43 research outputs found
Adult-onset muscular dystrophy in a cat associated with a presumptive alteration in trafficking of caveolin-3
No full textA 10-year-old spayed female domestic longhaired cat was referred for evaluation of thoracic limbs weakness and lameness. Muscular hypertrophy and firmness involved mainly proximal muscles, particularly the infraspinatus, supraspinatus, triceps and extensor carpi radialis of the right thoracic
limb and semitendinosus, semimembranosus and gluteal muscles of the right pelvic limb with no neurological deficits. Moderate increase of creatine kinase activity was also revealed. Muscle biopsy showed myopathic features such as rounded atrophic and hypertrophic fibres, increased number of
centrally located myofibre nuclei, scattered rimmed vacuoles, mild perimysial and endomysial fibrosis.
Myofibre necrosis with phagocytosis were present in the gluteal muscle. By immunohistochemistry,
absence of sarcolemmal caveolin-3 was observed in almost all muscle fibres and sarcoplasmic accumulation of the protein was observed in approximately 30% of myofibres. Since a normal
expression of caveolin-3 was detected by immunoblotting, a protein mislocalization in the sarcoplasm due to an aberrant trafficking towards the sarcolemma was suspected. This case represents the first
case of muscular dystrophy due to a caveolinopathy in animals
Iglesia, reforma e imperio. Antropología. Boletín Oficial del Instituto Nacional de Antropología e Historia. Num. 81 Nueva Época (2008) enero-marzo
No full textBravo Ugarte, José; Munguía, obispo y arzobispo de Michoacán (1810-1868), México, JUS, 1967.Knowlton, Robert J.; Los bienes del clero y la Reforma mexicana, 1856-1910, Juan José Utrilla (trad.), México, FCE, 1985, p. 69.Munguía, Clemente; Manifiesto que…, electo y confirmado obispo de Michoacán... dirige a la Nación Mexicana, Morelia, Imprenta de Ignacio Arango, 1851.Schellenberg, T. R.; Principios archivísticos de ordenación, México, Archivo General de la Nación, 1982
Tecendo histórias: a criança e sua produção narrativa
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação, Programa de Pós-Graduação em Educação, Florianópolis, 2010A questão fundamental desta pesquisa teve como foco a produção narrativa das crianças. Seu objetivo foi o de conhecer para compreender os processos de produção narrativa de um grupo de crianças no espaço escolar. Como objetivo paralelo, pensar sobre como estimular as crianças a contar histórias em tal ambiente. Em vista disso, procurou-se fazer um levantamento do repertório narrativo das crianças envolvidas na pesquisa, a fim de valorizá-lo, situá-lo e analisá-lo a partir de seus contextos social, histórico e cultural. Tratou-se, enfim, de tentar acessar o mundo da vida dessas crianças por meio da linguagem e, em particular, dos enunciados oralizados por elas. A pesquisa se deu numa perspectiva sócio-histórica, que serviu de suporte teórico-metodológico para observar e conhecer o campo de pesquisa, isto é, o meio social e cultural em que as crianças que faziam parte do trabalho se inserem. Além disso, essa perspectiva considera as condições e contradições que tais ambientes permitem à ampliação das experiências das crianças e à constituição de suas identidades culturais. A pesquisa envolveu, principalmente, rodas de narração de histórias com crianças entre cinco e seis anos de idade, que estudavam no primeiro ano do Ensino Fundamental de uma escola pública, para que as crianças produzissem suas narrativas. A pesquisa teve como aporte conceitual, que serviu de fundamento para as discussões acerca das produções orais das crianças, a teoria da linguagem proposta por Bakhtin, perspectiva na qual a palavra é concebida como elemento inscrito e constituído na dimensão social. Neste contexto, foi possível compreender que a criança, ao narrar as suas histórias, potencializa o desenvolvimento de sua imaginação e linguagem. Além disso, permite para a criança o exercício da sua criatividade, amplia suas experiências e suas formas de perceber e sentir as coisas do mundo, além de possibilitar-lhe explorar subjetivamente suas próprias experiências de vida
Notes on an Anthropological Expertise in the Central Valleys of Querétaro
No full textEn este artículo se sintetiza el contenido del peritaje antropológico elaborado en el poblado indígena de La D Chalmita, entre los meses de febrero y marzo de 2019, destacando los antecedentes y problemáticas asociados al peritaje, así como datos relevantes y reflexiones generales sobre los alcances de éste.This paper summarizes the content of the anthropological expertise conducted in the indigenous village of La D Chalmita, between February and March 2019, highlighting the background and problems associated with the survey, as well as relevant data and general reflections on its scope.Comisión Nacional para el Desarrollo de los Pueblos Indígenas (2019). Ley de Derechos y Cultura de los Pueblos y Comunidades Indígenas del Estado de Querétaro, México.
________ (2019b). “Catálogo de comunidades indígenas del Estado de Querétaro” en Ley de Derechos y Cultura de los Pueblos y Comunidades Indígenas del Estado de Querétaro, México.
