8 research outputs found
Relationship between phase angle measured with bioelectrical impedance analysis and nonalcoholic fatty liver disease in adults
No full textPurpose - The phase angle (PhA) measured by bioelectrical impedance analysis (BIA) is associated with nutritional status and cellular health, and it is a clinically important parameter used to assess the risk of various diseases. It remains unclear whether PhA is associated with nonalcoholic fatty liver. The purpose of this study is to investigate the relationship between the BIA parameter PhA and nonalcoholic fatty liver disease (NAFLD). Design/methodology/approach - This cross-sectional study was conducted with 300 adults aged 20-64 years (NAFLD: 196, normal: 104). Some biochemical findings of the participants were collected, and whole-body and segmental PhAs were measured using Tanita (MC-780) at 50 kHz. Findings - The PhA values of the whole body (p = 0.003), trunk (p < 0.001), right and left legs (p < 0.001 for both) were found to significantly differ according to the degrees of fatty liver. It was observed that the highest PhA values were in normal individuals. Logistic regression analysis showed that the reduction in PhAs of the whole body (p = 0.038), right (p = 0.019) and left legs (p = 0.049) and trunk (p = 0.001) after adjusting for all confounding factors increased the risk of NAFLD. Additionally, whole body PhA was significantly associated with age (year, p = 0.02), BMI (kg/m2; p < 0.001), fat mass (kg; p = 0.001), fat mass (%; p < 0.001), albumin (g/L; p < 0.001) and CRP (mg/dL; p = 0.001). Originality/value - The results of this study showed that PhA can be used in the management of NAFLD. To identify potential mechanisms in the relationship between the angle of the liver and NAFLD, large-scale prospective studies are needed.The authors are grateful to all individuals who participated in this study. Thanks to ChatGPT 4.0, which was used to improve language and readability in some sentences of this study. Funding: The author declares that no funds, grants or other support were received during the preparation of this manuscript. Authors' contributions: Conceptualization: Mustafa Capraz; Methodology: Cansu Memic nan, Mustafa Capraz; Formal analysis: Cansu Memic nan; investigation: Cansu Memic nan; writing - original draft: Cansu Memic nan; supervision: Mustafa Capraz. Availability of data and materials: The data sets used and/or analyzed during the current study are available from the corresponding author upon reasonable request. Declaration of conflicting interests: The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this study. Ethical statements approval: Informed written consent was obtained from all participants prior to data collection. Ethics Committee Permission was obtained from Amasya University for this study (No. 050.01.04-102553). All study procedures were conducted according to the guidelines of the Declaration of Helsinki
The Effect of Inhaled Budesonide and Formoterol on Bronchial Remodeling and HRCT Features in Young Asthmatics
No full textThe Study of Customer Attitudes towards SMS Advertisements
No full textAbstractThe use of mobile phones and the Internet has been increasing rapidly with the continuous developments in technology. This increase helps businesses have a more interactive relationship with their customers both increasing the customer satisfaction and the quality of the organizations. Especially, short message services are of importance to maintain the customer relations. The focus of communication has turned to mobile technologies with the availability of the Internet in mobile devices. Thanks to these developments in technology, businesses have begun to focus on mobile marketing in order to reduce the costs and address more people than before. In addition, whether they are positive or negative, the attitudes of customers can have a certain influence the reputation of the companies. This study aims to examine the attitudes of the college students at Trakya University, Kesan Yusuf Capraz School towards the sms marketing advertisements and the differences stemming from their ways of life
Carotid artery intima-media thickness correlates with oxidative stress in chronic haemodialysis patients with accelerated atherosclerosis
No full textBackground. Accelerated atherosclerosis is the major cause of mortality in patients on chronic haemodialysis (HD). Increased oxidative stress might be the major factor leading to high cardiovascular mortality rate in HD patients. The aim of our study was to clarify effects of uraemia and dialysis on oxidative stress parameters and explore the relation between oxidative stress markers and carotid artery intima-media thickness (CIMT) as an indicator of atherosclerosis. Methods. Twenty chronic HD patients, 20 predialytic uraemic patients and 20 healthy subjects were included in the study. Serum thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCO) and nitrite/nitrate levels were determined as oxidative stress markers. Serum vitamin E, plasma sulfhydryl (P-SH), erythrocyte glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were measured as antioxidants. CIMT was assessed by carotid artery ultrasonography. Results. Both chronic HD and predialytic uraemic patients had enhanced oxidative stress indicated by higher levels of nitrite/nitrate, TBARS and PCO, and lower levels of P-SH, SOD, CAT and GPx compared to controls. HD patients had significantly higher CIMT and nitrite/nitrate while significantly lower P-SH,vitamin E, SOD, CAT and GPx compared to predialytic uraemic patients. There was a significant positive correlation between CIMT and TBARS (r = 0.38, P = 0.003) and nitrite/nitrate levels (r = 0.41, P = 0.001), while there was a significant negative correlation between CIMT and SOD (r = -0.35, P = 0.01), CAT (r = -0.65, P 0.001) and P-SH levels (r = -0.50, P 0.001). A linear regression analysis showed that TBARS were still significantly and positively correlated with CIMT (P = 0.001), while CAT and P-SH were significantly and negatively correlated with CIMT (P = 0.002 and P = 0.048, respectively). Conclusions. HD exacerbates oxidative stress and disturbances in antioxidant enzymes in uraemic patients. We propose that serum TBARS and nitrite/nitrate can be used as positive determinants, while erythrocyte SOD, CAT and P-SH may be used as negative determinants of atherosclerosis assessed by CIMT in uraemic and HD patients. © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved
Role of serological rapid antibody test in the management of possible COVID-19 cases
