4,856 research outputs found
Modelling delay and noise in arbitrarily coupled RC trees.
No full textClosed-form equations for second-order transfer functions of general arbitrarily coupled resistance-capacitance (RC) trees with multiple drivers are reported. The models allow precise delay and noise calculations for systems of coupled interconnects with guaranteed stability and represent the minimum complexity associated with this class of circuits. Their accuracy is extensively compared against other relevant models and is found to be better or comparable to more expensive models. All results are derived from a theoretical approach, and their physical basis is examined. The simplicity, accuracy, and generality of the models make them suitable for use in early signal integrity analyses of complex systems and incremental physical optimization
Admission Rates, Healthcare Utilization, and Economic Burden of Radiation Cystitis (RC) in the United States
No full textINTRODUCTION AND OBJECTIVES: Radiation cystitis (RC) is a major cause of morbidity after radiotherapy for pelvic cancers. In the absence of a definite cure, patients may require repeated admissions, undergoing multiple - often morbid - urological procedures. Our aim was to study the inpatient economic burden and healthcare utilization associated with RC in the United States (US).
METHODS: We focused on 13,272 records of adult (age \u3e= 18) patients with a diagnosis of RC within the National Inpatient Sample (NIS) from 2008- 2014. Patients with a concurrent diagnosis of other bladder conditions (n=914) were excluded. Due to a change in NIS sampling methodology in 2012, trend of RC-associated admissions was analyzed for 2012-2014. ICD-9 diagnosis and procedure codes were used to study inpatient procedures performed during admission. Complex survey procedures were used to study the descriptive characteristics of RC patients and the procedures received during admission. Inflation- adjusted cost for each admission and cumulative annual cost of RC-associated admissions were calculated for the study period.
RESULTS: The 12,358 assessable patients represented 61,346 admissions for RC nationally per NIS survey weights. The number of admissions increased gradually from 1681 (weighted 8405) in 2012 to 1803 (weighted 9015) in 2014. Overall 84% of all RC-associated admissions were non-elective. 74% of the patients were males. A vast majority (82%) of the patients had Medicare/Medicaid insurance. The admissions were equally distributed between teaching (49%) and non-teaching (51%) hospitals, however, 90% of the admissions were in hospitals located in urban areas. Any RC-directed procedure code was recorded in 62% admissions. Of these, 3,331 (43%) admissions recorded more than one procedure code. Blood transfusion was the most frequently recorded code (33%), followed by transurethral procedures (28%) and cystoscopy (12.6%). Radical cystectomy was done in 1.3% of the admissions. The median length of stay was 4.4 days (IQR 2.2-8.4).The inflation-adjusted cost per admission was 9207 US dollars (IQR 5275 -17,573) overall, being higher in teaching hospitals (median 9802 vs 8463 US dollars in non-teaching hospitals. The cumulative cost of inpatient treatment of radiation cystitis was 63.5 million US dollars per year, amounting to a total of 952.2 million over the study period.
CONCLUSIONS: The incidence of RC-associated admissions is rising in the US. This disease is a major burden to US healthcare. The awareness of the inpatient economic burden and healthcare utilization associated with RC may have funding implications.https://scholarlycommons.henryford.com/merf2019qi/1020/thumbnail.jp
A Compact 10-MHz RC Frequency Reference With a Versatile Temperature Compensation Scheme
No full textThis article presents the design and implementation of a compact CMOS RC frequency reference. It consists of a frequency-locked loop (FLL) that locks the period of a voltage-controlled oscillator (VCO) to the time an RC network takes to charge to a reference voltage. Conventionally, an RC time constant with a near-zero temperature coefficient (TC) is realized by using a trimmed network of resistors with different TCs. In this work, such a network is used to realize a temperature-dependent reference voltage whose TC cancels that of a single-resistor RC time constant. Compared with the conventional approach, which requires resistors with TCs of opposite polarity, the proposed approach can be implemented with resistors with TCs of similar polarity, and so it can be implemented in most CMOS processes. To compensate for RC spread, a trimmed capacitor is used to adjust the nominal frequency. Two prototype chips were made, one based on p- /n-polysilicon resistors and other based on silicided/p-diffusion resistors. Fabricated in a standard 180-nm CMOS technology, the polysilicon-based prototype has an active area of 0.01 mm2 and an absolute inaccuracy of ±2800 ppm from -45 °C to 125 °C with a fixed TC-trim and a one-point frequency trim. After one week of accelerated aging at 150 °C, however, significant drift (5000 ppm) was observed. The diffusion-based prototype exhibits greater inaccuracy (±14 400 ppm) but much less drift (600 ppm).Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
