869 research outputs found
Better pain control with 8-gray single fraction palliative radiotherapy for skeletal metastases: a Bayesian network meta-analysis
No full textExternal Beam Radiotherapy (EBRT) allows remarkable pain control in patients with skeletal metastases. We performed a Bayesian network meta-analysis comparing the most commonly used radiotherapy regimens for palliative management in patients with skeletal metastases. The main online databases were accessed in October 2020. All randomized clinical trials evaluating the irradiation of painful bone metastases were considered. The following irradiation patterns were analysed and included in the present network meta-analysis: 8 Gy- and 10 Gy/single fraction, 20 Gy/5 fractions, 30 Gy/10 fractions. The Bayesian hierarchical random-effect model analysis was adopted in all comparisons. The Log Odds-Ratio (LOR) statistical method for dichotomic data was adopted for analysis. Data from 3595 patients were analysed. The mean follow-up was 9.5 (1 to 28) months. The cumulative mean age was 63.3 ± 2.9. 40.61% (1461 of 3595 patients) were female. The 8Gy/single fraction protocol detected reduced rate of 'no pain response' (LOR 3.39), greater rate of 'pain response' (LOR-5.88) and complete pain remission (LOR-7.05) compared to the other dose patterns. The 8Gy group detected a lower rate of pathological fractures (LOR 1.16), spinal cord compression (LOR 1.31) and re-irradiation (LOR 2.97) compared to the other dose patterns. Palliative 8Gy/single fraction radiotherapy for skeletal metastases shows outstanding results in terms of pain control, re-irradiations, pathological fractures and spinal cord compression, with no differences in terms of survivorship compared to the other multiple dose patterns.Level of evidence: I, Bayesian network meta-analysis of RCTs
NSAIDs for Prophylaxis for Heterotopic Ossification After Total Hip Arthroplasty: A Bayesian Network Meta-analysis
No full textNon-steroidal anti-inflammatory drugs (NSAID) have been recommended to prevent of heterotopic ossification (HO) after total hip arthroplasty (THA), but debates are still ongoing. The present Bayesian network meta-analysis of randomized clinical trials (RCTs) compared all available pathways of NSAID treatment as prophylaxis for HO after THA. The present Bayesian network meta-analysis was conducted according to The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions guidelines. All randomized clinical trials comparing two or more interventions to prevent HO after THA were considered for analysis. HO was classified according to Brooker. The quality of the methodological assessment was performed through the risk of bias summary tool of the Review Manager Software 5.3 (The Cochrane Collaboration, Copenhagen). The network meta-analysis was performed through a STATA routine for Bayesian hierarchical random-effects model analysis, with log odd ratio (LOR) effect measure. Data from 26 studies (6396 THAs; 58% females) were collected. The mean follow-up was 10.50 ± 5.7 months. ANOVA showed good comparability among mean age and gender (P > 0.5). Celecoxib demonstrated the highest rate of Brooker class 0 (LOR 6.96), followed by diclofenac (LOR 6.94). Naproxen demonstrated the lowest rate of Brooker I HO (LOR 2.82), followed by celecoxib (LOR 3.52). Celecoxib demonstrated lowest rate of Brooker class II HO (LOR 1.66), class III (LOR), and class IV (LOR 0.25). The equation for global linearity detected no statistically significant inconsistency (P > 0.5) in all the comparisons. The present Bayesian network meta-analysis encourages the use of celecoxib as a prophylaxis for HO. These conclusions must be interpreted in light of the limitations of the present study. Future investigations are required to establish more definitely the role of celecoxib.Level of Evidence: I, Bayesian network analysis of RCTs
Lateral retinacular release combined with MPFL reconstruction for patellofemoral instability: a systematic review
