1,721,052 research outputs found
Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation
No full textCELL BIOLOGY Correction for “MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation,” by Giulia Romano, Mario Acunzo, Michela Garofalo, Gianpiero Di Leva, Luciano Cascione, Ciro Zanca, Brad Bolon, Gerolama Condorelli, and Carlo M. Croce, which appeared in issue 41, October 9, 2012, of Proc Natl Acad Sci USA (109:16570–16575; first published September 24, 2012; 10.1073/pnas.1207917109)
Highly Homogeneous Biotinylated Carbon Nanodots: Red-Emitting Nanoheaters as Theranostic Agents toward Precision Cancer Medicine
No full textVery
recent red-emissive carbon nanodots (CDs) have shown potential
as near-infrared converting tools to produce local heat useful in
cancer theranostics. Besides, CDs seem very appealing for clinical
applications combining hyperthermia, imaging, and drug delivery in
a single platform capable of selectively targeting cancer cells. However,
CDs still suffer from dramatic dot-to-dot variability issues such
that a rational design of their structural, optical, and chemical
characteristics for medical applications has been impossible so far.
Herein, we report for the first time a simple and highly controllable
layer-by-layer synthesis of biotin-decorated CDs with monodisperse
size distribution, well established polymeric shell thickness, and
degree of surface functionalization, endowed with strong red luminescence
and the ability to convert NIR light into heat. These CDs, henceforth
named CDs-PEG-BT, consist of a carbonaceous core passivated with biotin-terminated
PEG2000 chains, which we demonstrate as active targeting
groups to recognize cancer cells. The CDs-PEG-BT are designed to efficiently
incorporate a high amount of anticancer drugs such as irinotecan (16–28%)
and to act as NIR-activated nanoheaters capable of triggering local
hyperthermia and massive drug release inside tumors, thus provoking
sudden and efficient tumor death. The potential of the irinotecan-loaded
CDs-PEG-BT (CDs-PEG-BT@IT) in fluorescence imaging was studied on
2D cultures and on complex 3D spheroids mimicking in vivo tumor architectures,
showing their capability of selectively entering cancer cells through
biotin receptors overexpressed in cell membranes. The efficient anticancer
effect of these CDs was thoroughly assessed on multicellular 3D spheroids
and patient organoids (tumor-on-a-dish preclinical models) to predict
the drug response in humans in view of personalized medicine applications.
CDs-PEG-BT@IT have a smart combination of properties, which pave the
way to their real-world use as anticancer theranostic agents for image-guided
photothermal applications
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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