103 research outputs found
Low-cost uni-directional PFC for 3-phase systems
No full textPower consumed by any equipment connected to the grid must be regulated to facilitate the reliable and efficient operation of the grid and for smooth equipment operation of other consumers. Power factor is one of the major power quality measurement tool. All the electrical equipment connected to the grid must comply with the power factor limits as specified under various standards. This thesis aims at the development of a cost-effective power factor correction converter for a motor drive with a power range up to 10 kW, which is also robust for line and load transients.Electrical Engineerin
American Sign Language (ASL) Fingerspelling dataset for Myo Sensor
No full textThis is the dataset used in the following publication. Please cite this publication if use this dataset:
This work was published on the 2017 ACM IUI .
@inproceedings{paudyal2016sceptre,
title={Sceptre: a pervasive, non-invasive, and programmable gesture recognition technology},
author={Paudyal, Prajwal and Banerjee, Ayan and Gupta, Sandeep KS},
booktitle={Proceedings of the 21st International Conference on Intelligent User Interfaces},
pages={282--293},
year={2016},
organization={ACM}
}
@inproceedings{paudyal2017dyfav,
title={Dyfav: Dynamic feature selection and voting for real-time recognition of fingerspelled alphabet using wearables},
author={Paudyal, Prajwal and Lee, Junghyo and Banerjee, Ayan and Gupta, Sandeep KS},
booktitle={Proceedings of the 22nd International Conference on Intelligent User Interfaces},
pages={457--467},
year={2017},
organization={ACM}
}
9 users wore the Myo Armband and data was collected for 5s. for each letter of the alphabet. The first 8 columns contain data for the 8 EMG pods, the next 3 are for Accelerometer, the next 3 are for Gyroscope and the final 3are for Orientation (Roll, Pitch and Yaw
Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.
No full textTranslation termination requires eRF1 and eRF3 for polypeptide-and tRNA-release on stop codons. Additionally, Dbp5/DDX19 and Rli1/ABCE1 are required; however, their function in this process is currently unknown. Using a combination of in vivo and in vitro experiments, we show that they regulate a stepwise assembly of the termination complex. Rli1 and eRF3-GDP associate with the ribosome first. Subsequently, Dbp5-ATP delivers eRF1 to the stop codon and in this way prevents a premature access of eRF3. Dbp5 dissociates upon placing eRF1 through ATP-hydrolysis. This in turn enables eRF1 to contact eRF3, as the binding of Dbp5 and eRF3 to eRF1 is mutually exclusive. Defects in the Dbp5-guided eRF1 delivery lead to premature contact and premature dissociation of eRF1 and eRF3 from the ribosome and to subsequent stop codon readthrough. Thus, the stepwise Dbp5-controlled termination complex assembly is essential for regular translation termination events. Our data furthermore suggest a possible role of Dbp5/DDX19 in alternative translation termination events, such as during stress response or in developmental processes, which classifies the helicase as a potential drug target for nonsense suppression therapy to treat cancer and neurodegenerative diseases
Effect of the COVID-19 pandemic response on intrapartum care, stillbirth, and neonatal mortality outcomes in Nepal: a prospective observational study
No full textBACKGROUND: The COVID-19 pandemic response is affecting maternal and neonatal health services all over the world. We aimed to assess the number of institutional births, their outcomes (institutional stillbirth and neonatal mortality rate), and quality of intrapartum care before and during the national COVID-19 lockdown in Nepal. METHODS: In this prospective observational study, we collected participant-level data for pregnant women enrolled in the SUSTAIN and REFINE studies between Jan 1 and May 30, 2020, from nine hospitals in Nepal. This period included 12·5 weeks before the national lockdown and 9·5 weeks during the lockdown. Women were eligible for inclusion if they had a gestational age of 22 weeks or more, a fetal heart sound at time of admission, and consented to inclusion. Women who had multiple births and their babies were excluded. We collected information on demographic and obstetric characteristics via extraction from case notes and health worker