334 research outputs found
MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro
No full textProanthocyanidin-rich extracts were prepared by fractionation of the fruit of the North American cranberry (Vaccinium macrocarpon). In vitro growth inhibition assays in eight tumor cell lines showed that selected fractions inhibited the growth of H460 lung tumors, HT-29 colon and K562 leukemia cells at GI(50) values ranging from 20 to 80 mu g ml(-1). Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) of one of these fractions found it to be composed of polyflavan-3-ols, which are primarily tetramers through heptamers of epicatechin containing one or two A-type linkages. Whole cranberry extract and the proanthocyanidin fractions were screened for effect on the expression of matrix metalloproteinases in DU 145 prostate carcinoma cells. The expression of MMP-2 and MMP-9 was inhibited in response to whole cranberry extract and to a lesser degree by the proanthocyanidin fractions. (c) 2005 Society of Chemical Industry.PT: J; CR: BOMSER J, 1996, PLANTA MED, V62, P212 CHA HJ, 1996, CANCER RES, V56, P2281 CHA HJ, 1998, ONCOGENE, V16, P771 FERGUSON PJ, 2004, J NUTR, V134, P1529 FOO LY, 2000, J NAT PROD, V63, P1225 GUTHRIE N, 2000, P EXP BIOL C SAN DIE HOWELL AB, 1998, NEW ENGL J MED, V339, P1085 HOWELL AB, 2002, CRIT REV FOOD SCI S, V42, P273 KANDIL FE, 2002, J AGR FOOD CHEM, V50, P1063 KOLODZIEJ H, 1995, PHYTOTHER RES, V9, P410 KRUEGER CG, 2000, J AGR FOOD CHEM, V48, P1663 KRUEGER CG, 2003, J AGR FOOD CHEM, V51, P538 MORROW DMP, 2001, MUTAT RES-FUND MOL M, V480, P269 MURPHY BT, 2003, J AGR FOOD CHEM, V51, P3541 NETO CC, 2005, S SERIES PHENOLICS F, P271 PORTER ML, 2001, J SCI FOOD AGR, V81, P1306 PUPA SM, 2002, J CELL PHYSIOL, V192, P259 SAMUEL SK, 1992, EMBO J, V11, P1599 SEERAM NP, 2004, J AGR FOOD CHEM, V52, P2512 SKEHAN P, 1990, J NATL CANCER I, V82, P1107 VAYALIL PK, 2004, CARCINOGENESIS, V25, P987 VINSON JA, 2001, J AGR FOOD CHEM, V49, P5315 YAN X, 2002, J AGR FOOD CHEM, V20, P5844 YE X, 1999, MOL CELL BIOCHEM, V196, P99 ZHAO J, 1999, CARCINOGENESIS, V20, P1737; NR: 25; TC: 2; J9: J SCI FOOD AGR; PG: 8; GA: 994DQSource type: Prin
Sevilha andando, com “A sevilhana que não se sabia” / Sevilha andando, with “A sevilhana que não se sabia”
No full textResumo: Em 1987, quando foi publicada a coleção de poemas de João Cabral de Melo Neto intitulada Crime na Calle Relator, “A sevilhana que não se sabia” era o segundo na ordem de exposição, logo após o poema homônimo ao livro. Aquele poema foi reproduzido como o primeiro da coleção seguinte do autor, intitulada Sevilha andando (1989), ao passo que deixou de figurar nas reedições do livro em que constara de início. Assim, o poema que era de um livro passou a compor outro, exclusivamente, por iniciativa do próprio autor, para quem importava a constituição do artefato estético que o livro vem a ser. Este traço diferencial na trajetória do autor incide retrospectivamente sobre toda sua obra, a partir desse evento marcante que interfere na compreensão do que constitui um livro, seja sua publicação ou a reunião de poemas que demanda uma apreciação particularizada, de caso a caso, dos poemas entrelaçados entre si. Acompanhando a repercussão do poema no contexto da obra poética em pauta, será feito um cotejo entre as edições disponíveis dos volumes implicados para se chegar a uma compreensão mais palpável do poema, perspectivado ao longo daquela produção poética.Palavras-chave: poesia brasileira moderna; João Cabral de Melo Neto; estilo; editoração.Abstract: In 1987, when the João Cabral de Melo Neto’s collection of poems was published under the title of Crime in Calle Relator (1987), “A sevilhana que não se sabia” was the second in the order of exhibition, shortly after the poem of the same name to the book. That poem was reproduced as the first of the author’s next collection, titled Sevilha andando (1989), while it ceased to appear in the reissues of the book in which it was initially listed. Thus, the poem that was from one book began to compose another, exclusively, at the initiative of the author himself, for whom it mattered the constitution of the aesthetic artifact that the book comes to be. This differential trait in the author’s trajectory focuses retrospectively on all his work, from this remarkable event that interferes with the understanding of what constitutes a book, be it its publication or the meeting of poems that demands an appreciation particularized, on a case-by-case basis, of the poems intertwined with each other. Following the repercussion of the poem in the context of the poetic work, it will be made a comparison between the available editions of the volumes involved, to reach a more palpable understanding of the poem, perspectived throughout that poetic production.Keywords: modern Brazilian poetry; João Cabral de Melo Neto; style; publishing
