343 research outputs found
DS_10.1369_0022155419860134 – Supplemental material for Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda
No full textSupplemental material, DS_10.1369_0022155419860134 for Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda by Masatomo Kawakubo, Hitomi Komura, Yukinobu Goso, Motohiro Okumura, Yoshiko Sato, Chifumi Fujii, Masaki Miyashita, Nobuhiko Arisaka, Satoru Harumiya, Kazuhiro Yamanoi, Shigenori Yamada, Shigeru Kakuta, Hiroto Kawashima, Michiko N. Fukuda, Minoru Fukuda and Jun Nakayama in Journal of Histochemistry & Cytochemistry</p
HUBUNGAN ASPEK SOSIOLOGI PENGARANG DENGAN UNSUR INTRINSIK DALAM NOVEL NIJUUSHI NO HITOMI
No full textThis study discusses the relationship between the author\u27s sociological aspects with intrinsic elements contained in the novel Nijuushi No Hitomi by Sakae Tsuboi. The purpose of this research is to know how the relationship between novel Nijuushi No Hitomi and sociology aspect Sakae Tsuboi as the author. The object of this research is a quote in the form of narrative and dialogue in the novel that is considered to have a relationship with the author\u27s sociological aspects. The research method used is descriptive method of analysis based on the theory of sociology author by Wellek & Warren (1994). The results of this study indicate a relationship between the author\u27s sociological aspects and intrinsic elements in the novel
Two Variables of Tanka Strips by Tomei Hitomi: Their Images, Reprints, and a Commentary
No full textAbstract Two extant long strips of paper, A and B, each of which bear a similar tanka poem by Tomei Hitomi(who founded Showa Women's University in 1920), are introduced. Research into the poet's background, analogous expressions found in his other works published during the Meiji and Taisho Periods, handwriting analyses of the two strips, and the name of a lecture course stamped on the reverse side of strip A, reveal that the verse written on strip A was created in 1916. The author notes a vital distinction between the two verses. In A, Hitomi uses ware-wa(I myself). He uses kokoro(mind)in B. The author surmises that the "kokoro" version was written a few years later than "ware-wa" version, and speculates that the poet's initial exuberant spirit has calmed down, and that in shifting to kokoro he is emphasizing the loneliness he then felt.7KJ00009460439departmental bulletin pape
HitoMi-Cam: A Shape-Agnostic Person Detection Method Using the Spectral Characteristics of Clothing
No full textWhile convolutional neural network (CNN)-based object detection is widely used, it exhibits a shape dependency that degrades performance for postures not included in the training data. Building upon our previous simulation study published in this journal, this study implements and evaluates the spectral-based approach on physical hardware to address this limitation. Specifically, this paper introduces HitoMi-Cam, a lightweight and shape-agnostic person detection method that uses the spectral reflectance properties of clothing. The author implemented the system on a resource-constrained edge device without a GPU to assess its practical viability. The results indicate that a processing speed of 23.2 frames per second (fps) (253 × 190 pixels) is achievable, suggesting that the method can be used for real-time applications. In a simulated search and rescue scenario where the performance of CNNs declines, HitoMi-Cam achieved an average precision (AP) of 93.5%, surpassing that of the compared CNN models (best AP of 53.8%). Throughout all evaluation scenarios, the occurrence of false positives remained minimal. This study positions the HitoMi-Cam method not as a replacement for CNN-based detectors but as a complementary tool under specific conditions. The results indicate that spectral-based person detection can be a viable option for real-time operation on edge devices in real-world environments where shapes are unpredictable, such as disaster rescue
Transcriptional regulatory regions for expression of the rat fatty acid synthase
