30 research outputs found
Prostaglandin F receptor expression in intrauterine tissues of pregnant rats
No full textIn this investigation, we studied the expression and localization of rat prostaglandin F (FP) receptor in uterine tissues of rats on gestational Days 10, 15, 18, 20, 21, 21.5 and postpartal Days 1 and 3 using Western blotting analysis, real-time PCR, and immunohistochemistry. A high level of immunoreactivity was observed on gestational Days 20, 21, and 21.5 with the most significant signals found on Day 20. FP receptor protein was expressed starting on gestational Day 15, and a fluctuating unsteady increase was observed until delivery. Uterine FP receptor mRNA levels were low between Days 10 and 18 of gestation (p < 0.05). The transcript level increased significantly on Day 20 and peaked on Day 21.5 just before labor (p < 0.05). There was a positive correlation between FP receptor mRNA expression and serum estradiol levels (rs = 0.78; p < 0.01) along with serum estradiol/progesterone ratios (rs = 0.79; p < 0.01). In summary, we observed an increase FP receptor expression in rat uterus with advancing gestation, a marked elevation of expression at term, and a concominant decrease during the postpartum period. These findings indicate a role for uterine FP receptors in the mediation of uterine contractility at term
Systemic rifampicin treatment accelerates inferior alveolar nerve regeneration: an experimental animal study
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Alendronate and pamidronate induce cytotoxicity and apoptosis in cultured human gingival fibroblasts
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The extrusion of root canal cement containing paraformaldehyde into the inferior alveolar nerve canal resulting in infection and numbness
No full textAge-related distribution of estrogen, progesterone and follicle stimulating hormone receptors in rat ovaries
No full textHistological evaluation of combined platelet-rich fibrin membrane and piezo-incision application in orthodontic tooth movement
No full textHelvacıoğlu, Fatma/0000-0002-6026-0045The aim of this study was to evaluate the effect of platelet-rich fibrin (PRF) membrane on tooth movement in comparison with shunt control and piezoelectric surgery. Sixteen White Vienna rabbits were included in the study and divided into two groups. Reciprocal forces (20 g) were applied on the maxillary incisors by an orthodontic appliance. In group 1, PRF membrane was placed subperiosteally on the distal alveolar bone surface of the right central incisors and the left side was kept as control. In group 2, piezo-incisions 3 mm in depth were performed and combined with PRF membrane on the distal alveolar bone surface of the right central incisors, while the left side was kept as control. All rabbits were euthanized on day 21 and bilateral alveolar bone segments from the distal regions were removed for histological evaluation. Isolated PRF membrane application increased the blood vessel (8.3 +/- 1.0; P= 0.026), osteoblast (6 +/- 0.8; P= 0.027), and osteoclast (2.3 +/- 0.8; P= 0.026) counts significantly compared to shunt control. Combined application of PRF membrane +piezo-incision increased the blood vessel (15.3 +/- 0.8; P= 0.027), osteoblast (9.8 +/- 1.4; P= 0.026), and osteoclast (3.3 +/- 0.8; P= 0.024) counts significantly compared to shunt control. The increases in blood vessel count and osteoblast cell count were more evident in the combined application group (both P= 0.002). PRF membrane application significantly increased bone turnover, and the combined application of PRF membrane + piezo-incision was found to be the best method for increasing bone turnover.Baskent University Research Fund [D-DA 13/05]The Baskent University Research Fund, Tukey Project number: D-DA 13/05 supported this study financially