Lipopolysaccharide, cranberry flavonoids, and regulation of ornithine decarboxylase [ODC] and spermidine
No full text
Leishmaniasis of the auricle mimicking carcinoma
No full textLeishmaniasis of the auricle has been rarely reported in our region of the world, where it is labeled as Old World Leishmaniasis. It may mimick other pathologies, such as malignancies or other infectious processes. We present a case of an auricular Leishmania lesion which was first suspected to be a carcinoma. Four previous auricular Old World Leishmania cases have been reported. The epidemiology, clinical presentation, diagnosis, and treatment of this entity are briefly reviewed. Crown Copyright © 2009.DESJEUX P, 1998, UNAIDS LEISHMANIA HI; Hepburn NC, 2000, CLIN EXP DERMATOL, V25, P363, DOI 10.1046-j.1365-2230.2000.00664.x; Karincaoglu Y, 2004, INT J DERMATOL, V43, P827, DOI 10.1111-j.1365-4632.2004.02324.x; Knio K, 2000, AM J TROP MED HYG, V63, P43; Marsella R, 1998, INT J DERMATOL, V37, P801, DOI 10.1046-j.1365-4362.1998.00449.x; Martinelli C, 2005, INT J DERMATOL, V44, P38, DOI 10.1111-j.1365-4632.2004.02190.x; NETO J, 1998, ANN AGR ENV MED, V5, P1; Quante G, 2006, HNO, V54, P35, DOI 10.1007-s00106-005-1282-6; Skevas A, 1997, LANCET, V349, P28, DOI 10.1016-S0140-6736(05)62160-5; Van der Vliet D, 2006, AM J TROP MED HYG, V75, P27063
Syphrea thurstonae Clark & Lillrose & Belo Neto 2013, new species
No full text<i>Syphrea thurstonae</i>, new species <p>(Figures 21, 38, 46)</p> <p> <b>Diagnosis.</b> In this species, the hind femora are greatly enlarged, there is a well-developed prebasal groove on the pronotum, and the body is strikingly bicolored, the head and prothorax being orangebrown, the elytra being dark with metallic blue or green luster. This combination of characters does not occur in any other chrysomelid known to occur in the Cayman Islands. Elsewhere in the West Indies, this species is similar in size and color to <i>Syphrea constanzae</i> (Blake), a species from Hispaniola, but the elytra of that species are much more coarsely punctate.</p> <p> <b>Description of male.</b> Body oval, glabrous. Head, prothorax, and legs pale orange-brown; elytra dark brown to black with blue-green metallic luster; ventral areas of mesothorax pale orange-brown; ventral areas of metathorax and abdomen dark brown. Length 1.8 mm; width across humeri 1.0 mm.</p> <p>Head pale orange-brown, similar in color to pronotum; labrum, palpi, and basal half of antennae pale orange-brown; distal half of antennae darker brown; tips of mandibles piceous. Eyes separated by about 0.6 times width of head. Vertex impunctate, polished; frontal tubercles subtriangular, shallowly delimited laterally, deeply delimited behind, deeply delimited from frontal ridge; frontal ridge distinct and narrow posteriorly, broadly expanded laterally in clypeal area.</p> <p>Pronotum 1.4-1.6 times as wide as long, 1.6 times as wide as head across eyes, 0.7 times as wide as elytra across humeri; lateral margins each with well-defined bead; anterior and posterior margins without bead; antebasal groove deep, extending to posterolateral corners; disc polished, minutely punctate; color pale orange-brown. Scutellum subtriangular, brown.</p> <p>Elytra together 1.4 times as long as wide at humeri, 2.8-3.1 times as long as pronotum. Punctures fine, confused, separated by a distance about twice as great as their diameters. Interpunctural areas polished. Color dark brown to black with blue-green metallic sheen.</p> <p>Ventral areas of prothorax polished, of same color as dorsal areas of pronotum; prosternum between coxae about as wide as antennae; procoxal cavities broadly open behind; ventral areas of mesothorax alutaceous, pale orange-brown; metasternum dark brown without metallic luster, mesally polished and sparsely pubescent, laterally glabrous and alutaceous; metepisternum dark brown without metallic luster, glabrous, alutaceous; abdomen dark brown, alutaceous, sparsely pubescent. Legs slightly darker than prothorax; tarsal claws bluntly appendiculate. Aedeagus as in Figure 38.</p> <p> <b>Description of female.</b> Characters as in male, but with spermatheca as in Figure 46.</p> <p> <b>Material examined.