No full textIntroduction!#!The role of the lateral retinaculum in patellofemoral instability is still debated. Lateral retinacular release (LRR), has been extensively performed in combination with different surgical procedures, including reconstruction of medio-patellofemoral ligament (MPFL). Despite controversial indications, the results from these studies seem promising. The present study conducts a systematic review about current biomechanical and clinical evidence concerning the role of LRR in combination with MPFL reconstruction. We performed a comprehensive literature research, comparing the outcomes of MPFL reconstruction with and without LRR.!##!Materials and methods!#!This systematic review was conducted according to the PRISMA guidelines. The literature search was performed in August 2020. All articles describing the outcome of isolated MPFL reconstruction alone or in combination with a LRR in patients with recurrent patellofemoral instability were considered for inclusion. Only articles reporting data on patients with a minimum of 12-month follow-up were included. Only articles reporting quantitative data under the outcomes of interest were included.!##!Results!#!A total of 63 articles were eligible for this systematic review, including 2131 knees. The mean follow-up was 40.87 ± 24.1 months. All scores of interests improved in favour of the combined group: Kujala + 3.8% (P = 0.01), Lysholm + 4.2% (P = 0.004), Tegner + 0.8 points (P = 0.04), IKDC + 9.8% (P = 0.02). The ROM was comparable between the two groups (P = 0.4). Similarity was found in terms of positivity to the apprehension test (P = 0.05), rate of complications (P = 0.1), re-dislocations (P = 0.8), and revision surgeries (P = 0.1).!##!Conclusion!#!There is no evidence that adding a lateral release impacts positively on the outcome of MPFL reconstruction.!##!Level of evidence!#!IV, Systematic review
Arne Garborg og fela
No full textFra og med 2017 er artiklene som publiseres i Musikk og tradisjon lisensiert under en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.The Norwegian author Arne Garborg (1851–1924) was one of Europe’s foremost intellectuals with a production of novels, short stories, poetry and articles, covering many fields and with a vast number of readers both in Norway and elsewhere. As a young man Garborg had learnt to play the fiddle. Later on, he learnt to play the Hardanger fiddle. The Norwegian public debate at the turn of the previous century witnessed a polarization between rural and urban ideological values, and Arne Garborg became the main spokesman for the rural part. The article raises two questions: What does one actually know about Arne Garborg’s fiddle playing? In what ways did the (Hardanger) fiddle and folk music influence Garborg’s life and ideological standpoints? This article follows two perspectives. First; music and fiddle playing seems to have been Garborg’s lifelong companions. Secondly; the Norwegianism movement, which Garborg became the main spokesman for, became a leading factor in the Norwegian public debate more or less at the same time as the Hardanger fiddle gained status as Norway’s national instrument. Drawing on different types of sources (written, graphic, and eyewitness), this article investigates the presence of music in Garborg’s life and shows that he can be regarded as a good amateur musician capable of expressing himself on both the fiddle and the Hardanger fiddle, and with a solid knowledge of Norwegian folk music. This opens for reflections regarding to what extent Arne Garborg may have looked upon folk music, folk dance, fiddle and Hardanger fiddle playing as vital parts of rural values worth pursuing for the Norwegianism movement.publishedVersio
The Spoken Wikipedia Corpora
No full textThe Spoken Wikipedia project unites volunteer readers of Wikipedia articles. Hundreds of spoken articles in multiple languages are available to users who are – for one reason or another – unable or unwilling to consume the written version of the article. Our resource, the Spoken Wikipedia Corpus, consolidates the Spoken Wikipediae, adding text segmentation, normalization, time-alignment and further annotations, making it accessible for research and fostering new ways of interacting with the material.
Timo Baumann and Arne Köhn and Felix Hennig. 2018. The Spoken Wikipedia Corpus Collection: Harvesting, Alignment and an Application to Hyperlistening, in Language Resources and Evaluation, Special Issue representing significant contributions of LREC 2016.
Arne Köhn, Florian Stegen, Timo Baumann. 2016. Mining the Spoken Wikipedia for Speech Data and Beyond, in Proceedings of the Tenth International Conference on Language Resources and Evaluation (LREC 2016).
CLARIN Metadata summary for The Spoken Wikipedia Corpora (CMDI-based)
Title: The Spoken Wikipedia Corpora
Description: The Spoken Wikipedia project unites volunteer readers of Wikipedia articles. Hundreds of spoken articles in multiple languages are available to users who are – for one reason or another – unable or unwilling to consume the written version of the article. Our resource, the Spoken Wikipedia Corpus, consolidates the Spoken Wikipediae, adding text segmentation, normalization, time-alignment and further annotations, making it accessible for research and fostering new ways of interacting with the material.
