266 research outputs found
Uso do azul de toluidina seguido Da quimioluminiscência como método euxiliar de diagnóstico clínco de lesões bucais cancerizáveis
No full textTCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.O diagnóstico precoce do câncer de boca é fundamental para elevar as taxas de sobrevida dos pacientes, no entanto, a maioria destas lesões continua sendo diagnosticada nos estágios tardios da doença. Evidências demonstram que o desenvolvimento do câncer bucal está associado ao aparecimento de lesões bucais com potencial de transformação carcinomatosa, conhecidas como lesões cancerizáveis. Deste modo, o desenvolvimento de técnicas que facilitem o diagnóstico clínico adequado destas condições merece destaque. Enfatiza-se a técnica da aplicação do Azul de Toluidina (AT) seguido da Quimioluminiscência (QL), que destaca características de lesões bucais suspeitas de malignidade, facilitando o diagnóstico e monitoramento, além de ajuda na seleção do melhor sítio para biópsia. A amostra foi composta por 50 pacientes adultos portadores de lesões bucais brancas, nos quais se aplicou a técnica em estudo. A área mais corada pelo AT foi biopsiada e os resultados histopatológicos foram comparados aos diagnósticos clínicos. Os resultados mostraram que 95,8% dos resultados histopatológicos foram compatíveis com os clínicos. As áreas mais coradas pelo AT foram as que apresentaram maior grau de displasia epitelial, portanto, maior risco de transformação maligna, o que faz do AT um importante método auxiliar na detecção de lesões suspeitas de malignidade e na seleção de sítios para biópsia. Já o dispositivo de QL melhorou a visualização dos bordos de algumas lesões, mas não acrescentou dados clínicos significativos ao diagnóstico, segundo critérios observacionais
Uso do azul de toluidina seguido da quimioluminiscência como método auxiliar de diagnóstico clínico de lesões bucais cancerizáveis
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Curso de Odontologia.O diagnóstico precoce do câncer de boca é fundamental para elevar as taxas de sobrevida dos pacientes, no entanto, a maioria destas lesões continua sendo diagnosticada nos estágios tardios da doença. Evidências demonstram que o desenvolvimento do câncer bucal está associado ao aparecimento de lesões bucais com potencial de transformação carcinomatosa, conhecidas como lesões cancerizáveis. Deste modo, o desenvolvimento de técnicas que facilitem o diagnóstico clínico adequado destas condições merece destaque. Enfatiza-se a técnica da aplicação do Azul de Toluidina (AT) seguido da Quimioluminiscência (QL), que destaca características de lesões bucais suspeitas de malignidade, facilitando o diagnóstico e monitoramento, além de ajuda na seleção do melhor sítio para biópsia. A amostra foi composta por 50 pacientes adultos portadores de lesões bucais brancas, nos quais se aplicou a técnica em estudo. A área mais corada pelo AT foi biopsiada e os resultados histopatológicos foram comparados aos diagnósticos clínicos. Os resultados mostraram que 95,8% dos resultados histopatológicos foram compatíveis com os clínicos. As áreas mais coradas pelo AT foram as que apresentaram maior grau de displasia epitelial, portanto, maior risco de transformação maligna, o que faz do AT um importante método auxiliar na detecção de lesões suspeitas de malignidade e na seleção de sítios para biópsia. Já o dispositivo de QL melhorou a visualização dos bordos de algumas lesões, mas não acrescentou dados clínicos significativos ao diagnóstico, segundo critérios observacionais
Melaena with Peutz-Jeghers syndrome: a case report
No full textIntroduction: Peutz-Jeghers syndrome (PJS) is a rare familial disorder characterised by mucocutaneous pigmentation, gastrointestinal and extragastrointestinal hamartomatous polyps and an increased risk of malignancy. Peutz-Jeghers polyps in the bowel may result in intussusception. This complication usually manifests with abdominal pain and signs of intestinal obstruction.
Case Presentation: We report the case of a 24-year-old Caucasian male who presented with melaena. Pigmentation of the buccal mucosa was noted but he was pain-free and examination of the abdomen was unremarkable. Upper gastrointestinal endoscopy revealed multiple polyps. An urgent abdominal computed tomography (CT) scan revealed multiple small bowel intussusceptions. Laparotomy was undertaken on our patient, reducing the intussusceptions and removing the polyps by enterotomies. Bowel resection was not needed.
