1,454 research outputs found
P<sub>2</sub> purinoceptor stimulation attenuates PTH inhibition of phosphate uptake by a G protein-dependent mechanism
No full text Pages F309'F316: E. D. Lederer and K. R. McLeish. “P2 purinoceptor stimulation attenuates PTH inhibition of phosphate uptake by a G protein-dependent mechanism.” The American Heart Association of Kentucky should have been acknowledged for their support of E. D. Lederer. </jats:p
P<sub>2</sub> purinoceptor stimulation attenuates PTH inhibition of phosphate uptake by a G protein-dependent mechanism
No full text Pages F309–F316: E. D. Lederer and K. R. McLeish. ”P2 purinoceptor stimulation attenuates PTH inhibition of phosphate uptake by a G protein-dependent mechanism.“ The American Heart Association of Kentucky should have been acknowledged for their support of E. D. Lederer. </jats:p
Leucocytozoon podargii Adlard & Peirce & Lederer 2002, n. sp.
No full textLeucocytozoon podargii n. sp. (gures 1–4) Type host. Podargus strigoides (Latham) (tawny frogmouth). Type locality. Currumbin, Queensland, Australia. Basis of description Macrogametocyte. Only round morphs occur, exhibiting the usual characteristics of the genus. Maximum diameter is about 15 m m (table 1). Cytoplasm is granular with occasional hyaline vacuoles present; nucleus generally oval in shape occupying a central to subcentral position but lacking a distinct karyosome. Maximum length of the host–parasite complex is 17 m m. The host cell nucleus forms a cap around the periphery covering about one-third (gure 1), but in most infections about half the parasites were observed without any remnant of the host cell nucleus (gure 2). Microgametocyte. Similar in size to the macrogametocyt e with the usual diOEerentiating characteristics. The nucleus is dispersed but has a distinctive karyosome which stains a deep red (gure 3). The prevalence of microgametocytes is very low with the ratio to macrogametocyte s being 1:50. Schizonts. In histopathology sections stained with H and E, the presence of schizonts was observed in skeletal muscle, lung and spleen. The schizonts in muscle were small compared to those in lung and spleen (gure 4). Megaloschizonts in lung and spleen tissue measured up to 163 m m in diameter and were characterized by cytomere formation with each section packed with merozoites. Hapantotype. IRCAH: G46311 2 (gametocytes) from Podargus strigoides, coll. Reid, 14 October 1999, Currumbin, Gold Coast, Queensland, Australia; IRCAH: G46311 3 (schizonts) from P. strigoides, coll. Lederer, 14 November 1998, Currumbin, Gold Coast, Queensland, Australia. Parahapantotype. IRCAH: G463114, G463115 and G463116 (gametoctyes) from P. strigoides, coll. Reid, 16 August 1999, 19 September 1999 and 10 October 1999; IRCAH: G46311 7 (schizonts) from P. strigoides, coll. Lederer, 14 November 1998, Currumbin, Gold Coast, Queensland, Australia. Other hosts. Probably occurs throughout the range of the Podargidae. Vectors. Unknown, but assumed to be simuliids. Etymology. Named after the genus of the type host. Comments. Leucocytozoon podargii is a parasite with only round morphs occurring in a small family of birds with a distribution restricted to the Australasian region. The inclusion of schizont stages is a bonus particularly as the presence of megaloschizonts occurs in the absence of second generation elongate morphs. In this respect L. podargii appears to have a life cycle similar to that of Leucocytozoon marchouxi Mathis and Leger (see Peirce et al., 1997). Nothing is currently known regarding the