100,821 research outputs found
Uma metodologia para determinação da necessidade de inspeção na manufatura /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.O planejamento da inspeção da qualidade visa garantir que ela seja realizada de forma segura e econômica. Observa-se na prática que inspeções tem sido definidas, sem no entanto haver uma análise sistemática sobre a sua real necessidade. Tanto o excesso quanto a falta de inspeção representam perda de qualidade e produtividade para a empresa, que podem ser minimizados através de uma avaliação mais criteriosa da necessidade da inspeção. Objetivo deste trabalho foi desenvolver uma metodologia para a determinação da necessidade de inspeção na manufatura, com aplicação primordial na indústria metal-mecânica produtora de peças. A metodologia desenvolvida em forma de um modelo conceitual define a necessidade de inspeção de um característico de produto ou de processo, a partir da correlação de sua importância com o risco de não conformidade do processo que o gera. Para tal, foi desenvolvida uma sistemática para a determinação da Relevância do Característico, e critérios para Avaliação do Risco do Processo, utilizando-se dos princípios da engenharia simultânea. Através de uma matriz é definida a necessidade ou não da inspeção, pautada sobre o princípio da análise e avaliação de risco. A metodologia apresenta como informação de saída a decisão (sim ou não) da inspeção do característico e subsidia análises referentes a possíveis otimizações no projeto do produto e no planejamento do processo. A metodologia sistematiza o processo de definição da inspeção, integrando-o no sistema de garantia da qualidade e no processo de desenvolvimento de produtos
[...?] Freudenberg b. Ifang
No full textUnidentifizierbares imposantes Gutshaus in der Bildmitte; kleinere Gebäude links, im Vordergrund bäuerliche Dorfszene mit KühenRudimentärer Entwurf einer nicht vollendeten Lithografie, die sich auf der Rückseite einer Zeichnung von Eggli befindetIn der Bildmitte handschriftliche Notiz in Bleistift von unbekannter Hand: "...(unleserlich) Freudenberg b. Ifang"Unten in Bleistift "T 98 Lang", oben rechts ehemalige interne Notize
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Some open problems in information geometry
No full textIn this paper we recall some open problems in Information Geometry
Engineering a powerful green cell factory for robust photoautotrophic diterpenoid production
No full textEinhaus A, Steube J, Freudenberg R, Barczyk J, Baier T, Kruse O. Engineering a powerful green cell factory for robust photoautotrophic diterpenoid production. Metabolic Engineering. 2022;73:82-90
Rational Promoter Engineering Enables Robust Terpene Production in Microalgae
No full textEinhaus A, Baier T, Rosenstengel M, Freudenberg R, Kruse O. Rational Promoter Engineering Enables Robust Terpene Production in Microalgae. ACS Synthetic Biology. 2021;10(4):847–856
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
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