Conclusion: Melaena in PJS needs to be urgently investigated through a CT scan even in the absence of abdominal pain and when clinical examination of the abdomen shows normal findings. Although rare, the underlying cause could be intussusception, which if missed could result in grave consequences
HERMENEUTICS OF THE WARIA: WARIA’S HERMENEUTICAL TAFSIR OF AL-FATIHAH
No full textQur’an, as it is believed by Muslims, is The Holy Book as well as the manifestation of The Words of God (Kalamullah). It has meanings which obviously was being ‘monopolized’ by The Ulama. In regarding of consequence, the authority of interpreting this Kalamullahseems ‘limited’ only for particular groups. Then, according the author it becomes the main factor leads the stagnancy of Quranic interpretation studies in this modern era. In this context, Schleiermacher’s teory about ‘psychological explication’ (1998), Paul Ricoeur’s theory about ‘distantiation and appropriation’ (1976), and ‘the marginalized reading of Scripture’ theory proposed by Simopoulos (2007), create a new path in interpreting Quran. From those theories, the author sheds the lights on hermeneutical interpretation of al-Fatihahby as one of the marginalized groups in Indonesia, the Waria. This paper concludes that the waria use their hermeneutical way of understanding the Scripture and produce not only anoriginal interpretation, but also contextual and full of theological reflections.Qur’an, as it is believed by Muslims, is The Holy Book as well as the manifestation of The Words of God (Kalamullah). It has meanings which obviously was being ‘monopolized’ by The Ulama. In regarding of consequence, the authority of interpreting this Kalamullahseems ‘limited’ only for particular groups. Then, according the author it becomes the main factor leads the stagnancy of Quranic interpretation studies in this modern era. In this context, Schleiermacher’s teory about ‘psychological explication’ (1998), Paul Ricoeur’s theory about ‘distantiation and appropriation’ (1976), and ‘the marginalized reading of Scripture’ theory proposed by Simopoulos (2007), create a new path in interpreting Quran. From those theories, the author sheds the lights on hermeneutical interpretation of al-Fatihahby as one of the marginalized groups in Indonesia, the Waria. This paper concludes that the waria use their hermeneutical way of understanding the Scripture and produce not only anoriginal interpretation, but also contextual and full of theological reflections
Matrice lipidique et biodisponibilité de l’acide alpha-linolénique
No full textLes acides gras poly-insaturés (AGPI) de la série oméga-3 (ω3) ont un rôle important dans la prévention de certaines pathologies. En plus d’être nécessaires dans des conditions physiologiques particulières (développement pré- et post-natal, croissance) (Riediger et al., 2009. J Am Diet Assoc 109 : 668–679), ils sont associés à des effets santé en termes de prévention, notamment au niveau de pathologies cardiovasculaires, inflammatoires, certains cancers et certaines maladies neuro-dégénératives (De Lorgeril et al., 1994. Lancet 343 : 1454–1459 ; Simopoulos, 2008. Exp Biol Med (Maywood, NJ) 233 : 674–688). Cependant, les dernières études épidémiologiques montrent que les apports en AGPI ω3, et notamment en acide alpha-linolénique (ALA), précurseur métabolique des AGPI à longue chaîne ω3, sont deux fois inférieurs aux recommandations de l’Agence national de sécurité sanitaire, de l’alimentation, de l’environnement et du travail (ANSES, 2011). Outre la nécessité d’augmenter l’apport en ALA, il est désormais nécessaire de prendre en considération les facteurs qui améliorent sa biodisponibilité. Dans ce contexte, nous avons testé plusieurs paramètres susceptibles de moduler le devenir métabolique de l’ALA. Nos recherches ont mis en évidence que plusieurs paramètres physiques et chimiques, tels que l’émulsification d’une huile linolénique avec de la lécithine de soja, la position de l’ALA sur le squelette glycérique du triglycéride alimentaire mais aussi la composition de la matrice permettraient de moduler la biodisponibilité et le devenir métabolique de l’ALA dans l’organisme
Matrice lipidique et biodisponibilité de l’acide alpha-linolénique
