6,763 research outputs found
Father Andrew Mullen 1790-1818: a study in early nineteenth century spirituality
No full textThis thesis is laid out in three parts: Part I. The life and death of Andrew Mullen. The life is based, to a large extent, on a long letter to his mother, Catherine Mullen, dated 7 January 1810. The letter gives a definite insight into his spirituality based on his membership of the Archconfraternity of the Blessed Sacrament. There is a hint that he had a premonition of an early death. Part II. The burial of Andrew Mullen and the immediate cult to him This is based on documentary evidence. Part III. Most of this part is a catalogue of testimonies taken from 1993 onwards. Then there is the conclusion on the popular devotion to Andrew Mullen stressing the theological aspect of the subject. In the course of writing the thesis it was decided to separate the documentary evidence from the oral tradition. This was advantageous in developing the thesis, and the documents provided a secure basis for the oral tradition. Two pieces of information were found in March 1997. They are death notices: 2 January 1819, The Leinster Journal and 7 January 1819, The Car low Morning Post. There is a slight discrepancy between the two on the date of his death. Also this discrepancy shows a slight difference from the date of the tombstone
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Bíblia da farmacologia e os antidepressivos: análise do livro texto de Goodman e Gilman - as bases farmacológicas da terapêutica de 1941 a 2006
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em Ciências Humanas, Florianópolis, 2010Se a dor e o sofrimento são inerentes à condição humana, a forma como lidamos com essas condições tem sido diversa em diferentes contextos socioculturais e históricos. O uso de medicamentos chamados antidepressivos para tratar situações relacionadas à tristeza com sintomas que caracterizam sofrimento físico e psíquico é uma estratégia terapêutica na biomedicina desde o surgimento dessas drogas. O uso abusivo desses medicamentos tem sido questionado. Estão sendo levantadas questões como a redução do sofrimento a aspectos puramente biológicos, excluindo desse modo uma abordagem compreensiva de problemas de saúde que não estariam restritos apenas à intervenção em alterações bioquímicas endógenas. O objetivo deste estudo é conhecer o modo como a armacologia e os medicamentos antidepressivos foram apresentados a profissionais e estudantes de medicina ao longo da segunda metade do século XX e analisar quais as estratégias argumentativas utilizadas para justificar o uso dessas drogas a partir do discurso científico. Para atingir esse objetivo, foram analisadas as diferentes edições do principal livro-texto de farmacologia, utilizado no século XX em diferentes países como modo de divulgação do conhecimento científico: o livro Goodman e Gilman: as bases farmacológicas da terapêutica, conhecido como a #bíblia da farmacologia#. Inicialmente foi feita uma abordagem dos quadros relacionados à depressão, categoria médica que deu origem aos #antidepressivos#, a partir da melancolia nos primórdios da biomedicina. Foram abordados textos de médicos como Pinel, Esquirol e Dagonet, do início do período em que #nasce# a medicina moderna, a segunda metade do século XVIII e o século XIX, com uma breve passagem pelo início do século XX, quando surgem os trabalhos de autores como Kraepelin e Freud, trazendo a questão da imprecisão dos diagnósticos médicos na área do sofrimento psíquico. Os livros-texto de Goodman e Gilman, desde sua 1ª edição (em 1941) até a 11ª edição (em 2006), foram analisados a partir de uma perspectiva histórica, utilizando como estratégia metodológica a análise de discurso. Buscou-se identificar questões que influenciaram tanto o desenvolvimento da farmacologia quanto o desenvolvimento dos medicamentos chamados antidepressivos. A partir da análise dos textos, pode-se concluir que: existe dificuldade para especificar as situações em que os antidepressivos são utilizados, por causa das incertezas do iagnóstico clínico; as tentativas realizadas a partir do conhecimento farmacológico para estabelecer uma relação causal entre diferentes substâncias endógenas e os sintomas clínicos não são comprovadas até a última edição do livro-texto; os avanços na área do conhecimento técnico-científico no sentido de controle dos sintomas têm obtido um êxito relativo (pelo menos em curto prazo, como, por exemplo, no controle dos efeitos colaterais e na facilidade de administração dos medicamentos), sendo esse um aspecto que tem dado força à expansão do uso dos antidepressivos; esses medicamentos, inicialmente utilizados para tratar sintomas depressivos (no sentido de pouca ou baixa atividade corporal) vêm tendo seu uso ampliado progressivamente para situações que não estão relacionadas aos sintomas que inicialmente lhes deram esse nome (antidepressivos); o desenvolvimento das pesquisas em farmacologia está vinculado a saberes e práticas de outras áreas do conhecimento, que, por sua vez, determinam o desenvolvimento de medicamentos; e, por fim, a industria farmacêutica está ligada ao desenvolvimento da farmacologia desde os primórdios desta.If pain and suffering are inherent to the human condition, the manner in which we deal with such conditions has been diverse in different sociocultural and historical contexts. The use of antidepressive medication to cure conditions related to sadness, which can