472 research outputs found
Gestão logística: o caso da Cavaletti S.A. cadeiras profissionais
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Administração.O presente estudo teve como objetivo analisar os processos de gestão da logística e dos estoques, bem como propor sugestões de melhoria. A organização estudada foi Cavaletti S.A. Cadeiras Profissionais, sendo que a metodologia utilizada foi pesquisa descritiva, pois busca descrever o fenômeno estudado; pesquisa de campo, por ter sido elaborada no local onde ocorreu o fenômeno; estudo de caso, por estudar o fenômeno dentro do contexto real em que ocorre; pesquisa bibliográfica, pois foi elaborada uma contextualização com o que já foi abordado sobre o tema; a coleta de dados ocorreu através de entrevista semi-estruturada e observação, sendo que os dados são qualitativos por prestarem informações sobre as características sociais e seus significados. Os aspectos abordados na análise foram a gestão da armazenagem, a gestão dos estoques, a gestão da distribuição física, os sistemas de informação logística e os processos de avaliação de desempenho logísticos, durante a análise também foi proposta uma ferramenta de avaliação de desempenho logístico, sendo estes aspectos os principais produtos deste estud
Self-reported Assessment of the Socio-economic Impact of Anticancer Chemotherapy-related Neurotoxicity
No full textOriginal (Italian) and English translation of the questionnaires used to perform the study.Original dataset used to perform the analysis (in Italian
Take a deep breath : Virtual reality and real anxiety
No full textThe fear of technology works as a sort of Leitmotiv in dystopian narratives, with many examples not only in movies, comics, and science fiction novels, but also in literature and philosophy. Among the technologies that feed dystopian visions of the future, a special role is played by virtual reality (VR), which we broadly identify with any set of devices providing immersive, multisensory, and multimodal experiences, by separating the user from “real reality” and absorbing her/him inside the representation.
Is it possible, however, to conceive an alternative scenario, in which a different connection can be configured between VR and negative emotions? Leaving aside the imagery and narratives of the new medium, how does the “real” virtual reality concretely works nowadays?
Our main goal in this chapter will be to overturn the anxiety of new technologies by taking into account the use of VR devices precisely in the medical treatment of anxiety. In this regard, two main paradigms of intervention will be outlined and discussed: the first one is grounded in the principle of exposure, it exploits the reproductive capacity of VR, and functions in a transitive way; the second one is grounded in the principle of isolation, it exploits the generative capacity of VR, and functions in an intransitive way
Sport-related peripheral nerve injuries : part 1
No full textSport–related strenuous physical activity and trauma are among the causes of peripheral nerves injuries, due in most cases to direct blow, compression or repeated traction or friction. Although in most cases the diagnosis is obvious, subtle peripheral nerve injuries can be difficult to recognize and, in most cases, require the support of appropriate instrumental evaluations. This review is divided into two parts devoted to the most common upper and lower limb peripheral nerves injuries, the anatomical reasons, the clinical presentation and the most helpful diagnostic tools
Ubiquitin Proteasome System and Microtubules Are Master Regulators of Central and Peripheral Nervous System Axon Degeneration
No full textAxonal degeneration is an active process that differs from neuronal death, and it is the hallmark of many disorders affecting the central and peripheral nervous system. Starting from the analyses of Wallerian degeneration, the simplest experimental model, here we describe how the long projecting neuronal populations affected in Parkinson’s disease and chemotherapy-induced peripheral neuropathies share commonalities in the mechanisms and molecular players driving the earliest phase of axon degeneration. Indeed, both dopaminergic and sensory neurons are particularly susceptible to alterations of microtubules and axonal transport as well as to dysfunctions of the ubiquitin proteasome system and protein quality control. Finally, we report an updated review on current knowledge of key molecules able to modulate these targets, blocking the on-going axonal degeneration and inducing neuronal regeneration. These molecules might represent good candidates for disease-modifying treatment, which might expand the window of intervention improving patients’ quality of life
Subacute combined degeneration in totally gastrectomized rats: an ultrastructural study
No full textSevere permanent cobalamin (Cbl) deficiency was induced in rats either by total gastrectomy (TG) or through prolonged dietary Cbl deprivation. This paper deals with an ultrastructural investigation of different parts of the central nervous system (CNS) of rats made Cbl-deficient through one of these of two procedures. In both totally gastrectomized (TGX) rats and in rats chronically fed a Cbl-deficient diet, we observed intramyelin edema, with splitting of the lamellae, and interstitial edema affecting the white matter, mainly in the spinal cord (SC). These lesions were also present in the subcortical white matter, although to a lesser degree. In both TGX-rats and in rats chronically fed a Cbl-deficient diet the pyramidal tract and the optic nerve were completely spared. Vascular lesions were never observed. Intramyelin edema and interstitial edema of the white matter account for the patchy myelopathic spongy vacuolation, which is the histological hallmark of human subacute combined degeneration and has been previously seen in SC white matter of TGX-rats. Macro- and micro-glial cells in the white matter were activated, at least as seen ultrastructurally. Interestingly enough, there were activated glial cells even in the gray matter, in which neurons showed absolutely no alterations. Chronic subcutaneous Cbl administration of TGX-rats partially repaired the CNS damage. However, the amelioration produced by this treatment was greater when Cbl was given shortly after TG than when given three and four months after TG, i.e. when the lesions have already been formed
Neuroprotectant drugs in cisplatin neurotoxicity.
No full textCisplatin (CDDP) is one among the most effective and widely used anticancer drugs. Its use is, however, often limited by its peripheral neurotoxicity, which may be severely disabling and sometimes not reversible. To prevent or reduce CDDP peripheral neurotoxicity several "neuroprotective" drugs have been proposed. This goal is of extreme importance in the treatment of cancer patients, especially in view of the better results obtained by anticancer chemotherapy in terms of longer disease-free survival which has made even more crucial than in the past the point of the quality of life of the long-surviving patients. The data of pre-clinical and clinical studies with neuroprotectant agents are often conflicting, in some cases because of inadequate methods of evaluation and/or study design used to examine their effectiveness. The aims of this review will be 1) to discuss and describe the most appropriate methods of evaluation of CDDP and neuro-protectant drugs in experimental in vitro and in vivo pre-clinical studies 2) to evaluate critically the results of the clinical trials reported so far with the combined treatment and 3) to explore the possible future strategies to achieve neuroprotection during high-dose CDDP treatment in humans
Take a Deep Breath. Virtual Reality and Real Anxiety
No full textThe fear of technology works as a sort of Leitmotiv in dystopian narratives, with many examples not only in movies, comics, and science fiction novels, but also in literature and philosophy. Among the technologies that feed dystopian visions of the future, a special role is played by virtual reality (VR), which we broadly identify with any set of devices providing immersive, multisensory, and multimodal experiences, by separating the user from “real reality” and absorbing her/him inside the representation. Is it possible, however, to conceive an alternative scenario, in which a different connection can be configured between VR and negative emotions? Leaving aside the imagery and narratives of the new medium, how does the “real” virtual reality concretely works nowadays? Our main goal in this chapter will be to overturn the anxiety of new technologies by taking into account the use of VR devices precisely in the medical treatment of anxiety. In this regard, two main paradigms of intervention will be outlined and discussed: the first one is grounded in the principle of exposure, it exploits the reproductive capacity of VR, and functions in a transitive way; the second one is grounded in the principle of isolation, it exploits the generative capacity of VR, and functions in an intransitive way
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