50,870 research outputs found
Woud: Trek je even terug in je concentratiebubbel
No full textHet was zo’n zonnige lentedag; heerlijk om lekker buiten te zijn. Ik zat binnen, in een vergadering – met de nodige moeite om mijn aandacht erbij te houden. Liever keek ik door het raam naar kersenbloesems. Afgeleid raken, wegdromen ofjuist onrustig zijn en niet stil kunnen zitten. Herkenbaar? Vast wel; iedereen heeft wel eens moeite om zich te concentreren. Maar voor sommige kinderen is dit een dagelijkse worsteling. Hoe ga je daar op een goede manier mee om in eenklaslokaal, een omgeving met constante prikkels en afleiding? Ontwerper Shion Ito ontwierp een mini-bos waar je je even in kunt terugtrekken om je rust terug te vindenGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Human-Centered DesignDesign Aesthetic
Fast identification of biological pathways associated with a quantitative trait using group lasso with overlaps.
No full textWhere causal SNPs (single nucleotide polymorphisms) tend to accumulate within biological pathways, the incorporation of prior pathways information into a statistical model is expected to increase the power to detect true associations in a genetic association study. Most existing pathways-based methods rely on marginal SNP statistics and do not fully exploit the dependence patterns among SNPs within pathways.We use a sparse regression model, with SNPs grouped into pathways, to identify causal pathways associated with a quantitative trait. Notable features of our "pathways group lasso with adaptive weights" (P-GLAW) algorithm include the incorporation of all pathways in a single regression model, an adaptive pathway weighting procedure that accounts for factors biasing pathway selection, and the use of a bootstrap sampling procedure for the ranking of important pathways. P-GLAW takes account of the presence of overlapping pathways and uses a novel combination of techniques to optimise model estimation, making it fast to run, even on whole genome datasets.In a comparison study with an alternative pathways method based on univariate SNP statistics, our method demonstrates high sensitivity and specificity for the detection of important pathways, showing the greatest relative gains in performance where marginal SNP effect sizes are small
Fast fashion ?!
No full textDiplomová práce vytváří dočasně místně specifickou instalaci. Téma instalace je mířeno záměrně do prostředí obchodního domu, tedy heterotopického místa, které problém rychlé módy reprodukuje a symbolizuje. Diplomová práce k problému přistupuje dvěma odlišnými způsoby, oba jsou konfrontační, ale každý jinak. První, obsahem, který s nadsázkou ilustruje problematiku fast fashion, jak jejich klady, tak i zápory. Jedná se o velkoformátovou instalaci, tvořené z odpadového materiálu, který fast fashion produkuje. Naopak druhý způsob je tvořen guerillovým charakterem s osvětovým potenciálem, jehož dopad bude monitorován. Konkrétně se jedná o samolepky s QR kódy, které budou odkazovat na web, který přehledně sdružuje české značky, které podporují slow fashion.This thesis describe temporary placed specific installation. Topic of installation in focused in shopping centre panorama for heterotopic place, which is troubled with fast fashion reproduction and its symbolization. This thesis approach this problem with two different solution. Both solution are confrontational but each one is different. First one illustrates a fast fashion problem with exaggeration with focus on its positives and negatives. It is a big format installation made from waste materials from the fashion industry. On the other hand the second approach is made by Guerillo character with lighting pottencional, which impact will be monitored. Specifically it is stickers with QR code, which will be linked to web service with well organized Czech brands which support slow fashion
Fast microtomography using bright monochromatic x-rays
No full textA fast microtomography system for high-resolution high-speed imaging has been developed using bright monochromatic x-rays at the BL29XU beamline of SPring-8. The shortest scan time for microtomography we attained was 0.25 s in 1.25 mu m effective pixel size by combining the bright monochromatic x-rays, a fast rotating sample stage, and a high performance x-ray imaging detector. The feasibility of the tomography system was successfully demonstrated by visualization of rising bubbles in a viscous liquid, an interesting issue in multiphase flow physics. This system also provides a high spatial (a measurable feature size of 300 nm) or a very high temporal (9.8 mu s) resolution in radiographs. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4751853]open11710sciescopu
Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin
No full textAmrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force. Here we performed experiments to elucidate the molecular mechanisms for these effects, with the additional aim to gain insight into the molecular mechanisms underlying the force-velocity relationship. In vitro motility assays established that amrinone reduces the sliding velocity of heavy meromyosin-propelled actin filaments by 30% at different ionic strengths of the assay solution. Stopped-flow studies of myofibrils, heavy meromyosin and myosin subfragment 1, showed that the effects on sliding speed were not because of a reduced rate of ATP-induced actomyosin dissociation because the rate of this process was increased by amrinone. Moreover, optical tweezers studies could not detect any amrinone-induced changes in the working stroke length. In contrast, the ADP affinity of acto-heavy meromyosin was increased about 2-fold by 1 mm amrinone. Similar effects were not observed for acto-subfragment 1. Together with the other findings, this suggests that the amrinone-induced reduction in sliding velocity is attributed to inhibition of a strain-dependent ADP release step. Modeling results show that such an effect may account for the amrinone-induced changes of the force-velocity relationship. The data emphasize the importance of the rate of a strain-dependent ADP release step in influencing the maximum sliding velocity in fast skeletal muscle. The data also lead us to discuss the possible importance of cooperative interactions between the two myosin heads in muscle contraction
Hoe krijg je fast fashion uit de mode
No full textWat trek je deze zomer aan? Best lastig, want kledingtrends volgen elkaar steeds sneller op. Hoe zorgt wetgeving ervoor dat jouw kleding minder vervuilend is en er meer oog is voor de makers?Na een brat summer met bijpassende groene outfits, staat er weer een nieuwe zomer voor de deur met micro-trends. Op social media zie je de unboxing videos voorbij komen met vele must-have kledingstukken. Maar achter deze populaire videos schuilt een fast fashion businessmodel dat milieu en mensen uitbuit. Hoog tijd dus om fast fashion achter ons te laten. Welke rol speelt wetgeving hierin?<br/
Hoe krijg je fast fashion uit de mode
No full textWat trek je deze zomer aan? Best lastig, want kledingtrends volgen elkaar steeds sneller op. Hoe zorgt wetgeving ervoor dat jouw kleding minder vervuilend is en er meer oog is voor de makers?Na een brat summer met bijpassende groene outfits, staat er weer een nieuwe zomer voor de deur met micro-trends. Op social media zie je de unboxing videos voorbij komen met vele must-have kledingstukken. Maar achter deze populaire videos schuilt een fast fashion businessmodel dat milieu en mensen uitbuit. Hoog tijd dus om fast fashion achter ons te laten. Welke rol speelt wetgeving hierin?<br/
Projector Model for Efficient List-Mode Reconstruction in PET Scanners with Parallel Planar Detectors
No full textWe have developed a new projector model specifically tailored for fast list-mode tomographic reconstructions in Positron emission tomography (PET) scanners with parallel planar detectors. The model provides an accurate estimation of the probability distribution of coincidence events defined by pairs of scintillating crystals. This distribution is parameterized with 2D elliptical Gaussian functions defined in planes perpendicular to the main axis of the tube of response (TOR). The parameters of these Gaussian functions have been obtained by fitting Monte Carlo simulations that include positron range, acolinearity of gamma rays, as well as detector attenuation and scatter effects. The proposed model has been applied efficiently to list-mode reconstruction algorithms. Evaluation with Monte Carlo simulations over a rotating high resolution PET scanner indicates that this model allows to obtain better recovery to noise ratio in OSEM (ordered-subsets, expectation-maximization) reconstruction, if compared to list-mode reconstruction with symmetric circular Gaussian TOR model, and histogram-based OSEM with precalculated system matrix using Monte Carlo simulated models and symmetries
Londen laat zien: verstedelijking kun je privaat bekostigen
No full textSimon van Zoest en Tom Daamen doen bij de leerstoel Gebiedsontwikkeling onderzoek naar de financiering en bekostiging van grootstedelijk openbaar vervoer. Zij kijken daarbij voorbij de instrumenten en verdiept zich in de motieven en succesfactoren achter de invoer van alternatieve bekostiging. Zo maakt Londen duidelijk dat een private bijdrage aan ov-investeringen mogelijk én wenselijk kan zijnPractice Chair Urban Area DevelopmentUrban Development Managemen
Tam Tam in je broekzak
No full textDit is het eindverslag van de stage "Tam Tam in je broekzak", die wij hebben uitgevoerd in het kader van IN3405 Bachelorproject. Deze stage is uitgevoerd bij Tam Tam B.V. te Rijswijk.Technische InformaticaComputer ScienceElectrical Engineering, Mathematics and Computer Scienc
- …
