662 research outputs found
Social responsibility and financial performance of family-owned and eponymous companies
No full textInternational audienc
Corporate Social Responsibility and performance: case of family firms
No full textInternational audienc
Rôle modérateur de la RSE dans la relation Orientation entrepreneuriale-performance
No full textInternational audienceL’insertion des entreprises africaines dans l’économie mondiale les pousse de plus en plus à adopter un style plus entrepreneurial ouvert à l’innovation, à la prise de risque et à la proactivité nécessaire à l’atteinte d’une performance meilleure. Ainsi, de nombreuses études démontrent l’impact positif de l’orientation entrepreneuriale OE sur la performance de l’entreprise (Wiklund et Shephred, 2005 ; Lumpkin et Dess, 2001 ; Li Y-H et al., 2009 ; De Clercq et al. 2010 ; Beauweraerts et Colot, 2020) Cet article examine l’impact de l’OE sur la performance des entreprises africaines ainsi que le rôle médiateur de la responsabilité sociale de l’entreprise RSE dans cette relation. Certains chercheurs considèrent que la RSE peut apporter des avantages notamment financiers aux entreprises qui l’adoptent (Fombrun, Gardberg, et Barnett, 2000), nous allons tenter de comprendre l’influence éventuelle du contexte social sur la relation OE-performance. Pour ce faire, un échantillon de petites et moyennes entreprises africaines sera analysé à l’aidede la méthode des équations structurelles (approche PLS). Trois étapes vont être suivies afin d’analyser les données. Une première consiste à décrire les résultats. Une deuxième sera consacrée à tester la validité et la fiabilité du modèle de mesure, et enfin la troisième étape va être reliée aux tests des liens structurels directs et indirects du modèle en question. Nous nous attendons à ce que la responsabilité sociale des entreprises clarifie la nature de la relation entre l’orientation entrepreneuriale et la performance de l’entreprise. Autrement dit, nous allons répondre à une question primordiale : pourquoi l’orientation entrepreneuriale est reliée à la performance
Pratique RSE, orientation entrepreneuriale et performance : cas des entreprises tunisiennes
No full textInternational audienceAfin de renforcer leur compétitivité, les entreprises cherchent à adopter certaines stratégies dont l’orientation entrepreneuriale (OE) et la responsabilité sociale qui gagnent en popularité. A partir d’une étude quantitative menée auprès de 144 entreprises tunisiennes, nous explorons le rôle médiateur de la Responsabilité Sociale de l’Entreprise (RSE) dans la relation entre l’OE et la Performance Financière (PF). Les données collectées ont été analysées par la technique des équations structurelles de moindres carrés partiels (SEM-PLS).Les résultats rapportent que l’OE a un effet positif et significatif sur la PF. En revanche la RSE ne joue pas de rôle médiateur dans cette relation. D’où l’importance de ce travail pour attirer l’attention des managers tunisiens pour engager un plan stratégique et plus de moyens financiers pour un meilleur entrepreneuriat durable et donc une meilleure performance
Anti - tumorigenic assessment of HELA cell growth characteristics in the presence of Meswak, 2016
No full textThere is a demand for newer, more effective therapeutic antagonist for bacterial threats. More specifically, overuse of currently available antibiotics, premature dosage -termination of prescription antibiotics and a growing resistance of bacteria to currently available antibiotics warrants the design, development and establishment of new and novel antibacterial therapeutics. Unfortunately, physician-scientists no longer have an antibiotic agent for an increasing number of multiple strains of bacteria. In this study, we investigate the holistic efficacy for which the plant Meswak can antagonize the vitality of some strains of bacteria and HeLa cell growth. The conclusions drawn from the findings of this investigation suggest Meswak as a potential antagonist for the growth of some strains of gram-positive and gram-negative bacteria. Preliminary studies have also revealed that Meswak acts as an inhibitor to HeLa cell growth and migration. Future studies are necessary to define the specific mechanism of action for which Meswak acts to inhibit bacterial viability and HeLa cell growth and migration
Responsabilité sociale et performance financière des entreprises familiales et éponymes
No full textInternational audienceThis article explores the relationship between corporate social responsibility (CSR), financial performance (FP) and the moderating effect of family ownership and eponymous companies, i.e. firms named after the founding family. We show that family firms and eponymous ones, engage more in CSR activities than non-family and non-eponymous firms, which has a positive impact on their FP. Our empirical study is based on a sample of French companies listed on the SBF 120 over the period 2016-2021. This research sheds theoretical and empirical light on the issue of ownership structure in relation to CSR. We conclude that corporate reputation is the factor that most influences the adoption of CSR strategies in family-owned and eponymous companies, resulting in superior performance. Regulators and stakeholders should be aware of the potential impact of CSR engagement.Cet article explore la relation entre la responsabilité sociale des entreprises (RSE), la performance financière (PF) et l'effet modérateur de la propriété familiale et des entreprises éponymes, c'est-à-dire les entreprises portant le nom de la famille fondatrice. Nous montrons que les entreprises familiales et éponymes s'engagent davantage dans des activités de RSE que les entreprises non familiales et non éponymes, ce qui a une incidence positive sur leurs performances financières. Notre étude empirique s’appuie sur un échantillon d'entreprises françaises cotées au SBF 120 au cours de la période 2016-2021. Cette recherche apporte un éclairage théorique et empirique sur la question de la structure de propriété en relation avec la RSE. Nous concluons que la réputation de l’entreprise est le facteur qui influence le plus l'adoption de stratégies de RSE dans les entreprises familiales et éponymes, ce qui se traduit par une supériorité en termes de performance. Les régulateurs et les parties prenantes devraient être conscients de l'effet potentiel de l'engagement dans la RSE
