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Majör depresif bozukluk tanılı hastalarda ince bağırsak aşırı bakteri çoğalması durumu
Get PDFDepresyon dünyada yaygın görülmekle birlikte yaşam kalitesini bozan ve yüksek
oranda tekrarlayan bir hastalıktır. Birçok çalışma mikrobiyotanın santral sinir sistemini
etkilediği göstermiş ve depresyonla ilişkilendirmiş olsa da, majör depresif bozukluğu olan
hastalardaki temel patogenezi tam olarak bilinmemektedir. İnce bağırsak bakteri aşırı
çoğalması, ince bağırsaktaki bakteri tiplerinin değişmesi ve/veya bakteri sayısının artışıdır.
Stresin mikrobiyotayı değiştirdiği bilinmekte ve bu nedenle SIBO'nun majör depresif
bozuklukla ilişkili olabileceği düşünülmektedir. Bu çalışma majör depresif bozukluk ile
SIBO arasındaki ilişkiyi ortaya koymayı amaçlamaktadır.
Çalışma 23.01.2019-15.07.2019 tarihleri arasında Başkent Üniversitesi Tıp Fakültesi
Ankara Hastanesi Aile Hekimliği, Gastroenteroloji ve Psikiyatri Ana Bilim Dalı ve Sağlık
Bilimleri Üniversitesi Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Psikiyatri
Ana Bilim Dalı polikliniklerine başvurmuş olan 45 majör depresif bozukluk tanılı hasta ile
49 sağlıklı gönüllü olmak üzere toplam 94 kişiyle yürütülmüştür. Hastalara oral glukoz
solüsyonu içirilmesini takiben Quintron Breath Tracker isimli cihaz kullanılarak nefeste H2
ve CH4 düzeyleri ölçülmüştür. Ayrıca demografik özellikleri, beck depresyon ölçeği, beck
anksiyete ölçeği ve kısa semptom envanteri değerlendirmeleri yapılmıştır.
Çalışmaya dahil edilen katılımcıların %60,6’sı (n=57) kadın, %39,4'i (n=37) erkekti.
Yaş ortalamaları hasta grupta 38,9±15,2, kontrol grubunda 35,8±11.1 olarak bulunmuştur.
BDÖ, BAÖ, KSE skorları sırasıyla hasta ve kontrol grubu olmak üzere ortalama 23,20±8,74
ve 4,86±2,85; 18,73±10,31 ve 6,06±4,57; 69,64±40,69 ve 17,63±11,93 olarak tespit edildi
(p<0,001).
Çalışmaya dahil edilen 94 kişinin %14,9'i (n=14) SIBO pozitif olup, gruplar arasında
anlamlı bir ilişki tespit edilememiştir (p>0,05). Bununla birlikte metan pozitifliği hasta
grubunda anlamlı olarak yüksek tespit edildi (p<0,05). Her iki grupta SIBO ile demografik
özellikler ve vücut kitle indeksi arasında anlamlı bir ilişki yoktu (p>0,05).
Bu çalışma majör depresif bozukluk ile SIBO'nun ilişkisini gösterememiş olmakla
birlikte daha fazla sayıda MDB popülasyonlarında araştırma yapılması gerekir.
Although depression is common in the world, it is a highly recurrent disease that
deteriorates the quality of life. The main pathogenesis of major depressive disorder (MDD)
is not fully understood, and many studies have shown that microbiota affects the central
nervous system and is associated with depression. Small intestinal bacterial overgrowth
(SIBO) is a change in the types of bacteria in the small intestine and / or an increase in the
number of bacteria. Stress is also known to alter the microbiota, and therefore SIBO is
thought to be associated with MDD. This study aims to reveal the relationship between MDD
and SIBO.
The study was carried out with 45 MDD patients and 49 healthy volunteers who were
admitted to the outpatient clinic of Başkent University Faculty of Medicine Ankara Hospital
and Health Sciences University Dışkapı Yıldırım Beyazıt Training and Research Hospital
between 23.01.2019-15.07.2019. Beck Depression Inventory (BDI), Beck Anxiety
Inventory (BAI) and Brief Symptom Inventory (BSI) were performed. For the evaluation of
SIBO, H2 and CH4 levels in breath were measured using Quintron Breath Tracker following
oral glucose solution.
