we show how the Voronoi summation formula of [13] can be rewritten to incorporate hyper-Kloosterman sums of various dimensions on both sides. This generalizes a formula for with ordinary Kloosterman sums on both sides that was used in [1] to prove nonvanishing of GL(4) -functions by GL(2)-twists, and later by the second-named author in [16].</jats:p
Computing the symmetric -homology
Full text linkThe symmetric -homologies, introduced by Robert and Wagner,
provide a categorification of the Reshetikhin--Turaev invariants corresponding
to symmetric powers of the standard representation of quantum
. Unlike in the exterior setting, these homologies are already
non-trivial when . Moreover, in this case, their construction can be
greatly simplified. Our first aim is giving a down-to-earth description of the
non-equivariant symmetric -homology, together with relations
that hold in this setting. We then find a basis for the state spaces of graphs,
and use it to construct an algorithm and a program computing the invariant for
uncolored links.Comment: 37 pages, many figures, 1 table. Comments welcome
Descent of splendid Rickard equivalences in
Full text linkLet be a positive integer and a prime power. We prove that a refined
version of Brou\'{e}'s abelian defect group conjecture holds for unipotent
-blocks of , where . We also give a
sufficient condition on general -blocks of to satisfy the
refined abelian defect group conjecture. We explain by an example that this
sufficient condition does not hold in general.Comment: the final versio
Bethe Vectors for Composite Models with gl(2|1) and gl(1|2) Supersymmetry
Full text linkSupersymmetric composite generalized quantum integrable models solvable by the algebraic Bethe ansatz are studied. Using a coproduct in the bialgebra of monodromy matrix elements and their action on Bethe vectors, formulas for Bethe vectors in the composite models with supersymmetry based on the super-Yangians Y[gl(2|1)] and Y[gl(1|2)] are derived.The author wants to express his gratitude to N.A. Slavnov for the proposal to investigate this
topic and discussions. He thanks also to S. Pakuliak for discussions and to A.P. Isaev and
C. Burd´ık for their support. The work of the author has been supported by the Grant Agency ˇ
of the Czech Technical University in Prague, grant No. SGS15/215/OHK4/3T/14, and by the
Grant of the Plenipotentiary of the Czech Republic at JINR, Dubna
Combinatorial results on (1,2,1,2)-avoiding -orbit closures on
No full text35 pages, 18 figuresInternational audienceUsing recent results of the second author which explicitly identify the "-avoiding" -orbit closures on the flag manifold as certain Richardson varieties, we give combinatorial criteria for determining smoothness, lci-ness, and Gorensteinness of such orbit closures. (In the case of smoothness, this gives a new proof of a theorem of W.M. McGovern.) Going a step further, we also describe a straightforward way to compute the singular locus, the non-lci locus, and the non-Gorenstein locus of any such orbit closure. We then describe a manifestly positive combinatorial formula for the Kazhdan-Lusztig-Vogan polynomial in the case where corresponds to the trivial local system on a -avoiding orbit closure and corresponds to the trivial local system on any orbit contained in . This combines the aforementioned result of the second author, results of A. Knutson, the first author, and A. Yong, and a formula of Lascoux and Sch\"{u}tzenberger which computes the ordinary (type ) Kazhdan-Lusztig polynomial whenever is cograssmannian
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