170,332 research outputs found
Book discussion on 'The democracy project,' Apr 5, 2013
No full textDavid Graeber talked about his book, The Democracy Project: A History, A Crisis, A Movement, in which he argues that America’s political system is only responsive to the wealthy and has disenfranchised the remainder of the population. The author argued that the country’s understandings of democracy must be redefined and focused on inclusion and a greater engagement by the majority of the population. David Graeber spoke with Thomas Frank, author of What’s the Matter with Kansas, at the Martin Luther King, Jr. Memorial Library in Washington, D.C
In Memoriam: David Graeber (1961-2020)
No full textTo our shock, David Graeber passed away on 2 September. In this piece Charles Stewart reflects on and celebrates David’s recent work
Beyond Zuccotti Park: freedom of assembly and the occupation of public space edited by Ron Shiffman, Rick Bell, Lance Jay Brown and Lynne Elizabeth Oakland, CA: New Village Press, 2012, xxii + 410 pp, £12.84 paperback ISBN 978-1-61332-009-9
No full textMulticystic Interstitial Lung Disease Due to a Novel Biallelic C-C Chemokine Receptor Type 2 Variant
No full textObjective: We are presenting two individuals with biallelic C-C chemokine receptor type 2 (CCR2) deficiency carrying the novel c.644C>T p.L215P variant, who presented with chronic respiratory symptoms during infancy and developed multiple diffuse cystic lesions during childhood. Methods: The patients were diagnosed by means of whole exome sequencing and functional validation of the variant was performed in primary patient cells. Results: While size and extent of the cysts were stable over years, progressive lung function decline was noted in adolescence and adulthood respectively. The CCR2 p.L215P variant was found to be loss-of-expression and patient monocytes displayed a migration defect upon stimulation with the CCR2 ligand C-C motif ligand 2 (CCL2). Conclusion: With a follow-up of up to 25 years, this report expands our understanding of lung disease in CCR2 deficiency and offers another monogenic cause of cystic lung disease. Early genetic diagnosis of affected individuals might allow potentially curative treatment by haematopoietic stem cell transplantation
About Bullshit Jobs, Tribute to David Graeber. A podcast in three episodes: A podcast in three episodes.
No full textManifet, C. 2022. A propos des Jobs à la Con, Hommage à David Graeber, Une émission sonore en trois épisodes (Épisode 1(27mn), Épisode 2 (23mn), Épisode 3 (27mn), [https://www.canal-u.tv/chaines/ut2j/a-propos-des-jobs-ala-con-hommage-a-david-graeber-cala-con-hommage-a-david-graeber-]“David Graeber died suddenly on September 2, 2020. He was 59 years old. This podcast in three episodes (27 minutes, 23mn, and 27mn) aims to ward off this brutal death, by discussing his work, Bullshit Jobs, in French ‘Jobs à la Con’ (JAC), because it is a beautiful work of black humor! In this book, David Graeber argues that many of us have jobs that are inconsistent, useless, and even toxic to others and to ourselves. And, if our jobs are not bullshit jobs, they are still earned by bullshitization, that is to say that part of our tasks are bullshit jobs, unproductive, useless, even toxic . Bullshitization also evokes a growing phenomenon. Behind the subversive statement, the anthropologist carries a message of hope regarding the humanist rebuilding of our societies. He defends the interest of a universal income which would make it possible to disconnect work from remuneration and allow everyone to work less, to share work better, to gain freed up time for everyone, to think about what is really useful to produce in a society that would be more egalitarian and in accordance with its ecosystem. In this book, David Graeber puts us to the test: what if we had bullshit jobs? Are we able to laugh with him and laugh at ourselves? Are we able to consider recasting the rules of the social game? Let’s try: let’s listen to David Graeber [Christelle Manifet].” Episode 1: Presented here are the major questions that the anthropologist asked to identify his subject and objectify it in support of methods that are those of the social sciences: what are the generic attributes of Bullshit jobs? What are the external forms through which they manifest themselves? David Graeber distinguishes 5 main types of Bullshit Jobs.In the second episode and in support of the typology developed by the author, it is a question of asking ourselves if we are concerned: do we, ourselves, have Bullshit Jobs?The third and final episode is driven by the question of why? Why do Bullshit Jobs exist and proliferate? What is David Graeber's explanatory theory?Keywords: Anthropology -- Methodology; Professions; Value of work; Utility (economy); Labor Value, Theory of ; Social recognition; Job satisfaction; Personal -- Motivation; Sociology of workUne émission sonore en trois épisodes (Épisode 1(27mn), Épisode 2 (23mn), Épisode 3 (27mn). Pour écouter, c'est ici : https://www.canal-u.tv/chaines/ut2j/a-propos-des-jobs-ala-con-hommage-a-david-graeber-christelle-manifet Présentation « David Graeber est décédé brutalement le 2 septembre 2020. Il avait 59 ans. Cette émission vise à conjurer cette mort brutale, en traitant de son ouvrage, Bullshit Jobs, en français 'Jobs à la Con', parce que c'est une belle oeuvre d'humour noir
About Bullshit Jobs, Tribute to David Graeber. A podcast in three episodes: A podcast in three episodes.
