8,084 research outputs found

    Naxwaha Sifayneed ee Afsoomaaliga: mugga kowaad (mi): Ereyeynta

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    Qoraagu wuxuu buuggan ku lafagurayaa qaybaha hadalka ee Af-soomaaliga, gaar ahaan xagga sarfaha ereyga.In questo testo, l'autore presenta un'analisi relativa alle parti del discorso della lingua somala, con un particolare focus sulla morfologia.In this text, the author presents an analysis of the parts of speech of the Somali language, with a particular focus on morphology

    Characterisation and genome analysis of novel quorum sensing soil bacteria / Robson Ee Han Jen

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    Quorum sensing (QS) describes bacterial communication using signalling molecules. QS is important for regulation of various gene expressions, most notably for the survival and adaptation of a population of bacteria to the surrounding environment. The objective of this study was to isolate and characterise novel QS bacteria. Preliminary screening of QS activity was performed using both Chromobacterium violeceum CVO26 and Escherichia coli [pSB401] biosensors. Isolates exhibiting QS activity were subsequently identified using polyphasic identification methods and their QS profile was eventually characterised using mass spectrometry. Out of 60 isolates, only two novel QS isolates were selected for further investigation. The first novel QS bacterium was Chania multitudinisentens RB-25T which was a newly proposed genus in the family of Enterobacteriaceae. This isolate was found to produce 3 AHLs: C4-HSL, C6-HSL and 3-oxo-C6-HSL. Various taxonomical analyses (for example phenotypic and genotypic characterization) according to Bergey’s Manual of Systematic Bacteriology had been conducted to characterise this isolate. The complete genome sequences unveiled presence of two pairs of luxI/R in C. multitudinisentens RB-25T and gene cloning performed validated the AHL synthesis activities of these AHL synthases. This discovery added C. multitudinisentens RB-25T to the increasing documentation of QS members in the phylum of Proteobacteria. The second novel QS bacterium isolated was strain RB-38 which was later identified as Pandoraea pnomenusa. Mass spectrometry analysis revealed that C8-HSL was the only signaling molecules detected from the spent supernatant of P. pnomenusa RB38. As this was the first documentation of QS activity in Pandoraea genus, we sequenced the complete genome of P. pnomenusa RB-38 to study its QS synthase. A set of luxI/R (designated as ppnI/R1) and an orphan ppnR2 were identified from the genome in which functional studies of PpnI conducted confirmed its role in the production of C8-HSL

    Fundamental view of the outcomes of entrepreneurship education

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    The research paper presents a holistic framework of the outcomes of entrepreneurship education (EE) at educational and socio-economic levels. Employing the general scientific research methods, monograph and logical construction, the author investigates the fundamental origins of the European Competence Framework for entrepreneurial learning and identifies a scientific justification for its implementation. This work is also the first to exploit an integral view of entrepreneurship as a combination of employability, intrapreneurship and venture creation – for measuring the impact of entrepreneurship education, and to set linkages between learning outcomes in real life and educational settings. The target audiences for this paper include entrepreneurship educators, researchers and EE decision-makers. </p

    Factors associated with the follow-up of high risk infants discharged from a neonatal intensive care unit

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    © 2022 Taiwan Pediatric AssociationBackground: The study aimed to identify factors associated with compliance to follow-up (FU) appointments among infants following their discharge from the neonatal intensive care unit (NICU). Methods: This retrospective cohort study reviewed 657 infants (birth weight &lt;1500 g or gestational age [GA] &lt;32 weeks), born between 2011 and 2015. A total of 525 eligible infants were classified into two groups: the compliant group (n = 360), who attended clinics from 18 to 24 months, and the non-compliant group (n = 165), who were lost to FU before 18 months. Results: The non-compliant group was more likely to have higher usage rate of assisted reproductive technology (p = 0.023), GA (p &lt; 0.001), weight (p &lt; 0.001), height (p &lt; 0.001), and head circumference (p &lt; 0.001) at birth. The sibling number was higher in the non-compliant group (p = 0.011). Moreover, the non-compliant group demonstrated higher Apgar scores at 1 min and 5 min (p = 0.002 and p = 0.031, respectively). The compliant group was more likely to live in metropolitan or larger cities with a borderline significance (p = 0.056). Furthermore, the non-compliant group was less likely to suffer from respiratory distress syndrome (p &lt; 0.001), patent ductus arteriosus (p = 0.002), retinopathy of prematurity (p = 0.007), necrotizing enterocolitis (p = 0.019), and bronchopulmonary dysplasia (p &lt; 0.001). Moreover, it demonstrated lower postmenstrual age at discharge (p = 0.005) and a shorter length of stay in the NICU (p &lt; 0.001). The compliance with FU appointment varied with the assigned doctor (p &lt; 0.001). The multivariate regression analysis mentioned that the birth weight (OR = 0.903), residence in metropolitan or larger cities (OR = 1.495), and an experience of magnetic resonance imaging (OR = 1.920) were associated with compliance. The compliance to FU appointments was different according to the assigned doctor at admission (OR = 0.357). Conclusion: The birth weight, residence in metropolitan or larger cities, an experience of MRI, and the assigned doctors were associated with compliance to FU at a corrected age of 18–24 months.N