No full textBACKGROUND Although the detection of viral particles by reverse transcription polymerase chain reaction (RT-PCR) is the gold standard diagnostic test for coronavirus disease 2019 (COVID-19), the false-negative results constitute a big challenge. AIM To examine a group of patients diagnosed and treated as possible COVID-19 pneumonia whose multiple nasopharyngeal swab samples were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by RT-PCR but then serological immunoglobulin M/immunoglobulin G (IgM/IgG) antibody against SARS-CoV-2 were detected by rapid antibody test. METHODS Eighty possible COVID-19 patients who had at least two negative consecutive COVID-19 RT-PCR test and were subjected to serological rapid antibody test were evaluated in this study. RESULTS The specific serological total IgM/IgG antibody against SARS-CoV-2 was detected in twenty-two patients. The mean age of this patient group was 63.2± 13.1-years-old with a male/female ratio of 11/11. Cough was the most common symptom (90.9%). The most common presenting chest computed tomography findings were bilateral ground glass opacities (77.2%) and alveolar consolidations (50.1%). The mean duration of time from appearance of first symptoms to hospital admission, to hospital admission, to treatment duration and to serological positivity were 8.6 d, 11.2 d, 7.9 d, and 24 d, respectively. Compared with reference laboratory values, serologically positive patients have shown increased levels of acute phase reactants, such as C-reactive protein, ferritin, and procalcitonin and higher inflammatory markers, such as erythrocyte sedimentation rate, lactate dehydrogenase enzyme, and fibrin end-products, such as D-dimer. A left shift on white blood cell differential was observed with increased neutrophil counts and decreased lymphocytes. CONCLUSION Our study demonstrated the feasibility of a COVID-19 diagnosis based on rapid antibody test in the cases of patients whose RT-PCR samples were negative. Detection of antibodies against SARS-CoV-2 with rapid antibody test should be included in the diagnostic algorithm in patients with possible COVID-19 pneumonia. © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved
Oxidative Stress and Trace Elements in Patients with Non-Diabetic Hemodialysis
No full textSeveral evidences show that oxidative stress is high among patients with hemodialysis. This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis. In a case - control study 60 non-diabetic hemodialysis patients referred to hospital hemodialysis 1387 were studied. Lipid profile, glucose, creatinine, urea, total protein, albumin, zinc, copper, malondialdehyde, total antioxidant capacity and superoxide dismutase and glutathione peroxidase enzymes were measured in both groups. The results using the software T test and Pearson correlation coefficient was used to measure the dependence between variables in the SPSS 16 statistical was used. The amount of blood sugar, cholesterol, triglycerides, total protein, albumin Significantly less than the control group. Superoxide dismutase and glutathione peroxidase enzyme activity of red blood cells serum total antioxidant capacity in hemodialysis patients was significantly higher than healthy individuals. Concentrations of the Copper and malondialdehyde in the two groups did not differ significantly.This study shows that in non-diabetic hemodialysis patients, increased activity of antioxidant enzymes prevent oxidative stress is increased. Zinc deficiency was also observed in these patients
Role of serological rapid antibody test in the management of possible COVID-19 cases
No full textBACKGROUND Although the detection of viral particles by reverse transcription polymerase chain reaction (RT-PCR) is the gold standard diagnostic test for coronavirus disease 2019 (COVID-19), the false-negative results constitute a big challenge. AIM To examine a group of patients diagnosed and treated as possible COVID-19 pneumonia whose multiple nasopharyngeal swab samples were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by RT-PCR but then serological immunoglobulin M/immunoglobulin G (IgM/IgG) antibody against SARS-CoV-2 were detected by rapid antibody test. METHODS Eighty possible COVID-19 patients who had at least two negative consecutive COVID-19 RT-PCR test and were subjected to serological rapid antibody test were evaluated in this study. RESULTS The specific serological total IgM/IgG antibody against SARS-CoV-2 was detected in twenty-two patients. The mean age of this patient group was 63.2± 13.1-years-old with a male/female ratio of 11/11. Cough was the most common symptom (90.9%). The most common presenting chest computed tomography findings were bilateral ground glass opacities (77.2%) and alveolar consolidations (50.1%). The mean duration of time from appearance of first symptoms to hospital admission, to hospital admission, to treatment duration and to serological positivity were 8.6 d, 11.2 d, 7.9 d, and 24 d, respectively. Compared with reference laboratory values, serologically positive patients have shown increased levels of acute phase reactants, such as C-reactive protein, ferritin, and procalcitonin and higher inflammatory markers, such as erythrocyte sedimentation rate, lactate dehydrogenase enzyme, and fibrin end-products, such as D-dimer. A left shift on white blood cell differential was observed with increased neutrophil counts and decreased lymphocytes. CONCLUSION Our study demonstrated the feasibility of a COVID-19 diagnosis based on rapid antibody test in the cases of patients whose RT-PCR samples were negative. Detection of antibodies against SARS-CoV-2 with rapid antibody test should be included in the diagnostic algorithm in patients with possible COVID-19 pneumonia. © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved
Can we predict patients that will not benefit from invasive mechanical ventilation? A novel scoring system in intensive care: the IMV Mortality Prediction Score (IMPRES)
No full textConclusion: The present study included a large number of patients from various geographical areas of the country who were admitted to various types of ICUs, had diverse diagnoses and comorbidities, were intubated with various indications in either urgent or elective settings, and were followed by physicians from various specialties. Therefore, our data are more general and can be applied to a broader population. This study devised a new scoring system for decision-making for critically ill patients as to whether they need to be intubated or not and presents a rapid and accurate prediction of mortality and prognosis prior to ICU admission using simple clinical data