demonstrate symptoms characterized by physical and psychic suffering, is a biomedicinal therapeutic strategy used since the emergence of such drugs. The abuse of such medication has become highly questioned. Inquiries have surfaced in relation to the reduction of suffering to purely biological aspects, thereby excluding a comprehensive approach of health problems that would not be solely restricted to an intervention of endogenous biochemical alterations. The aim of this study is to identify how pharmacology and the antidepressant drugs were introduced to physicians and medical students in the second half of XX century and to analyze which argumentative strategies are utilized in justifying the use of such drugs via scientific discourse. In order to achieve this aim, we have analyzed the different editions of the primary textbook of pharmacology, used in various countries during the XX century as a means of disseminating scientific knowledge: Goodman and Gilman: The Pharmacological Basis of Therapeutics, the commonly recognized #bible of Pharmacology#. Initially examined are the clinical conditions related to depression, a medical category that gave origin to #antidepressants#, by means of melancholia in the early days of biomedicine. Analyzed were texts from doctors such as Pinel, Esquirol, and Dagonet from earlier periods, in which modern medicine was #born#, the second half of the XVIII century, the XIX century, and a brief passage through the beginning of the XX century, when works from such authors as Kraeplin and Freud brought forth questions regarding the imprecision of medical diagnosis in the area of psychological distress. Goodman and Gilman#s textbooks, from the first edition (in 1941) through the eleventh edition (in 2006), have been analyzed from a historical perspective, using discourse analysis as a methodological strategy. We tried to identify issues that influenced both the development of knowledge in the area of pharmacology as well as the development of such medications labeled antidepressants. From the analysis of texts, one can conclude that: difficulties exist when specifying the situations in which the antidepressants are utilized, via the uncertainties of clinical diagnosis; the attempts, from de pharmacological knowledge, to establish a causal relationship between various endogenous substances and clinical symptoms are not supported in any of the textbook editions; the advances in the field of technicalscientific knowledge in order to control the symptoms have obtained a relative amount of success (at least short-term, for example, in the control of side effects and in the ease of administering medication), this being one aspect that has given strength to the expansion of antidepressants being used; these drugs, originally used to treat depressive symptoms (in the sense of little or low body activity), have had their use extended progressively to situations that are not related to the symptoms that initially gave them that name (antidepressants); the development of research in pharmacology is linked to understandings and practices from other areas of knowledge, which in turn determine the development of such drugs as antidepressants; and finally, that the pharmaceutical industry is associated to the development of pharmacology since its inception
The Grouped Author-Topic Model for Unsupervised Entity Resolution
No full textThis paper describes a generative approach for tackling the problem of identity resolution in a completely unsupervised context with no fixed assumption regarding the true number of identities. The problem of entity resolution involves associating different references to authors (in a paper's author list, for example) with real underlying identities. The references may be written in differing forms or may have errors, and identical references may refer to different real identities. The approach taken here uses a generative model of both the abstract of a document and its list of authors to resolve identities in a corpus of documents. In the model, authors and topics are associated with latent groups. For each document, an abstract and an author list are generated conditioned on a given group. Results are presented on real-world datasets, and outperform the best performing unsupervised methods.</p
Personal Papers (MS 80-0002)
No full textInvitation from Irving M. Engel to dinner in honor of Andrew Goodman to inaugurate the 1960 Campaign of Joint Defense Appeal. A list of dinner officers and sponsors is listed on the reverse side
Well-differentiated hepatocellular neoplasm of uncertain malignant potential: proposal for a new diagnostic category
No full textTo the EditorPierre Bedossa, Alastair D. Burt, Elizabeth M. Brunt, Francesco Callea, Andrew D. Clouston, Hans-Peter Dienes, Zachary D. Goodman, Annette S.H. Gouw, Stefan G. Hubscher, Eve A. Roberts, Tania Roskams, Luigi Terracciano, Dina G. Tiniakos, Michael S. Torbenson, Ian R. Wanles
Handbook of thermoset plastics /
