1,146 research outputs found
Introduction by Manuela Gieri
No full textIn the introduction to the volume, the author outlines the development of Italian cinema from its early days to the present
Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
No full textCorrection to: Nature Genetics, 50, 928–936 (2018), https://doi.org/10.1038/s41588-018-0142-8, published online 11 June 2018.
In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.No Full Tex
Le credenze epistemologiche circa il sapere medico: quale ruolo nei comportamenti del paziente?
No full textViene presentato uno studio condotto con 84 soggetti adulti attraverso la somministrazione di tre questionari self-report: il ???Questionario sulle Credenze Epistemologiche in Medicina??? (Antonietti e Ferraro, 2013), la versione adattata del questionario ???Come conosco??? (Antonietti e Ferraro, 2013) volto a rilevare le credenze epistemologiche in maniera contestualizzata e un questionario di valutazione del grado di health literacy. Il campione è stato suddiviso in base all???età, al livello di istruzione, al livello di alfabetizzazione medica e al tipo di esperienze sanitarie avute negli ultimi 5 anni. Dall???analisi dei dati emerge che al crescere del grado di istruzione aumentano le visioni epistemologiche relativistiche, mentre i soggetti con recenti o ripetute esperienze di ricovero tendono ad avere una visione più assolutistica del sapere medico. Non risulta l???incidenza né dell???età, né delle conoscenze dominio-specifiche. Vengono approfondite le accezioni del concetto di health literacy e lo statuto delle conoscenze implicate nel rapporto medico-paziente
A neural strategy for the inference of SH3 domain-peptide interaction specificity
Full text linkThe SH3 domain family is one of the most representative and widely studied cases of so-called Peptide Recognition Modules (PRM). The polyproline II motif PxxP that generally characterizes its ligands does not reflect the complex interaction spectrum of the over 1500 different SH3 domains, and the requirement of a more refined knowledge of their specificity implies the setting up of appropriate experimental and theoretical strategies. Due to the limitations of the current technology for peptide synthesis, several experimental high-throughput approaches have been devised to elucidate protein-protein interaction mechanisms. Such approaches can rely on and take advantage of computational techniques, such as regular expressions or position specific scoring matrices (PSSMs) to pre-process entire proteomes in the search for putative SH3 targets. In this regard, a reliable inference methodology to be used for reducing the sequence space of putative binding peptides represents a valuable support for molecular and cellular biologists
La biografía de Manuela Cambronero
No full textManuela Cambronero’s biography has been a pending issue until now, given that her figure has not aroused interest and no studies which focus on clarifying her origins and chronology have been published. This information is essential as a starting point for any work on the author, which is why elucidating these unknowns through direct archive research is a sine qua non. Consequently, locating Manuela Cambronero’s baptismal, marriage and death certificates is the only reliable way to dispel any doubt about her provenance and to determine the exact places and dates of the trans-cendental events of her life.La biografía de Manuela Cambronero ha sido una cuestión pendiente hasta ahora, pues, como su figura no ha suscitado interés, no se han publicado estudios centrados en esclarecer su origen y su cronología. Esta información es esencial como punto de partida para cualquier trabajo sobre la autora, por lo que dilucidar estas incógnitas a través de la búsqueda directa en archivos se convierte en una condición sine qua non. En consecuencia, la localización de los certificados de bautismo, de matrimonio y de defunción de Manuela Cambronero es la única vía fiable para disipar las dudas sobre su procedencia y para concretar los lugares y fechas exactas de los eventos trascendentales de su vida
Manuela Sáenz en varios textos
No full textThis report is an attempt to analyze the narrative discourse order in the novel “La esposa del Dr. Thorne” (Dr. Thorne’s Wife) of the Venezuelan writer Denzil Romero, in the light of ¨Las cuatro estaciones de Manuela” (“The Four Seasons of Manuela”) of the American author Víctor W. von Hagen, and of “Manuela. Sus diarios perdidos y otros papeles”, (Manuela. Lost Diaries and Other Papers) of the Ecuadorian Carlos Álvarez Saá. This paper is a risky comparison between a book of fiction, presumably based on real facts, where Manuela’s eroticism is the central theme in Romero, the large literary chronicles issued by von Hagen and the compilation and discovery of alleged original and historic texts (letters and diaries) produced by Álvarez Saá. It is also a research exercise where, whimsically, what the official discourse says, as it may be viewed