326 research outputs found
Lesione del credito da parte di terzi, lesione del possesso e altre vicende
No full textIl contributo si articola in tre parti. Nella prima viene analizzata la vicenda della lesione del credito da parte di terzi dagli storici casi Meroni e Superga alla ricostruzione dei Fallgruppen in cui può razionalizzare la tutela aquiliana del credito. Nella seconda parte vengono esaminate figure di dubbia collocazione quali i danni da uccisione e infine, nella terza parte, viene affrontato il tema della tutela del possess
Some Remarks on the Recent SRM Related Case-Law of the CJEU with Special Regard to the Meroni Doctrine
No full textThe study elaborates on the development of the Meroni doctrine, derived from the Meroni judgment of the Court of Justice of the European Coal and Steel Community under a different Founding Treaty framework and its applicability to the Banking Union under the current Treaty framework. To fulfil this aim, the author first elaborates on the Advocate General’s opinion and the Judgment of the Court of Justice in the Meroni case and then briefly introduces the evolution and the literature on the issue. After a short introduction of the Banking Union’s institutional order, the author introduces two cases in which issues related to the Meroni doctrine were raised before the General Court, as well as the appellate procedures before the Court of Justice in one of these cases
Artifact-Driven Business Process Monitoring - A Novel Approach to Transparently Monitor Business Processes, Supported by Methods, Tools, and Real-World Applications
No full textThis book proposes a novel technique, named artifact-driven process monitoring, by which multi-party processes, involving non-automated activities, can be continuously and autonomously monitored. This technique exploits the Internet of Things (IoT) paradigm to make the physical objects, participating in a process, smart. Being equipped with sensors, a computing device, and a communication interface, such smart objects can then become self-aware of their own conditions and of the process they participate in, and exchange this information with the other smart objects and the involved organizations. To allow organizations to reuse preexisting process models, a method to instruct smart objects given Business Process Model and Notation (BPMN) collaboration diagrams is also presented. The work constitutes a revised version of the PhD dissertation written by the author at the PhD School of Information Engineering of Politecnico di Milano, Italy. In 2019, the PhD dissertation won the “CAiSE PhD award”, granted to outstanding PhD theses in the field of Information Systems Engineering
Should we increase instruction time in low achieving schools? Evidence from Southern Italy
No full textAbstractThis paper investigates the short term effects of a large scale intervention, funded by the European Social Fund, which provides additional instruction time to selected classes of lower secondary schools in Southern Italy. Selection is addressed using institutional rules that regulate class formation: first year students are divided into groups distinguished by letters, they remain in the same group across grades at the school, and the composition of teachers assigned to groups is stable over time. Using a difference-in-differences strategy, we consider consecutive cohorts of first year students enrolled in the same group. We compare participating groups to non-participating groups within the same school, as well as to groups in non-participating schools. We find that the intervention raised scores in mathematics for students from the least advantaged backgrounds. We also find that targeting the best students with extra activities in language comes at the cost of lowering performance in mathematics. We go beyond average effects, finding that the positive effect for mathematics is driven by larger effects for the best students
The italian school psychologists’ role: A qualitative study about professional practices and representations
No full textSchool psychologists’ relevance has been broadly affirmed. However, there is no shared definition of their professional role, and more efforts are needed to promote an organisational and whole-school approach. The present study aims to investigate practices and representations of Italian school psychologists, advance knowledge of the status and development of school psychology, and learn more about the approaches currently adopted in schools. A qualitative method was used and 11 focus groups with a total of 86 participants were carried out. Ad hoc instruments were defined. The results highlighted that school psychologists are more focused on building one-on-one relationships, whereas relationships with the organisation as a whole appear to be more difficult. However, participants reported a wide range of activities, targeted to both the individual and the organisation. Moreover, efforts to strengthen the relationships with school principals and the entire school community were described. Specific needs emerged and the necessity to better define the school psychologists’ role was reported by the participants. More efforts are needed to promote an organisational approach among Italian school psychologists and specific training should be offered
Toward a Science Campus in Milan : a Snapshot of Current Research at the Physics Department Aldo Pontremoli
No full textThis book is a collection of multidisciplinary papers presented at the Department of Physics of Milan University's congress on 28 and 29 June 2017, which was also intended as a kick-off meeting for the design of a novel science campus at the Expo site in Milan. The congress presented a snapshot of the department's research to the academic community, the media, policymakers and authorities as well as the public at large, and also provided an opportunity to strengthen interdisciplinary collaborations between the members of the department and other communities. This book is a valuable resource for scientists looking for synergetic projects, policymakers wanting to grasp scientists' points of view and for prospective graduate students seeking expanding areas of research
Fostering collaboration between start-ups and students for mutually beneficial inspiring learning
No full textThis two-voiced paper is the result of a student-teacher interaction in which the teacher simply paves the floor for a student’s narrative and commentary, from their perspective, of an innovative projectbased studio experience. By partnering with an incubation and start-up program for social innovators in Milan, university faculty considered how to design a studio to stimulate both students and innovators in their different educational and personal trajectories by organising "pairs of teams" with the same design goal(s), conscientious of social innovation, environmental sustainability within a circular economy, and striving for radical solutions. The team for which this student-author is sharing their experience in this paper has been paired with the start-up team “NoLo Ricicla - ilVespaio”, whose innovation idea was based on the question “How could a system of plastic packaging recovery, production and distribution of recycled artefacts be organised on a neighbourhood scale in the neighbourhood of NoLo?