    Hysteresis in price efficiency and the economics of slow-moving capital

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    Will arbitrage capital flow into markets experiencing shocks, mitigating adverse effects on price efficiency? Not necessarily. In a dynamic model with privately informed capital-constrained arbitrageurs, price efficiency plays a dual role, determining both the profitability of new arbitrage and the ability to close existing positions profitably. An adverse shock to efficiency lengthens arbitrage duration, effectively reducing the amount of arbitrage capital available for new positions. If this falls below a critical mass, arbitrage capital flows out, amplifying the impact on price efficiency. This creates endogenous regimes: temporary shocks can trigger “hysteresis,” a persistent shift in price efficiency

    Noninvasive Neurally Adjusted Ventilation in Postextubation Stabilization of Preterm Infants: A Randomized Controlled Study

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    Objective To compare the effects of noninvasive neurally adjusted ventilatory assist (NIV-NAVA) to nasal continuous positive airway pressure (NCPAP) in achieving successful extubation in preterm infants. Study design This prospective, single-center, randomized controlled trial enrolled preterm infants born at &lt;30 weeks of gestation who received invasive ventilation. Participants were assigned at random to either NIV-NAVA or NCPAP after their first extubation from invasive ventilation. The primary outcome of the study was extubation failure within 72 hours of extubation. Electrical activity of the diaphragm (Edi) values were collected before extubation and at 1, 4, 12, and 24 hours after extubation. Results A total of 78 infants were enrolled, including 35 infants in the NIV-NAVA group and 35 infants in the NCPAP group. Extubation failure within 72 hours of extubation was higher in the NCPAP group than in the NIV-NAVA group (28.6% vs 8.6%; P = .031). The duration of respiratory support and incidence of severe bronchopulmonary dysplasia were similar in the 2 groups. Peak and swing Edi values were comparable before and at 1 hour after extubation, but values at 4, 12, and 24 hours after extubation were lower in the NIV-NAVA group compared with the NCPAP group. Conclusions In the present trial, NIV-NAVA was more effective than NCPAP in preventing extubation failure in preterm infants.N

    Effect of selenium-free parenteral nutrition on serum selenium of neonates and infants maintained on long-term parenteral nutrition

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    © 2021 American Society for Parenteral and Enteral Nutrition.Background: The risk of selenium deficiency increases for infants receiving long-term parenteral nutrition (PN). This study analyzed selenium deficiency in neonates and infants requiring long-term PN and evaluated the effect of intravenous (IV) selenium provision. Methods: This study was a retrospective study of neonates and infants who were admitted to a neonatal intensive care unit from January 2010 to December 2019, received PN for ≥2 weeks, and had their serum selenium concentration measured. Patients were divided into two groups, depending on their serum selenium concentration, a deficient group (n = 55) and a nondeficient group (n = 47). Results: Of the study participants, 53.9% (55 of 102) were deficient in selenium. No difference in demographic and clinical characteristics existed except bronchopulmonary dysplasia. A subgroup analysis was performed for patients (n = 29). The average dose of IV selenium administered to patients was 2.7 ± 1.0 mcg/kg/day. The average initial serum selenium concentration was 36.5 ± 18.0 mcg/L, and the serum concentration significantly increased to 52.5 ± 19.1 mcg/L after IV selenium administration (P &lt;.001). The correlation between the average IV selenium dose and the change in serum selenium concentrations was statistically significant (r =.423; P =.022). Conclusion: Selenium deficiency is common in neonates and infants receiving long-term PN. Serum selenium concentration increased proportionally as the IV selenium dose increased. Therefore, it is recommended to supply a proper dose of IV selenium depending on the degree of selenium deficiency.N

    Java EE and Spring Platform Comparison in Web Application Development

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    Java EE un Spring ir populārākās Java tīmekļa lietotņu izstrādes platformas. Vēsturiski Java EE platformas sākotnējās versijas sarežģītā izstrādes procesa un resursu patēriņa dēļ izstrādātāju vidū iemantoja "smagsvara" platformas slavu. Kā alternatīva "vieglā svara" platforma tika radīta Spring platforma. Laika gaitā Java EE tika uzlabota, un platformas jaunākajās versijās izstrādes procesa sarežģītība ir mazinājusies. Darbā tiek apskatītas Java EE 6 un Spring 3 platformu piedāvātās iespējas un analizēta to funkcionalitāte. Izmantojot autora izstrādātas lietotnes, tiek testēta un analizēta platformu veiktspēja. Noslēgumā tiek doti ieteikumi platformas izvēlē atkarībā no realizējamā projekta specifikas.Java EE and Spring are most popular Java web application platforms. Early versions of Java EE platform had complicated development process and high resource usage so in developer community it was called "heavy-weight". Spring platform emerged as an alternative "light-weight" platform. Later Java EE was updated and development complexity was decreased. Paper describes features of Java EE 6 and Spring 3 platform and analyses platform functionality. Performance of both platforms is tested using applications developed by author. In conclusion author gives recommendations for platform choice depending on project characteristics

    Positron source for FCC-ee

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    International audienceThe FCC-ee is a high-luminosity, high-precision circular collider to be constructed in a new 100 km tunnel in the Geneva area. The physics case is well established and the FCC-ee operation is foreseen at 91 GeV (Z-pole), 160 GeV (W pair production threshold), 240 GeV (Higgs resonance) and 365 GeV (ttˉt \bar{t} threshold). Due to the large 6D production emittance and important thermal load in the production target, the positron injector, in particular the positron source, is one of the key elements of the FCC-ee, requiring special attention. To ensure high reliability of the positron source, conventional and hybrid targets are currently under study. The final choice of the positron target will be made based on the estimated performances. In this framework, we present a preliminary design of the FCC-ee positron source, with detailed simulation studies of positron production, capture and primary acceleration
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