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KORELASI ANTARA KADAR 25-HYDROXYVITAMIN D SERUM DENGAN INTERLEUKIN-4 DAN THYROTROPIN RECEPTOR ANTIBODY PADA PENYAKIT GRAVES
Full text linkPendahuluan
Penyakit Graves dipengaruhi oleh sistem imun bawaan dan adaptif serta faktor lingkungan, seperti vitamin D. Terkait dengan respons imun yang terjadi pada penyakit Graves, vitamin D atau 25-Hidroxyvitamin D (25(OH)D) merupakan hormon yang memiliki efek non-klasik sebagai imunomodulator. Peran vitamin D dalam penyakit autoimun masih terus diteliti. Kemungkinan hubungannya dimulai dari temuan epidemiologi bahwa penyakit autoimun lebih sering ditemukan di daerah dengan paparan sinar matahari yang rendah.
Metode
Penelitian observational analitik di Poliklinik Khusus Penyakit Dalam RSUP Dr. M. Djamil dan RS Swasta di Padang selama 6 bulan. Sampel dipilih secara Consecutive sampling, dengan total 30 orang. Terhadap subjek yang potensial dilakukan skrining awal kemudian dilakukan pemeriksaan kadar 25-Hydroxyvitamin D, interleukin-4 dan TRAb dengan metode ELISA.
Hasil
Adanya korelasi yang bermakna antara kadar vitamin D serum dengan kadar interleukin-4 serum (p<0,001) dengan arah korelasi negatif dan kekuatan korelasi sangat kuat (koefisien korelasi r=-0,888). adanya korelasi yang bermakna antara kadar vitamin D serum dengan kadar TRAb serum (p<0,001) dengan arah korelasi negatif dan kekuatan korelasi sangat kuat (koefisien korelasi r=-0,834).
Diskusi
Kadar vitamin D rendah pada penyakit Graves sedangkan kadar interleukin-4 dan TRAb tinggi pada penyakit Graves
Krisis Tiroid pada Wanita Multipara Usia 42 Tahun
Full text linkKrisis tiroid selama kehamilan dapat mengancam nyawa ibu maupun janin. Kematian pada ibu disebabkan karena terjadinya henti jantung dan kematian janin disebabkan oleh keguguran, berat badan lahir rendah, kelahiran premature, preeklamsi dan malformasi kongenital. Dilaporkan seorang wanita multipara 42 tahun yang telah dikenal hipertiroid datang dengan penurunan kesadaran sejak 1 hari sebelum masuk rumah sakit, usia kehamilan 20 minggu. sebelumnya pasien mengeluhkan palpitasi, demam, berkeringat, tremor, diare, dan sesak nafas. Berdasarkan pemeriksaan fisik, pasien tampak delirium, dengan tekanan darah 110/50 mmHg, nadi 115 kali/menit, dan suhu 38,4oC. Pada pemeriksaan mata tampak Rosenbach dan Enroth. Tanda oftalmopati Graves adalah NOSPEC 1. Berdasarkan palpasi kelenjar tiroid, ukuran 9 x 5 x 2 cm, difus, dan simetris.Pada pemeriksaan fisik ditemukan kardiomegali dan hepatomegali. Skor index Wayne adalah 22 (hipertiroid) dan Skor Burch dan Wartofsky adalah 60 (krisis tiroid). Pemeriksaan laboratorium menunjukkan kadar FT4 43,49 pmol/L, tyroid-stimulating hormone (TSH) 0,1 UIU/mL, dan peroksida anti-tiroid (anti-TPO) 0,31 IU/mL (negatif). Pemeriksaan USG tiroid menunjukkan struma difusa. Pasien mendapat terapi 600 mg PTU dan diikuti dengan 200 mg PTU empat kali sehari. Propanolol 40 mg sehari, Deksametason 40 mg sehari melalui intravena, dan Iodin Lugol empat kali sehari. Selama pengobatan, kondisi klinis pasien membaik, krisis tiroid teratasi dan keadaan janin dalam keadaan baik
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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