9 research outputs found
EFFICACY AND SAFETY OF BOTULINUM NEUROTOXIN IN GERIATRIC PATIENTS WITH AN OVERACTIVE BLADDER: A MULTICENTRIC STUDY FROM TURKEY
No full textIntroduction: To evaluate the clinical efficacy and safety of botulinum neurotoxin A injection in geriatric patients with an overactive bladder. Materials and Method: Data of 34 patients aged >65 years who received botulinum neurotoxin A injections (100 U) for overactive bladder at two different urology clinics from 2012 to 2018were retrospectively evaluated. Number of incontinence episodes, urinary frequency, nocturia occurrence, daily pad usage, maximum flow rate, post-void residual urine volume, treatment benefit scale and quality of life scores were evaluated for all patients at pretreatment and then at 3 and 6 months post treatment. Results: Comparison of the pre-treatment and the 3- and 6-month post-treatment data revealedno significant changes in maximum flow rate values (p=0.504 and 0.458, respectively); however, a statistically significant decrease was recorded in the urinary frequency, nocturia occurrence, daily pad usage and number of incontinence episodes (p=0.0001). The post-void residual urine volume significantly increased at 3 and 6 months post treatment (p=0.0001). Significant improvements were detected in the quality of life score at 3-months post treatment (p=0.0001). Conclusion: Botulinum neurotoxin A injection is an efficacious and safe option for treating geriatric patients and improving their symptoms of overactive bladder and quality of life
Inflammatory Pseudotumor of the Kidney
No full textInflammatory pseudotumor of the kidney is a rare benign condition with unknown etiology that can mimic malignancy. We report a case of inflammatory pseudotumor of the kidney. A 59-year-old male patient was admitted with a complaint of right flank pain and hematuria. Ultrasonography and magnetic resonance imaging of the patient revealed a 9 cm × 10 cm mass originating from the renal parenchyma with posterior extension. Operative findings revealed a mass adhering to the psoas muscle. Histopathologic examination demonstrated spindle-shaped fibroblast cells accompanying inflammatory cells. The pathological diagnosis was renal inflammatory pseudotumor. Repeated US and computed tomography revealed complete remission.</jats:p
Role of Diffusion MRI and Apparent Diffusion Coefficient Measurement in the Diagnosis, Staging and Pathological Classification of Bladder Tumors
No full textObjectives: Our aim was to investigate the role of simultaneous apparent diffusion coefficient (ADC) measurement and diffusion-weighted MRI (DWMRI) in the diagnosis and differentiation of bladder masses. Methods: We examined 45 patients presenting with hematuria by dynamic and diffusion MRI (at b100, b600, b1000 gradients) and cystoscopy. Thirty healthy volunteers without hematuria were also included in the study. Results from imaging techniques were compared to cystoscopic and histopathologic findings. The ADC values of benign and malignant bladder masses, and bladder tissue in healthy subjects were measured and compared with each other. Results: The mean ADC values of benign (n = 10) and malignant lesions (n = 35) were significantly lower than the mean ADC values of adjacent bladder walls and bladder walls of healthy subjects at all 3 gradients (p 0.05). Mean ADC values of invasive tumors were significantly lower than superficial malignancies at b600 and b1000 gradients. The mean ADC values of transitional cell tumors were significantly higher than squamous cell tumors at b100 and b600 gradients. Conclusion: Simultaneous measurement of ADC and DWMRI provided useful information in the diagnosis, staging and histopathological classification of bladder tumors. Copyright (C) 2011 S. Karger AG, Base
Technetium Tc 99m sulphur colloid seminal vesicle scintigraphy: A novel approach for the diagnosis of the ejaculatory duct obstruction
No full textOBJECTIVES To define a novel technique in the diagnosis of partial and complete ejaculatory duct obstruction (EDO)
Circulating Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels Are Associated With Erectile Dysfunction in Patients Without Known Coronary Artery Disease