NDT RC: Normal Distribution Transform Occupancy 3D Mapping with recentering
No full textThe Normal Distribution Transform Occupancy Map (NDT OM) is a mapping algorithm able to represent a dynamic 3D environment. The resulting map has fixed boundaries, thus a robot with unbounded displacement might fall outside of the map due to memory limitation. In this paper, a recentering algorithm called NDT RC is proposed to avoid this issue. NDT RC extends the use of NDT OM for vehicles with unbounded displacements. NDT RC provides a seamless translation of the map as the robot gets far from the center of the previous map. The influence of NDT RC on the precision of the estimated trajectory of the robot, or odometry, is examined on two publicly available datasets, the KITTI and Ford datasets. An analysis of the sensitivity of the NDT RC to its tuning parameters is carried out using the Ford dataset, while the KITTI dataset is used to measure the influence of the density of the input point cloud. The results show that the proposed recentering strategy improves the accuracy of the odometry calculated by registering the latest lidar scan on the generated map compared to other NDT based approaches (NDT OM, NDT OM Fusion, SE-NDT). In particular, the proposed method, which does not perform loop closure, reduces the mean absolute translation error by 16% and the runtime by 88% compared to the NDT OM Fusion on the Ford dataset.Engineering and Physical Sciences Research Council (EPSRC): EP/K504324/1IEEE Transactions on Intelligent Vehicle
A CMOS Dual-RC frequency reference with ±250ppm inaccuracy from -45°C to 85°C
No full textTo comply with wired communication standards such as USB, SATA and PCI/PCI-E, systems-on-chip require frequency references with better than 300ppm accuracy. LC-based references achieve 100ppm accuracy [1], but suffer from high power consumption (∼20mW). Thermal diffusivity (TD) references require less power (∼2mW), at the expense of less accuracy (1000ppm) [2]. RC-based references offer the lowest power consumption, but their accuracy is typically limited to ∼0.1% [3]. In RC relaxation oscillators, comparator offset and delay are the major sources of inaccuracy [4,5]. References based on frequency-locked loops (FLLs) circumvent these by locking an oscillator's frequency to the time-constant of an RC filter, but their accuracy is then limited by the nonlinear temperature dependency of on-chip resistors [3,6].Session 3.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Instrumentation(OLD)Applied Quantum ArchitecturesMicroelectronic
Transcriptomics Analysis of ADPKD Cysts Shows Remodeling of Purinergic Receptors in Pkd1RC/RC Mice
No full textBackground: Polycystic kidney diseases (PKD) are characterized by development of multiple cysts, dilations of nephron segments, which replace normal tissues and lead to kidney insufficiency.
Methods: To identify new gene pathways affected by cyst development in collecting ducts, we used a bulk RNAseq approach comparing gene expression of normal microdissected cortical collecting ducts (n=3) vs cysts (n=4) microdissected from the same Pkd1RC/RC mice.
Results: Bulk-RNA analysis identified 18,000 genes and allowed statistical comparison of over 15,000 genes. Our data reveals that although cysts originate from normal collecting ducts, cystic epithelium show 2692 down-regulated and 2278 upregulated genes (p\u3c0.05 pAdj. FDR). Ingenuity Pathways Analysis identifies the following intracellular mechanisms mostly affected by transition: Rac and Rho signaling, fibrosis signaling, epithelial-to-mesenchymal transition, cytoskeleton rearrangement and ERK/MAPK signaling. Our previous publication reported that development of cysts in an autosomal recessive model of PKD is associated with a shift of P2Y to P2X receptor abundance. In the current study we found that in the autosomal dominant Pkd1RC/RC mice model purinergic signaling undergoes similar remodeling. The most abundant ionotropic receptors with reduced expression were P2ry2 and P2ry4, whereas ionotropic receptors P2rx5 and P2rx7 increased expression (2.88 and 1.53, log2). Additionally, analysis detected elevated abundance of P2ry6, P2ry12 and P2ry13 RNA level. We hypothesize that the physiological significance of the predominant P2X signaling in the cysts include their role in regulation of ATP release via pannexin-1 channels. Abnormal ATP accumulation in the cyst space was shown earlier to contribute in cystogenesis and we previously showed that pannexin-1 mediates ATP release to the cyst lumen. In the presented study, RNAscope confirms hyperexpression of P2rx7 mRNA in cysts. In a heterologous CHO cells system, interaction of P2X7 with pannexin-1 upregulates channel activity and both proteins co-immuno precipitate.