No full textThermosetting plastics are a distinct category of plastics whose high performance, durability and reliability at high temperatures makes them suitable for specialty applications ranging from automotive and aerospace through to electronic packaging and consumer products (your melamine kitchen worktop is a thermoset resin!). Recent developments in thermoset plastics technology and processes has broadened their use exponentially over recent years, and these developments continue: in November 2011, French scientists created a new lightweight thermoset that is as strong and stable as previous materials yet can be easily reworked and reshaped when heated which makes it unique amongst thermosets and allows for repair and recycling. The Handbook of Thermoset Plastics, now in its 3rd edition, provides a comprehensive survey of the chemical processes, manufacturing techniques and design properties of each polymer, along with their applications. Written by a team of highly experienced practitioners, the practical implications of using thermoset plastics are presented - both their strengths and weaknesses. The data and descriptions presented here enable engineers, scientists and technicians to form judgments and take action on the basis of informed analysis. The aim of the book is to help the reader to make the right decision and take the correct action - avoiding the pitfalls the authors' experience has uncovered. The new edition has been updated throughout to reflect current practice in manufacturing and processing, featuring: Case Studies to demonstrate how particular properties make different polymers suitable for different applications, as well as covering end-use and safety considerations. A new chapter on using nanoparticles to enhance thermal and mechanical properties. A new chapter describing new materials based on renewable resources (such as soy-based thermoset plastics). A new chapter covering recent developments and potential future technologies such as new catalysts for Controlled Radical Polymerization. Goodman and Dodiuk-Kenig provide a comprehensive reference guide to the chemistry, manufacturing and applications of thermosets. Updated to include recent developments in manufacturing - from biopolymers to nanocomposites. Case Studies illustrate applications of key thermoset plastics.Thermosetting plastics are a distinct category of plastics whose high performance, durability and reliability at high temperatures makes them suitable for specialty applications ranging from automotive and aerospace through to electronic packaging and consumer products (your melamine kitchen worktop is a thermoset resin!). Recent developments in thermoset plastics technology and processes has broadened their use exponentially over recent years, and these developments continue: in November 2011, French scientists created a new lightweight thermoset that is as strong and stable as previous materials yet can be easily reworked and reshaped when heated which makes it unique amongst thermosets and allows for repair and recycling. The Handbook of Thermoset Plastics, now in its 3rd edition, provides a comprehensive survey of the chemical processes, manufacturing techniques and design properties of each polymer, along with their applications. Written by a team of highly experienced practitioners, the practical implications of using thermoset plastics are presented - both their strengths and weaknesses. The data and descriptions presented here enable engineers, scientists and technicians to form judgments and take action on the basis of informed analysis. The aim of the book is to help the reader to make the right decision and take the correct action - avoiding the pitfalls the authors' experience has uncovered. The new edition has been updated throughout to reflect current practice in manufacturing and processing, featuring: Case Studies to demonstrate how particular properties make different polymers suitable for different applications, as well as covering end-use and safety considerations. A new chapter on using nanoparticles to enhance thermal and mechanical properties. A new chapter describing new materials based on renewable resources (such as soy-based thermoset plastics). A new chapter covering recent developments and potential future technologies such as new catalysts for Controlled Radical Polymerization. Goodman and Dodiuk-Kenig provide a comprehensive reference guide to the chemistry, manufacturing and applications of thermosets. Updated to include recent developments in manufacturing - from biopolymers to nanocomposites. Case Studies illustrate applications of key thermoset plastics.Includes index.Print version record.Includes bibliographical references and index.1. Introduction / Hanna Dodiuk and Sidney H. Goodman -- 2. Phenol-formaldehydes / A. Pizzi and C.C. Ibeh -- 3 Polybenzoxazine -- new generation phenolics / K.S. Santhosh Kumar and C.P. Reghunadhan Nair -- 4 Aminos / A. Pizzi and C.C. Ibeh -- 5. Furans / A. Gandini and M.N. Belgacem -- 6. Unsaturated polyesters and vinyl esters / Andreas Kandelbauer, Gianluca Tondi and Sidney H. Goodman -- 7. Allyls / Gianluca Tondi, Andreas Kandelbauer and Sidney H. Goodman -- 8. Epoxies / Witold Brostow, Sidney H. Goodman and Joshua Wahrmund -- 9 Polyurethanes / Helena Janik, Maciej Sienkiewicz and Justyna Kucinska-Lipka -- 10 High-performance polyimides and high temperature resistant polymers / Kreisler S.Y. Lau -- 11. Cyanate esters / Andreas Kandelbauer -- 12. Maleimide-based alder-enes / M. Satheesh Chandran and C.P. Reghunadhan Nair -- 13. Syntactic foams / Bibin John and C.P. Reghunadhan Nair -- 14. Silicones / Gunter Lorenz, Andreas Kandelbauer -- 15. Biobased thermosets / Ana Dotan -- 16. Nanotechnology based thermosets / Olga Shepelev, Sam Kenig and Hanna Dodiuk -- 17. Crosslinked thermoplastics / Rodney Patterson [and three others] -- 18. Processing / Andreas Kandelbauer.Elsevie
Scalar soliton quantization with generic moduli