No full textManifet, C. 2022. A propos des Jobs à la Con, Hommage à David Graeber, Une émission sonore en trois épisodes (Épisode 1(27mn), Épisode 2 (23mn), Épisode 3 (27mn), [https://www.canal-u.tv/chaines/ut2j/a-propos-des-jobs-ala-con-hommage-a-david-graeber-cala-con-hommage-a-david-graeber-]“David Graeber died suddenly on September 2, 2020. He was 59 years old. This podcast in three episodes (27 minutes, 23mn, and 27mn) aims to ward off this brutal death, by discussing his work, Bullshit Jobs, in French ‘Jobs à la Con’ (JAC), because it is a beautiful work of black humor! In this book, David Graeber argues that many of us have jobs that are inconsistent, useless, and even toxic to others and to ourselves. And, if our jobs are not bullshit jobs, they are still earned by bullshitization, that is to say that part of our tasks are bullshit jobs, unproductive, useless, even toxic . Bullshitization also evokes a growing phenomenon. Behind the subversive statement, the anthropologist carries a message of hope regarding the humanist rebuilding of our societies. He defends the interest of a universal income which would make it possible to disconnect work from remuneration and allow everyone to work less, to share work better, to gain freed up time for everyone, to think about what is really useful to produce in a society that would be more egalitarian and in accordance with its ecosystem. In this book, David Graeber puts us to the test: what if we had bullshit jobs? Are we able to laugh with him and laugh at ourselves? Are we able to consider recasting the rules of the social game? Let’s try: let’s listen to David Graeber [Christelle Manifet].” Episode 1: Presented here are the major questions that the anthropologist asked to identify his subject and objectify it in support of methods that are those of the social sciences: what are the generic attributes of Bullshit jobs? What are the external forms through which they manifest themselves? David Graeber distinguishes 5 main types of Bullshit Jobs.In the second episode and in support of the typology developed by the author, it is a question of asking ourselves if we are concerned: do we, ourselves, have Bullshit Jobs?The third and final episode is driven by the question of why? Why do Bullshit Jobs exist and proliferate? What is David Graeber's explanatory theory?Keywords: Anthropology -- Methodology; Professions; Value of work; Utility (economy); Labor Value, Theory of ; Social recognition; Job satisfaction; Personal -- Motivation; Sociology of workUne émission sonore en trois épisodes (Épisode 1(27mn), Épisode 2 (23mn), Épisode 3 (27mn). Pour écouter, c'est ici : https://www.canal-u.tv/chaines/ut2j/a-propos-des-jobs-ala-con-hommage-a-david-graeber-christelle-manifet Présentation « David Graeber est décédé brutalement le 2 septembre 2020. Il avait 59 ans. Cette émission vise à conjurer cette mort brutale, en traitant de son ouvrage, Bullshit Jobs, en français 'Jobs à la Con', parce que c'est une belle oeuvre d'humour noir
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The Potential for Genetically Altered Microglia to Influence Glioma Treatment
No full textDiffuse and unstoppable infiltration of brain and spinal cord tissue by neoplastic glial cells is the single most important therapeutic problem posed by the common glioma group of tumors: astrocytoma, oligoastrocytoma, oligodendroglioma, their malignant variants and glioblastoma. These neoplasms account for more than two thirds of all malignant central nervous system tumors. However, most glioma research focuses on an examination of the tumor cells rather than on host-specific, tumor micro-environmental cells and factors. This can explain why existing diffuse glioma therapies fail and why these tumors have remained incurable. Thus, there is a great need for innovation. We describe a novel strategy for the development of a more effective treatment of diffuse glioma. Our approach centers on gaining control over the behavior of the microglia, the defense cells of the CNS, which are manipulated by malignant glioma and support its growth. Armoring microglia against the influences from glioma is one of our research goals. We further discuss how microglia precursors may be genetically enhanced to track down infiltrating glioma cells.NHMRC [570398
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