921 research outputs found
GeMo: a web-based platform for the visualization and curation of genome ancestry mosaics
No full textIn silico chromosome painting is a technique by which contributions of distinct genetic groups are represented along chromosomes of hybrid individuals. This type of analysis is used to study the mechanisms by which these individuals were formed. Such techniques are well adapted to identify genetic groups contributing to these individuals as well as hybridization events. It can also be used to follow chromosomal recombinations that occurred naturally or were generated by selective breeding. Here, we present GeMo, a novel interactive web-based and user-oriented interface to visualize in a linear-based fashion results of in silico chromosome painting. To facilitate data input generation, a script to execute analytical commands is provided and an interactive data curation mode is supported to ensure consistency of the automated procedure. GeMo contains preloaded datasets from published studies on crop domestication but can be applied to other purposes, such as breeding programs Although only applied so far on plants, GeMo can handle data from animals as well
GEmo-CLAP: Gender-Attribute-Enhanced Contrastive Language-Audio Pretraining for Accurate Speech Emotion Recognition
No full textContrastive cross-modality pretraining has recently exhibited impressive
success in diverse fields, whereas there is limited research on their merits in
speech emotion recognition (SER). In this paper, we propose GEmo-CLAP, a kind
of gender-attribute-enhanced contrastive language-audio pretraining (CLAP)
method for SER. Specifically, we first construct an effective emotion CLAP
(Emo-CLAP) for SER, using pre-trained text and audio encoders. Second, given
the significance of gender information in SER, two novel multi-task learning
based GEmo-CLAP (ML-GEmo-CLAP) and soft label based GEmo-CLAP (SL-GEmo-CLAP)
models are further proposed to incorporate gender information of speech
signals, forming more reasonable objectives. Experiments on IEMOCAP indicate
that our proposed two GEmo-CLAPs consistently outperform Emo-CLAP with
different pre-trained models. Remarkably, the proposed WavLM-based SL-GEmo-CLAP
obtains the best WAR of 83.16\%, which performs better than state-of-the-art
SER methods.Comment: 5 page
Kommunale Gremienarbeit ohne persönliche Anwesenheit - Chancen und Risiken des §37a GemO
No full textAnhand dem neuen §37a GemO wird die kommunale Gremienarbeit ohne persönliche Anwesenheit hinsichtlich der praktischen Umsetzbarkeit und der daraus entstehenden Chancen und Risiken betrachtet
On the interaction of replication and transcriptional regulation
No full textDNA replication introduces a gradient of gene copy numbers, and in Bacteria it affects gene expression accordingly. In E. coli and other species, the slope of the gradient averaged over the population can be predicted on the basis of its relationship with growth rate. In this work we integrated this growth- and position-dependent gradient into a classical transcriptional regulation model, to highlight their interaction. The theoretical treatment of our model highlights that the sensitivity to transcription factor-mediated regulations acquires an additional dimension related to the position of a locus on the oriter axis and to division time. This reinforces the idea of replication as an additional layer in gene regulation. We highlight here that replication- and transcription factor-mediated regulations can in theory work in concert or counteract each other, and we discuss why this is important from an evolutionary point of view with respect to both steady state transcript abundance and its variance across conditions. Finally, we note that this treatment may improve the estimation of kinetic parameters for transcription factor activity using RNA-seq data, and the estimation of the dispersion factor in differential gene expression analysis when division time across conditions changes significantly
GEMO: grammatical evolution memory optimization system
No full textIn Grammatical Evolution (GE) individuals occupy more space than required, that is, the Actual Length of the individuals is longer than their Effective Length. This has major implications for scaling GE to complex problems that demand larger populations and complex individuals. We show how these two lengths vary for different sizes of population, demonstrating that Effective Length is relatively independent of population size, but that the Actual Length is proportional to it. We introduce Grammatical Evolution Memory Optimization (GEMO), a two-stage evolutionary system that uses a multi-objective approach to identify the optimal, or at least, near-optimal, genome length for the problem being examined. It uses a single run with a multi-objective fitness function defined to minimize the error for the problem being tackled along with maximizing the ratio of Effective to Actual Genome Length leading to better utilization of memory and hence, computational speedup. Then, in Stage 2, standard GE runs are performed restricting the genome length to the length obtained in Stage 1. We demonstrate this technique on different problem domains and show that in all cases, GEMO produces individuals with the same fitness as standard GE but significantly improves memory usage and reduces computation time. </p