López, R. et al. (2019). Peritaje etno-antropológico, localidad La D Chalmita, Pedro Escobedo, Querétaro, Departamento de Trámites y Servicios Legales del Área de Jurídico del Centro INAH Querétaro, México.
Mendoza, Rico M., Ferro Vidal L. y Solorio Santiago E. (2006). Otomíes del semidesierto queretano. México: Comisión Nacional para el Desarrollo de los Pueblos Indígenas.
Prieto, D. y Utrilla, B. (2003). “Ar ngú, ar hnini, ya meni. La casa, el pueblo, la descendencia (los otomíes de Querétaro)” en Saúl Millán y Julieta Valle (coords.). La comunidad sin límites: la estructura social y comunitaria de los pueblos indígenas de México. México: INAH.
Questa, A. y Utrilla, B. (2006). Otomíes del norte del Estado de México y sur de Querétaro. México: Comisión Nacional para el Desarrollo de los Pueblos Indígenas.
Soustelle, J. (2013 [1937]). La familia otomí-pame del México central. México: Fondo de Cultura Económica.
TEEQ-JLD-82/2018, Juicio local de los derechos político-electorales, Tribunal Electoral del Estado de Querétaro, México.
TEEQ-JLD-4/2019, Juicio local de los derechos político-electorales, Tribunal Electoral del Estado de Querétaro, México
Machine Learning Techniques for Canine Myxomatous Mitral Valve Disease Classification: Integrating Anamnesis, Quality of Life Survey, and Physical Examination
No full textAuthor Contributions: J.E.-M. and J.I.R.: study design, analysis, and interpretation of data; drafting of the manuscript; data analysis: J.I.R. and L.D., J.E.-M., J.I.R., J.A.M.-A., O.M.-U., Y.R.-D., J.I.M., A.C.-V. and L.G.-G.: revision of the manuscript. All authors participated in the discussion of the results, corrected, read, and approved the final manuscript. All authors have read and agreed to the published version of the manuscript.Myxomatous mitral valve disease (MMVD) is a prevalent canine cardiac disease typically diagnosed and classified using echocardiography. However, accessibility to this technique can be limited in first-opinion clinics. This study aimed to determine if machine learning techniques can classify MMVD according to the ACVIM classification (B1, B2, C, and D) through a structured anamnesis, quality of life survey, and physical examination. This report encompassed 23 veterinary hospitals and assessed 1011 dogs for MMVD using the FETCH-Q quality of life survey, clinical history, physical examination, and basic echocardiography. Employing a classification tree and a random forest analysis, the complex model accurately identified 96.9% of control group dogs, 49.8% of B1, 62.2% of B2, 77.2% of C, and 7.7% of D cases. To enhance clinical utility, a simplified model grouping B1 and B2 and C and D into categories B and CD improved accuracy rates to 90.8% for stage B, 73.4% for stages CD, and 93.8% for the control group. In conclusion, the current machine-learning technique was able to stage healthy dogs and dogs with MMVD classified into stages B and CD in the majority of dogs using quality of life surveys, medical history, and physical examinations. However, the technique faces difficulties differentiating between stages B1 and B2 and determining between advanced stages of the disease.Depto. de Medicina y Cirugía AnimalFac. de VeterinariaTRUEpu
Love and social customs in the Spanish Golden Age: amorous and exemplary novels by María de Zayas y Sotomayor
No full textEste trabajo tiene como principal objetivo ahondar en las costumbres sociales y
amorosas del Siglo de Oro español y con hincapié en el siglo XVII, así como en la vida
de las mujeres de la nobleza en dicha época. Todo esto basado en dos pilares: el primero,
las Novelas amorosas y ejemplares (1637) de la autora española María de Zayas y
Sotomayor; el segundo, los principales tratados filosóficos y de comportamiento para la
juventud que se desarrollaron en el período que estamos tratando. Para un mejor
entendimiento del lector sobre lo que se está explicando con los tratados, se procederá a
ejemplificar lo expuesto en dichos tratados con la trama de la obra de María de Zayas. The main objective of this work is to delve into the social and amorous customs
of the Spanish Golden Age, with special emphasis on the 17th century, as well as on the
life of noble women in that period. All of this is based on two pillars: the first, the
Amorous and Exemplary Novels (1637) by the Spanish author María de Zayas y
Sotomayor. The second, the main philosophical treaties and conduct and behaviourial
books for young people that were developed in the period we are dealing with. For a
better understanding of the reader of what is being explained with the treatises, we will
proceed to exemplify what is exposed in these treatises with the plot of the work of María
de Zayas
Sala los Pueblos Indios: Museo Regional de Querétaro
No full textEsta sala tiene por objeto presentar al público los diversos elementos socioculturales e históricos que dan a las comunidades indígenas de Querétaro (otomí-ñáñho y pamexi'ui) identidad, singularidad y relevancia. En el momento actual subsisten en Querétaro más de 100 comunidades cuya población, en una medida importante, mantiene características culturales distintivas en lo que se refiere a su lengua materna, su organización social y sus costumbres y tradiciones.</p
Love and social customs in the Spanish Golden Age: amorous and exemplary novels by María de Zayas y Sotomayor
No full textEste trabajo tiene como principal objetivo ahondar en las costumbres sociales y
amorosas del Siglo de Oro español y con hincapié en el siglo XVII, así como en la vida