</b> <b>Holotype:</b> “CAYMAN, Grand Cayman Mastic Trailhead S, bl trap 21 May 2009, Thomas, Turnbow & Ball” (male, FSCA). <b>Paratypes:</b> Cayman Islands, Cayman Brac, Bight Rd. at Major Donald Dr., Brac Parrot Preserve, 23-V-2009, M. C. Thomas (8 females, FSCA); Cayman Islands, Cayman Brac, Brac Parrot Reserve, 23-V-2009, R. Turnbow (1 female, BYUC; 1 female, RHTC); Cayman Islands, Cayman Brac, Major Donald Dr., 0.6 km E jct. Ashton Reid Dr., 6-VI-2008, M. C. Thomas, B. K. Dozier, blacklight trap (1 male, FSCA); Cayman Islands, Grand Cayman, 3 km W Colliers, 19°2l2 N, 81°072W, 21-II-1993, W. E. Steiner & J. M. Swearingen, at black light in cut-over forest near ponds (2 females, USNM); Cayman Islands, Grand Cayman, Mastic Trailhead S, 21-V-2009, Thomas, Turnbow & Ball, bl trap (1 female, BYUC); Cayman Islands, Little Cayman, North Coast Rd., 26-V-2009, R. Turnbow (1 female, RHTC).</p> <p> <b>Plant associations.</b> Unknown. Related species are associated with Euphorbiaceae.</p> <p> <b>Etymology.</b> The species epithet of this taxon honors the mother of the second author.</p> <p> <b>Comments.</b> As currently constituted, the genus <i>Syphrea</i> Baly, including the West Indian species formerly classified in <i>Hermaeophaga</i> Foudras, is a somewhat heterogeneous assemblage. The placement of Cayman Islands material in this genus does not necessarily indicate a close relationship with the type species, <i>S. pretiosa</i> Baly. It merely reflects a close similarity to several other West Indian species that are now included in the genus.</p>Published as part of <i>Clark, Shawn M., Lillrose, Tiffany & Belo Neto, Luiz A., 2013, Leaf Beetles of the Cayman Islands (Coleoptera: Chrysomelidae), pp. 1-41 in Insecta Mundi 2013 (279)</i> on page 28, DOI: <a href="http://zenodo.org/record/5175767">10.5281/zenodo.5175767</a>
Avaliação da presença de guia de desoclusão lateral e protrusiva da mandíbula
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2014.Neste estudo avaliou-se a presença de guias de lateralidade e protrusão em alunos do curso de Odontologia da Universidade Federal de Santa Catarina. Participaram da pesquisa, 187 voluntários, com idade média de 22 anos, de ambos os sexos. Os mesmos foram submetidos a questionamentos sobre tratamento ortodôntico prévio e disfunção têmporo-mandibular, ausência e/ou agenesia dentária, bem como foram submetidos ao exame clínico por um operador calibrado para observar a presença ou ausência das guias citadas, tanto do lado direito como do lado esquerdo. Os indivíduos foram classificados como guia de desoclusão oclusal do tipo canina, em grupo ou em outro tipo de guia. Do lado direito, possuíam guia em canino 43,3%; guia em grupo apenas 4,8% e o restante possuíam um outro dente como guia (41,2%). Já do lado esquerdo, 51,8% apresentavam guia em canino; 0,5% em grupo e o restante tinham outro dente como guia (34,8%). Guia lateral canina bilateral foi presente em 40,1%. Em relação à presença de guia anterior, 60,4% dos participantes a possuíam e esta obteve uma forte associação com a prévia realização de tratamento ortodôntico (pAbstract : In this study evaluated the presence of lateral and protrusive guidance in Dentistry students, from Federal University of Santa Catarina. The research involved 187 volunteers with an average age of 22 years, both gender. They were questioned about temporomandibular dysfunction and previous orthodontic treatment, absence and / or dental agenesis, and also underwent a clinical examination by a calibrated operator to observe the presence or absence of guidance, at both sides. The subjects were classified by their guidance occlusal protection type as canine, group or other type of guide . At the right side, canine guidance acquired 43,3%; guide group only 4,8% and another tooth as a guidance 41,2%. At the left side were found 51,8% with canine guidance , 0,5% group and another type of guide obtained 34,8%. Bilateral canine guidance was present in 40,1%. Regarding the presence of anterior guidance, 60,4% of participants leading a strong association with the prior execution of orthodontic treatment (p< 0,006) . No other association was found with types of orthodontic treatment and temporomandibular disorders, except for the presence of in the left canine guidance and make come true orthodontic treatment, which obtained a weak association (p<0,038 %). In addition, there was association between female gender and existence of any condition of dysfunction. Thus, there was no correlation between any type of guide and problems for patient, as well as presence of many different guides types in most of people surveyed
Álbum de Caliban: Coelho Neto e a literatura pornográfica na Primeira República
