170,833 research outputs found
Uso de metodologia ágil em uma empresa de meio de pagamento pós-pago: estudo de caso na empresa Koin
Get PDFTCC (graduação) - Universidade Federal de Santa Catarina. Campus Araranguá. Curso de Tecnologias da Informação e Comunicação.Devido a grande competitividade entre as organiza¸c˜oes a busca por entregar produtos com qualidade e na velocidade que o mercado atualmente exige, faz com que muitas empresas adotem m´etodos que dizem suprir estas necessidades. Os m´etodos ´ageis prometem atender tais requisitos valorizando as pessoas e as intera¸c˜oes entre elas, ao inv´es de focar nos processos e nas ferramentas como as metodologias cl´assicas. E por estes motivos, a empresa Koin resolveu adotar no seu processo de desenvolvimento o Scrum, com o intuito de melhorar a produtividade e a qualidade dos seus produtos. Esta monografia tem como objetivo documentar e analisar os impactos ocasionados pela implanta¸c˜ao de princ´ıpios ´ageis, nos processos e nas pessoas envolvidas acerca dos fatores que influenciam positivamente ou negativamente na implantação.Due to the high competitiveness between organizations Search by delivering quality products and the speed that the market currently demands, causes many companies to adopt methods they say meet these needs. Agile methods promise meet such requirements valuing people and the interactions between them, rather than focusing on the processes and tools such as classical methodologies. And for these reasons, the company decided Koin adopt in its development process Scrum, in order to improve productivity and quality of their products. This monograph focuses on documenting and analyzing the impacts caused by the deployment of agile principles, processes and the people involved about the factors that influence positively or negatively on the implementation
Center for Community and Regional Research Report
No full textSupported by the Center for Community and Regional Research, University of Minnesota, Duluth, through a grant from the Center for Urban and Regional AffairsOllenburger, Jane C; Geis, Michelle K; Gruba, Jim. (1991). Formative Evaluation of 'Our House': Transitional Housing for Homeless Mentally Ill Women.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/219127
Updated Review and Clinical Recommendations for the Diagnosis and Treatment of Patients with Retroperitoneal Sarcoma by the Spanish Sarcoma Research Group (GEIS)
No full textSoft tissue sarcomas (STS) are an uncommon and biologically heterogeneous group of tumors arising from mesenchymal cells. The incidence is estimated at five cases per 100,000 people per year. Retroperitoneal sarcomas (RPS) account for 10–15% of all STS, and their management depends on their anatomical characteristics and histotype. Due to their very low incidence, it is recommended that RPS be treated in reference centers and evaluated by an experienced multidisciplinary team (MDT). In Spain, the Spanish Group for Research in Sarcomas (GEIS) brings together experts from various specialties to promote research on sarcomas and improve treatment results. This paper summarizes the GEIS recommendations for the diagnosis, treatment, and follow-up of patients with RPS.Depto. de Medicina Legal, Psiquiatría y PatologíaDepto. de Radiología, Rehabilitación y FisioterapiaFac. de MedicinaTRUEpu
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca2+ signaling
No full textConvergent extension movements are the main driving force of Xenopus gastrulation. A fine-tuned regulation of cadherin-mediated cell-cell adhesion is thought to be required for this process. Members of the Wnt family of extracellular glycoproteins have been shown to modulate cadherin-mediated cell-cell adhesion, convergent extension movements, and cell differentiation. Here we show that endogenous Wnt/beta -catenin signaling activity is essential for convergent extension movements due to its effect on gene expression rather than on cadherins. Our data also suggest that XLEF-1 rather than XTCF-3 is required for convergent extension movements and that XLEF-1 functions in this context in the Wnt/beta -catenin pathway to regulate Xnr-3. In contrast, activation of the Wnt/Ca2+, pathway blocks convergent extension movements, with potential regulation of the Wnt/beta -catenin pathway at two different levels. PKC, activated by the Wnt/Ca2+ pathway, blocks the Wnt/beta -catenin pathway upstream of beta -catenin and phosphorylates Dishevelled. CamKII, also activated by the Wnt/Ca2+ pathway, inhibits the Wnt/beta -catenin signaling cascade downstream of beta -catenin. Thus, an opposing cross-talk of two distinct Wnt signaling cascades regulates convergent extension movements in Xenopus. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved
AMČR - projekt C-201664124
No full textStav: 6Podnět: Logistický areál - GEIS-HUB Parcel Modletice.Označení projektu: UAPPSC 410/201
AMČR - projekt C-201018694
No full textStav: 6Podnět: Výstavba Areál Geis - hala Nokian II, hala Parcel, přemístění nádrže a přeložka inž.s
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Edward C. Ranck bookplate
No full textThis bookplate of Edward C. Ranck has an image of a man reading a book in a study or a library. Bookshelves form a backdrop for the man, who wears the large, flat cap and flowing robes of a Renaissance scholar. The bookplate's title is "Reading Maketh a Full Man." Text at the bottom reads: "Edward C. Rank His Book.
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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