2,414 research outputs found
A new intelligent ECG recognition approach based on CNN and improved ALO-SVM
No full textCardiovascular disease is one of the most common diseases, which seriously threatens people's life and health. Therefore, cardiovascular disease prevention becomes one of the most attractive research topics in health care system design. Intelligent recognition of electrocardiogram (ECG) signals represents an effective method for rapid diagnosis and the evaluation of cardiovascular diseases in medicine. Realization and efficiency of the classification of ECG signals in real time play major roles in the detection of cardiovascular diseases. This paper is concerned with the proposition of an intelligent ECG signal recognition method based on a convolutional neural network (CNN) and support vector machines (SVM) with an improved antlion algorithm (ALO). First, the ECG signal is denoised and pre-processed by lifting the wavelet. Subsequently, CNN is used to extract the signal characteristics of the denoising signal, and the extracted signal characteristics are used as the input characteristics of the SVM. Finally, an improved ALO algorithm is used to optimize the relevant input functions of the SVM to achieve a better signal classification. In our algorithm, the performance is enhanced by improving the threshold estimation method of the lifting wavelet, to improve the filtering effect. The proposed CNN architecture is tested with multi-lead ECG signals from the MIT-BIH ECG signal data set. The results display that the method has obtained an average accuracy, sensitivity, and specificity values of 99.97% 99.97%, and 99.99%,respectively. Compared with the existing results, the proposed approach has a better recognition performance
Lentivirus-mediated superoxide dismutase1 gene delivery protects against oxidative stress-induced liver injury in mice
No full textBACKGROUND:
The exposure of liver to hepatotoxins, and their subsequent metabolism, results in increased reactive oxygen species (ROS), one of the major culprits in causing both acute liver cell injury and chronic liver diseases. The aim of this present study is to investigate the protective effects of lentiviral vector-mediated copper-zinc superoxide dismutase (LV-SOD1) gene transfer against ROS-induced cytotoxicity in Hep G2 cells and liver injury in mice.
METHODS:
In vitro SOD1 efficacy was tested against two ROS-generating systems: hypoxanthine/xanthine oxidase (HX/XO) and hydroxyethyl radicals (HER), whereas in vivo SOD1 efficacy was evaluated in carbon tetrachloride (CCl4)-induced liver injury in C57BL/6 mice.
RESULTS:
LV-SOD1 transduction in Hep G2 cells resulted in a significant increase in SOD activity in cell lysates, and it significantly decreased the toxicity induced by HX/XO and HER. High SOD1 expression in the liver was achieved via portal vein injection of LV-SOD1 in mice and these high levels were observed for 30 days, the length of the experiment to date. SOD1 overexpression significantly decreased the toxicity and restored liver function in the CCl4-treated mice.