No full textLes acides gras poly-insaturés (AGPI) de la série oméga-3 (ω3) ont un rôle important dans la prévention de certaines pathologies. En plus d’être nécessaires dans des conditions physiologiques particulières (développement pré- et post-natal, croissance) (Riediger et al., 2009. J Am Diet Assoc 109 : 668–679), ils sont associés à des effets santé en termes de prévention, notamment au niveau de pathologies cardiovasculaires, inflammatoires, certains cancers et certaines maladies neuro-dégénératives (De Lorgeril et al., 1994. Lancet 343 : 1454–1459 ; Simopoulos, 2008. Exp Biol Med (Maywood, NJ) 233 : 674–688). Cependant, les dernières études épidémiologiques montrent que les apports en AGPI ω3, et notamment en acide alpha-linolénique (ALA), précurseur métabolique des AGPI à longue chaîne ω3, sont deux fois inférieurs aux recommandations de l’Agence national de sécurité sanitaire, de l’alimentation, de l’environnement et du travail (ANSES, 2011). Outre la nécessité d’augmenter l’apport en ALA, il est désormais nécessaire de prendre en considération les facteurs qui améliorent sa biodisponibilité. Dans ce contexte, nous avons testé plusieurs paramètres susceptibles de moduler le devenir métabolique de l’ALA. Nos recherches ont mis en évidence que plusieurs paramètres physiques et chimiques, tels que l’émulsification d’une huile linolénique avec de la lécithine de soja, la position de l’ALA sur le squelette glycérique du triglycéride alimentaire mais aussi la composition de la matrice permettraient de moduler la biodisponibilité et le devenir métabolique de l’ALA dans l’organisme
Hermeneutics of the Waria: Waria's Hermeneutical Tafsir of Al-fatihah Fazlul Rahman Icrs Universitas Gadjah Mada, YOGYAKARTA
No full textQur‟an, as it is believed by Muslims, is The Holy Book as well as the manifestation of TheWords of God (Kalamullah). It has meanings which obviously was being „monopolized‟by The Ulama. In regarding of consequence, the authority of interpreting thisKalamullahseems „limited‟ only for particular groups. Then, according the author itbecomes the main factor leads the stagnancy of Quranic interpretation studies in thismodern era. In this context, Schleiermacher‟s teory about „psychological explication‟(1998), Paul Ricoeur‟s theory about „distantiation and appropriation‟ (1976), and „themarginalized reading of Scripture‟ theory proposed by Simopoulos (2007), create a newpath in interpreting Quran. From those theories, the author sheds the lights onhermeneutical interpretation of al-Fatihahby as one of the marginalized groups inIndonesia, the Waria. This paper concludes that the waria use their hermeneutical way ofunderstanding the Scripture and produce not only anoriginal interpretation, but alsocontextual and full of theological reflections
“Lipid Nutrition Guidelines: A Comprehensive Analysis” by Harumi Okuyama, Sheriff Sultan, Naoki Ohara, Tomohito Hamazaki, Peter H. Langsjoen, Rokuro Hama, Yoichi Ogushi, Tetsuyuki Kobayashi, Shunji Natori, Hajime Uchino, Yoko Hashimoto, Shiro Watanabe, Kenjiro Tatematsu, Daisuke Miyazawa, Mikio Nakamura and Kentaro Oh-hashi
No full textThis book, “Lipid Nutrition Guidelines: A Comprehensive Analysis” by Professor Harumi Okuyama et al [...
The Omega-3 Fatty Acid Eicosapentaenoic Acid Accelerates Disease Progression in a Model of Amyotrophic Lateral Sclerosis
No full textPMCID: PMC3631166This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Etiological Spectrum and Treatment Outcome of Obstructive Jaundice at a University Teaching Hospital in Northwestern Tanzania: A Diagnostic and Therapeutic Challenges.
No full textObstructive jaundice poses diagnostic and therapeutic challenges to general surgeons practicing in resource-limited countries. This study was undertaken to highlight the etiological spectrum, treatment outcome of obstructive jaundice in our setting and to identify prognostic factors for morbidity and mortality. This was a descriptive prospective study which was conducted at Bugando Medical Centre between July 2006 and June 2010. All patients with a clinical diagnosis of obstructive jaundice were, after informed consent for the study, consecutively enrolled into the study. Data were collected using a pre-tested structured questionnaire and analyzed using SPSS computer software version 11.5. A total of 116 patients were studied. Females outnumbered males by a ratio of 1.3:1. Patients with malignant obstructive jaundice were older than those of benign type. Ca head of pancreas was the commonest malignant cause of jaundice where as choledocholithiasis was the commonest benign cause. Abdominal ultrasound was the only diagnostic imaging done in all patients and revealed dilated intra and extra-hepatic ducts, common bile stones and abdominal masses in 56.2%, 78.9%, 58.1% and 72.4% of the cases respectively. A total of 110 (94.8%) patients underwent surgical treatment and the remaining 6 (5.2%) patients were unfit for surgery. The complication rate was 22.4% mainly surgical site infections. The mean hospital stay and mortality rate were 14.54 days and 15.5% respectively. A low haematocrit and presence of postoperative sepsis were the main predictors of the hospital stay (P < 0.001), whereas age > 60 years, prolonged duration of jaundice, malignant causes and presence of postoperative complications mainly sepsis significantly predicted mortality (P < 0.001). Obstructive jaundice in our setting is more prevalent in females and the cause is mostly malignant. The result of this study suggests that early diagnosis and treatment plays an important role in the prognosis of patients with obstructive jaundice
- …
