521 research outputs found
sj-pdf-2-jbf-10.1177_22808000231221067 – Supplemental material for In vitro assessment of Momordica charantia/Hypericum perforatum oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering
No full textSupplemental material, sj-pdf-2-jbf-10.1177_22808000231221067 for In vitro assessment of Momordica charantia/Hypericum perforatum oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering by Emre Fatih Ediz, Cansu Güneş, Meltem Demirel Kars and Ahmet Avcı in Journal of Applied Biomaterials & Functional Materials</p
sj-pdf-1-jbf-10.1177_22808000231221067 – Supplemental material for In vitro assessment of Momordica charantia/Hypericum perforatum oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering
No full textSupplemental material, sj-pdf-1-jbf-10.1177_22808000231221067 for In vitro assessment of Momordica charantia/Hypericum perforatum oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering by Emre Fatih Ediz, Cansu Güneş, Meltem Demirel Kars and Ahmet Avcı in Journal of Applied Biomaterials & Functional Materials</p
In vitro assessment of Momordica charantia/Hypericum perforatum oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering
No full textThe research on tissue engineering applications has been progressing to manufacture ideal tissue scaffold biomaterials. In this study, a double-layered electrospun biofiber scaffold biomaterial including Polycaprolactone (PCL)/Collagen (COL) fibrous inner layer and PCL/ Momordica charantia (MC) and Hypericum perforatum (HP) oils fibrous outer layer was developed to manufacture a functional, novel tissue scaffold with the advantageous mechanical and biological properties. The main approach was to combine the natural perspective using medicinal oils with an engineering point of view to fabricate a potential functional scaffold for tissue engineering. Medicinal plants MC and HP are rich in functional oils and incorporation of them in a tissue scaffold will unveil their potential to augment both new tissue formation and wound healing. In this study, a novel double-layered scaffold prototype was fabricated using electrospinning technique with two PCL fiber layers, first is composed of collagen, and second is composed of oils extracted from medicinal plants. Initially, the composition of plant oils was analyzed. Thereafter the biofiber scaffold layers were fabricated and were evaluated in terms of morphology, physicochemistry, thermal and mechanical features, wettability, in vitro bio-degradability. Double-layered scaffold prototype was further analyzed in terms of in vitro biocompatibility and antibacterial effect. The medicinal oils blend provided antioxidant and antibacterial properties to the novel PCL/Oils layer. The results signify that inner PCL/COL layer exhibited advanced biodegradability of 8.5% compared to PCL and enhanced wettability with 11.7° contact angle. Strength of scaffold prototype was 5.98 N/mm2 thanks to the elastic PCL fibrous matrix. The double-layered functional biofiber scaffold enabled 92% viability after 72 h contact with fibroblast cells and furthermore provided feasible attachment sites for the cells. The functional scaffold prototype’s noteworthy mechanical, chemical, and biological features enable it to be suggested as a different novel biomaterial with the potential to be utilized in tissue engineering applications
A computational study of visual complexity in architecture, focusing on the Sehzade Mosque, Suleymaniye Mosque, and Selimiye Mosque.
No full textPurpose: The study aims to (i) examine the characteristics of Sinan's architecture and the & Scedil;ehzade, S & uuml;leymaniye, and Selimiye mosques in light of insights from historians and researchers, (ii) conduct three-layered fractal analyses of the facades of these works and provide mathematical definitions, and (iii) ultimately, compare numerical analyses within the context of conceptual discussions on Sinan's architecture in terms of periodical differences. Theory and Methods: Within the scope of the research, a study was conducted on three mosques designed by Sinan using the fractal analysis method, a computational analysis technique. This study compared and examined the information that architectural historians and theorists have established about Sinan through quantitative methods. Results: When the three frequently studied masterpieces of Sinan are examined through shape grammar and fractal analysis methods, it is observed how his design philosophy simplified and evolved over time. It has been determined that with each new structure, he added innovations, thereby enhancing his knowledge base. Furthermore, it has been identified that the patrons of Sinan's works had significant influences on the visual complexity and the formal and spatial configurations of the structures. Conclusion: The use of fractal dimension in the architectural context emerges as an extremely effective tool for deeply analyzing the transformation and development processes of architectural constructs, from largescale planning to detailed design. In this study, the fractal dimension was employed to meticulously examine the evolutionary changes and inter-structural relationships in the works of Mimar Sinan. The intuitive and cognitive architectural theoretical knowledge has been supported with quantitative data. This integration has bridged various disciplines such as architectural design, architectural history, and mathematics, adding new perspectives to architectural criticism and debates
Recall this Book 56: Merve Emre on Natalia Ginzburg's "The Dry Heart"
No full textLike our podcast, B-Side Books focuses on those moments when books topple off their shelves, open up, and start bellowing at you. The one that buttonholed Merve Emre (Oxford literature professor and author most recently of The Personality Brokers) was a novella by the luminous midcentury Italian pessimist, Natalia Ginzburg. And if you think you know precisely why a mid-century Italian writer would have a dark and bitter view of the world (already thinking of the Nazi shadows in work by Italo Calvino, Primo Levi and Giorgio Bassani) Ginzburg's The Dry Heart will have you thinking again. Merve started her piece by asking that age-old question: "When should a woman kill her husband?
