1,699 research outputs found
Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity
No full text Pages R837–R847: K. A. Engelke, D. F. Doerr, and V. A. Convertino. “Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity.” On p. 837, the author line of the article and abstract and the affiliation line should read as follows: KEITH A. ENGELKE, DONALD F. DOERR, CRAIG G. CRANDALL, AND VICTOR A. CONVERTINO Department of Physiology, University of Florida, Gainesville, Florida 32610; National Aeronautics and Space Administration-Kennedy Space Center, Cape Canaveral, Florida 32899; Department of Physiology, University of North Texas Health Science Center, Ft. Worth, Texas 76107; and Physiology Research Branch, Clinical Science Division, Brooks Air Force Base, Texas 78235 </jats:p
Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity
No full text Pages R837–R847: K. A. Engelke, D. F. Doerr, and V. A. Convertino. “Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity.” On p. 837, the author line of the article and abstract and the affiliation line should read as follows: KEITH A. ENGELKE, DONALD F. DOERR,CRAIG G. CRANDALL, AND VICTOR A. CONVERTINO Department of Physiology, University of Florida, Gainesville, Florida 32610; National Aeronautics and Space Administration-Kennedy Space Center, Cape Canaveral, Florida 32899;Department of Physiology, University of North Texas Health Science Center, Ft. Worth, Texas 76107; and Physiology Research Branch, Clinical Science Division, Brooks Air Force Base, Texas 78235 </jats:p
Lipid-coated zinc oxide nanocrystals as innovative ROS-generators for photodynamic therapy
No full textPhotodynamic Therapy (PDT) is a medical treatment that combines the administration of a nontoxic drug, called photosensitizer (PS), with light irradiation of the targeted region. It has been proposed as a new cancer therapy, promising better selectivity and fewer side-effects compared to traditional chemo- and radio-therapies. PSs indeed can accumulate specifically within the region of interest so that when the light is directly focused only in that region the therapeutic effect is highly localized. Traditional PSs, like chlorins and porphyrins, suffer from several drawbacks such as aggregation in biological media and poor biocompatibility. Thus, the development of innovative photosensitizers able to overcome these issues is crucial to the therapeutic action of PDT. Among the others, nanostructured Zinc Oxide (ZnO) has been recently proposed as new therapeutic agent and PS thanks to its semiconducting properties, biocompatible features, and ease of functionalization [1]. Nevertheless, further efforts are needed in order to improve its colloidal stability in biological media and to unravel the effective therapeutic mechanism. Here, we propose the synthesis and characterization of lipid-coated ZnO nanoparticles as new photosensitizer for cancer PDT [2]. First, by Dynamic Light Scattering (DLS) experiments, we show that the lipid-coating increases the colloidal stability of the ZnO NPs in Phosphate buffered saline (PBS). Then, using Electron Paramagnetic Resonance (EPR) coupled with the spin-trapping technique, we demonstrate and characterize the ability of bare and lipid-coated ZnO NPs to generate Reactive Oxygen Species (ROS) in water only when remotely actuated via light irradiation. Interestingly, our results aware that the surface chemistry of the NPs greatly influence the type of photo-generated ROS. Finally, we show that our NPs are effectively internalized inside human epithelial carcinoma cells (HeLa) via a lysosomal pathway and that they are able to generate ROS inside cancer cells. [1] B. Dumontel, M. Canta, H. Engelke, A. Chiodoni, L. Racca, A. Ancona, T. Limongi, G. Canavese and V. Cauda, J. Mater. Chem. B. under revision. [2] A. Ancona, H. Engelke, N. Garino, B. Dumontel, W.Fazzini and V. Cauda, to be submitted. The support from ERC Starting Grant - Project N. 678151 "Trojananohorse" is gratefully acknowledged
Seinen| academischen Freunden gewidmet : Stammbuch F. W. Droege / von F.W. Dröge…| Saalathen im Octobr. 98
No full textEnthält 232 Stammbucheinträge in Deutsch und Latein u.a. von F.H. Alberti; B.G. Braunschweig; I. Conring; Denninghoff; C.H.F. Dieterichs; T.W. Dröge; C.W.A. Engelke; C.F. Ernst; F. Gerstein; Victor Heuer; Horst; C. Jacobi; G.W. Kellner; Johann Anton Kirchhoff; C. Kögel; G. Kreyenberg; L. von Heyligenstaedt; Leopold von Hohenhausen; C. Hoyer; G.C. Lange; L. Ledebur; Heinrich Liebrecht; I.C. Loesing; F.L. Marmelstein; Johann Samuel Martin; Theodor Mellmann; F.L.G. Meinecke; C.W. Merten; C. Moellenhoff; C. Nemitz; E.A. Perrellet; H.W.A. Pflug; Carl Schaeffer; F. Schiffer; C.F. Schnedermann; B.U. Schulte; H. Schultz; F. Sporleder; F.M. Striebech; F.L.G. Thebesius; Friedrich Carl Wanderer; Memorabilia S. 12-23; 45; 84-89; 112-113; 242-243; Register enthaltenHandschrift DE-3, GND 2024680-8, Signatur: Yg St. 8° 66/76Einband: Ledereinband, marmoriertes Leder über Pappe; Rollenstempelverzierung (Goldprägung); Filete; goldgeprägtes Rückenetikett: Tempel der Freundschaft (Fragment); Vorderdeckel mit geprägtem Monogramm in Goldpressung: F. W. Droege; Rückdeckel mit Jahreszahl: 1798; Kapitale; Stehkantenverzierung (Goldprägung), punzierter Goldschnitt, Vor- und Nachsatz marmoriertes Papier.Zustand: Papier leicht gebräunt und fingerfleckig; Eintrag S. 134, 135, 148 kopfstehend; Einband mit Gebrauchsspuren, Buchblock angebrochen; Rückenleder gebrochen und am Kopf beschädigt; Ecken und Kanten berieben.Exlibris der Vorbesitzers (Stula) im VorderspiegelI-III vorangebundenEintragungsorte: Halle (220), ReideburgZirkelzeichen der Unilisten und Concordisten S. I, II, 1, 3, 5, 12, 17-22, 25-31, 33-35, 37, 41, 43-45, 48, 53, 55-62, 64, 65, 68, 69, 76, 78-80, 86, 90, 91, 95-100, 102-129, 133-135, 137, 138, 143, 218-221, 223-225, 228, 229, 233-246; 252; Porträtskizze (Tinte) S. 254
Zur Sauerstoff-Inhalationstherapie bei chronischen Lungenerkrankungen (insbesondere Emphysem u. schwerer Silikose) von 0. Zorn, H. Engelke, F. Friehoff.
No full textDiagnostic performance of retrospectively ECG-gated multislice CT of acute pulmonary embolism
No full textAim: This study determined the diagnostic performance of ECG-gated MSCT in comparison with conventional MSCT. Materials and Methods: Forty-five consecutive patients prospectively underwent ECG-gated (group 1, n = 23) or non-ECG-gated (group 2, n = 22) 8-slice MSCT of the pulmonary arteries. Image data were interactively evaluated by three independent chest radiologists with respect to the presence of emboli at different arterial levels, and with regard to cardiac motion artefacts. Consensus reading by two experienced chest radiologists served as diagnostic gold standard. ROC analysis was carried out for the different vascular sections. Results: Twenty-five patients (56%) were diagnosed to have pulmonary embolism (13 from group 1, 12 from group 2). Cardiac motion artefacts were significantly more frequent in group 2 (70% in group 2 versus 13% in group 1, p < 0.05). There was no significant difference between the two groups in the overall sensitivities (0.92 vs. 0.95) and specificities (0.92 vs. 0.98) or in sensitivities and specificities at any assessed pulmonary arterial level. Conclusion: ECG-gated MSCT pulmonary angiography does not significantly influence the diagnostic performance of MSCT in these patients. Therefore no recommendation for routine clinical practice can be given
Bone augmentation in rabbit tibia using microfixed cobalt-chromium membranes with whole blood, tricalcium phosphate and bone marrow cells
No full textTo assess bone augmentation based on a non-critical defect, 1.5 mm deep cobalt-chromium (Co-Cr) barrier membranes were placed on seven adult California rabbits with three different grafting situations: whole blood, whole blood with tricalcium phosphate (TCP), and TCP mixed with bone marrow cells. Macroscopic assessment of the animals was performed once a week and densitometric studies were performed once a month. Three months post-surgery, after detaching the membranes, tibias were sectioned and followed the routine laboratory processing for decalcified sections, with inclusion in paraffin and staining by hematoxylin and eosin technique. Bone augmentation was observed for each animal, even sometimes over the Co-Cr membranes. Compact bone was mostly observed for every situation, with a higher cellular activity on those samples with bone grafts. This could be due to the presence of graft remains at the growth area. It could be concluded that blood supply to the site providing growth factors by the blood clot formation, and the placement of an osteoconductive non-resolvable membrane that favors osseoinduction, may be sufficient elements to achieve bone augmentation in a period of three months in rabbit tibia
Sticky subjects, sticky objects: The substance of African Christian healing
No full textThroughout history and across social and cultural contexts, most systems of belief-whether religious or secular-have ascribed wisdom to those who see reality as that which transcends the merely material. Yet, as the studies collected here show, the immaterial is not easily separated from the material. Humans are defined, to an extraordinary degree, by their expressions of immaterial ideals through material forms. The essays in Materiality explore varied manifestations of materiality from ancient times to the present. In assessing the fundamental role of materiality in shaping humanity, they signal the need to de-center the social within social anthropology in order to make room for the material.Considering topics as seemingly diverse as theology, technology, finance, and art, the contributors-most of whom are anthropologists-examine the many different ways in which materiality has been