potential pathogenicity of L. podargii; the reason for euthanasia in this particular bird was related to causes other than the Leucocytozoon infection. The low prevalence of microgametocyte s in all the positive birds examined seems to be a characteristic of L. podargii infections. The earliest published record of leucocytozoids from the Podargidae was by Cleland (1915) who recognized Leucocytozoon sp. from P. strigoides from Eidsvold in southern Queensland. Later, Mackerras and Mackerras (1960) assigned leucocytozoids from the same host and locality to Leucocytozoon caprimulgi Kerandel originally described from the nightjar Caprimulgus fossii Hartlaub, a species with Afro-Tropical distribution. Their contention was that host relationships dictated conspecicity of the leucocytozoid. However, C. fossii is placed within the family Caprimulgidae (see Sibley and Monroe, 1990, 1993) while it has long been recognized that P. strigoides is a member of the Australasian-endemic bird family, Podargidae. Taking into account the established host-specicity at family level of Leucocytozoon spp. (see discussion in Bennett et al., 1991) and in the absence of any data to the contrary, we describe this species as L. podargii.Published as part of Adlard, R. D., Peirce, M. A. & Lederer, R., 2002, New species of Leucocytozoon from the avian families Otidae, Podargidae and Threskiornithidae, pp. 1261-1267 in Journal of Natural History 36 (11) on pages 1262-1263, DOI: 10.1080/00222930110049962, http://zenodo.org/record/529850
Surfactant protein A and D polymorphisms and methylprednisolone pharmacogenetics in donor lungs
No full textObjective: Surfactant proteins A and D are important molecules involved in lung allograft innate immunity. Genetic polymorphisms of surfactant proteins A and D are associated with various lung diseases. In this study, surfactant protein A and D expression responses were investigated during pharmacogenetics upon methylprednisolone treatment as observed during lung transplantation. Methods: A human cell line (NCI-H441) and precision-cut lung slices from 16 human donors were incubated with methylprednisolone, and surfactant protein A1, surfactant protein A2, and surfactant protein D messenger RNA and surfactant protein A protein expression were assayed. Surfactant protein A1, A2, and D polymorphisms and surfactant protein A gene and protein expressions were determined. Results: In NCI-H441 cells, methylprednisolone treatment at 10−5 M and 10−6 M reduced surfactant protein A1 and surfactant protein A2 messenger RNA and surfactant protein A protein expression (P <.05). A pharmacogenetic relationship was observed in human donor precision-cut lung slices between the surfactant protein A2 (1Ax) variants: Surfactant protein A1, A2, and D messenger RNA expression were greater for 1A0 versus 1A1 (P <.05); surfactant protein A1/surfactant protein A2 genotype 6A26A2/1A01A0 (n = 5) showed greater surfactant protein A1, A2, and D messenger RNA expression and surfactant protein A protein expression compared with the other surfactant protein A1/surfactant protein A2 genotypes (n = 11) (P <.05). Conclusions: The surfactant protein A genotype and methylprednisolone stimuli influence donor lung surfactant protein A and D expression. Lungs carrying the surfactant protein A2 variant 1A0 have a greater expression of surfactant protein A when treated with methylprednisolone. Surfactant protein A polymorphisms could be used to personalize immunosuppressive regimens
Leucocytozoon otidis Adlard & Peirce & Lederer 2002, n. sp.