by the school of Venezuela or that of Quito, is mixed with the fictionalization of that discourse. It is, too, a possible vindication of Manuela Sáenz as a person and/or predominant character in the fights for the independence of America beyond her ¨circumstantial¨ relationship with Simón Bolívar. It is, to a certain extent, a look into how literary texts and the perceptions of history about a character (Manuela) tend to a “rearrangement” in present times and how there has been an attempt to consolidate the figure of Manuela Sáenz as a heroine, awarding a victory to what von Hagen calls “the school of Quito”.Si prese l’analisi dell’ordine discorsivo narrativo del romanzo dell’autore venezuelano Denzil Romero, La sposa del Dott.re Thorne, attraverso le comparazioni delle opere dell’autore statunitense Víctor W. Von Hagen, Le quattro stagioni di Manuela e dell’ autore ecuadoregno Carlos Álvarez Saá, Manuela, i suoi diari persi ed altre carte. È una comparazione azzardadata tra un libro di finzione, forse basato in fatti reali, dove l’erotismo della donna (Manuela) costituisce la tematica centrale, nell’opera di Romero, con la lunga cronaca letteraria che fa von Hagen e la compilazione e la scoperta di supposti testi originali e storici (lettere, diari) che fa Álvarez Saá. È un esercizio di ricerca dove si mescolano, in modo capriccioso, il campo d’attività del Venezuela o quello del Quito, e la finzione di quello ufficiale. È anche la rivendicazione possibile di Manuela Sáenz come persona e/o personaggio preponderante nelle lotte indipendentistiche dell’America che era aldilà della relazione congiunturale con Simón Bolívar. Si vuole vedere, fino a un certo punto, come i testi letterari e le percezioni della storia su un personaggio (Manuela) tendono a sistemarsi con i tempi attuali e come si ha voluto affiancare la figura eroica di Manuela Sáenz, concedendole il trionfo, forse secondo la tesi di von Hagen: quella che lui definisce la scuola di Quito.Se pretendeu analisar a ordem discursivo-narrativa do romance do venezuelano Denzil Romero, “La esposa del Dr. Thorne”, à luz das obras do americano Víctor W. von Hagen, ¨Las cuatro estaciones de Manuela” e do equatoriano Carlos Álvarez Saá, “Los diários perdidos de Manuela Sáenz y otros papeles”. Este trabalho é a comparação arriscada entre um livro de ficção, baseado aparentemente em fatos reais, no qual o erotismo da mulher (Manuela) é o tema central, em Romero, com a extensa crônica literária que lhe faz von Hagen e a recopilação e a descoberta de aparentes textos originais e históricos (cartas, diários) que faz Álvarez Saá. Também é um exercício de pesquisa em que, de maneira especial, se mistura o que diz o discurso histórico oficial, segundo seja visto pela escola da Venezuela ou a de Quito, com a visão dada pela ficção a esse discurso. É, ao mesmo tempo, um pouco a possível reivindicação de Manuela Sáenz como pessoa e/ou personagem preponderante nas lutas de independência da América que chegavam além do seu ¨controvertido¨ relacionamento com Simón Bolívar. É ver, de certa forma, como os textos literários a as percepções da história sobre uma personagem (Manuela) têm tendência a ¨se readaptar” nos tempos atuais e como se quis dar força à figura de heroína de Manuela Sáenz, dando uma vitória a ela na que, tal vez, von Hagen denomina “a escola de Quito”.Se pretendió el análisis del orden discursivo narrativo de la novela del venezolano Denzil Romero, “La esposa del Dr. Thorne”, a luz de las obras del estadounidense Víctor W. von Hagen, ¨Las cuatro estaciones de Manuela” y del ecuatoriano Carlos Álvarez Saá, “Manuela. Sus diarios perdidos y otros papeles”. Este trabajo es la comparación riesgosa entre un libro de ficción, basado presumiblemente en hechos reales, donde el erotismo de la mujer (Manuela) es el tema central, en Romero, con la larga crónica literaria que hace von Hagen y la recopilación y descubrimiento de presuntos textos originales e históricos (cartas, diarios) que hace Álvarez Saá. Es también un ejercicio de investigación donde de manera caprichosa se mezcla lo que dice el discurso histórico oficial, según sea visto por la escuela de Venezuela o de Quito, y la ficcionalización de ese discurso. Es también un poco la posible reivindicación de Manuela Sáenz como persona y/o personaje preponderante en las luchas independentistas de América que iban más allá de la ¨coyuntural¨ relación con Simón Bolívar. Es ver, hasta cierto punto, cómo los textos literarios y las percepciones de la historia sobre un personaje (Manuela) tienden a ¨reacomodarse” en los tiempos actuales y cómo se ha querido afianzar la figura de heroína de Manuela Sáenz, dándole el triunfo, tal vez, a lo que llama von Hagen “la escuela de Quito”
The mis-exaptation of the prediction capability of humans and emergence of intolerant religious beliefs
