170,098 research outputs found
Are There Options to Prevent Early Occurring Deaths in Acute Myocardial Infarction: Prospective Evaluation of All < 24 h In-Hospital Deaths, 2004-2006-The MONICA/KORA Augsburg Infarction Registry
No full textObjectives: To provide valid clinical data of early in-hospital deaths with presumed acute myocardial infarction (AMI) who are often not included in clinical trials or registries. Methods: From August 2004 to August 2006 all patients (age 25-84 years) dying within 24 h after hospitalization in a large tertiary care academic teaching hospital were screened regarding an underlying cardiovascular cause of death. Results: After validation, 79 out of 1,352 patients remained with a final diagnosis of AMI. Sixty-six percent of these experienced prehospital cardiac arrest or shock. In 37% no resuscitation attempts were performed in-hospital, the most common reason being multimorbidity. Only 23% could be transferred to coronary angiography for revascularisation attempts. An independent panel of clinicians judged that only in one patient would another management strategy have been promising. Of interest, 33% of the deceased patients had typical or atypical chest pain the days before the lethal event. Conclusion: A large percentage of AMI patients who died soon after hospitalization were in critical circulatory state directly before hospitalization. In 37%, in-hospital resuscitation attempts were omitted for understandable reasons. Options for improvement in acute care in the investigated setting were not found. However, in one third of the cases earlier preventive measures might have been reasonable. Copyright (C) 2010 S. Karger AG, Base
Paleomagnetic inclination and declination from three‐component borehole magnetometer data—New insights from logging in the Louisville seamounts
No full textWe carried out measurements of the magnetic field vector at two sites during Integrated Ocean Drilling Program (IODP) Expedition 330 to the Louisville Seamount Chain. The aim was to impose constraints on the magnetization direction and to contribute to the reconstruction of possible hot spot motion. The measurements were conducted using the Gottingen Borehole Magnetometer (GBM). It comprises three fiber optic gyros (FOG) that can be used to reorient the magnetic field data. To improve accuracy, we are using a new algorithm that combines FOG data and data of two inclinometers. As can be evaluated by comparing downlog and uplog of the measurements, the three-dimensional magnetic field data obtained is of good quality. An interpretation of the magnetic field data using a state of the art method based on horizontal layers yields results inconsistent with measurements of the natural remanent magnetization (NRM) of drill core samples. In the following, we define the magnetization from the horizontal layer as apparent magnetization and develop a new interpretation method based on dipping layers. Our method includes a new approximate forward modeling algorithm and considerably improves the consistency of the borehole measurements and the NRM data. We show that a priori information about the geometry of a layer is required to constrain the inclination and declination of magnetization. Especially the azimuth of a layer and the declination of magnetization cannot be determined separately. Using azimuth and layer dip information from borehole images, we obtain constraints on inclination and declination for one particular layer.DFG [Ho1506/21-1, Le1293/2-1
Reorientation of three‐component borehole magnetic data
No full textThree-component borehole magnetics provide important additional information compared to total field or horizontal and vertical measurements. These data can be used for several tasks such as the localization of ferromagnetic objects, the determination of apparent polar wander curves and the computation of the magnetization of rock units. However, the crucial point in three-component borehole magnetics is the reorientation of the measured data from the tool's frame to the geographic reference frame North, East and Downwards. For this purpose, our tool, the Gottinger Borehole Magnetometer, comprises three orthogonally aligned fibre optic gyros along with three fluxgate sensors. With these sensors, the vector of the magnetic field along with the tool rotation can be recorded continuously during the measurement. Using the high-precision gyro data, we can compute the vector of the magnetic anomaly with respect to the Earth's reference frame. Based on the comparison of several logs measured in the Outokumpu Deep Drill Hole (OKU R2500, Finland), the repeatability of the magnetic field vector is 0.8 degrees in azimuthal direction, 0.08 degrees in inclination and 71 nT in magnitude.DFG [HO 1506/16 1, LE 1293/1 1
Analysis of the Importance of SMART Therapy in the German Asthma Network
No full textHinze C, Ehmann R, Jandl M, et al. Analyse des Stellenwertes der SMART Therapie im German Asthma Network. Pneumologie . 2024;78(Suppl. 1):S5
