7 research outputs found
Analisis Efek Samping Peningkatan Tes Fungsi Hati Pada Pasien TB RO Dengan Terapi Jangka Pendek Dan Terapi Individual (Penelitian dilaksanakan di Poli Rawat Jalan TB MDR RSUD Dr. Soetomo Surabaya)
No full textDrug-Resistant TB is a case of Tuberculosis (TB) in which the bacteria are considered not susceptible or do not respond to one or more types of drugs in the first line of Anti-Tuberculosis Drug regimen based on culture results. Anti-Tuberculosis Drugs are one of the most common groups of hepatotoxicity causes in worldwide. Globaly, hepatotoxicity would occur when TB therapy accounts for more than 7% of all side effects. Several risk factors for the development of hepatotoxicity such as age, sex, body mass index (BMI) and acetylator status have been investigated in previous studies. This study aims to see the prevalence of hepatotoxic side effects in Drug-Resistant TB therapy with short-term and individual regimens and to analyze the risk factors for hepatotoxic side effects. This study was conducted retrospectively to assess the role of these risk factors on the incidence of hepatotoxicity in the therapy of Drug-Resistant TB patients receiving short-term and individual therapy regimens at Dr. Soetomo, Surabaya. A total sample of 129 patients met the inclusion and exclusion criteria. The results showed that the prevalence of hepatotoxic side effects was 54 cases. A total of 2 patients occurred hepatotoxicity in the first 2 weeks and 52 patients developed hepatotoxicity in the late 2 weeks. The management performed to overcome the side effects was in accordance with the Drug-Resistant TB guidelines from the Ministry of Health. History of alcohol use was the sole risk factor for hepatotoxicity
STABILITAS SENYAWA (-)- EPIGALOKATEKIN-3-GALAT (EGCG) DALAM MINUMAN TEH HIJAU INSTAN PADA LEMARI PENDINGIN SUHU 8oC DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI (KCKT)
No full text(-)-Epigallocatechin gallate the higest phytochemical product contained from tea leaf (Camellia sinensis) that used as improving blood flow, preventing cardiovascular disease, eliminating various toxins and improving resistance to various diseases, and also anti-oxidant activity. Green tea catechins especially EGCG can undergo degradation and epimerization during storage condition. Many factors could contribute to the stability of green tea catechins basically EGCG , such as temperature, and duration of storage. The research focusing on the study of duration of storage in refrigerator low temperature (8oC) for 32 hours using HPLC. HPLC conditions was as follows RP C- 18 μbondapak 10μm, 3.9 x 300 mm used as column, the mobile phase was metanol : water : acetic acid (2%) = 35 : 60 : 5 (v/v/v), flow rate 1.0 ml/min, and detection monitored at 276.0 nm with spectrophotometry UV-Vis. The levels of EGCG during 32 hours storage using refrigerator (8oC) in green tea instant beverage product decreased by 20,11%. Using one-samples t-test, it was proven that there are significant differences between decrease the levels of EGCG in green tea instant beverage product in refrigerator (8oC)
SGOT/SGPT levels in blood serum on rats (Rattus norvegicus) that CCl4 induced then its treatment by ethanol extract of Curcuma xanthorrhiza rhizome as hepatoprotector
No full textCCl4 is a xenobiotic compound that could be entered into body by digestion and ingestion system. It trigger to produce ROS until lipid peroxydation which can increase SGOT/SGPT levels on blood serum. Both SGOT and SGPT are transaminase enzymes that activated on blood serum and they were produced in hepatocyte. If there are radicals in hepatocyte as final product of lipid peroxydation, then they are exit from cytoplasm on hepatocyte to intravenous so theirs levels is increase in blood. Producing of radicals from ROS in lipid peroxydation can be scavenged by antioxidant compounds on ethanol extract of Curcuma xanthorrhiza rhizome. This research are aimed to determine of SGOT/SGPT levels on blood serum in each of groups. This research used male rats that divided into five groups, that were negative control (A group), positive control (CCl4 10% induced (B group)) and therapy groups (200, 400, and 800 mg/kg