CONCLUSIONS:
These findings demonstrate for the first time that LV transduction led to the long-term expression of fully functional transgene expression in both in vitro and in vivo systems
Low-temperature fabrication of oxide composites for solid-oxide fuel cells
No full textComposites of yttria-stabilized zirconia (YSZ) with Sr-doped LaCrO(3) (LSC) and Sr-doped LaMnO(3) (LSM) were prepared by impregnation of a porous YSZ matrix with aqueous solutions of the appropriate metal salts, followed by sintering to various temperatures. XRD measurements showed that perovskite phases formed after sintering at 1073 K, a temperature well below that at which solid-state reactions with YSZ occur. The conductivities of the LSC-YSZ and LSM-YSZ composites prepared in this way were maximized at a sintering temperature of 1373 K for LSC-YSZ and 1523 K for LSM-YSZ, although reasonable conductivities were achieved at much lower temperatures. The conductivities of the two composites increased much more rapidly with the content of the conductive oxide than has been found with conventional composites formed by mixing and sintering the oxide powders. The implications for using this approach to develop novel electrodes for SOFC applications are discussed
Freshwater fishes distribution in Taiwan and continent of China and its biogeographical significance
No full textThrough the comparative analysis of primary freshwater fishes in Chinese continent and the Taiwan Island, we summarize the three distinctions of distribution of freshwater fishes in these areas: (i) there exists a high similarity of freshwater fish fauna between Taiwan and the southeastern shore of the continent; (ii) some species of freshwater fish are found both in the Taiwan Island and East Himalayans; (iii) different freshwater fishes have different distributions in island arch of western Pacific where Taiwan is located, but the distribution pattern shows a similarity to that of adjacent continent. The characteristic distributions of the fishes are closely related to the change in paleogeography and geology in the area. The parsimony analysis of endemicity (PAE analysis) indicates that the three distribution patterns can be explained by the vicariance theory
Compressive behaviour of metal matrix syntactic foams
No full textThe compressive behaviour of three different metal matrix syntactic foams (MMSFs) were investigated. The results showed that the engineering factors as the size of the used hollow spheres, the aspect ratio (height / diameter ratio) of the specimens and the temperature of the compression tests have significant effects on the compressive strength and properties. The smaller microballoons with thinner wall ensured higher compressive strength due to their more flawless microstructure and better mechanical stability. The higher aspect ratio of the specimens resulted in worse compressive characteristics (lower strength, lower specific energy consuming capacity). The elevated temperature tests revealed ~30% drop in the compressive strength. However, the strength remained high enough for structural applications; therefore MMSFs are good choices for light structural parts working at elevated or room temperature. The proper size selection of the reinforcing hollow spheres ensures potential for tailoring the compressive characteristics of MMSFs
Yy Karai: fortalecimento e celebração de nomes mbya guarani
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2025.Esta dissertação de mestrado pesquisa o Yy Karai que é um dos rituais de nomeação mais preservados e sagrados na cultura guarani. Ele se insere dentro do conceito Nhemongarai que nomeia vários rituais que podem ter celebração de nome: Yy Karai, Mbojape'i Nhemongarai e Ka?a?i Nhemongarai. Estes rituais são a mais forte cerimônia que temos na nossa devoção cultural, o que mais fortalece o nosso espírito e a nossa vida. São os mais praticados nas aldeias e devem ser sempre preservados para não serem esquecidos. Estes rituais são a maior celebração de nome que nós temos na nossa cultura. Através dos rituais a gente recebe o nome verdadeiro, tery ete, e ouve as palavras sagradas ayvu maraey dos anciões e sábios xeramoi kuery e assim a gente pode ouvir, conhecer, se fortalecer. Através dos nomes vivemos e buscamos o nosso conhecimento, os nossos saberes, por meio dos mais velhos. Esta pesquisa faz parte da minha vida, da minha trajetória, sendo um caminho de busca de conhecimento. Cada um tem um jeito de traduzir e forma de expressar sentimento, cada um tem conhecimento diferente, o sentido é o mesmo, o modo de contar é diferente. Com cada tradução, com cada reflexão, com cada conhecimento, vai complementando e fortalecendo.Abstract: Kova'e kuaxia re ma ambopara yy karai regua. Haxy ete ma jurua kuery nhande reko oupity pa