Directional location of buried objects using three-component magnetic borehole data demonstrated for the case of a drill string
No full textOne of the main applications of magnetic field measurements in boreholes is the detection of unexploded ordnance or buried utility structures like pipes or tiebacks. Even though the advantage of fully oriented magnetic vector measurements have long been recognized and could significantly reduce costs and risks, the tools used for those purposes typically measure only the total magnetic field, the vertical and horizontal components or gradients thereof. The Gottingen Bohrloch Magnetometer uses three fibre optic gyros to record its orientation and thus enables us to compute high-quality three-component magnetic vector data regardless of borehole orientation. The measurements described in this paper were run in the scientific borehole Cuxhaven Ludingworth 1/1A, which was drilled as a part of the 'Coastal Aquifer Test field' project to study the dynamics of the saltwater/freshwater interface. As the drill string got stuck during drilling of the first borehole, a second hole was drilled in the immediate vicinity. The drill string lies at a depth between 80 and 114 m at a distance of only 2.5 m southeast of the borehole used for the measurements, making it an ideal target to demonstrate the benefits of vector magnetic surveys. Although the theories to calculate magnetic fields of objects with different shapes is well established and do not need to be tested, they almost exclusively include approximations of the geometry. It is not obvious whether these approximations are suited to describe real data, or whether additional effects or refinements have to be considered. We use both a simplified monopole model and a cylinder model to fit the data and are able to determine the position of the drill string within a statistical error of approximately 10 cm. Additionally, we show that the location of the drill string could not have been determined by measurements of the total field or its horizontal and vertical component alone and that those methods would require the drilling of additional boreholes to obtain an unambiguous result.Empting Kran- und Handelsgesellschaf
Narrative Language as an Expression of Individual and Group Identity
No full textScientific Narrative Psychology integrates quantitative methodologies into the study of identity. Its methodology, Narrative Categorical Analysis, and its toolkit, NarrCat, were both originally developed by the Hungarian Narrative Psychology Group. NarrCat is for machine-made transformation of sentences in self-narratives into psychologically relevant, statistically processable narrative categories. The main body of this flexible and comprehensive system is formed by Psycho-Thematic modules, such as Agency, Evaluation, Emotion, Cognition, Spatiality, and Temporality. The Relational Modules include Social References, Semantic Role Labeling (SRL), and Negation. Certain elements can be combined into Hypermodules, such as Psychological Perspective and Spatio-Temporal Perspective, which allow for even more complex, higher level exploration of composite psychological processes. Using up-to-date developments of corpus linguistics and Natural Language Processing (NLP), a unique feature of NarrCat is its capacity of SRL. The structure of NarrCat, as well as the empirical results in group identity research, is discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Lacunar and reed-sternberg-like cells in follicular lymphomas are clonally related to the centrocytic and centroblastic cells as demonstrated by laser capture microdissection
No full textTwo cases of follicular lymphoma (FL) with numerous large cells resembling the lacunar and Hodgkin and Reed-Sternberg (HRS) cells of classic Hodgkin lymphoma were studied to determine clonal relationships between the HRS-like cells and centrocytic and centroblastic (CCCB) cells. In both cases, CCCB cells were typical of FL; CD45RB, CD20, CD10, and bcl-2 positive. In case 1, the HRS-like cells were positive for CD45RB, CD20, CD10, CD30, OCT2, and BOB.1 and negative for CD15 and bcl-2. In case 2, the HRS-like cells were positive for CD30, fascin, CD20, OCT2, and BOB.1 and negative for CD45RB, CD10, CD15, and bcl-2. CCCB and single HRS-like cells were isolated by laser capture microdissection followed by polymerase chain reaction amplification and sequencing of immunoglobulin heavy chain gene rearrangements. In both cases, identical sequences were obtained from CCCB and HRS-like cells. These findings confirm that although the HRS cells and CCCB cells in these cases demonstrate morphologic and immunophenotypic divergence, they share a common cell of origin. These cases further highlight the potential diagnostic pitfall presented by FL with HRS-like cell
Narrative Social Psychology and the Narrative Categorical Content Analysis (NarrCat) in the Study of Social Representations of History
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