No full textSome neurobiological aspects and social consequences of religious beliefs are briefly discussed. A basic aspect to be considered is the capability of several living beings to prospect future scenarios. In this context, however, it has to be underlined that only humans know that they have to die. Consequently, all human cultures have proposed dreams, visions and religious beliefs to dispel the fear of death. Awareness of the end of life has played a fundamental role in the emergence of religious beliefs. The social aspects of religions will be considered from Bloch’s perspective that modern humans are the only living beings capable of peculiar social inter-relationships, namely the transcendental social, which consists of the creation of essentialized roles and groups that exist separately from the individual who holds them. In other words, the transcendental social bonds not only real groups, such as tribes, clans or nations, but also imaginary groups, such as ancestors or gods, thereby allowing the emergence of religion as a uniquely human activity. In the present paper, it is suggested that the concept of exaptation can shed some light on the origin of religions and on their potential positive effects on individual lives and human societies. On the other hand, the concept of mis-exaptation can shed some light on the possible perverse side-effects of religious beliefs. Thus, some aspects of the possible conceptual and neurobiological links
between exaptation and mis-exaptation of the religious beliefs will be analyzed
La biografía de Manuela Cambronero
No full textLa biografía de Manuela Cambronero ha sido una cuestión pendiente hasta ahora, pues, como su figura no ha suscitado interés, no se han publicado estudios centrados en esclarecer su origen y su cronología. Esta información es esencial como punto de partida para cualquier trabajo sobre la autora, por lo que dilucidar estas incógnitas a través de la búsqueda directa en archivos se convierte en una condición sine qua non. En consecuencia, la localización de los certificados de bautismo, de matrimonio y de defunción de Manuela Cambronero es la única vía fiable para disipar las dudas sobre su procedencia y para concretar los lugares y fechas exactas de los eventos trascendentales de su vida.Manuela Cambronero’s biography has been a pending issue until now, given that her figure has not aroused interest and no studies which focus on clarifying her origins and chronology have been published. This information is essential as a starting point for any work on the author, which is why elucidating these unknowns through direct archive research is a sine qua non. Consequently, locating Manuela Cambronero’s baptismal, marriage and death certificates is theonly reliable way to dispel any doubt about her provenance and to determine the exact places and dates of the trans-cendental events of her life
A Comparative Analysis of Shoes Designed for Subjects with Obesity Using a Single Inertial Sensor: Preliminary Results
Full text linkWalking remains a highly recommended form of exercise for the management of obesity. Thus, comfortable and adequate shoes represent, together with the prescription of a safe adapted physical activity, an important means to achieve the recommended physical activity target volume. However, the literature on shoes specific for obese individuals is inadequate. The aim of the present study was to compare the performance of shoes specifically designed for subjects with obesity with everyday sneakers during instrumented 6-min walking test and outdoor 30-min ambulation in a group of subjects with obesity using a single wearable device. Twenty-three obese individuals (mean age 58.96 years) were recruited and classified into two groups: deconditioned (n = 13) and non-deconditioned patients (n = 10). Each participant was evaluated with his/her daily sneakers and the day after with shoes specifically designed for people with obesity by means of a questionnaire related to the comfort related to each model of shoes and instrumentally during the i6MWT and an outdoor walking test. The results showed that the specifically designed shoes displayed the higher score as for comfort, in particular in the deconditioned group. During the i6MWT, the distance walked, and step length significantly increased in the deconditioned group when specifically designed shoes were worn; no significant changes were observed in the non-deconditioned individuals. The deconditioned group displayed longer step length during the outdoor 30-min ambulation test. In the non-deconditioned group, the use of specific shoes correlated to better performance in terms of gait speed and cadence. These data, although preliminary, seem to support the hypothesis that shoes specifically conceived and designed for counteracting some of the known functional limitations in subjects with obesity allow for a smoother, more stable and possibly less fatiguing gait schema over time
Author Correction:Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
No full textIn the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.</p
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