Engineering the catalytic batchwise synthesis of H2O2 from its elements
No full textHydrogen peroxide is a versatile oxidizing agent with several industrial applications. It is also one of “greenest”, since its oxidation by-product is only water. The global demand of the peroxide is increasing, due to its recent usage in new large scale oxidation processes, such as the epoxidation of propylene to propylene oxide and the synthesis of caprolactam. Nowadays most of the world production of H2O2 is carried out by the anthraquinone autoxidation process. Though very safe (H2 and O2 are never in direct contact), the costs related to the high energy consumption for the extraction and purification of the peroxide produced, together with the usage and periodic replacement of toxic and expensive solvents, stimulated the interest in new production paths. Among the several alternatives proposed, the most fascinating one is the direct synthesis (DS) from H2 and O2. It is a environmentally friendly process that would be economically profitable for an in-situ production, requiring lower investments and operating costs. During the last thirty years this system has been under intensive study both by industries as well as academia. However, it has not been commercialized yet, mainly because of poor selectivity and safety concerns.
While most of the efforts on improving DS must address the catalyst, there are reaction engineering aspects that deserve attention. DS is frequently carried out in solvents other than water, both to improve H2 solubility and isolate the undesired product (H2O). Further, CO2 is used for safety, H2 solubility and H2O2 stability. However, the lack of information about the solubility of the reagents makes it difficult to develop a realistic kinetic description of the reactions involved in the DS process. Hence, the first step of the research presented herein dealt with solubility measurements, at temperatures in the range 268-288 K and pressures between 0.37 and 3.5 MPa. Measurements were focused on H2, i.e. the limiting reagent during the reaction. At all conditions investigated a linear relation between hydrogen partial pressure and concentration was observed. Increasing the temperature resulted in an enhanced H2 solubility at the same H2 partial pressure. At constant H2 fugacity, the presence of CO2 favored the dissolution of hydrogen in the liquid phase. Correlation and generalization of the measurements were provided through an EoS-based thermodynamic model for the estimation of H2 solubility at reaction conditions.
A batch apparatus for the direct synthesis of hydrogen peroxide was developed, to carry out activity measurements on new catalysts and develop a quantitative model of the kinetics. Hydrogenation, disproportionation and direct synthesis reactions were studied on a commercial 5 wt.% Pd/C catalysts at temperatures in the range 258-313 K and pressure up to 2 MPa. Separate experiments were performed to highlight the role of each reaction. An enhanced H2O2 production was obtained adopting different H2 feeding policies, although selectivity did not exceeded 30%.
A model of the gas bubbling, batch slurry reactor for H2O2 direct synthesis was developed. A sensitivity analysis on the mass transfer coefficients excluded any limitations occurring at experimental conditions. Comparable temperature dependence was observed for H2O production, hydrogenation and disproportionation (activation energies close to 45 kJ mol-1), while H2O2 synthesis had a much lower activation energy (close to 24 kJ mol-1), suggesting that a higher selectivity is achievable at low temperature. Disproportionation reaction had a very limited influence on the overall peroxide production rate, while hydrogenation was the most rapid side reaction. Water formation was significant, prevailing at higher temperatures.
Following these results, Pd and PdAu catalysts supported on SBA15 were prepared and investigated for H2O2 direct synthesis. Catalysts were doped with bromine, a promoter in the H2O2 direct synthesis. Productivity and selectivity decreased when bromine was incorporated in the catalysts, suggesting a possible poisoning due to the grafting process. A synergetic effect between Pd and Au was observed both in presence and absence of bromopropylsilane grafting on the catalyst. Three modifiers of the SBA15 support (Al, CeO2 and Ti) were chosen to elucidate the influence of the surface properties on metal dispersion and catalytic performance. Higher productivity and selectivity were achieved incorporating Al into the SBA15 framework, whereas neither Ti nor CeO2 improved H2O2 yields. The enhanced performance observed for the PdAu/Al-SBA15 catalysts was attributed to the increased number of Brønsted acid sites.