Author response
No full textDetecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al., 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior to infection. Here we show that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors mediate avoidance of LPS in feeding and egg laying assays. We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance. Furthermore, LPS stimulates Drosophila neurons in a TRPA1-dependent manner and activates exogenous dTRPA1 channels in human cells. Our findings demonstrate that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.sponsorship: Vlaams Instituut voor Biotechnologie Alessia Soldano Luis Franco Guangda Liu Natalia Mora Emre Yaksi Bassem A Hassanr Fonds Wetenschappelijk Onderzoek G.0702.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0077.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0680.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0681.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0503.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0654.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0761.10N Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0596.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0565.07 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven GOA/14/011 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar European Commission IUAP P7/13 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekensr KU Leuven OT/12/091 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven PF-TRPLe Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talavera (Vlaams Instituut voor Biotechnologie, Fonds Wetenschappelijk Onderzoek|G.0702.12, Fonds Wetenschappelijk Onderzoek|G.0077.15, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0681.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Fonds Wetenschappelijk Onderzoek|G.0654.15, Fonds Wetenschappelijk Onderzoek|G.0761.10N, Fonds Wetenschappelijk Onderzoek|G.0596.12, KU Leuven|GOA/14/011, KU Leuven|OT/12/091, European Commission|IUAP P7/13, KU Leuven PF-TRPLe)status: Publishe
Approach for siting a support facility for transporting supplies in emergency cases in the Republic of Bulgaria
No full textIn this paper, the author determines the most suitable transportation location for intervention in a large scale disaster in the Republic of Bulgaria, by means of the Weber Problem and the Weiszfeld method. The objective is to minimise the cost of transporting emergency supplies across the country by locating a support facility, and thus reaching the area of event at the lowest possible cost. A brief description of the Weiszfeld method is provided in the paper. Further, using recent population data of both provinces and municipalities, the method is applied respectively to obtain the results. They were compared in terms of spatial correspondence and the final facility location was fixed. Erecting the supply site is recommended to help decrease the losses
Comparing clusterings and numbers of clusters by aggregation of calibrated clustering validity indexes
No full textAkhanli, Serhat Emre/0000-0001-7173-3277WOS: 000543319300001A key issue in cluster analysis is the choice of an appropriate clustering method and the determination of the best number of clusters. Different clusterings are optimal on the same data set according to different criteria, and the choice of such criteria depends on the context and aim of clustering. Therefore, researchers need to consider what data analytic characteristics the clusters they are aiming at are supposed to have, among others within-cluster homogeneity, between-clusters separation, and stability. Here, a set of internal clustering validity indexes measuring different aspects of clustering quality is proposed, including some indexes from the literature. Users can choose the indexes that are relevant in the application at hand. In order to measure the overall quality of a clustering (for comparing clusterings from different methods and/or different numbers of clusters), the index values are calibrated for aggregation. Calibration is relative to a set of random clusterings on the same data. Two specific aggregated indexes are proposed and compared with existing indexes on simulated and real data.EPSRCEngineering & Physical Sciences Research Council (EPSRC) [EP/K033972/1]The work of the second author was supported by EPSRC grant EP/K033972/1