Predictive factors of tmj involvement in 230 consecutive jia patients regularly screened from 2000 to 2014 in a single pediatric rheumatology centre
No full textBackground: Juvenile Idiopathic Arthritis (JIA) has been shown to involve frequently the temporo-mandibular joint (TMJ). An important prognostic aspect is to diagnose and treat it promptly.
Objectives: To evaluate in a consecutive JIA patients (pts) cohort, regularly screened from year 2000 to 2014, the predictive factors of the TMJ involvement.
Methods: 230 consecutive pts (152 females, 78 males) affected by JIA according to ILAR classification, 164 oligoarthritis, 4 polyarthritis rheumatoid factor (RF) +, 34 polyarthritis RF-, 22 systemic onset JIA (soJIA), 4 enthesitis-related arthritis (ERA) HLA B27+, and 2 psoriatic arthritis were included in a retrospective evaluation. Mean disease onset age was 6.5 yrs (range 1-16), mean disease duration 12.7 yrs (range 0.2-46.2).
We analyzed the correlation between TMJ involvement with the following items: ILAR categories, age at onset, gender, pattern of articular involvement (large joints, small ones, hips, cervical spine).
Results: 88/230 patients (38.3%), 36.8% of females and 41% of males showed a clinical TMJ involvement. Mean age at onset (or diagnosis) of TMJ involvement was 8.3 yrs. 62/88 pts (70.5%) had a bilateral clinical signs of condylar alteration.
The involvement of TMJ was observed in 38.3% of the whole population (54.5% of oligoarthritis, 27.3% polyarthritis RF negative, 2.3% polyarthritis RF positive, 9.1% soJIA, 4.5% ERA and 2.3% juvenile psoriatic arthritis)
3 cases (2 females and 1 male) presented with an involvement of TMJ at the diagnosis of JIA.
The rate of TMJ involvement was higher in the pts with an early onset of the disease (52.3% in the 0-6 yrs group, vs 36.4% in 7-12 yrs group and 11.3% in 13-16 yrs group).
In 56/88 pts (63.3%) TMJ disease was associated with an involvement of large joints, in 4/88 (4.54%) with small joints, in 24/88 (27.7%) with hips and in 18/88 (20.45%) with cervical spine.
Conclusions: An early onset of JIA, the oligoarticular ILAR category and a pattern of large joints involvement seem correlated with a higher rate of TMJ disease. Predictive factors of TMJ involvement should be confirmed in a larger JIA population and may be useful for clinicians to adopt appropriate prevention strategies of TMJ disease
Predictive factors of remission in juvenile idiopathic arthritis patients treated with biological therapies 13-year experience of a single center
No full textPREDICTIVE FACTORS OF REMISSION IN JUVENILE IDIOPATHIC ARTHRITIS PATIENTS TREATED WITH BIOLOGICAL THERAPIES. 13-YEAR EXPERIENCE OF A SINGLE CENTER M. Romano1, I. Pontikaki1, I. Ardoino2, M. Gattinara1, E. del giudice3, P. Boracchi2, S. Lodi-Rizzini1, P.L. Meroni1, V. Gerloni1 1Division of Rheumatology, Istituto Ortopedico G.Pini 2Unit of Medical Statistic and Biometry “G.A. Maccacaro”, University of Milan, Italy., Milan 3Dep. of Pediatrics, Sapienza, University of Rome, Italy, Rome, Italy Background: Juvenile Idiopathic Arthritis (JIA) is the most prevalent chronic rheumatic disease in childhood. The term JIA means a group of clinically heterogeneous arthritides, beginning before the age of 16 years, of unknown cause, and persistent for more then 6 weeks. The prognosis is often severe and many children are still suffering from active disease in adulthood. Objectives: Juvenile Idiopathic Arthritis (JIA) is the most prevalent chronic rheumatic disease in childhood. The term JIA means a group of clinically heterogeneous arthritides, beginning before the age of 16 years, of unknown cause, and persistent for more then 6 weeks. The prognosis is often severe and many children are still suffering from active disease in adulthood. Methods: All JIA patients (pts) treated in our Center with BTs, are prospective followed every 2 months for the evaluation of safety and efficacy (according to ACR-Pedi core set criteria). Charts of all 363 pts enrolled between November 1999 and November 2012, have been reviewed. In total 750 BTs were administered to our 363 pts. The outcome measures needed to define the achievement of the status of ID, CRM and CR, at several follow-up moments, were analysed. Results: Two hundred ninety-four JIA pts (who received in total 535 BT) were statistically evaluated for predicting factors of CRM during the 1st course of BT. Median age at disease onset was 5.4 yrs (mean 6.7, range 0.5-16). At starting of the 1st BT median disease duration was 7.9 yrs (mean 9.6, range 0.2 - 41.4), median age was 15.2 yrs (mean 16.3, range 1.9 - 49.8). Median treatment duration of the 1st BT was 2.06 yrs (mean 1.96, range 0.03-10.35). CRM was achieved with 172 out of all 535 BTs (32.1%) and with 136 out of 294 1st courses of BTs (46.2%). 