Of the participants included in the study, 60,6% (n = 57) were female and 39,4% (n
= 37) were male. The mean age was 38.9 ± 15.2 in the patient group and 35,8 ± 11.1 in the
control group. BDI, BAI, BSI scores were 23,20±8,74 and 4,86±2,85; 18,73±10,31 and
6,06±4,57; 69,64±40,69 and 17,63±11,93, respectively (p <0.001). 14,9% (n = 14) of the
participants (n = 94) were SIBO positive and there was no significant relationship between
the groups (p> 0.05). However, methane positivity was significantly higher in the patient
group (p <0.05). There was no significant relationship between SIBO and demographic
characteristics and body mass index in both groups (p> 0.05).
Although this study did not show the relationship between MDD and SIBO, more
MDD populations need to be investigated
Diferansiye tiroid karsinomunda radyoaktif iyot tedavisinin kemik iliği üzerine etkileri ve sekonder kanser gelişimi
No full textTiroid kanserleri endokrin maligniteler içinde en sık görülen kanser olup kadınlarda en sık görülen ikinci kanserdir. Tiroid kanserlerinin büyük çoğunluğunu diferansiye tiroid kanserleri (DTK) oluşturmaktadır. Tiroid kanserinin insidansının artması ve iyi prognozlu olması, özellikle radyoiyodin tedavisinden sonra sekonder kanser gelişimi açısından endişeye yol açmaktadır. Bu çalışmada amacımız; RAİ tedavisinin zaman içinde kemik iliği üzerine etkilerini ve sekonder kanser gelişimini incelemektir.
Bu çalışma, Başkent Üniversitesi Ankara Hastanesi’nde Ocak 2000 ve Aralık 2012 yılları arasında tiroid kanseri tanısı olan ve cerrahi işlem sonrası RAİ tedavisi alan 259 hastanın verileri retrospektif olarak taranarak yapılmıştır. Uygulanan RAİ tedavisinin öncesinde ve sonrasındaki 5 yıllık süreçte hastaların tam kan parametreleri, TSH ve tiroglobulin değerlerinin zaman içindeki değişimi incelendi. Ayrıca hastalarda sekonder kanser gelişimi olup olmadığı araştırıldı.
Hastalara uygulanan ortalama RAİ dozu 118 mCi olarak tespit edilmiştir. Hastaların RAİ tedavisinden sonra kısa süreli takiplerinde kemik iliği supresyonu olduğu, ancak bu supresyonun uzun süreli takiplerinde normale döndüğü gözlenmiştir. Hastaların takiplerinde sekonder kanser gelişimi tespit edilmemiştir.
RAİ tedavisinde 100 mCi üzeri yüksek doz olarak kabul görmekte ve bazı çalışmalarda RAİ sonrası sekonder kanser varlığından bahsedilmektedir. Bu çalışmalarda sekonder kanser varlığı ile RAİ ilişkisinin kesin olmadığı ve gelişen kanserlerin genetik yatkınlık, çevresel faktörler sebebiyle olabileceği de akılda tutulmalıdır. Türkiye’de verilen RAİ tedavisine bağlı sekonder kanser gelişiminin olmaması da RAİ’nin ülkemizde güvenle kullanılabileceğini düşündürmektedir.
Thyroid cancers are the most common cancer among endocrine malignancies and the second most common cancer in women. The majority of thyroid cancers are differentiated thyroid cancers (DTK). Increasing incidence and good prognosis of thyroid cancer have led to concern about the development of second malignancy, especially after radioiodine treatment. Our aim in this study is; The effects of RAI treatment on bone marrow over time and the development of secondary cancer are examined.
The study was carried out retrospectively from 259 patients diagnosed with thyroid cancer between January 2000 and December 2012 at the Ankara Hospital of Başkent University, Ankara, Turkey. The changes in whole blood parameters, TSH and thyroglobulin values of patients were examined over time before and after RAI treatment in 5 years. In addition, patients were investigated for the development of secondary cancer.
The mean RAI administered to the patient was found to be 118 mCi. Patients had bone marrow suppression in short-term follow-up from RAI treatment, but this suppression was observed to return to normal in long-term follow-up. In patients' follow-up, the development of secondary cancer was not detected.
It is accepted as a high dose of 100 mCi in the treatment of RAI, and in some studies, the presence of secondary cancer after RAI is mentioned. It should be kept in mind that in these studies, the presence of secondary cancer is not definitive, and that developing cancers may be due to genetic susceptibility, environmental factors. In the absence of secondary cancer development in Turkey linked to given RAI treatment, it is thought that RAI can be used safely in our country
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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