102,123 research outputs found
Ueber die Bedeutung der Moose für die Wasservertheilung auf der Erdoberfläche
No full textvon Robert Gerwig. Geschrieben im Jahre 1861(Abdruck aus Försters Allgemeiner Bauzeitung, Jahrgang 1862
Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide
No full textThis work characterizes the protective effects of ANP preconditioning in ischemia-reperfusion
injury of the isolated perfused rat liver. It was of particular interest to evaluate
the influence of ANP on the mode of cell death occurring during cold ischemia and
reperfusion and to elucidate the involved signal transduction pathways.
Apoptotic cell death was mainly seen after cold liver storage, whereas necrosis was
predominant in the reperfusion period.
It could be demonstrated for the first time that preconditioning with ANP was able to
reduce both apoptotic as well as necrotic cell death. After cold ischemia, in particular
hepatocytes were protected against apoptosis. After reperfusion, protection against
necrosis comprised hepatocytes and sinusendothelial cells predominantly in the periportal
liver areas.
As target molecules for ANP action, the cGMP-dependent protein kinases did not seem to
be responsible for the conferred cytoprotection. In the liver, no expression of these
kinases could be detected and a functional connection could not be derived. In contrast,
the cAMP-dependent protein kinases were identified to promote survival. This was further
supported by the ability of ANP to directly activate cAMP-dependent protein kinases in
livers and hepatocytes.
An early transcriptional induction of HO-1 by ANP independent of cGMP could be
demonstrated. The induction of heme oxygenase-1 by ANP might not be responsible for
the observed hepatoprotection, since inhibition of HO-1 activity did not abrogate the ANP
effect. Interestingly, cell-type specific evaluation detected that induction of HO-1 in livers
by ANP is exclusively restricted to Kupffer cells.
In summary, this thesis gives new insights into the actions of the cardiovascular hormone
ANP in IRI of the rat liver. This data helps to understand the mechanisms of how ANP
mediates cytoprotection by illuminating effects and potential pathways, an important
prerequisite for a rational application in therapy.
This work was supported by the Deutsche Forschungsgemeinschaft (DFG: Ge 576/14-2
and FOR 440/1, TP2)
Projet d'un chemin de fer par le St. Gotthard : dressé à la demande du Comité du St. Gotthard
No full textNo. 1 Plan général de Lucerne et Zug à Camerlata et LocarnoNo. 2 Profil en long de Lucerne à FluelenNo. 3 Profil en long de Zug à FluelenNo. 4 Profil en long de Buonas (jonction avec la ligne Zurich - Lucerne) à FluelenNo. 5 Profil en long de Fluelen à Biasca, project direct de Goeschenen à AiroloNo. 6 Profil en long de Fluelen à Biasca, variante par HospenthalNo. 7 Profil en long de Fluelen à Biasca, variante par AbfrutNo. 8 Profil en long de Biasca à Locarno dressé par [Kaspar] WetliNo. 9 Profil en long de Bellinzona à Chiasso dressé par [Kaspar] WetliNo. 10 Plan et profil géologiques de Goeschenen à Airolo dressés d'après les meilleurs matériaux existants[No. 11] Résultats principaux des projets par Amsteg et par Attinghausen dressés par K. Wetli[No. 12] Profil en long [du] projet de Fluelen à Biasca par Attinghausen de [Kaspar] Wetli[No. 13] Profil en long [du] projet de Fluelen à Biasca par Amsteg de [Kaspar] Wetlidressé par A. Beckh et R. Gerwig ; avec une annexe renfermant le projet proposé par K. WetliHöhenmassstab des Profils No. 10: 1:50 000Bl. [12] und [13]: "Bâle, Lith. G. Wolf"Bl. gef. 33 x 22 cm, in Mapp
The protein tyrosine kinases EpsB and PtkA differentially affect biofilm formation in <em>Bacillus subtilis</em>
No full textThe Gram-positive soil bacterium Bacillus subtilis is able to choose between motile and sessile lifestyles. The sessile way of life, also referred to as biofilm, depends on the formation of an extracellular polysaccharide matrix and some extracellular proteins. Moreover, a significant portion of cells in a biofilm forms spores. The first two genes of the 15-gene operon for extracellular polysaccharide synthesis, epsA and epsB, encode a putative transmembrane modulator protein and a putative protein tyrosine kinase, respectively, with similarity to the TkmA/PtkA modulator/kinase couple. Here we show that the putative kinase EpsB is required for the formation of structured biofilms. However, an epsB mutant is still able to form biofilms. As shown previously, a ptkA mutant is also partially defective in biofilm formation, but this defect is related to spore formation in the biofilm. The absence of both kinases resulted in a complete loss of biofilm formation. Thus, EpsB and PtkA fulfill complementary functions in biofilm formation. The activity of bacterial protein tyrosine kinases depends on their interaction with modulator proteins. Our results demonstrate the specific interaction between the putative kinase EpsB and its modulator protein EpsA and suggest that EpsB activity is stimulated by its modulator EpsA.</p
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
The CERN CMS Barrel Design team: J. Andre, M.-H. Bovard, G. Duthion, J.-P.Girod, J.-P. Grillet, P. Petiot, L. Veillet, T. de Visser, G. Waurick, H. Gerwig, A. Herve.
No full textAfter 7 years of design, calculation and hard work the first barrel ring of CMS stands free in the surface hall of P5. 1200 tonnes of steel nearly 17m high and 15m in diamter. The width is 2.5 meter. The Ferris Wheel served as a jig to build up the 3-layered ring. At the end of the assembly the ring is separated from the jig by rotating the special corner pieces and then move the whole mass on air pads
Primary structure of the N-linked carbohydrate chains of calreticulin from spinach leaves
No full textCalreticulin is a multifunctional Ca2+-binding protein of the endoplasmic reticulum of most eukaryotic cells. The 56 kDa Calreticulin glycoprotein isolated from spinach (Spinacia oleracea L.) leaves was N-deglycosylated by PNGase-F digestion. The carbohydrate moiety was isolated by gel permeation chromatography and purified by high-pH anion-exchange chromatography. The fractions were investigated by 500 MHz H-1-NMR spectroscopy, in combination with monosaccharide analysis and fast-atom bombardment-mass spectrometry. The following carbohydrate structure could be established as the major component (Man(8)GlcNAc(2)):
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Heterogeneity was demonstrated by the presence of two minor components being Man(7)GlcNAc(2) lacking a terminal residue (D-1 or D-3), compared to the major component. A. cross-reactivity with an antibody against the endoplasmic reticulum retention signal HDEL was also found
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