Extraction of Ethanolic Extract of Red Betel Leaves and Its Cytotoxicity Test on HeLa Cells
No full textAbstractExtraction and identification of active compounds in red betel leaves (Piper crocatum Ruiz&Pav.) have been conducted. Ethanolic extract of red betel leaves was obtained by Soxhlet extraction followed by solvent removal step using rotary evaporator. Compound identification of the extract was performed by GCMS. The concentrated ethanol extract was then examined through cytotoxicity test on Hela cells. Results from GCMS spectrum depicted several compounds which were identified in the extract, i.e. neophytadiene, elimicin and propionic acid. Cytotoxicity test was conducted on Hela cells using in vitro method and calculated using Probit method. LC50 value from the ethanolic extract of red betel leaf was 0.81 + 0.26mg/ml. This result showed that the bioactive compounds potentially inhibited proliferation of Hela cells
Opposed to the being of Henrietta: bioslavery, pop culture and the third life of HeLa cells
No full textOperating at the intersection of thanatopolitics and African-American cultural studies, this essay argues that the commercial sale of HeLa-themed art and other bioproducts perpetuates the bioslavery of HeLa cells, a circumstance created by legal and medical discourses tracing back to US racial slavery. Racial slavery normalised economic, social and legal inequities that the nation continues to struggle with and, the article posits, laid foundation for the dynamics that currently exist between Henrietta Lacks' genealogical family, the HeLa cell line, and the medical-pharmaceutical establishment. The author turns to fashion ethics discourse and trademark law as potential sites for reparations
Validation of a Strategy for Cancer Therapy: Delivering Aminoglycoside Drugs to Mitochondria in HeLa Cells
No full textMitochondria in human cancer cells have been implicated in cancer cell proliferation, invasion, metastasis, and even drug-resistance mechanisms, making them a potential target organelle for the treatment of human malignancies. Gentamicin (GM), an aminoglycoside drug (AG), is a small molecule that functions as an antibiotic and has ototoxic and nephrotoxic characteristics. Thus, the delivery of GM to mitochondria in cancer cells would be an innovative anticancer therapeutic strategy. In this study, we attempted mitochondrial delivery of GM in HeLa cells derived from a human cervical cancer. For the mitochondrial delivery, we used MITO-Porter, a liposomal nanocarrier for mitochondrial delivery via membrane fusion. We first encapsulated GM in the aqueous phase of the carrier to construct GM-MITO-Porter. Flow cytometry analysis and fluorescent microscopy observations permitted us to confirm that the GMeMITO-Porter was efficiently taken up by HeLa cells and accumulated in mitochondria, whereas naked GM was not taken up by the cells. Moreover, cell viability assays using HeLa cells showed that the GMeMITO-Porter induced strong cytotoxic effects related to mitochondrial disorder. This finding is the first report of the mitochondrial delivery of an AG to cancer cells for cancer therapeutic strategy. (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved
Small-angle neutron scattering (SANS) and spinecho SANS measurements reveal the logarithmic fractal structure of the large-scale chromatin organization in HeLa nuclei
No full textThis paper reports on the two-scale fractal structure of chromatin organization in the nucleus of the HeLa cell. Two neutron scattering methods, small-angle neutron scattering (SANS) and spin-echo SANS, are used to unambiguously identify the large-scale structure as being a logarithmic fractal with the correlation function (r) - ln(r/E). The smaller-scale structural level is shown to be a volume fractal with dimension DF = 2.41. By definition, the volume fractal is self-similar at different scales, while the logarithmic fractal is hierarchically changed upon scaling. As a result, the logarithmic fractal is more compact than the volume fractal but still has a rather high surface area, which provides accessibility at all length scales. Apparently such bi-fractal chromatin organization is the result of an evolutionary process of optimizing the compactness and accessibility of gene packing. As they are in a water solution, the HeLa nuclei tend to agglomerate over time. The large-scale logarithmic fractal structure of chromatin provides the HeLa nucleus with the possibility of penetrating deeply into the adjacent nucleus during the agglomeration process. The interpenetration phenomenon of the HeLa nuclei shows that the chromatin-free space of one nucleus is not negligible but is as large as the volume occupied by chromatin itself. It is speculated that it is the logarithmic fractal architecture of chromatin that provides a comfortable compartment for this most important function of the cell.</p
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