BW of Curcuma xanthorrhiza rhizome ethanol extracts (C, D, E groups respectively)). SGOT/SGPT levels was analyzed, its result was 165/92, 264/141, 161/64, 130/59 and 135/55 U/L respectively. Based on the Tukey’s HSD test (p = 0.1), SGOT/SGPT levels in positive control was significance different (p < 0.1) to negative control, but theirs levels in 400 and 800 mg/kg BW of Curcuma xanthorrhiza rhizome ethanol extract therapy groups were not significance different (p > 0.1) to negative control. Thereby, 400 and 800 mg/kg BW of Curcuma xanthorrhiza rhizome ethanol extracts was more effective as hepatoprotector which known from decreasing of SGOT/SGPT levels
STUDI TOKSISITAS SUBKRONIK EKSTRAK KULIT BAWANG MERAH (ALLIUM SP) PADA PARU TIKUS (RATTUS NORVEGICUS) DIINDUKSI OLEH KETOROLAC
No full textKetorolac adalah obat antiinflamasi nonsteroid (NSAID) yang sering digunakan karena efektivitasnya dalam meredakan nyeri dan inflamasi. Namun, penggunaan jangka panjang atau dosis tinggi dapat menyebabkan toksisitas organ, termasuk paru-paru. Kerusakan jaringan paru akibat ketorolac sering melibatkan edema, inflamasi difus, dan fibrosis ringan. Untuk mengatasi efek samping ini, ekstrak kulit bawang merah (Allium sp.), yang kaya akan senyawa flavonoid dan antioksidan seperti quercetin, dievaluasi potensinya sebagai agen pelindung paru. Tujuan dari penelitian ini adalah untuk mengetahui efek protektif dan potensi toksisitas subkronik ekstrak kulit bawang merah terhadap jaringan paru tikus putih (Rattus norvegicus) yang diinduksi ketorolac. Desain penelitian ini bersifat eksperimental dengan lima kelompok perlakuan: kontrol negatif, ketorolac, ketorolac+ranitidine, serta ketorolac dengan ekstrak kulit bawang merah dosis 100 mg/kgBB dan 200 mg/kgBB. Evaluasi dilakukan selama 7 hari melalui pengamatan histopatologis paru menggunakan pewarnaan Hematoxylin-Eosin, dan penilaian dilakukan dengan skoring terhadap edema, inflamasi, dan fibrosis. Hasil menunjukkan bahwa kelompok ketorolac mengalami kerusakan paling parah, sedangkan pemberian ekstrak 200 mg/kgBB mampu menurunkan tingkat edema dan inflamasi secara signifikan serta memperbaiki struktur alveoli. Kesimpulannya, ekstrak kulit bawang merah pada dosis 200 mg/kgBB memberikan efek protektif terhadap jaringan paru yang rusak akibat ketorolac. Penelitian ini membuka peluang penggunaan bahan alam sebagai terapi adjuvan dalam pengurangan toksisitas obat, namun diperlukan studi lanjutan pada tingkat molekuler dan klinis
Mikosis Paru dengan TB MDR Riwayat Loss To Follow Up dan HIV Naive: Laporan Kasus pada Pasien CAP dan Pneumothorax Spontan Sekunder
No full textLatar Belakang: Infeksi jamur pada paru dapat muncul sebagai infeksi primer maupun sekunder. Timbulnya infeksi sekunder pada paru dapat disebabkan oleh kelainan atau kerusakan jaringan paru seperti pada tuberkulosis paru. Kesamaan dalam pola presentasi infeksi jamur invasif dan tuberkulosis mengakibatkan kesalahan diagnosis yang sering dikaitkan dengan peningkatan lama rawat inap di rumah sakit, kerugian ekonomi, peningkatan morbiditas dan luaran klinis yang buruk. Kasus: Seorang wanita muda dirujuk ke rumah sakit dengan keluhan sesak nafas memberat sejak 1 minggu yang lalu disertai demam dan batuk. Pemeriksaan penunjang biakan khusus jamur berupa Candida albicans. Pasien dengan riwayat putus pengobatan tuberkulosis (TB) paru dengan obat anti-tuberkulosis (OAT) kategori I pada bulan April sampai Juni 2023 selama 2 bulan. Pasien dengan komorbid HIV naive. Masalah medis pada pasien ini adalah badan lemah membaik, anemia mikrositik hipokromik terkoreksi, hemoptoe derajat 1 (kriteria Purcel) membaik, pneumothorax spontan sekunder dextra minimal, TB Paru MDR kasus loss to follow up on OAT individual regimen bulan ke-1. Simpulan: Pasien TB yang putus berobat atau gagal pengobatan mengalami peningkatan risiko untuk mengalami resistansi obat. Riwayat pengobatan TB memiliki hubungan signifikan dengan kejadian resistensi rifampisin pada pasien TB-HIV. Mikosis ditemukan pada sputum pasien TB paru dengan pengobatan lebih dari 2 bulan serta sebagian besar diakibatkan infeksi Candida sp