136 out of 172 successful treatments (79.1%) were 1st BTs. During the 1st BT, 136 out of 294 pts (46.3%) obtained one or more periods of CRM of variable duration. Only 4 pts reached CR. The statistical multivariate analysis showed that the probability of CRM with the 1st BT is positively correlated with male gender (p=0.005), non-soJIA (p<0.05) and shorter disease duration before starting the 1st BT (p<0.05). Conclusions: Upon treatment with the 1st BT, nearly half of children and young people affected by JIA, although they had suffered from long-standing, refractory disease non responder to DMARDs, reached at least one sustained period of CRM. Nevertheless a persistent CR off medication remains a rare event. References: 1. Wallace CA, Ruperto N, Giannini EH. Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J Rheumatol 2004;31:2290-4. 2. Lurati A, Salmaso A, Gerloni V, Gattinara M, Fantini F. Accuracy of Wallace criteria for clinical remission in juvenile idiopathic arthritis: a cohort study of 761 consecutive cases. J Rheumatol. 2009 Jul;36(7):1532-5. 3. Fantini F, Gerloni V, Gattinara M, Cimaz R, Arnoldi C, Lupi E. Remission in juvenile chronic arthritis: a cohort study of 683 consecutive cases with a mean 10 year followup. J Rheumatol. 2003 Mar;30(3):579-84
Drug survival and reasons for discontinuation of the first course of biological therapy in 363 juvenile idiopathic arthritis patients
No full textBackground: The introduction of TNF-blocking agents since 2000 has tremendously changed the treatment of JIA. From randomized controlled trials (RCTs) there is evidence that TNF-blocking agents are efficacious and safe, but data on their long-term expected and unexpected effects remain relatively scarce.
Objectives: To determine long-term effectiveness and safety of 1st biological treatment (BT) in a cohort of 363 Juvenile Idiopathic Arthritis (JIA) pts, non-responders to DMARDs, in terms of drug survival (continuation rate on therapy) and to identify the baseline predictors of treatment discontinuation.
Methods: Each JIA pt enrolled in BT is prospectively assessed at the start of treatment and then every 2 months for the evaluation of safety and efficacy according to ACR-Pedi core set criteria. All clinical charts of pts who started a BT between Nov'99 and Jul'10 have been reviewed. Survival analysis methods suitable for competing risks were used to study time to drug discontinuation due to disease control (defined according to Wallace criteria) or failure (adverse event [AE], lack of efficacy [LaE] or loss of efficacy [LoE].
Results: In total 750 different courses of BTs were administered to our 363 pts. In 287/363 pts a BT treatment is still ongoing, 147 pts maintain the 1st BT, 140 pts switched one or more times. 298 pts were included in the analysis for drug discontinuation. A median follow-up on treatment, before discontinuation due to every causes, was 53.7 months (range 0.45-124.45). One hundred and sixty-five pts discontinued BT: 27 due to disease control, 135 because of failure (78 AEs, 12 LaE and 45 LoE), 3 pts temporarily stopped for pregnancy. Among 135 pts who discontinued for failure, 117 switched to a 2nd BT. Among 27 pts who discontinued due to disease control, 13 pts restarted on BT for relapse of disease activity (10 pts restarted with the same BT, 3 switched to a different one). Predictors of discontinuation due to AE were female gender (p=0.1) and longer disease duration (p=0.02). Predictors of discontinuation due to LaE or LoE were systemic onset and polyarthritis FR positive (vs other JIA subtypes) (p<0.05) and use of mAb-anti-TNF (vs sTNFR) (p=0.02). Predictors of discontinuation due to inactive disease were male gender and shorter disease duration (p<0.05).
Conclusions: Although only few pts discontinued BT due to a complete and persistent disease control, the majority of them remained on BT for a long time, suggesting that in our cohort of JIA pts, affected by a severe long lasting refractory disease, BT was globally well tolerate and efficacious in controlling the disease.
References:
1. Gerloni V, Pontikaki I, Gattinara M, Fantini F. Focus on adverse events of tumour necrosis factor α blockade in juvenile idiopathic arthritis in an open monocentric long-term prospective study of 163 patients. Ann Rheum Dis 2008; 67: 1145-52.
2. Tynjälä P, Vähäsalo P, Honkanen V, Lahdenne P. Drug survival of the first and second course of anti-TNF agents in juvenile idiopathic arthritis. Ann Rheum Dis 2009; 68: 552-7
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