186,606 research outputs found
Clear cell endometrial cancer: A CTF multicentre Italian study
No full textEuropean Journal of Gynaecological Oncology
Volume 36, Issue 4, 2015, Pages 428-431
Clear cell endometrial cancer: A CTF multicentre Italian study (Article)
Maggino, T.a , Zola, P.b, Sartori, E.c, Fuso, L.d, Papadakis, C.a, Gadducci, A.e, Landoni, F.f
a Department of Obstetrics and Gynecology, Dell'Angelo Hospital, Via Paccagnella, 11, Zelarino-Venice, Italy
b Department of Gynecologic Oncology, University of Turin, Turin, Italy
c Obstetrics and Gynecology Institute, University of Brescia, Brescia, Italy
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Abstract
Endometrial clear cell carcinoma (CCC) is a rare entity and only accounts for 1-6% of all endometrial cancers. CCC is considered an aggressive subtype of endometrial cancer with worse prognosis compared with type I cancer and more frequent relapses at distant and extrapelvic sites. These characteristics require specific treatment modalities, but rarity of the disease does not allow to identify evidence based indications for therapies. Objective of the present study is to analyse a series of cases treated in a multicentre Italian setting. Materials and Methods: Sixty-five endometrial CCC were treated in the period 1990-2010 in the participating institutions. Slides of the pathological specimens were reviewed by a single pathologist of each institution and debatable cases were collegially reviewed. Clinical records were collected by a common database. Demographic, surgical pathological, and follow-up data were registered. Results: All patients received primary surgery. Stage of disease according FIGO 2009 was as follow: la: 16.9%, lb: 35.4%, 2: 9.2%, 3a: 9.2%, 3b: 3.1%, 3c: 16.9%, 4a: 3.1%, and 4b: 6.1%. Adjuvant post-operative treatment was adopted in 53.8% of cases. A relapse was detected in 29.2% of cases with a majority of extrapelvic sites (68.4%). Five-year survival rate was significantly related to stage of disease with an excellent prognosis for Stage Ia e Ib disease with a complete staging. In these cases adjuvant treatment does not show significant improvement of survival. Relapsed cases show a response rate to treatment in 26% of cases (predominantly chemotherapy). Conclusion: CCC requires extensive surgical staging. Stage I disease completely staged does not require adjuvant therapy. More advanced stages require adjuvant chemotherapy
Leucose aviaire myéloïde et sarcome fuso-cellulaire
No full textMornet Paul, Sane M. Leucose aviaire myéloïde et sarcome fuso-cellulaire. In: Bulletin de l'Académie Vétérinaire de France tome 102 n°4, 1949. pp. 199-200
Sister Mary Joseph's nodule and colorectal cancer: an aggressive treatment for an aggressive disease
No full textSister Mary Joseph's nodul
Sarcome fuso-cellulaire généralisé sur un Daim Moucheté (Dama dama L.)
No full textFerney Jean, Van Haverbeke Georges, Collin P. Sarcome fuso-cellulaire généralisé sur un Daim Moucheté (Dama dama L.). In: Bulletin de l'Académie Vétérinaire de France tome 117 n°6, 1964. pp. 295-300
Correction to: Real-world ANASTASE study of atezolizumab+nab-paclitaxel as first-line treatment of PD-L1-positive metastatic triple-negative breast cancer (npj Breast Cancer
No full textNature Portfolio 1 13 0 2024 Springer Nature Limited 2024 No Unnumbered 2024 1 24 0 0 Regular NonStandardArchiveJournal Unnumbered OpenChoice OpenAccess OpenAccess OpenAccess OpenAccess OpenAccess OpenAccess false BodyRef/PDF/41523_2024_Article_619.pdf Typeset OnlinePDF Regular Erratum Biomedicine Biomedicine, general Cancer Research Oncology Human Genetics Cell Biology Biomedical and Life Sciences true Correction to: npj Breast Cancerhttps://doi.org/10.1038/s41523-023-00579-2, published online 08 September 2023 In this article the author name Paola Fuso was incorrectly written as Paolo Fuso. The original article has been corrected
Development of a protocol for fractionating and characterising fibres from lignocellulosic food waste
No full textThis study aims to explore an advanced protocol for characterising dietary fibre (DF) fractions to meet the growing demand for accurate and reliable data. Although current enzymatic-gravimetric approaches, e.g., AOAC and Van Soest analysis, provide information about soluble and insoluble DF quantification, they present limitations related to the lack of fractions characterisation. To overcome these limitations, the proposed protocol integrates the official AOAC 991.43 method with the sequential fibre fractionation by exploiting the different resistance of the fibre fractions to acid hydrolysis treatments (TFA and H2SO4), utilising hazelnut shells as a case-study. Each hydrolysed fraction was quantified and characterised through GC–MS analysis of monosaccharides. The data obtained for hemicellulose, cellulose, and lignin fractions were then discussed and compared with the Van Soest method. This approach yields a comprehensive procedure applicable to different food and nutraceutical products, emphasising the importance of DF characterisation for a deeper understanding of their bio-functional properties
Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor.
No full textAtherosclerosis and neointimal hyperplasia formation are induced by alterations in the homeostatic balance between cell growth and cell death. Apoptosis is a physiological cell death process that, when deregulated, may be involved in many pathological conditions. Cigarette smoking is a primary risk factor for vascular disease and nicotine seems to exert its atherogenic effects in part through the increase of smooth muscle cell (SMC) proliferation. The aim of this study was to investigate the effect of nicotine on SMC apoptosis. Nicotine added for 24 and 72 h to serum deprived cell cultures resulted in a decrease of apoptotic SMCs. The inhibition was direct and not mediated by platelet-derived growth factor, basic fibroblast growth factor, and transforming growth factor β1, autocrinally released by nicotine-treated SMCs, because it was not influenced by addition of specific neutralizing antibodies. Apoptosis inhibition as well as the proliferation increase, and basic fibroblast growth factor expression on nicotine-treated SMCs were blocked by nicotinic acetylcholine receptor antagonists, including α-bungarotoxin, a competitive antagonist of α subunits of nicotinic receptor. In conclusion, we propose that nicotine could lead to the increase of neointimal SMCs in vascular lesions by inducing the inhibition of physiological SMC apoptosis and the increase of SMC proliferation. We also showed that nicotine signaling occurs as a result of activation of the classical nicotine receptor pathways
A collection-mode near-field microscope to analyze a variety of local optical properties
No full textPulsed laser deposition of YBCO thin films on metal substrates with YSZ buffer layer
No full textWe have deposited by pulsed laser ablation YBCO/YSZ bilayers on flexible Ni-based (Inco alloy C-276) substrates. As confirmed by X-ray diffraction spectra, the YBCO film grows mainly along the c-axis direction. However, a mosaic spread of 10 degrees, evaluated from the (005) YBCO pole figure, and the results of a film texture analysis indicate that more effort is required to obtain a complete c-axis orientation along with in-plane alignment for the YBCO layer
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