Publication date: 2017
Data owner: Timo Baumann - Universität Hamburg
Contributors: Timo Baumann (author), Arne Köhn (author), Florian Stegen (author)
Languages: English (eng), German (deu), Dutch (nld)
Size: 5397 article, 1005 hour
Segmentation units: other
Genre: encyclopedia
Modality: spoken
References: Timo Baumann; Arne Köhn; Felix Hennig (2018) The Spoken Wikipedia Corpus Collection: Harvesting, Alignment and an Application to Hyperlistening References: Arne Köhn; Florian Stegen; Timo Baumann (2016) Mining the Spoken Wikipedia for Speech Data and Beyon
Isolated Arthroscopic Lateral Retinacular Release for Lateral Patellar Compression Syndrome
No full textIntroduction: Evidence concerning the role of isolated lateral retinacular release (LRR) for lateral patellar compression syndrome (LPCS) dates back at least three decades. Appropriate indications, execution and outcomes still remain unclear and controversial. The present investigation analyzed the midterm result of isolated and arthroscopic LRR for LPCS in a cohort of patients who underwent such procedure at our institution. Material and methods: Patients undergoing isolated arthroscopic LRR for LPCS were identified retrospectively from our electronic database. All procedures were performed by two experienced surgeons. Patients with bony and/or soft tissues abnormalities, patellofemoral instability, moderate to severe chondral damage were not included. Patients with previous surgeries were not included, as were those who underwent combined interventions. Clinical scores and complications were recorded. Results: 31 patients were recruited in the present investigation. The mean follow-up was 86.0 ± 22.8 months. The mean age of the patients at the index operation was 34.2 ± 13.1 years. A total 55% (17 of 31) were women, and 58% (18 of 31) had involved the right knee. The mean hospitalization length was 3.5 ± 1.4 days. At a mean follow-up of 86.0 ± 22.8 months, the numeric rating scale (NRS) was 1.2 ± 0.8, the Kujala score was 91.3 ± 11.3, the Lysholm score was 93.1 ± 15.0, and the Tegner score was 5.0 ± 1.8. At the latest follow-up, 9 of 31 (29.0%) of patients experienced compilations. One patient (3.2%) had a post-operative hemarthrosis which was managed conservatively. Six patients (19.4%) reported a persistent sensation of instability, without signs of patellar dislocation or subluxation. One patient underwent an arthroscopic meniscectomy, and another patient an anterior cruciate ligament (ACL) reconstruction. Conclusion: isolated arthroscopic lateral retinacular release for lateral patellar compression syndrome is feasible and effective, achieving satisfying results at more than seven years following the procedure
Surgical Management of Focal Chondral Defects of the Talus: A Bayesian Network Meta-analysis
No full textBACKGROUND: No consensus has been reached regarding the optimal surgical treatment for focal chondral defects of the talus. PURPOSE: A Bayesian network meta-analysis was conducted to compare the clinical scores and complications of mosaicplasty, osteochondral auto- and allograft transplant, microfracture, matrix-assisted autologous chondrocyte transplant, and autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the talus at midterm follow-up. STUDY DESIGN: Bayesian network meta-analysis; Level of evidence, 4. METHODS: This Bayesian network meta-analysis followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions. PubMed, Embase, Google Scholar, and Scopus databases were accessed in February 2021. All clinical trials comparing 2 or more surgical interventions for the management of chondral defects of the talus were accessed. The outcomes of interest were visual analog scale (VAS) score, American Orthopaedic Foot and Ankle Society (AOFAS) score, rate of failure, and rate of revision surgery. The network meta-analysis were performed through the routine for Bayesian hierarchical random-effects model analysis. The log odds ratio (LOR) effect measure was used for dichotomous variables, and the standardized mean difference (SMD) was used for continuous variables. RESULTS: Data from 13 articles (521 procedures) were retrieved. The median length of the follow-up was 47.8 months (range, 31.7-66.8 months). Analysis of variance revealed no difference between the treatment groups at baseline in terms of age, sex, body mass index, AOFAS score, VAS score, and mean number of defects. AMIC demonstrated the greatest AOFAS score (SMD, 11.27) and lowest VAS score (SMD, –2.26) as well as the lowest rates of failure (LOR, 0.94) and revision (LOR, 0.94). The test for overall inconsistency was not significant. CONCLUSION: At approximately 4 years of follow-up, the AMIC procedure for management of focal chondral defects of the talus produced the best outcome
Arne Sucksdorff professor incômodo no Brasil
