1,721,110 research outputs found
Editor Profile: Eric Chevet
No full textInternational audienceIn this special interview series, we profile members of The FEBS Journal Editorial Board to highlight their research focus, perspectives on the journal and future directions in their field. Eric Chevet is Research Director at the French National Institute of Health (INSERM) and Director of the INSERM Unit U1242 'Oncogenesis, Stress, Signaling' in the Comprehensive Cancer Centre Eugene Marquis at the University of Rennes. He has served as Editorial Board Member of The FEBS Journal since 2019
Introducing Emerging Methods and Technologies
No full textInternational audienceWith the current issue of The FEBS Journal, we are introducing a new category of invited review article contributions on Emerging Methods and Technologies. These articles provide an overview and discussion of recent, emerging methods that significantly advance and improve research efforts in the different fields of molecular and cellular research of our The FEBS Journal authors and readers. Deputy Editorial Manager Manuel Breuer and our Emerging Methods and Technologies Commissioning Editor Eric Chevet introduce the series
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Integrative analysis of small GTP binding proteins in «Caenorhabditis elegans»: functional clustering and role in the endoplasmic reticulum stress signaling
No full textSmall G proteins of the Ras superfamily were reported as major regulators of various cellular functions and are known to play a role in numerous human pathologies, such as cancer. They are currently classified according to their amino acid sequence into five subfamilies (Ras, Rho, Rab, Arf and Ran). In order to systematically study their functions and redundancy, we have selected C. elegans as an experimental model. This organism was chosen since it provides a reliable simple model for the study of small G proteins: In addition to providing experimental advantages over other higher eukaryotes, C. elegans expresses well conserved small G proteins, in limited number. We used this model to perform an integrative analysis of the biochemical activities of small G proteins and to study the role of these enzymes in the maintenance of the endoplasmic reticulum homeostasis. We have first constructed a library of vectors containing 53 C. elegans GTPase genes cloned in various expression vectors. This strategy appeared very efficient since the success rate of our cloning approach was above 89%. Using two high throughput technologies, we have then developed assays to measure enzymatic activities (GTP affinity, exchange and hydrolysis activities) of small G proteins. Integration and analysis of these enzymatic results revealed that the amino acid sequence clustering only partially represents the enzymatic characteristics of small G proteins. This suggests that a biochemical classification would be more representative of small G protein function similarities than their current amino acid sequence-based classification. To develop on this idea, we have generated and collected data related to RNAi phenotypes, cellular and tissue localizations and mRNA co-expression to integrate various functional properties and proposed a more complete clustering of the Rho subfamily of proteins. Another biochemical characteristic studied in this project was the role of small G proteLes petites protéines G de la famille des Ras sont impliquées dans de nombreux processus biologiques et elles sont impliquées dans plusieurs pathologies humaines telles que les cancers. Elles sont présentement classifiées à partir de leur séquence en acides aminés en cinq sous familles nommées Ras, Rho, Rab, Arf et Ran. Dans le but d'étudier leurs propriétés biochimiques, leurs fonctions et leur niveau de redondance de manière systématique, nous avons choisi le nématode C. elegans comme modèle expérimental. En plus des avantages expérimentaux que confère cet organisme, les petites protéines G y sont grandement conservées et beaucoup moins abondantes que chez les mammifères. Par conséquent, nous avons utilisé cet organisme pour étudier diverses fonctions de ces protéines, proposé une nouvelle classification fonctionnelle de la superfamille des Ras et étudier le rôle des GTPases dans la régulation des voies du stress du réticulum endoplasmique. Pour réaliser ce projet, nous avons tout d'abord identifié les gènes codant pour des GTPases chez C. elegans et construit une bibliothèque de vecteurs d'expression pour 53 d'entre eux. Cette stratégie s'est avérée très efficace, avec un rendement de clonage de plus de 89%. Ensuite, nous avons développé de puissants essais enzymatiques pour mesurer leurs activités biochimiques (affinité et hydrolyse du GTP et activité d'échange) en utilisant deux technologies à haut débit. De plus, l'intégration et l'analyse de ces valeurs enzymatiques nous ont permis de démontrer que la classification usuelle des petites protéines G ne corrèle pas totalement avec l'activité enzymatique de ces dernières. Par conséquent, nous avons collecté des données relatives à la localisation tissulaire et cellulaire, aux phénotypes ARNi ainsi qu'à la co-expression des ARNm de ces gènes afin de proposer une classification fonctionnelle des petites protéines G de la sous famille des Rho
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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