No full textAbstractWe previously mapped the sequences responsive to insulin/glucose stimulation and polyunsaturated fatty acid (PUFA) suppression in proximal promoter region from −57 to −35 of fatty acid synthase (FAS) gene of rat liver [Fukuda et al. (1996) Biochem. Mol. Biol. Int. 38, 987–996]. When two copies of the sequences spanning −57 to −35 were linked to a reporter gene containing heterologous promoter and were used for transfection, the reporter activity significantly increased in response to insulin/glucose treatment in hepetocytes. This increase was inhibited by addition of PUFA. Gel mobility shift assays using the sequence from −57 to −35 as a probe revealed nuclear factor(s) from rat liver that specifically complexed with the sequences. In addition, by antibody supershift assays, we have detected the binding of the transcriptional factor Sp1 at the GC-rich region located within −57 to −35 of the FAS promoter. Cotransfection studies in rat hepatocytes, with the Sp1 expression vector and FAScat constructs, showed the inactivation of the promoter. These results were similar to those for the region from −68 to −52 of FAS gene (an insulin response element). The region from −68 to −52 of FAS gene competed for the formation of DNA–protein complexes to the region from −57 to −35 in the gel shift assay. Mutational analysis showed that the overlapping region of these two sequences was essential for the binding of Sp1. It has been demonstrated that both the regions from −57 to −35 and from −68 to −52 of the FAS gene are responsible for regulation due to insulin/glucose and PUFA, and Sp1 may be involved in the regulation
Security Analysis of two Distance-Bounding Protocols
No full textIn this paper, we analyze the security of two recently proposed distance bounding protocols called the “Hitomi” and the “NUS” protocols. Our results show that the claimed security of both protocols has been overestimated. Namely, we show that the Hitomi protocol is susceptible to a full secret key disclosure attack which not only results in violating the privacy of the protocol but also can be exploited for further attacks such as impersonation, mafia fraud and terrorist fraud attacks. Our results also demonstrates that the probability of success in a distance fraud attack against the NUS protocol can be increased up to (34 )n and even slightly more, if the adversary is furnished with some computational capabilities
Transcriptional regulation of leptin gene promoter in rat
No full textAbstractTo investigate the DNA regulatory sequences required for stimulation and suppression of leptin gene expression, primary cultured hepatocytes and adipocytes of rats were transfected with plasmids containing the 5′-flanking sequences of the rat leptin gene fused to the luciferase gene. When two copies of the sequences spanning nucleotides −101 to −83 of the leptin promoter were used for transfection, the reporter activity significantly increased in the presence of glucose/insulin in comparison with glucose alone. The glucose/insulin stimulation of the transcription was inhibited by addition of polyunsaturated fatty acids. These results were similar to those found earlier for the transcription of the fatty acid synthase, FAS(−57/−35) and ATP citrate-lyase, ACL(−64/−41) genes. Cotransfection studies in the cells with a Sp1 expression vector and leptin (−101/−83) constructs showed the inactivation of the leptin promoter by Sp1. Gel mobility shift assays using an end-labeled leptin(−101/−83) construct as a probe revealed that nuclear factor(s) from rat liver or adipose tissue specifically formed complexes with the sequence. The DNA-protein complexes were common to the glucose/insulin-responsive regions of the leptin, ACL and FAS genes, suggesting that these genes are coordinately regulated. In addition, by antibody supershift assays, the transcription factor Sp1 was found to bind the GC-rich region located between nucleotides −101 and −83 of the leptin gene. Mutational analysis of this region showed that the sequence of the region was critical for glucose/insulin stimulation of transcription. Thus, we postulated that the region from −101 to −83 of the leptin gene is responsible for glucose/insulin stimulation of transcription, and that Sp1 is somehow involved in this regulation
Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity
No full text©2022 Ohyama, Ouchi, Kimura, Kurashima, Yasumatsu, Nishida, Hitomi, Ubaidus, Kuroda, Ito, Takano, Ono, Mizoguchi, Katakura and Shibukawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
The Absent and Disinterested Other: Henry James’s Experimental First Person Narrative in “The Ghostly Rental” (1876)
