73 research outputs found
Information content and analysis methods for multi-modal high-throughput biomedical data.
No full textThe spectrum of modern molecular high-throughput assaying includes diverse technologies such as microarray gene expression, miRNA expression, proteomics, DNA methylation, among many others. Now that these technologies have matured and become increasingly accessible, the next frontier is to collect "multi-modal" data for the same set of subjects and conduct integrative, multi-level analyses. While multi-modal data does contain distinct biological information that can be useful for answering complex biology questions, its value for predicting clinical phenotypes and contributions of each type of input remain unknown. We obtained 47 datasets/predictive tasks that in total span over 9 data modalities and executed analytic experiments for predicting various clinical phenotypes and outcomes. First, we analyzed each modality separately using uni-modal approaches based on several state-of-the-art supervised classification and feature selection methods. Then, we applied integrative multi-modal classification techniques. We have found that gene expression is the most predictively informative modality. Other modalities such as protein expression, miRNA expression, and DNA methylation also provide highly predictive results, which are often statistically comparable but not superior to gene expression data. Integrative multi-modal analyses generally do not increase predictive signal compared to gene expression data
A fast non-ferric kicker for the muon (g-2) experiment
No full textA fast, non-ferric kicker has been designed, built and installed in the muon (g - 2) experiment at the Brookhaven Alternating Gradient Synchrotron. A current pulse of 4200 A peak, and base-width of 400 ns, is passed in opposite directions through parallel plates 10 cm apart on either side of the muon storage region in the (g - 2) storage ring. A field integral of 0.1 Tm was achieved, which kicks the 3.09 GeV/c muon beam by about 10 mrad. This kick is achieved by employing three identical 1.76 m long sections, each powered by a separate pulse-forming network. The design and performance of the kicker is presented. (C) 2002 Elsevier Science B.V. All rights reserved
SMoT: A Smartphone-Based Mobile Testbed for Human-Centric Wireless Networks
No full textRecently, wireless sensor networks (WSNs) are becoming vital to a wide range of application domains, from precision agriculture and smart buildings to health systems and monitoring of humans, animals, crowds and robots. In particular, there is an increasing number of sensor devices that are worn by persons who interact with them on a daily basis. In these applications, networks are formed by the persons who wear the sensor devices and as a result the mobility comes from them. This results in new protocols and applications for this kind of networks and new challenges arise. Human factors are crucial aspects in this case and researchers should consider them in their designs. The protocols and applications developed, should be tested and verified before their final deployment. We argue that a testbed, exposing the human characteristics is needed. In this thesis, we define the fundamental requirements that a testbed for experimentation with human-centric wireless networks must fulfil. We design and implement a fully functional testbed that allows researchers to run experiments in a realistic and controlled testing environment. We show that our testbed has the appropriate features and tools to make the running of the experiments easy and effortless. In addition, our testbed gives the ability to the researchers to observe how human diversity and variability (like body orientation or walking speed) affect their work. Furthermore, we evaluated the mechanisms of our testbed and present how they affect the execution of an experiment.MSc Embedded SystemsEmbedded Software GroupElectrical Engineering, Mathematics and Computer Scienc
The Brookhaven muon (g-2) storage ring high voltage quadrupoles
No full textThe design, construction, and operation of the electrostatic quadrupoles used in the muon (g - 2) experiment E821 of BNL are described in detail. A new lead design allowed the construction of a very reliable system which could operate for hundreds of thousands pulses with no sparking. The new design also made possible the elimination of systematic errors associated with the E, B fields generated by the low energy trapped electrons present in Penning traps under medium vacuum conditions. (C) 2003 Elsevier Science B.V. All rights reserved
An investigation of the variability of start-up lost times and departure headways at signalized intersections in urban areas
No full textAn investigation of the variability of start-up lost times and departure headways at signalized intersections in urban areas
No full textMonte Carlo GPS based Solution for speed limit indicator.
No full textA comprehensive research has been undertaken to design and develop the GPS based, low cost and easily installable speed limit indicator in public and private vehicles. The device includes the building efficient GPS mapping technique for defining sentinels and a database for sentinel’s storage utilizing minimum memory. These sentinels contain all concerned information required for navigation. Road safety is a crucial issue, ignorance of which can lead to fatalities. These fortuities happen due to speeding which often occurs due to lack of available information about speed limits on particular roads. An algorithm is developed and implemented in C language for simulation purposes by analysing complexities of road structures. Various road tests are performed to illuminate the technical problems in real time. Roads characteristics are examined and different hazards have been optimized through algorithm to resolve problems, faced by drivers. More importantly, it has been implemented within a Field Programmable Gate Array (FGPA), which verifies the simulation result as well
Sistemática de levantamento, representação e análise de parâmetros geométricos para projetos de melhoramentos de rodovia
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Civil.Uma rede de estradas é, geralmente, resultante da necessidade de acomodação do tráfego, o qual, por sua vez, é determinado pela distribuição espacial da população, pelo aproveitamento de determinadas áreas e pelas realidades geográficas. O conhecimento das condições dos muitos segmentos que formam a rede de estradas é, sem dúvida, imprescindível para o planejamento e gerência, influenciando diretamente nos investimentos que devem ser feitos para manter a rede em boas condições. A fim de obter um melhor aproveitamento desses investimentos, o conhecimento das condições da rodovia implica, necessariamente, em uma apropriada identificação, descrição e análise dos locais onde as deficiências foram encontradas, assim como a identificação dos segmentos que estão em condições satisfatórias. O desenvolvimento urbano, o crescimento do tráfego, as alterações no ambiente no qual a rodovia foi implantada, vão aos poucos exigindo que sejam realizados investimentos para adaptar a via às necessidades atuais de seus usuários. Nesse contexto, este trabalho propõe uma metodologia para identificar, descrever e analisar as características geométricas de uma estrada com o objetivo de facilitar o desenvolvimento de planos de melhoramentos de rodovias. Após a descrição da metodologia, uma aplicação prática em um segmento existente de estrada é apresentada, junto com os resultados obtidos. Além disso, uma avaliação de seu desempenho é realizada. Conclui-se que a metodologia proposta é operacionalmente fácil de ser aplicada, que conduz a uma clareza na escolha dos critérios para as melhorias, que é adequada para a identificação de prioridades pelos planejadores e que traz dividendos pelo fato de uma atribuição melhor do investimento financeiro é alcançada em conseqüência de sua adoção
Augmented Bridges: Investigating the potential of augmented reality for the design of configurable bridges
No full textThe paper expands on the potential of using Augmented Reality (AR) for the design and customization of bridges. Following a literature review on the use of AR in architectural design, and in particular in design education, the authors discuss educational experiences gained in two digital design studios. These two courses were taught remotely at the University of Thessaly and the Frankfurt University of Applied Sciences and cross-informed each other. The teaching experiences of the authors were evaluated and subsequently used to develop the curriculum of “Augmented Bridges”, an experimental AR design studio. The aim of the paper is to present current research in AR and the interactive design process of site-specific bridges, using digital and augmented media. The studio results offered valuable insight into the educational and creative value of AR technologies in architecture. © The Author(s) 2022
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