de las mujeres de la nobleza en dicha época. Todo esto basado en dos pilares: el primero,
las Novelas amorosas y ejemplares (1637) de la autora española María de Zayas y
Sotomayor; el segundo, los principales tratados filosóficos y de comportamiento para la
juventud que se desarrollaron en el período que estamos tratando. Para un mejor
entendimiento del lector sobre lo que se está explicando con los tratados, se procederá a
ejemplificar lo expuesto en dichos tratados con la trama de la obra de María de Zayas. The main objective of this work is to delve into the social and amorous customs
of the Spanish Golden Age, with special emphasis on the 17th century, as well as on the
life of noble women in that period. All of this is based on two pillars: the first, the
Amorous and Exemplary Novels (1637) by the Spanish author María de Zayas y
Sotomayor. The second, the main philosophical treaties and conduct and behaviourial
books for young people that were developed in the period we are dealing with. For a
better understanding of the reader of what is being explained with the treatises, we will
proceed to exemplify what is exposed in these treatises with the plot of the work of María
de Zayas
Life at oxygen minimum zone: bacterial symbiosis in the gills of the bivalve Kelliella miliaris
No full textKelliella miliaris (Philippi, 1844) is a minute bivalve, living on the surface of soft sediments, from the continental shelf to bathyal depths, commonly in the oxygen minimum zones (OMZ) and/or in reducing habitats. The scarcity of data on the biology of Kelliella prompted us to investigate, at ultrastructural level, specimens found in southern Spain. Kelliella miliaris shows several morphological characteristics that would be adaptive for living in the OMZ: (1) presence of numerous muscular fibers in the mantle, mantle edge and gills-visceral mass connection; all of which would allow to actively move the gills and/or enable a better control of the ventral opening in relation to vertical movements of the animal; (2) high number (in relation to body size) and large size of gill filaments, mainly in the large inner demibranch; and (3) long cilia which would provide a large surface for capture of oxygen and a highly effective uptake of oxygen from water. We have observed in all the specimens examined the presence of numerous rod shaped bacteria among the gill cilia. These bacteria show the typical double membrane of Gram-negative bacteria. The analysis of the bacterial DNA revealed that Gammaproteobacteria is the most abundant class, with 53.69% of total reads. The latter, together with the peak of oxygen and the presence of sulfur inside the electron dense granules from the bacteria, determined by TEM-EDX analysis, point to the involvement of these bacteria in the oxidization of the sulfide to thiosulfate. The presence of bacteria in the gills of Kelliella miliaris highlights the importance of the chemosynthetic symbiosis in the OMZs of the oceans that has been probably overlooked up to now. The presence of different microorganisms in the stomach indicates heterotrophy. We have found spermatozoids inside the female gonad, which confirms internal fertilization in K. miliaris. However, the presence of protoconch I and protoconch II, indicates planktotrophic larval development.The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by PPRO_RNM141-G-2023 through Junta de Andalucía, Consejería de Univerdidad, Investigación e Innovación and FEDER funds and by the project PID2023-146394NB-I00, of the Spanish Ministry of Science, Innovation and Universities (MCIN/AEI/10.13039/501100011033/”FEDER Una manera de hacer Europa”).Peer reviewe
La de(con)strucción de la Historia de España o metaficción historiográfica a la española: "Fabulosas narraciones por historias", de Antonio Orejudo Utrillla
No full textThe goal of the latest historical novel (also called historiographical metafiction) in Spain is to “de(con)struct”, that is to say, to interpret again and even to destroy the official history, and not so much to reconstruct it. This goal is directly related to the aesthetic paradigm to which it belongs: the postmodernism. At the same time, it is realist in a broader sense, as it mimetises the plural ontology of the advanced industrial societies, in which reality is not a stable concept any more, but it is identified with fiction. This is what Fabulosas narraciones por historias, by Antonio Orejudo Utrilla (1996), shows: the author turns the history of Spanish literature upside down and rallies for the postmodern historical revisionism, at the same time as he offers us a very critical glance at Occident past.El objetivo de la novela histórica española última (también denominada metaficción historiográfica) es “de(con)struir”, es decir, reinterpretar e incluso destruir la historia oficial, y no tanto reconstruirla. Este objetivo se relaciona directamente con el paradigma estético al que pertenece: el posmodernismo. Pero, al mismo tiempo, es realista en un sentido más amplio, puesto que mimetiza la ontología plural de las sociedades industriales avanzadas, en las que la realidad ha dejado de ser un concepto firme para identificarse con la ficción. Esto es lo que nos demuestra Fabulosas narraciones por historias de Antonio Orejudo Utrilla (1996), en la que el autor da la vuelta a la historia de la literatura española y se alista a las filas del revisionismo histórico posmoderno, ofreciéndonos una mirada al pasado profundamente crítica hacia Occidente