No full textThe article is an analysis of Henry James’s ghost story titled “The Ghostly Rental.” The author focuses, first of all, on the first-person narrat ion in this story, published in 1876, soon after James left the United States. The author also examines the figure of the narrator’s friend.</p
Caracterização dos gerentes e práticas gerenciais na atenção primária à saúde em municípios de pequeno porte da região norte do Paraná
No full textCom o processo de municipalização, decorrente da implantação do Sistema Único de Saúde (SUS), torna-se necessário a organização local para garantir a saúde como direito da população. O objetivo deste estudo é caracterizar o perfil dos gerentes da atenção primária à saúde (APS) e descrever as práticas gerenciais nos serviços de APS em 49 municípios de pequeno porte das 16ª, 17ª e 18ª Regionais de Saúde do Paraná. Trata-se de um estudo de natureza descritiva, no qual foi aplicado questionário semi-estruturado para 90 gerentes. Para análise estatística, utilizou-se o programa EpiInfo 3.5.1, e o desfecho nos resultados não foi homogêneo, visto que algumas questões não obtiveram 100% de respostas dos participantes. O perfil dos gerentes aponta 91,1% do sexo feminino, 50,0% com idade predominante entre 21 a 30 anos e 75,6% pós graduados. Quanto ao ingresso no emprego, 70,0% foram por meio de concurso público/teste seletivo, com atuação profissional de 40,0% acima de 5 anos, 43,4% inseridos na APS acima de 5 anos e 32,2% na unidade básica de saúde atual há menos de 1 ano. Sobre treinamento específico para desempenho da função gerencial, 71,1% não fizeram nenhum curso, mas 37,7% já atuaram como gerentes. Quanto às práticas gerenciais citadas, 85,6% realizavam reunião com a equipe; 77,8% conheciam metas e indicadores de saúde de 2010; 73,3% planejavam as ações; 70,0% realizavam reunião com a comunidade; 64,5% discutiam as metas e indicadores com os trabalhadores da unidade; 61,1% conheciam os indicadores de saúde de 2009; 61,1% realizavam avaliação das ações e serviços de saúde; 54,4% realizavam educação permanente em saúde com os trabalhadores, mas somente 37,8% realizavam avaliação dos trabalhadores. Conclui-se que o cargo de gerência não está instituído, os participantes realizavam práticas gerenciais informalmente e há falta de profissionalização para o desempenho desta função já que somente 23,3% relataram ter feito curso de gestão.With the process of municipalization, arising from the deployment of the unified health system (SUS), it is necessary the local organization to ensure health as a population right. The objective of characterizing the profile of primary care managers and describe the actions of management practices in the services of APS in 49 small municipalities of 16th, 17th and 18th North of Paraná Regional Health. It is a study of a descriptive nature, in which a semi structured questionnaire was applied to 90 managers. For statistical analysis, used the program EpiInfo 3.5.1, pointing out that the outcome results were not homogeneous since some issues were not fully responded by the participants. The results of managers profile showed that 91.1% were women, 50,0% aged 21 to 30 years and 75.6% in expertise level. Concerning the entry into employment, 70,0% were through public contest/selective test, 40,0% worked professionally up to 5 years, 43,4% were inserted into ABS up to 5 years and 32,2% on the current UBS less than 1 year. Regarding the specific managerial role performance training, 71,1% had done no courses and 37,8% already acted as managers. As regards managerial practices cited, 85.6% were meeting with the team; 77.8% knew about the goals and indicators of health in 2010; 73.3% planned actions; 70.0% were meeting with the community. 64.5% of managers discussed the goals and indicators with the workers of the unit; 61.1% knew the health indicators of 2009; 61.1% evaluated actions and health services; 54.4% performed permanent health education with the workers and only 37.7% evaluated the workers. It is concluded that the management position is not established, the participants have possibility of keeping on the employment since hiring through public contests and selective test predominates, performed managerial practices informally and there is lack of professionalization for the performance of this function since only 23,3% reported having done management course
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