No full textThis article is distributed under the terms of the Creative Commons
Attribution License (CC-BY 4.0), which permits any use, distribution and reproduction in
any medium, provided the original author(s) and source are credArticle funded by SCOAP3. CP is
a Royal Society Research Fellow and partly supported by the U.S. Department of Energy
under grants DOE-SC0010008, DOE-ARRA-SC0003883 and DOE-DE-SC0007897. ABR
is supported by the Mitchell Family Foundation. We would like to thank the Mitchell
Institute at Texas A&M and the NHETC at Rutgers University respectively for hospitality
during the course of this work. We would also like to acknowledge the Aspen Center
for Physics and NSF grant 1066293 for a stimulating research environment which led to
questions addressed in this paper
Engineering semiconductor quantum dots for quantitative imaging of cell motility and invasion
No full textQuantum dots (QDs) are photo-luminescent nanocrystals that possess unique optical properties such as a narrow emission range and high photo-stability, which makes them useful for a variety of biological imaging applications. In this study, QDs presenting different chemical moieties were used to quantify non-specific binding to different extracellular matrix (ECM) proteins. QDs coated with poly-maleic anhydride (PMA), which had been modified to present alkane, alkene, alkyne, PEG and carboxylic acid, carboxylic acid, and solely PEG, were incubated on poly-l-lysine, collagen, fibronectin, and gelatin coated glass coverslips. Based upon the emission intensity normalized by the quantum yield (QY), the binding of the QDs were directly compared. The QD coated substrates exhibited photoluminescent enhancement (PLE) resulting in an increased emission intensity when excited over time. Based upon this increase, a more accurate QY was calculated, allowing for proper comparison between the QDs. Different ECM proteins possessed different binding affinities to different chemical moieties. Poly-L-lysine was shown to bind well to PEG/carboxylic acid particles, but paradoxically, not as well to carboxylic acid. Collagen exhibited an affinity to the alkyne coated particles. Fibronectin showed high binding to PEG/carboxylic acid QDs, but also bound well to the alkane, alkene, and alkyne. Gelatin, like fibronectin, also showed affinity to most of the particles. Due to differences in the QY and PLE, the QDs that bound the most to each protein did not produce the most uniform and brightest substrates.
MDA-MB-231 human breast cancer cells were then seeded on gelatin substrates coated with the QDs for 24 hours. Evidence of uptake and degradation of the matrix was observed, but could not be quantified using wide-field fluorescent microscopy. As a result, confocal images were required to properly characterize the degradation.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2017-12-01The student, Andrew Zhao, accepted the attached license on 2015-12-11 at 12:16.The student, Andrew Zhao, submitted this Thesis for approval on 2015-12-11 at 12:19.This Thesis was approved for publication on 2015-12-11 at 13:52.DSpace SAF Submission Ingestion Package generated from Vireo submission #9016 on 2016-03-02 at 14:07:55Made available in DSpace on 2016-03-02T20:24:20Z (GMT). No. of bitstreams: 2
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Household accessibility to heat refuges: Residential air conditioning, public cooled space, and walkability.
No full textabstract: Access to air conditioned space is critical for protecting urban populations from the adverse effects of heat exposure. Yet there remains fairly limited knowledge of the penetration of private (home air conditioning) and distribution of public (cooling centers and commercial space) cooled space across cities. Furthermore, the deployment of government-sponsored cooling centers is likely to be inadequately informed with respect to the location of existing cooling resources (residential air conditioning and air conditioned public space), raising questions of the equitability of access to heat refuges. We explore the distribution of private and public cooling resources and access inequities at the household level in two major US urban areas: Los Angeles County, California and Maricopa County, Arizona (whose county seat is Phoenix). We evaluate the presence of in-home air conditioning and develop a walking-based accessibility measure to air conditioned public space using a combined cumulative opportunities-gravity approach. We find significant variations in the distribution of residential air conditioning across both regions which are largely attributable to building age and inter/intra-regional climate differences. There are also regional disparities in walkable access to public cooled space. At average walking speeds, we find that official cooling centers are only accessible to a small fraction of households (3% in Los Angeles, 2% in Maricopa) while a significantly higher number of households (80% in Los Angeles, 39% in Maricopa) have access to at least one other type of public cooling resource such as a library or commercial establishment. Aggregated to a neighborhood level, we find that there are areas within each region where access to cooled space (either public or private) is limited which may increase heat-related health risks.Corresponding Author:
Andrew M. Fraser
Arizona State University
[email protected]
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