327,390 research outputs found
Microdeletions and molecular genetics
No full textEducational Items on Microdeletions and molecular genetics
General resources in Genetics and/or Oncology
No full textReview on General resources in Genetics and/or Oncolog
General resources in Genetics and/or Oncology
No full textReview on General resources in Genetics and/or Oncolog
Exploring the Status of Population Genetics: The Role of Ecology
No full textThe status of population genetics has become hotly debated among biologists and philosophers of biology. Many seem to view population genetics as relatively unchanged since the Modern Synthesis and have argued that subjects such as development were left out of the Synthesis. Some have called for an extended evolutionary synthesis or for recognizing the insignificance of population genetics. Yet others such as Michael Lynch have defended population genetics, declaring "nothing in evolution makes sense except in the light of population genetics" (a twist on Dobzhansky's famous slogan that "nothing in biology makes sense except in the light of evolution"). Missing from this discussion is the use of population genetics to shed light on ecology and vice versa, beginning in the 1940s and continuing until the present day. I highlight some of that history through an overview of traditions such as ecological genetics and population biology, followed by a slightly more in-depth look at a contemporary study of the endangered California Tiger Salamander. I argue that population genetics is a powerful and useful tool that continues to be used and modified, even if it isn't required for all evolutionary explanations or doesn't incorporate all the causal factors of evolution
Correction: A Systems Genetics Approach Identifies <i>CXCL14</i>, <i>ITGAX</i>, and <i>LPCAT2</i> as Novel Aggressive Prostate Cancer Susceptibility Genes
No full text<p>Correction: A Systems Genetics Approach Identifies <i>CXCL14</i>, <i>ITGAX</i>, and <i>LPCAT2</i> as Novel Aggressive Prostate Cancer Susceptibility Genes</p
From observational to dynamic genetics
No full textTwin and family studies have shown that most traits are at least moderately heritable. But what are the implications of finding genetic influence for the design of intervention and prevention programs? For complex traits, heritability does not mean immutability, and research has shown that genetic influences can change with age, context, and in response to behavioral and drug interventions. The most significant implications for intervention will come when we move from observational genetics to investigating dynamic genetics, including genetically sensitive interventions. Future interventions should be designed to overcome genetic risk and draw upon genetic strengths by changing the environment
Importance of secondary and tertiary genepools in barley genetics and breeding: I. Cytogenetics and molecular analysis
No full textThere have been no plant breeding developments using species from the te1tiary genepool of cultivated barley for breeding or genetics since the VIIIth International Barley Genetics Symposium in 2000. Hence, the first part of this review describes progress since 2000 in developing and characterising recombinant lines derived from hybridisations between the sole species in the secondary genepool, Hordeum bulbosum L., and cultivated barley, Hordeum vulgare L. The topics discussed in part I are cytogenetics and molecular analysis of recombinant lines
Genetics in clinical practice: general practitioners' educational priorities in European countries
No full textPURPOSE: To assess how general practitioners (GPs) from European countries prioritized their genetic educational needs according to their geographic, sociodemographic, and educational characteristics. METHODS: Cross-sectional survey, random and total samples of GPs in five European countries (France, Germany, the Netherlands, Sweden, and United Kingdom), mailed questionnaires; Outcome: Genetic Educational Priority Scale (30 items; six subscores). RESULTS: A total 1168 GPs answered. Priorities differed (P < 0.001) but were consistently ranked across the countries. Previous education had a marginal effect on priorities. Women gave higher priorities than men to Genetics of Common Disorders (adjusted odds ratio [ORadj], 2.5; 95% confidence interval [CI], 1.6-3.8), Psychosocial and Counseling Issues (ORadj, 1.6; 95% CI, 1.1-2.5), and Ethical, Legal, and Public Health Issues (ORadj, 1.3; 95% CI, 1.1-1.8), but lower than men to Techniques and Innovation in Genetics (ORadj, 0.7; 95% CI, 0.5-0.9). Older physicians gave higher priorities to Basic Genetics and Congenital Malformations (ORadj, 1.5; 95% CI, 1.1-1.9), and to Techniques and Innovation in Genetics (ORadj: 1.3; 95% CI, 1.0-1.7), compared with their younger colleagues. CONCLUSIONS: Expressed genetic educational needs vary according to the countries and sociodemographics. In accordance, training could be more focused on genetics of common disorders and on how to approach genetic risk in clinical practice rather than on ethics, new technologies, or basic concepts
Correction: Imputation-Based Population Genetics Analysis of <i>Plasmodium falciparum</i> Malaria Parasites
No full textCorrection: Imputation-Based Population Genetics Analysis of Plasmodium falciparum Malaria Parasite
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