No full textA partir de 1880, configura-se no Brasil um espaço novo de circulação de histórias licenciosas. O impresso pornográfico começa a aparecer nos anúncios de livrarias nos jornais de grande circulação. Surgem novos editores e livrarias, como a Livraria do Povo e a Livraria Moderna. A percepção de que havia um mercado para esse gênero de literatura era crucial para a decisão dos editores de investir nessas edições. Sob o pseudônimo Caliban, da peça A Tempestade (1611), de William Shakespeare, Coelho Neto criou uma persona para atender à demanda de literatura pornográfica, fabricando contos e crônicas licenciosos que foram publicados nos jornais de todas as regiões do país até o começo do século XX. Entre 1897 e 1898, os textos foram editados pela Livraria Laemmert em fascículos e reunidos no volume Álbum de Caliban. Neste estudo, vamos conhecer a faceta de autor licencioso de Coelho Neto e investigar sua atuação no incipiente mercado de literatura pornográfica na Primeira República.</jats:p
Dietary effects of chelated zinc supplementation and lysine levels in ISA Brown laying hens on early and late performance, and egg quality
No full textIt has been hypothesized that zinc (Zn) levels beyond those that are nutritionally required may favor the utilization of dietary lysine, and consequently reduce the level of its inclusion into the diet. Therefore, the possible effects of interaction between chelated Zn and the level of lysine (Lys) on egg production and egg quality of laying hens were evaluated. In total, 720 ISA Brown layer hens aged 24 to 36 wk (early phase) and 48 to 60 wk (late phase) were allotted in a completely randomized factorial design that used 3 Zn and 5 Lys levels (6 replications, 8 birds/replication). All birds aged 37 to 47 wk (between early and late phases) were fed a standard diet and maintained under the same experimental design. The Zn levels used were 137, 309, and 655 mg/kg; and the Lys levels were 0.560, 0.612, 0.677, 0.749, and 0.851%. The optimal levels of Lys digestibility were based on laboratory analyses with regard to the weighted average relationship between 83.5% digestibility and the total Lys from principal ingredients. There was no effect of interaction found between the dietary levels of Zn and Lys for most of the variables studied; however, each had an independent effect on the variables. An increase in Zn from 137 to 655 mg/kg had no significant effect (P > 0.05) on the performance of hens in both phases; however, it showed a significant effect on egg quality (P < 0.01), principally on mineral composition. Increased Zn resulted in decreased shell weight, percentage of ash, yolk ash deposition, and total ash deposition. On the other hand, an increase in Lys from 0.560 to 0.851% significantly affected (P < 0.002) several performance parameters and the chemical composition of the eggs, including feed intake, feed conversion efficiency, BW gain, egg weight, and production. In conclusion, there was no interaction found between Zn and Lys, but higher dietary levels of chelated Zn reduced bird performance and egg quality parameters, whereas higher Lys levels could be beneficial to bird performance and egg quality
Proanthocyanidins from the American Cranberry (Vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways
No full textProstate cancer is one of the most common cancers in the Western world, and it is believed that an individual's diet affects his risk of developing cancer. There has been an interest in examining phytochemicals, the secondary metabolites of plants, in order to determine their potential anti-cancer activities in vitro and in vivo. In this study we document the effects of proanthocyanidins (PACs) from the American Cranberry (Vaccinium macrocarpon) on matrix metalloproteinase (MMP) activity in DU145 human prostate cancer cells. Cranberry PACs decreased cellular viability of DU145 cells at a concentration of 25 mu g/ml by 30% after 6 h of treatment. Treatment of DU145 cells with PACs resulted in an inhibition of both MMPs 2 and 9 activity. PACs increased the expression of TIMP-2, a known inhibitor of MMP activity, and decreased the expression of EMMPRIN, an inducer of MMP expression. PACs decreased the expression of PI-3 kinase and AKT proteins, and increased the phosphorylation of both p38 and ERK1/2. Cranberry PACs also decreased the translocation of the NF-kappa B p65 protein to the nucleus. Cranberry PACs increased c-jun and decreased c-fos protein levels. These results suggest that cranberry PACs decreases MMP activity through the induction and/or inhibition of specific temporal MMP regulators, and by affecting either the phosphorylation status and/or expression of MAP kinase, PI-3 kinase, NF-kappa B and AP-1 pathway proteins. This study further demonstrates that cranberry PACs are a strong candidate for further research as novel anti-cancer agents. J. Cell. Biochem. 111: 742-754, 2010. (c) 2010 Wiley-Liss, Inc
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