understood and the consequences of these differences. Their case-studies show that the latest forms of financial trading instruments can be compared with the oldest ideals of ancient Egypt, that the promise of software can be compared with an age-old desire for an unmediated relationship to divinity. Whether focusing on the theology of Islamic banking; Australian Aboriginal art; derivatives trading in Japan; or textiles which respond directly to their environment, each essay adds depth and nuance to the project that Materiality advances: a profound acknowledgment and rethinking of one of the most basic properties of being human.Contributors. Matthew Engelke, Webb Keane, Susanne Küchler, Bill Maurer, Lynn Meskell, Daniel Miller, Hirokazu Miyazaki, Fred Myers, Christopher Pinney, Michael Rowlands, Nigel ThriftDaniel Miller is Professor of Anthropology at University College London. He is the author of many books including The Sari (with Mukulika Banerjee); Capitalism: An Ethnographic Approach; A Theory of Shopping; and The Internet: An Ethnographic Approach (with Don Slater). He is the editor, most recently, of Home Possessions: Material Culture behind Closed Doors and Car Cultures
Quantitative Ultrasound of Cortical Bone in the Femoral Neck Predicts Femur Strength: Results of a Pilot Study
No full textArticle first published online: 15 JAN 2013 Pour consulter la version éditeur DOI: 10.1002/jbmr.1742A significant risk of femoral neck (FN) fracture exists for men and women with an areal bone mineral density (aBMD) higher than the osteoporotic range, as measured with dual-energy X-ray absorptiometry (DXA). Separately measuring the cortical and trabecular FN compartments and combining the results would likely be a critical aspect of enhancing the diagnostic capabilities of a new technique. Because the cortical shell determines a large part of FN strength a novel quantitative ultrasound (QUS) technique that probes the FN cortical compartment was implemented, aimed at testing the sensitivity of the method to variations of FN cortical properties and FN strength. Nine femurs (women, mean age 83 years) were subjected to QUS to measure the through transmission time-of-flight (TOF) at the FN and mechanical tests to assess strength. Quantitative computed tomography (QCT) scans were performed to enable analysis of the dependence of TOF on bone parameters. DXA was also performed for reference. An ultrasound wave propagating circumferentially in the cortical shell, which TOF was not influenced by the properties of the trabecular compartment Q3, was measured in all specimens. Averaged TOF for nine FN measurement positions/orientations was significantly correlated to strength (R² = 0.79) and FN cortical QCT variables: total BMD (R² = 0.54); regional BMD in the inferoanterior (R² = 0.90) and superoanterior (R² = 0.57) quadrants; and moment of inertia (R² = 0.71). The results of this study demonstrate that QUS can perform a targeted measurement of the FN cortical compartment. Because the method involves mechanical guided waves, the QUS variable is related to the geometric and material properties of the cortical shell (cortical thickness, tissue elasticity, and porosity). This work opens the way to a multimodal QUS assessment of the proximal femur, combining our approach targeting the cortical shell with the existing modality sensitive to the trabecular compartment. In vivo feasibility of our approach has to be confirmed with experimental data in patients
Bone augmentation in rabbit tibia using microfixed cobalt-chromium membranes with whole blood, tricalcium phosphate and bone marrow cells
No full textTo assess bone augmentation based on a non-critical defect, 1.5 mm deep cobalt-chromium (Co-Cr) barrier membranes were placed on seven adult California rabbits with three different grafting situations: whole blood, whole blood with tricalcium phosphate (TCP), and TCP mixed with bone marrow cells. Macroscopic assessment of the animals was performed once a week and densitometric studies were performed once a month. Three months post-surgery, after detaching the membranes, tibias were sectioned and followed the routine laboratory processing for decalcified sections, with inclusion in paraffin and staining by hematoxylin and eosin technique. Bone augmentation was observed for each animal, even sometimes over the Co-Cr membranes. Compact bone was mostly observed for every situation, with a higher cellular activity on those samples with bone grafts. This could be due to the presence of graft remains at the growth area. It could be concluded that blood supply to the site providing growth factors by the blood clot formation, and the placement of an osteoconductive non-resolvable membrane that favors osseoinduction, may be sufficient elements to achieve bone augmentation in a period of three months in rabbit tibia
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