No full textAim. Endothelial dysfunction and microvascular damage are involved in the pathogenesis of erectile dysfunction (ED). Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) is identified endothelial receptor for oxidized low-density lipoprotein (ox-LDL) that plays a pivotal role in ox-LDL-induced endothelial dysfunction. The purpose of the current study was to determine the association between sLOX-1 and ED in patients without known coronary artery disease (CAD). Main Outcome Measures. Diagnosis of ED was based on the International Index of Erectile Function Score-5. Levels of sLOX-1 were measured in serum by enzyme-linked immunosorbent assay. Methods. One hundred thirty-eight subjects with ED patients without known CAD (ED group) and 75 age-matched subjects without ED and known CAD (Non-ED Group) were included in this study. Results. Plasma levels of sLOX-1 were significantly higher in ED than in Non-ED group (9587 and 49 +/- 30pg/mL, respectively, P75pg/mL predicts ED with 26.8% sensitivity and 96.0% specificity on receiver operator characteristic analysis. Conclusions. Our study demonstrated that serum sLOX-1 levels were associated with endothelial dysfunction that predicts ED. Moreover, the current study revealed that there was strong negative correlation between the levels of circulating sLOX-1 and score of ED. This study suggested sLOX-1 may be involved in the pathogenesis of ED in patients without known CAD. Kobat MA, Frdolas F, Balin M, Celik A, Bentli R, and Baydas A. Circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are associated with erectile dysfunction in patients without known coronary artery disease. J Sex Med 2013;10:2782-2789
Comparison of retrograde intrarenal surgery and percutaneous nephrolithotomy for the treatment of renal stones greater than 2 cm
No full textErectile dysfunction in testicular cancer patients treated with chemotherapy
No full textInformation on male potency in testicular cancer (TC) patients treated with
chemotherapy is insufficient. We aimed to assess the levels of depression and
anxiety symptoms, sexual function and gonodotrophins. Participants (n = 27)
were identified and recruited from the genitourinary services of two medical
centres, one in Inonu University and the other in the Firat University. All
patients are TC patients treated with chemotherapy after unilateral orchiectomy.
Participants completed follow-up assessments after the completion of the
chemotherapy regimen. Serum luteinising hormone, follicle-stimulating hormone
and testosterone levels were determined after blood samples had been
taken in the morning after an overnight fast. International Index of Erectile
Function (IIEF-15) was also used to evaluate erectile dysfunction (ED) score.
Beck Depression and Beck Anxiety Scale were used to assess psychological
symptoms. The findings indicated that men treated with chemotherapy had
significantly different IIEF-15 and Beck Anxiety scores compared with men
who did not receive chemotherapy. But no statistically significant difference
was determined in the serum gonodotrophin levels and depression score
between the two groups. It is concluded that patients with TC undergoing chemotherapy
have greater risk than normal men for ED, independently of the
gonodotrophin’s level
Evaluation of Prolidase Activity, Oxidative Stress, and Antioxidant Enzyme Levels in Testicular and Penile Tissues after Human Chorionic Gonadotropin Treatment in Rats by Predicting Infertility and Erectile Dysfunction
No full text<b><i>Objectives:</i></b> Prolidase plays a vital role in collagen turnover, matrix remodeling, and cell growth. We aimed to evaluate the association between treatment with chorionic gonadotropin and infertility and erectile dysfunction by investigating tissue prolidase activity, oxidative stress, and levels of antioxidant enzymes. <b><i>Materials and Methods:</i></b> The 16 male Wistar albino rats used in this study were randomly divided into 2 groups: rats treated with human chorionic gonadotropin (hCG) and control rats (<i>n</i> = 8 in each group). The rats in the hCG group were subcutaneously injected with 50 IU hCG daily for 15 days, while the rats in the control group were subcutaneously injected isotonic saline. All of the rats were sacrificed by a lethal overdose of sodium pentobarbital at the first month after hCG administration. Prolidase activity and levels of malonyl aldehyde, glutathione reductase, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were estimated in the testicular and penile tissue.<b><i></i></b> The testicles and penis were transversely dissected and placed in formalin. <b><i>Results:</i></b> Levels of prolidase and malonyl aldehyde in the testicular and penile tissues were significantly higher in the hCG group than in the control group (<i>p</i> &#x3c; 0.001), while levels of glutathione reductase, SOD, GSH-Px, and CAT were significantly lower in the hCG group than in the control group (<i>p</i> &#x3c; 0.001). <b><i>Conclusions:</i></b> In this study, we observed that<b><i></i></b> treatment with hCG increased prolidase activity and oxidative stress and decreased the antioxidant capacity of penile and testicular tissues; therefore, this may affect fertility and erectile function.</jats:p
