197,916 research outputs found
Absence of the lactase-persistence-associated allele in early Neolithic Europeans
No full textLactase persistence (LP), the dominant Mendelian trait conferring the ability to digest the milk sugar lactose in adults, has risen to high frequency in central and northern Europeans in the last 20,000 years. This trait is likely to have conferred a selective advantage in individuals who consume appreciable amounts of unfermented milk. Some have argued for the ‘‘culture-historical hypothesis,’’whereby LP alleles were rare until the advent of dairying early in the Neolithic but then rose rapidly in frequency under natural selection. Others favor the ‘‘reverse cause hypothesis,’’ whereby dairying was adopted in populations with preadaptive high LP allele frequencies. Analysis based on the conservation of lactase gene haplotypes indicates a recent origin and high selection coefficients for LP, although it has not been possible to say whether early Neolithic European populations were lactase persistent at appreciable frequencies. We developed a stepwise strategy for obtaining reliable nuclear ancient DNA from ancient skeletons, based on (i) the selection of skeletons from archaeological sites that showed excellent biomolecular preservation, (ii) obtaining highly reproducible human mitochondrial DNA sequences, and (iii) reliable short tandem repeat (STR) genotypes from the same specimens. By applying this experimental strategy, we have obtained high-confidence LP-associated genotypes from eight Neolithic and one Mesolithic human remains, using a range of strict criteria for ancient DNA work. We did not observe the allele most commonly associated with LP in Europeans, thus providing evidence for the culture-historical hypothesis, and indicating that LP was rare in early European farmers.J. Burger, M. Kirchner, B. Bramanti, W. Haak and M. G. Thoma
”Cultuurbarbaren, welkom!” Het verheffingsdiscours in het tv-programma Cultuurshake
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Romein (J. M.), Haak (J.), Apparaat voor de studie der geschiedenis, édit. revue par J. G. F. Hasekamp
No full textPaquet Jacques. Romein (J. M.), Haak (J.), Apparaat voor de studie der geschiedenis, édit. revue par J. G. F. Hasekamp. In: Revue belge de philologie et d'histoire, tome 55, fasc. 1, 1977. Antiquité — Oudheid. pp. 312-314
Romein (J. M.), Haak (J.), Apparaat voor de studie der geschiedenis, édit. revue par J. G. F. Hasekamp
No full textPaquet Jacques. Romein (J. M.), Haak (J.), Apparaat voor de studie der geschiedenis, édit. revue par J. G. F. Hasekamp. In: Revue belge de philologie et d'histoire, tome 55, fasc. 1, 1977. Antiquité — Oudheid. pp. 312-314
Eén pot nat of niet? Distincties in de Nederlandstalige muziek
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VIVO2016-Presentation-HaakHerbertMichalek.pptx
No full textPresentation at VIVO2016 entitled "Using
VIVO and Other Tools to Achieve a Strategic Vision at Texas A&M”. Authors are Bruce
Herbert, Texas A&M, Laurel Haak, ORCID,
and Andrea
Michalek, Plum Analytics.</p
Genetic discontinuity between local hunter-gatherers and central Europe's first farmers
No full textAfter the domestication of animals and crops in the Near East some 11,000 years ago, farming had reached much of central Europe by 7500 years before the present. The extent to which these early European farmers were immigrants or descendants of resident hunter-gatherers who had adopted farming has been widely debated. We compared new mitochondrial DNA (mtDNA) sequences from late European hunter-gatherer skeletons with those from early farmers and from modern Europeans. We find large genetic differences between all three groups that cannot be explained by population continuity alone. Most (82%) of the ancient hunter-gatherers share mtDNA types that are relatively rare in central Europeans today. Together, these analyses provide persuasive evidence that the first farmers were not the descendants of local hunter-gatherers but immigrated into central Europe at the onset of the Neolithic.B. Bramanti, M. G. Thomas, W. Haak, M. Unterlaender, P. Jores, K. Tambets, I. Antanaitis-Jacobs, M. N. Haidle, R. Jankauskas, C.-J. Kind, F. Lueth, T. Terberger, J. Hiller, S. Matsumura, P. Forster and J. Burge
Título: Pars prima rationis medendi in nosocomio practico Vindobonensi
No full textSign.: *\p4\s, A-L\p8\s, M\p7\sError de pag. en última pPort. con viñeta xi
High Quality de Novo Transcriptome Assembly of Croton tiglium
No full textHaak M, Vinke S, Keller W, et al. High Quality de Novo Transcriptome Assembly of Croton tiglium. Frontiers in Molecular Biosciences. 2018;5: 62
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