performance via direct observation by independent clinical researchers. We used regression analyses to assess changes in the number of institutional births, quality of care, and mortality before lockdown versus during lockdown. FINDINGS: Of 22 907 eligible women, 21 763 women were enrolled and 20 354 gave birth, and health worker performance was recorded for 10 543 births. From the beginning to the end of the study period, the mean weekly number of births decreased from 1261·1 births (SE 66·1) before lockdown to 651·4 births (49·9) during lockdown-a reduction of 52·4%. The institutional stillbirth rate increased from 14 per 1000 total births before lockdown to 21 per 1000 total births during lockdown (p=0·0002), and institutional neonatal mortality increased from 13 per 1000 livebirths to 40 per 1000 livebirths (p=0·0022). In terms of quality of care, intrapartum fetal heart rate monitoring decreased by 13·4% (-15·4 to -11·3; p<0·0001), and breastfeeding within 1 h of birth decreased by 3·5% (-4·6 to -2·6; p=0·0032). The immediate newborn care practice of placing the baby skin-to-skin with their mother increased by 13·2% (12·1 to 14·5; p<0·0001), and health workers' hand hygiene practices during childbirth increased by 12·9% (11·8 to 13·9) during lockdown (p<0·0001). INTERPRETATION: Institutional childbirth reduced by more than half during lockdown, with increases in institutional stillbirth rate and neonatal mortality, and decreases in quality of care. Some behaviours improved, notably hand hygiene and keeping the baby skin-to-skin with their mother. An urgent need exists to protect access to high quality intrapartum care and prevent excess deaths for the most vulnerable health system users during this pandemic period. FUNDING: Grand Challenges Canada
Dynamics of ribosomes and release factors during translation termination in E. coli
No full textRelease factors RF1 and RF2 promote hydrolysis of peptidyl-tRNA during translation termination. The GTPase RF3 promotes recycling of RF1 and RF2. Using single molecule FRET and biochemical assays, we show that ribosome termination complexes that carry two factors, RF1–RF3 or RF2–RF3, are dynamic and fluctuate between non-rotated and rotated states, whereas each factor alone has its distinct signature on ribosome dynamics and conformation. Dissociation of RF1 depends on peptide release and the presence of RF3, whereas RF2 can dissociate spontaneously. RF3 binds in the GTP-bound state and can rapidly dissociate without GTP hydrolysis from termination complex carrying RF1. In the absence of RF1, RF3 is stalled on ribosomes if GTP hydrolysis is blocked. Our data suggest how the assembly of the ribosome–RF1–RF3–GTP complex, peptide release, and ribosome fluctuations promote termination of protein synthesis and recycling of the release factors.</jats:p
Conducting Polymer Transistors Making Use of Activated Carbon Gate Electrodes
No full textThe characteristics of the gate electrode
have significant effects on the behavior of organic electrochemical
transistors (OECTs), which are intensively investigated for applications
in the booming field of organic bioelectronics. In this work, high
specific surface area activated carbon (AC) was used as gate electrode
material in OECTs based on the conducting polymer poly(3,4-ethylenedioxythiophene)
(PEDOT) doped with poly(styrenesulfonate) (PSS). We found that the
high specific capacitance of the AC gate electrodes leads to high
drain-source current modulation in OECTs, while their intrinsic quasi-reference
characteristics make unnecessary the presence of an additional reference
electrode to monitor the OECT channel potential
K2-260 b: A hot Jupiter transiting an F star, and K2-261 b: A warm Saturn around a bright G star