aguã ramo jepe nda?eveipa re mavy ambopara yy karai jurua kuery omboayvu aguã nhande yy karai. Nhande kuery ma jareko Kova'e yy karai anho he?y, jareko ma ka?a?i nhemongarai, mbojape?i Nhemongarai ha'e gu?mbe?i Nhemongarai. Ramo jepe kova'e kuaxia re amboparave yy karai regua. YY karai py ma jaiporu petyngua tataxina nhambo guejy aguã nhane amba?i re ha'e kova'e yy karai rupi ma teryete?i onhe moexãkã nhane ramoi kuery pe nhane mboery?i aguã.Tery ma onhe mombe'u tarova?i rupi nhane ramoi kuery ogu?rõ porandu ramo. Yy karai py ma nhande kuery petei tei jajapo va?e rã tata rendy?i nhane nhe?e kuery pe mbaraete ha mby?a guaxu rã jajerojy reve nha moendy?i aguã. Ha?e nhemongarai py ma Nhe e moak? yary pire ry py ha?e nhane ramoi kuery ha?e nhande jaryi kuery omo nhendu va?e rã ayvu porã ayvu marãe'? gui gua. Kova'e gui ae ma nhande kuery jareko mbarete ha?e mby?a guaxu. Kova'e yy karai gui ma nda?eveu nhande mbya kuery nhande rexaipa aguã. Kova'e ma Nhanderu Tenonde gua oikuaa uka raka?e nhande vy mbya kuery opy re jaro jeapo aguã. Haxy ete rei ma yy karai regua re jurua py nha mbopara aguã. Tove katu pav?'i mbya kuery nhande kuai va?e tekoa jave re tanha nembaraete
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies
No full textMutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of major RPGR isoforms (RPGR 1-19 and RPGR ORF15), we have generated isoform-specific antibodies and examined their expression and localization in the retina. Using sucrose-gradient centrifugation, immunofluorescence and co-immunoprecipitation methods, we show that RPGR isoforms localize to distinct sub-cellular compartments in mammalian photoreceptors and associate with a number of cilia-centrosomal proteins. The RCC1-like domain of RPGR, which is present in all major RPGR isoforms, is sufficient to target it to the cilia and centrosomes in cultured cells. Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors
A non-linear analysis of the longitudinal static stability of light, multi-engined aircraft
No full textThe longitudinal handling qualities of light aircraft have
traditionally been assessed in terms of the slope of the static
stability trim curves. This method of assessment is simple in terms
of analysis as well as being a relatively easy task for the pilot to
perform. The theory is however based on a simple linearised model of
.
the aircraft'and omits, amongst other things, the effects of power.
A comparison between the estimated and measured trim curves of a
typical light aircraft shows that the linearised theory severely
overestimates its static stability. A design based on the linear
assumptions would be unlikely to comply with airworthiness requirements.
In Part II the main omissions from the linearised model are
considered individually and their effect on the trim curves found.
In Part I the individual contributions from Part II are used to
complete the full, non-linear, trim equations and these are solved in
terms of elevator angle and incidence to trim, n and
ä. The solution
shows that the non-linear analysis provides a good simulation of the
flight measured trim curve data thus verifying the methods of
estimation developed in Part II.
The trim curves are considered in terms of incidence and
lift coefficient and show that assumption of a linear lift-incidence
relationship may cause some misleading interpretations of the trim
curves drawn in terms of lift coefficient
Study on the anomalous quartic W+W-yy couplings of electroweak bosons in e-p collisions at the LHeC and the FCC-he
No full textIn this paper, a study is carried out on the e−p --> e−y*p --> pW−ynu_e production to probe quartic W+W−yy couplings at the Large Hadron electron Collider (LHeC) with s= 1.30, 1.98 TeV and at the Future Circular Collider-hadron electron (FCC-he) with s= 3.46, 5.29 TeV. Production cross-sections are determined for both at leptonic and hadronic decay channels of the W-boson. With the data from future e−p colliders, it is possible to obtain sensitivity measures at 95% C.L
An experimental field trial of PON based digital CATV network
No full textA CATV network which has switched double star configuration, fiber to the home (FTTH) and full digital transmission has been tested to see the feasibility with one Head-End (HE), one Central Office (CO), one Distribution Center (DC), and 25 subscribers. Also POTS and NISDN services have been provided to 5 subscribers. Single mode optical Fibers are fully deployed from a WE to subscribers. A PON with TDM/polling scheme has been implemented considering the economic issue. Also in the outside plant, we tried to use the existing facility including the in-house duct. This paper deals with the results or the trial and some issues on the operational view
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