Conclusions: Development and establishment of ADPKD cysts involves massive transcriptome remodeling of collecting ducts which include a shift in purinergic signaling that facilitates pathogenic pannexin-1 hyperactivity
Experimental and theoretical investigation of crack width calculation methods for RC ties
No full textThis paper theoretically and experimentally investigates the semi-empirical formulas recommended by Eurocode 2 (EC2), fib Model Code 2010 (MC2010), and Eurocode 2 with the German National Annex (DIN) for calculating crack widths in reinforced concrete. It is shown that the formulas can be derived from the principles for the idealized behavior of RC ties. However, instead of explicitly solving the resulting differential equations, the use of simplifications leads to inconsistent formulas. An experimental study was carried out involving the testing of eight RC ties to discover the modeling uncertainty of the formulas. It was found that EC2 substantially overestimated the crack widths for the RC ties. MC2010 and DIN seemed to predict the crack widths better, but gave rather a large number of nonconservative crack width predictions. These experimental results, combined with the theoretical study, suggest that a more consistent calculation model should be formulated by explicitly solving the resulting differential equation.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Applied Mechanic
RC SMOOTHING OF SPECTRA
No full textAuthor Institution: Department of Physics, Michigan State University East LansingBy convoluting an exponential function with calculated spectra consisting of single and multiple sets of lines of various widths and line shapes, we have determined the effects that time constant (RC) has on recorded spectra. For equivalent experiments, in which the scanning rates d/dt are equal, we have concluded that the optimum value of RC is essentially independent of whether the spectrum is to be digitized or not, and independent of the sampling rate if digitization is used. A trade-off among the desirable and undesirable effects of RC leads us to recommend a value of RC about one-tenth of the full width at half height of the sharpest individual lines in the observed spectrum. This research was supported by a grant from the National Science Foundation
Nonlinear analysis to investigate effect of connection type on behavior of steel plate shear wall in RC frame
No full textIn the reinforced concrete (RC) structures with steel plate shear walls (SPSWs) as a lateral resisting system, to obtain maximum capacity of SPSW, implementing proper connections play an important role to transfer force from wall to the frame. In this paper, four connection types are proposed and numerically investigated to transfer the tension field forces between SPSW and RC frame (RCF). Three types of connections are applicable for rehabilitating of existing RC structures and one type can be used for new construction. The behavior of connections has been evaluated using non-linear finite element analysis (NLFEA). Results of the specimens with different types of connections demonstrated that the use of SPSW in RCF with appropriate connections could provide excellent ductility as well as high load carrying capacity and initial stiffness by distributing the yielding zone in SPSW along the wall height
AgnostiqHQ/covalent: v0.234.1-rc.0
No full text<h2>[0.234.1-rc.0] - 2024-05-10</h2>
<h3>Authors</h3>
<ul>
<li>Andrew S. Rosen <a href="mailto:[email protected]">[email protected]</a></li>
<li>Sankalp Sanand <a href="mailto:[email protected]">[email protected]</a></li>
<li>Co-authored-by: Alejandro Esquivel <a href="mailto:[email protected]">[email protected]</a></li>
<li>Casey Jao <a href="mailto:[email protected]">[email protected]</a></li>
<li>Co-authored-by: Santosh kumar <a href="mailto:[email protected]">[email protected]</a></li>
</ul>
<h3>Fixed</h3>
<ul>
<li>Sublattice electron function strings are now parsed correctly</li>
<li>The keys of dictionary inputs to electrons no longer need be strings.</li>
<li>Fixed inaccuracies in task packing exposed by no longer uploading null attributes upon dispatch.</li>
</ul>
<h3>Operations</h3>
<ul>
<li>Fixed nightly workflow's calling of other workflows.</li>
<li>Fixed input values for other workflows in <code>nightly-tests</code> workflow.</li>
</ul>
<h3>Operations</h3>
<ul>
<li>Removing author email from changelog action</li>
<li>Fixed nightly worfkflow's calling of other workflows.</li>
</ul>
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