No full textLeucocytozoon otidis n. sp. (gures 7, 8) Type host. Ardeotis kori Burchell (Kori bustard). Type locality. Kajiado, Kenya. Basis of description Macrogametocyte. A small parasite with round morphs only, with a diameter of about 14 m m (table 1), exhibiting the usual staining characteristics. The cytoplasm is granular with the presence of numerous small hyaline vacuoles; nucleus is central to sub-central, round to oval in shape with a distinctive dark staining karyosome (gures 7, 8). The host–parasite complex has an overall length of about 16 m m and the host cell nucleus forms a cap on the periphery of the parasite covering between a quarter and a third of the circumference (gures 7, 8). Microgametocyte. Similar to the macrogametocyt e with the usual diOEerentiating staining characteristics. The prevalence of microgametocytes is low and the ratio to macrogametocytes is 1:25. Hapantotype. IRCAH: G46310 3 from Ardeotis kori, coll. Joyner, 18 March 1967, Kajiado, Kenya. Parahapantotypes. IRCAH: G46310 4 and G463105 from Clamydotis undulata (Jacquin), coll. Silvanose, 7 June 1999, Abu Dhabi, UAE (birds imported from Pakistan). Other hosts. There are records of Leucocytozoon from several species of Otidae in the IRCAH database (Bennett et al., 1982; Bishop and Bennett, 1992), but no slides were available for study. It is assumed that all records can be referred to L. otidis. Vectors. Unknown, but assumed to be simuliids. Etymology. Named after the host family. Comments. Leucocytozoon otidis is a relatively small round morph and is considered to be a distinct species based on assumed host-specicity at the family/subfamily level (Bennett et al., 1991). The Otidae have a wide distribution throughout Europe, Africa and Asia and it is likely that L. otidis occurs throughout this range. Bustards generally inhabit dry bushland and savannah which probably accounts for the apparent low prevalence of L. otidis as the vectors would be sparse in such areas.Published as part of Adlard, R. D., Peirce, M. A. & Lederer, R., 2002, New species of Leucocytozoon from the avian families Otidae, Podargidae and Threskiornithidae, pp. 1261-1267 in Journal of Natural History 36 (11) on page 1266, DOI: 10.1080/00222930110049962, http://zenodo.org/record/529850
New species of Leucocytozoon from the avian families Otidae, Podargidae and Threskiornithidae
No full textFIGS 1–4. (1) Macrogametocyte of Leucocytozoon podargii showing presence of host cell nucleus on periphery. (2) Macrogametocyte of L. podargii without host cell nucleus attachment. (3) Microgametocyte of L. podargii showing very hypertrophied host cell nucleus (arrow). (4) Megaloschizont of L. podargii in spleen of Podargus strigoides (H and E). Scale bar: 10 mm (gures 1–3), 50 mm (gure 4).Published as part of Adlard, R. D., Peirce, M. A. & Lederer, R., 2002, New species of Leucocytozoon from the avian families Otidae, Podargidae and Threskiornithidae, pp. 1261-1267 in Journal of Natural History 36 (11) on page 1262, DOI: 10.1080/00222930110049962, http://zenodo.org/record/529850
Translation Training in Italy: an Analysis of Students' Perceptions
No full textIl contributo riporta i risultati di un'analisi statistica, svolta nel 2006 all'interno della Scuola Superiore di Lingue Moderne per Interpreti e Traduttori dell'Università di Bologna (sede di Forlì), per verificare le aspettative e il livello di soddisfazione degli studenti in merito alla preparazione professionale ricevuta, specialmente per quanto attiene l'avviamento alla professione di traduttore e interprete. L'analisi si focalizza su aspetti più specificatamente legati alla traduzione e all'interpretazione rispetto ai questionari annualmente somministrati agli studenti dagli Atenei, con quesiti specifici riguardo il ruolo delle attività pratiche ai fini dello sviluppo di specifiche competenze traduttive, l'importanza della lingua di insegnamento e le misure specifiche suggerite dagli studenti per il miglioramento della didattica e del rapporto tra offerta formativa e sbocchi occupazionali nell'ambito della traduzione/ interpretazione
Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome
No full textChronic lung allograft dysfunction (CLAD) is the major factor limiting long-term success of lung transplantation. Polymorphisms of surfactant protein D (SP-D), an important molecule within lung innate immunity, have been associated with various lung diseases. We investigated the association between donor lung SP-D polymorphisms and posttransplant CLAD and survival in 191 lung transplant recipients consecutively transplanted. Recipients were prospectively followed with routine pulmonary function tests. Donor DNA was assayed by pyrosequencing for SP-D polymorphisms of two single-nucleotide variations altering amino acids in the mature protein N-terminal domain codon 11 (Met(11) Thr), and in codon 160 (Ala(160) Thr) of the C-terminal domain. CLAD was diagnosed in 88/191 patients, and 60/191 patients have died. Recipients of allografts that expressed the homozygous Met(11) Met variant of aa11 had significantly greater freedom from CLAD development and better survival compared to those with the homozygous Thr(11) Th variant of aa11. No significant association was noted for SP-D variants of aa160. Lung allografts with the SP-D polymorphic variant Thr(11) Th of aa11 are associated with development of CLAD and reduced survival. The observed genetic differences of the donor lung, potentially with their effects on innate immunity, may influence the clinical outcomes after lung transplantation
Thermal model of water and CO activity of Comet C/1995 O1 (Hale-Bopp)
No full textAn investigation of the activity of Comet C/1995 O1 (Hale-Bopp) with a thermophysical nucleus
model that does not rely on the existence of amorphous ice is presented. Our approach incorporates
recent observations allowing to constrain important parameters that control cometary activity. The
model accounts for heat conduction, heat advection, gas diffusion, sublimation, and condensation in
a porous ice�dust matrix with moving boundaries. Erosion due to surface sublimation of water ice
leads to a moving boundary. The movement of the boundary is modeled by applying a temperature
remapping technique which allows us to account for the loss in the internal energy of the eroded surface
material. These kind of problems are commonly referred to as Stefan problems. The model takes
into account the diurnal rotation of the nucleus and seasonal effects due to the strong obliquity of
Hale-Bopp as reported by Jorda et al. (Jorda, L., Rembor, K., Lecacheux, J., Colom, P., Colas, F., Frappa,
E., Lara, L.M. [1997]. Earth Moon Planets 77, 167�180). Only bulk sublimation of water and CO ice are
considered without further assumptions such as amorphous ices with certain amount of occluded CO
gas. Confined and localized activity patterns are investigated following the reports of Lederer and
Campins (Lederer, S.M., Campins, H. [2002]. Earth Moon Planets 90, 381�389) about the chemical heterogeneity
of Hale-Bopp and of Bockel�©e-Morvan et al. (Bockel�©e-Morvan, D., Henry, F., Biver, N., Boissier,
J., Colom, P., Crovisier, J., Despois, D., Moreno, R., Wink, J. [2009]. Astron. Astrophys. 505, 825�
843) about a strong CO source at a latitude of 20. The best fit to the observations of Biver et al.
(Biver, N. et al. [2002]. Earth Moon Planets 90, 5�14) is obtained with a low thermal conductivity
of 0.01Wm1 K1. This is in agreement with recent results of the Deep Impact mission to 9P/Tempel
1 (Groussin, O., A�Hearn, M.F., Li, J.-Y., Thomas, P.C., Sunshine, J.M., Lisse, C.M., Meech, K.J., Farnham,
T.L., Feaga, L.M., Delamere, W.A. [2007]. Icarus 187, 16�25) and with previous thermal simulations
(K�¼hrt, E. [1999]. Space Sci. Rev. 90, 75â��82). The water production curve matches the production rates
well from 4 AU pre-perihelion to the outgoing leg while the model does not reproduce so well the
water production beyond 4 AU pre-perihelion. The CO production curve is a good fit to the measurements
of Biver et al. (2002) over the whole measured heliocentric range from 7 AU pre- to 15 AU
post-perihelion
Representação e interpretação da noção de L1, L2, LE e troca de código em desenhos de crianças multilíngues
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2013.O presente trabalho visa discutir noções de um grupo de crianças multilíngues, em fase de alfabetização, sobre L1, L2, Ln..., LE e troca de código expressas através de politextos. O estudo considera igualmente os câmbios de sentido entre modalidades semióticas: verbal e não verbal, respectivamente, texto escrito e desenho, como processo incontornável à interpretação das produções. Os corpora, ou politextos, serão investigados a partir dos pressupostos teóricos de Moore (2010) e Molinié (2009). A perspectiva metodológica decorre prioritariamente dos postulados desenvolvidos por Perregaux (2009) e Moore (2010) com base na hermenêutica de Schleiermacher (1838, 2009) também discutida por Seleskovitch & Lederer (1993). A investigação comporta três patamares de análise, cujos cernes remetem: (i) às discussões dos pesquisadores; (ii) à análise reflexiva dos aprendizes; (iii) à ótica de observadores externos. A pesquisa inicia-se com um estudo piloto, preliminar às análises, que definiu rumos para a instauração da proposta central <br
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