Nezihe Araz'ın Dertli Dolap ve Jacques Lacarrıere'in Dünyanın Tozu romanlarında kahramanın yolculuğu: "Yunus Emre"
No full textYunus Emre, Türk toplumu için derin bir bilgelik kaynağıdır. Onun, toplumu yüksek değerlere ulaştırmak için, yüzyıllar öncesinden yaktığı aydınlanma ışığı, bugün hâlâ dünyayı aydınlatmaya devam etmektedir. Jacques Lacarrière'in (1925-2005) Dünya'nın Tozu (1999) (La Poussière du Monde) (1997) romanında kahraman "Yunus Emre"'dir. Bir Fransız yazar olan Lacarrière "Yunus Emre"'yle ilgili menkıbeleri öğrendikten sonra "Yunus Emre"'yi kahraman yaptığı bir roman kurgular. Bu romanda yazarın sadece duydukları üzerinden bir kurgu oluşturmadığını görürüz. Yazar aynı zamanda "Yunus Emre"'yi kendi kültür çerçevesinden anlamaya da çalışan sorular sorar. Diğer yandan çocukluğundan beri duyduğu "Yunus Emre" dizeleri ve menkıbelerinin etkisinde olan Türk yazar Nezihe Araz, (1920-2009) Dertli Dolap (1961) romanını çocukluğundan bugüne kalbinde yetiştirdiği bir kahraman olan "Yunus Emre"'nin yaşamı üzerine kurgular. "Yunus Emre"'nin tekâmül yolculuğunu onun dizeleri üzerinden ilerleyen bir kurguyla aktarır. Bu iki romanı ortak noktada buluşturan kahraman "Yunus Emre", insanın kendi özüne yaptığı yolculuğun en önemli temsilcilerinden birisidir. Öze yolculuk, Carl Gustav Jung'a (1875-1961) göre, arketipler aracılığıyla aktarılan bireyleşmenin başka bir ifade biçimidir. Jung'un bu görüşünden yola çıkan Joseph Campbell, yolculuğu ve bireyleşmeyi kahramanın geçirdiği yolculuk aşamaları bağlamında anlamayı ve açıklamayı önerir ve bu süreci "kahramanın sonsuz yolculuğu " olarak adlandırır. Çalışmamızda, Joseph Campbell'in bu modeli çerçevesinde, farklı iki kültüre ait iki yazarın romanlarında ortak kahraman olan "Yunus Emre"nin, kahramanın yolculuğuna ne ölçüde uyum sağladığının ve iki yazardaki "Yunus Emre" algısının farklılığının tespit edilmesi amaçlanmıştır."Yunus Emre" is a deep source of wisdom for Turkish society. The light of enlightenment that he lit centuries ago in order to bring the society to high values still continues to illuminate the world today. In Jacques Lacarrière's novel La Poussière du Monde, the hero is "Yunus Emre. After learning the legends about Yunus Emre, Lacarrière, a French writer, constructs a novel in which he makes Yunus Emre a hero. In this novel, we see that the author does not create a fiction based on only what he hears. The author also asks questions that try to understand Yunus Emre from his own cultural framework. On the other hand, Turkish writer Nezihe Araz, who has been influenced by Yunus Emre verses and legends that she has heard since her childhood, constructs her novel Dertli Dolap on the life of Yunus Emre, a hero whom he raised in her heart from her childhood. She conveys Yunus Emre's journey of evolution with a fiction that proceeds through his verses. Yunus Emre is the hero who brings together these two novels at a common point and he is also one of the most important representatives of the journey which a person makes to his\her own essence. According to Carl Gustav Jung , (1875-1961) journey to the essence is another expression way of individualism which is transmitted through archetypes. Based on this view of Jung, Joseph Campbell, offers to understand and express the journey and individualism with in the context of the journey's periods which the hero has experienced and he names this process as "the hero's endless journey". The aim of our study is to determine to what extent "Yunus Emre", who is the comman hero of the two novels by two novelists from different cultures , adapts to hero's journey and to identify the differences between the "Yunus Emre" perceptions of the two novelists within the framework of Joseph Campbell's this model. Key words: Nezihe Araz, Jacques Lacarrière, Dertli Dolap, Dünyanın Tozu, Yunus Emre, Hero, journey
- …