No full textThis article discusses the film course by Swedish filmmaker Arne Sucksdorff between November 1962 and March 1963 in Rio de Janeiro, which was an invitation from UNESCO and the Ministry of Foreign Affairs of Brazil. This experience involved the first Nagra equipment to capture direct sound to arrive in Brazil, and the strained relations between an award-winning foreign master, author of a cinema difficult to classify, and his young engaged students that contributed to the cinema to come.Cet article présente le cours de cinéma dispensé par le cinéaste suédois Arne Sucksdorffentre novembre 1962 etmars 1963à Rio de Janeiro, à l’invitation de l’UNESCO et du ministère brésilien des Affaires étrangères. Cette expérience, avec le premier équipement Nagra à capturer le son direct au Brésil et des relations tendues entre un maître étranger primé, auteur d’un cinéma difficile à classer, et ses jeunes étudiants engagés, qui ont contribué au cinéma à venir.Esse artigo discute o curso de cinema ministrado pelo cineasta sueco Arne Sucksdorff entre novembro de 1962 e março de 1963 no Rio de Janeiro, a convite da UNESCO e do Ministério das Relações Exteriores do Brasil. Essa experiência envolve o primeiro equipamento Nagra de captação de som direto a chegar ao país e relações tensasentreummestreestrangeiropremiado,autordeumcinemadifícildeclassificar, e seus jovens alunos engajados que contribuíram para o cinema por vir.Este artículo aborda el curso de cine impartido por el cineasta sueco Arne Sucksdorffentrenoviembrede1962ymarzode1963enRíodeJaneiro,porinvitación de la UNESCO y del Ministerio de Relaciones Exteriores de Brasil. Esa experiencia implica el primer equipo Nagra de captación de sonido directo y relaciones tensas entre un galardonado maestro extranjero, autor de un cine difícil de clasificar, y sus jóvenes estudiantes comprometidos, que contribuyeron al cine por venir
About the Code of Practice of the European Mathematical Society
No full textThe Executive Committee of the European Mathematical Society created an Ethics Committee in the Spring of 2010. The first task of the Committee was to prepare a Code of Practice. This task was completed in the Spring of 2012 and went into effect on 1 November 2012.Arne Jensen, author of this article, is Chair of the EMS Ethics Committe
The Ligamentum condylicum posterius as a precursor structure of the Processus condylicus posterior, another Proatlas‐Manifestation of the human occipital bone
No full textIn this study and the resulting publication, a hitherto almost neglected ligamentous structure of the human occipital bone, the posterior condylar ligament (LCP), was examined and these results were related to the manifestation of an osseous variation of the human occipital bone, the Processus condylicus posterior (PCP), which has also received little attention in past. The basis of the investigation of this ligamentous structure is the preparation and subsequent maceration of 50 human craniocervical junctions including axis, atlas and occipital bone. The examined structure has been found in 98% of all cases. Bony spurs or elongated ossicles located in the ligament were found at the insertion points on the occipital bone. In two cases, the bony formation of a PAP (4 %) was found, what provided the opportunity to further investigate the anatomy of the ligament in these cases. The aim of this work was to show and discuss whether the LCP and the bony structures may have originated from tissue derived from the material of the dorsal arch of the Proatlas, a rudimentary vertebra between the occipital bone and the atlas. To test this thesis, the Ponticulus atlantis posterior (PAP) was additionally considered as another Proatlas-manifestation whose origin from the dorsal arch of the proatlas is widely accepted in literature. This bony variant was found in 11 specimens (22%) in the present study and additionally served to classify and interpret the findings of the much rarer PCP. The essential common element of both variants, besides a basic topographical similarity, is the fact that in the absence of the bony manifestation, ligamentous connective tissue bands can be found instead, which we interpret as precursor structures. Another indication that both bony variants are formed by the same dorsal arch material of the proatlas is the fact that in none of the specimens examined so far can both a PCP and a PAP be found. We interpret this as being due to the fact that the proatlas material manifests either as a spur at the occiput or as an osseous bridge at the atlas. As a result of this series of preparations and a review of the literature on this neglected topic, a typology of manifestations of the LCP, the PCP and related structures was introduced. In conclusion, (1) the LCP is part of the regular anatomy of the craniocervical junction and (2) there is reason to believe that this ligament is a precursor structure of the osseous process and to assume a common descent from the dorsal Proatlas material. This hypothesis is confirmed by previous studies as well as by the present investigation. Future computed tomographic studies must, on the one hand, accurately image the structures originating from the dorsal arch of the Proatlas and, on the other hand, clarify the clinical significance of the bony process and its associated structures on the basis of comprehensive clinical data. However, the basic condition for these further investigations is first of all a higher image resolution in order to be able to adequately depict these fine osseous structures, which could already be shown by preparation
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