Supported catalysts were also synthesized depositing Pd on a highly acidic, macroporous PS-DVB resin (Lewtit K2621). Catalysts with active metal content in the range 0.3-5 wt.% were tested batchwise for the direct synthesis of H2O2. Preliminary H2O2 measurements and X-ray photoelectron spectroscopy (XPS) analysis revealed that the reduced form of Pd was more selective than PdO towards the peroxide. Transmission electron microscopy (TEM) images showed that smaller nanoclusters favored the production of H2O, likely due to their O-O bond breaking aptitud
Beyond Modern Science: Ryemo Gemo (Chasing Away Evil Spirits), Tradition and Faith during the COVID-19 Pandemic among the Acoli in Northern Uganda
No full textBackground: This was a historical study of the Ryemo Gemo tradition among the Acoli people of Northern Uganda, and its implications in the context of the COVID-19 pandemic. It explored strategies indigenous people adopted for epidemic control and prevention anchored on their tradition and belief systems passed, during the COVID-19 pandemic. Methods: The study adopted the qualitative approach and ethno-historical design. It explored community meanings, beliefs, values, practices and lived experiences of Ryemo Gemo during the COVID-19 pandemic in 2020. The study was conducted in Gulu City, and the districts of Gulu, Omoro, Lamwo, Kitgum and Agago, where the ritual of Ryemo Gemo was conducted during the COVID-19 pandemic. Data was collected using Key Informant interviews, one-on-one interviews and six Focused Group Discussions. A sample size of 63 participants based on the data saturation point, and their knowledge and experience of Ryemo Gemo, was selected using the snowball and networking approach. They included: Cultural leaders, elderly persons, spiritual mediums, and health workers. Findings: Gemo was a calamity brought by bad spirits. The spirits acted as an early warning system, foreseeing and informing the people through spirit mediums of a looming calamity. Whereas Gemo was a calamity sent by bad spirits, others argued that COVID-19 was not a Gemo as it was man-made. Ryemo Gemo fostered a sense of identity, unity, and shared values, principles and practices. It promoted cultural continuity and connection between the living and the dead. Conclusion: Ryemo Gemo reflects the Acoli spirituality, beliefs and collective approach to managing calamities, reinforcing community bonds and cultural continuit
Corporate culture in company GEMO Olomouc, spol. s r. o.
No full textTato práce je zaměřená na aplikaci teoretických poznatků v praxi na konkrétním příkladu. První část bakalářské práce sumarizuje, blíže specifikuje a objasňuje teoretickou problematiku firemní kultury včetně identifikace a popisu vybraných prvků, struktury a typologie organizační kultury. Dále tato práce poukazuje na úzké a důležité propojení organizační kultury a dalších funkčních prvků podniku, které mají významný vliv na hospodářskou činnost podniku a dosahování stanovených cílů podniku. V praktické části jsou teoretické poznatky aplikovány na příkladu společnosti GEMO Olomouc, spol. s r. o., která má velmi specifickou firemní kulturu. Tato práce se snaží zdůraznit potřebu praktické aplikace firemní kultury.This bachelor work is intent on application theoretical pieces of knowledge in practice. The first part f bachelor work sum sup, specifies and shows up theoretical problematic of corporate culture including identification and description of selected elements, structure and types of corporate organization. This work also shows close and important relationship of corporate culture and another elements in company, which are very important for economic activity of organization. In practical part are theoretical pieces of knowledge apply on GEMO Olomouc, spol. s r. o., which has very specific corporate culture. This work tries to emphasize practical application of corporate cultureInstitut bezpečnostních technologiíobhájen
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