No full textWe present the discovery and confirmation of two new transiting giant planets from the Kepler extended mission K2. K2-260 b is a hot Jupiter transiting a V = 12.7 F6V star in K2 Field 13, with a mass and radius of M = 1.39-0.06+0.05M⊙and R = 1.69 \ub1 0.03 R. The planet has an orbital period of P = 2.627 d, and a mass and radius of MP= 1.42-0.32+0.31MJand RP= 1.552-0.057+0.048RJ. This is the first K2 hot Jupiter with a detected secondary eclipse in the Kepler bandpass, with a depth of 71 \ub1 15 ppm, which we use to estimate a geometric albedo of Ag~ 0.2. We also detected a candidate stellar companion at 0.6 arcsec from K2-260; we find that it is very likely physically associated with the system, in which case it would be an M5-6V star at a projected separation of ~400 au. K2-261 b is a warm Saturn transiting a bright (V = 10.5) G7IV/V star in K2 Field 14. The host star is a metal rich ([Fe/H] = 0.36 \ub1 0.06), mildly evolved 1.10-0.02+0.01M⊙star with R = 1.65 \ub1 0.04 R. Thanks to its location near the main-sequence turn-off, we can measure a relatively precise age of 8.8-0.3+0.4Gyr. The planet has P = 11.633 d, MP= 0.223 \ub1 0.031 MJ, and RP= 0.850-0.022+0.026RJ, and its orbit is eccentric (e = 0.39 \ub1 0.15). Its brightness and relatively large transit depth make this one of the best-known warm Saturns for follow-up observations to further characterize the planetary system
Streamlining Cross-Organizational Aircraft Development: Results from the AGILE Project
No full textThe research and innovation AGILE project developed the next generation of aircraft Multidisciplinary Design and Optimization processes, which target significant reductions in aircraft development costs and time to market, leading to more cost-effective and greener aircraft solutions. The high level objective is the reduction of the lead time of 40% with respect to the current state-of-the-art. 19 industry, research and academia partners from Europe, Canada and Russia developed solutions to cope with the challenges of collaborative design and optimization of complex products. In order to accelerate the deployment of large-scale, collaborative multidisciplinary design and optimization (MDO), a novel methodology, the so-called AGILE Paradigm, has been developed. Furthermore, the AGILE project has developed and released a set of open technologies enabling the implementation of the AGILE Paradigm approach. The collection of all the technologies constitutes AGILE Framework, which has been deployed for the design and the optimization of multiple aircraft configurations. This paper focuses on the application of the AGILE Paradigm on seven novel aircraft configurations, proving the achievement of the project’s objectives.</p
A pulsar in a binary with a compact object in the mass gap between neutron stars and black holes
No full textAmong the compact objects observed in gravitational wave merger events a fewhave masses in the gap between the most massive neutron stars (NSs) and leastmassive black holes (BHs) known. Their nature and the formation of theirmerging binaries are not well understood. We report on pulsar timingobservations using the Karoo Array Telescope (MeerKAT) of PSR J0514-4002E, aneccentric binary millisecond pulsar in the globular cluster NGC 1851 with atotal binary mass of solar masses. The companion to thepulsar is a compact object and its mass (between and solarmasses, 95% confidence interval) is in the mass gap, so it either is a verymassive NS or a low-mass BH. We propose the companion was formed by a mergerbetween two earlier NSs.<br
Standardization of Dooshivishahari Agada through HPTLC
No full textAyurveda medicines are a time-tested and valuable resource for healing, even today, globally. Hence the quality control standards for the Ayurvedic formulations is the need of time because of commercialization. Despite the availability of modern equipment and techniques, not all Ayurvedic formulations have been standardized as per modern day protocol. Dooshivishari agada (DVA), a herbo-mineral preparation; mentioned in the text of Asthangha hrudaya in the context of treatment of poisoning, specifically for dooshivisha (cumulative poison). High-performance thin-layer chromatography (HPTLC) is a validated analytical tool for qualitative and quantitative analysis of chromatographic information. In this present study, an effort has been made to standardize DVA through HPTLC. HPTLC photo documentation of DVA showed 8, 11, and 10 spots under short UV, long UV, and under white light after derivatization respectively. Densitometric scan at 254 nm revealed 3 high peaks corresponding to 3 different compounds in the ethanol extract, compounds, at 366 nm and 620 nm there were three high peaks. These Physico-chemical constants, TLC photo documentation, the unique Rf values, and densitogram obtained at different wavelengths can be used as a fingerprint to identify DVA
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