184,187 research outputs found
Measuring the change in R&D efficiency of the Japanese pharmaceutical industry - revised
No full textDepartment of Social Systems and Management Discussion Paper Series ; no. 1145This is a revised version of the paper: Hashimoto A. and Haneda S. Measuring the change in R&D
efficiency of the Japanese pharmaceutical industry. Dept. Social Systs Mgmt Discussion Pap. Ser. 1128,
Univ. Tsukuba 2005.technical repor
Aspectos ultrasonográficos da tireóide na doença de hashimoto.
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Médica, Curso de Medicina, Florianópolis, 200
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
"Focal thyroid inferno" on color Doppler ultrasonography: A specific feature of focal Hashimoto's thyroiditis
No full textPurpose: To evaluate color-Doppler features predictive of focal Hashimoto's thyroiditis. Materials and methods: A total of 521 patients with 561 thyroid nodules that underwent surgeries or gun biopsies were included in this study. These nodules were divided into three groups: focal Hashimoto's thyroiditis (104 nodules in 101 patients), benignity other than focal Hashimoto's thyroiditis (73 nodules in 70 patients), and malignancy (358 nodules in 350 patients). On color Doppler sonography, four vascularity types were determined as: hypovascularity, marked internal flow, marked peripheral flow and focal thyroid inferno. The chi(2) test was performed to seek the potential vascularity type with the predictive ability of certain thyroid pathology. Furthermore, the gray-scale features of each nodule were also studied. Results: The vascularity type I (hypovascularity) was more often seen in focal Hashimoto's thyroiditis than other benignity and malignancy (46% vs. 20.5% and 19%). While the type II (marked internal flow) showed the opposite tendency (26.9% [focal Hashimoto's thyroiditis] vs. 45.2% [other benignity] and 52.8% [malignancy]). However, type III (marked peripheral flow) was unable to predict any thyroid pathology. Importantly, type IV (focal thyroid inferno) was exclusive to focal Hashimoto's thyroiditis. All 8 type IV nodules appeared to be solid, hypoechoic, and well-defined. Using "focal thyroid inferno" as an indicator of FHT, the diagnostic sensitivity and specificity were 7.7% and 100% respectively. Conclusions: The vascularity type of "focal thyroid inferno" is specific for focal Hashimoto thyroiditis. Recognition of this particular feature may avoid unnecessary interventional procedures for some solid hypoechoic thyroid nodules suspicious of malignancy. (C) 2012 Elsevier Ireland Ltd. All rights reserved.Radiology, Nuclear Medicine & Medical ImagingSCI(E)PubMed1ARTICLE113319-33258
Measuring the change in R&D efficiency of the Japanese pharmaceutical industry - revised
No full textThis is a revised version of the paper: Hashimoto, A. and Haneda, S., Measuring the change in R&D
efficiency of the Japanese pharmaceutical industry. Dept. Social Systs Mgmt Discussion Pap. Ser. 1128,
Univ. Tsukuba, 2005
Catestatin and Advanced Glycation End-Products: Potential Indicators of Cardiovascular Risk in Hashimoto’s Thyroiditis
No full textAccumulating evidence suggests that overt hypothyroidism is associated with accelerated atherosclerosis, thereby increasing the risk for major cardiovascular events. The present study aimed to investigate the associations between serum catestatin levels and advanced glycation end-products (AGEs), indicators of vascular health, in individuals with Hashimoto’s thyroiditis compared to healthy controls. A total of 100 female patients with Hashimoto’s thyroiditis and 100 age-matched healthy controls were included in the study. Serum catestatin levels (10.2 (6.5–15.8) vs. 6.4 (4.1–9.3) ng/mL, p < 0.001) and tissue levels of AGEs (2.21 ± 0.55 ng/mL vs. 1.89 ± 0.56, p < 0.001) were both significantly higher in the Hashimoto’s group compared to the healthy age-matched controls. A positive correlation was observed between catestatin and AGEs in the overall population (r = 0.489, p < 0.001) and within the Hashimoto’s group (r = 0.457, p < 0.001). Additionally, weak positive correlations were noted between catestatin and high-sensitivity C-reactive protein, as well as anti-thyroid peroxidase antibodies (r = 0.277, p = 0.005 and r = 0.229, p = 0.024, respectively). All of these associations were confirmed through multivariate analyses. The present analysis indicates that catestatin might be implicated in cardiovascular consequences of Hashimoto’s thyroiditis. However, future research should focus on longitudinal studies to explore if the causal relationship exists
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Choroba Hashimoto — aspekt genetyczny i środowiskowy
No full textChronic lymphocytic thyroiditis, which is also known as Hashimoto’s thyroiditis is an autoimmune condition. Pathogenesis of this disease is determined by impaired immune system and breakedown of immunological self-tolerance, associated with lymphocytic infiltration of thyroid follicles resulting in autoimmune glandular destruction and hypothyroidism. This article discuss new aspects of etiopathogenesis both genetic and environmental factors as the cause of Hashimoto’s thyroiditis. Main focus is on the iodine surplus and selenium deficiency in the diet.Przewlekłe limfocytarne zapalenie tarczycy typu Hashimoto to choroba o podłożu autoimmunizacyjnym. Patogenezę tej choroby determinuje zaburzona praca układu odpornościowego, przejawiająca się nagromadzeniem autoreaktywnych limfocytów przy jednoczesnej utracie immunologicznej tolerancji na własne tkanki, co w efekcie prowadzi do destrukcji gruczołu tarczowego i wytworzenia niedoczynności tarczycy. Artykuł ten porusza aktualne aspekty związane z etiopatogenezą oraz z czynnikami r yzyka występowania choroby Hashimoto. Omówiony został przede wszystkim problem nadmiaru jodu oraz niedoboru selenu w diecie
Epistle to America; have we forgotten Justice?
No full textLetter from Hideo Hashimoto, pastor of the Japanese Methodist Church in Fresno, California, "on the eve of evacuation." Printed on backside of an article by Caleb Foote titled "Have we forgotten justice?" published by the Fellowship of Reconciliation.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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