Tackling Indonesia’s Diabetes Challenge with Indonesian Traditional Herbs as Dietary Supplementation to Reduce Development of Cardiovascular Complications: Promotion The Use of Natural Product
No full textIndonesia’s biggest challenge in the next 10-15 years is non-communicable diseases (NCD) like cardiovascular and diabetes with its complication which are accounted for nearly 50 percent of deaths in the country. As of 2014, Indonesia’s diabetes population was the fifth largest in the world, International Diabetes Federation (IDF) predicted more than 14 million Indonesians will suffer diabetes in 2035. Dietary supplementation can reduce the risk of diabetes development and its cardiovascular complication. Indonesia as a country that is rich in natural sources has the opportunity to maximise the utilization and benefits of its natural products. Indonesian traditional herbs have been used to treat disease and nowadays they are being scientifically developed for therapies. These natural products are considered to have potentials in delaying the development of diabetes and its complications and to be able to cure the metabolic abnormalities using a variety of mechanism. Comprehensive literatures were used to review Indonesian traditional herbs used in the management of diabetes. An online database research from Elsevier, Science Direct, and PubMed was conducted to find literature on herbs growth in Indonesia that improves health outcomes in the development of diabetes and its cardiovascular complication. Indonesian traditional herbs such as Momordica chatarantia, Trigonella foenum- graecum, Tinospora cordifolia, Zingiber officinale, Allium sativum have been proven to produce significant improvement of blood glucose, 2 hours post load glucose, A1C, LDL-C, blood pressure level as compared with control which have antidiabetic and cardioprotective activity with various mechanism of action. Indonesian scientifically proven traditional herbs have great potentials to be used as dietary supplementation to reduce the development of diabetes and its complication. It can be the investation to tackle the global challenge for reducing deaths caused by diabetes and its cardiovascular complication.
A Systematic Review of Relationship between Green Tea Consumption and Improvement of Lipid Profile as Action Plan for Preventing Cardiovascular Disease (CVD) Development
No full textTea (Camellia sinensis) is one of the most popular beverages in Asia. Tea divided into three categories based on degree of fermentations, one of them is green tea. Many researchers have reported antioxidant activity of green tea to prevent chronic diseases. Daily consumption of green tea can reduce the development of atherosclerotic complication related to stroke, myocardial infarction, coronary heart disease, and cardiovascular diseases (CVD). There are evidences from clinical studies that prove green tea can play protective role in the development of CVD. Various components of green tea, especially polyphenol, have antioxidant and antidyslipidemic activities. The aim of this study was to review the relationship between green tea consumption and CVD development. Published randomized controlled trial (RCT) and meta-analysis (2007-2017) were identified based on searches of on-line databases (Cochrane Library, PubMed, Science Direct). The search terms used included green tea and cardiovascular. From electronic searches database we found 3.642 articles, 6 research articles met inclusion criteria have been conducted and summarized. There were significant reduction of total cholesterol (TC) (p<.05) found in 3 articles, low-density lipoprotein cholesterol (LDL) found in 4 articles, triglyceride (TG) found in 3 articles, and significant increment of high-density lipoprotein (HDL) found in 2 articles. The articles also showed reduction of CVD risk including blood glucose concentration, blood pressure, inflammatory biomarker and anthropometrical measurements. Green tea consumption might be associated inversely with the development of CVD. The consumption of green tea extract indicates improvement of lipid profile and reduction of CVD risk. The utilization of dietary supplement, such as green tea and its polyphenol component, have promising potential to prevent the development of CVD complications.
