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Exploring rapidly changing sensory-motor mappings in behaviour and MEG
No full text*Joint first authors
Behavioural, MEG and eye tracking data from an experiment exploring how humans achieve rapid switches between arbitrary stimulus to response mappings. The experimental procedure is described in one of the preregistrations associated with the study (https://osf.io/hnwfr)
The Risāla Commentary Corpus (RCC)
No full textThe “commentary” (sharḥ, taʿlīq, ḥāshiya, taqrīr, etc.) has arguably been the dominant genre of post-classical Islamic scholarly writing from the 13th century CE onwards. Despite this genre’s dominance, its versatility and innumerable avenues for exploration, etic Orientalist scholarship has initially struggled to come to terms with this kind of text dismissing it as “unoriginal, slavish, repetitive” and the hallmark of an alleged era of intellectual decline. In fact, this dismissive stance can also be observed in some emic Arabic scholarly milieus of the 20th century. This has begun to change and new research has already shown that commentaries are complex writings that can fulfil a plethora of functions. Commentators engage in all kinds of intellectual activity ranging from interpreting the base text (matn) and explaining it, to criticising, rejecting, endorsing, justifying choices made, proving, disproving, adding, correcting, updating, editing, structuring, contextualising and much more.
A desideratum in the study of the commentary genre is the study of commentary corpora that formed around certain base texts, which can cover the entire gamut of disciplines, particularly but not exclusively Islamic law (fiqh). These corpora represent the written manifestation of interpretive communities of these base texts and could reach staggering numbers of titles, span wide geographical areas and persist for many centuries. As such, a commentary corpus can embody a transregional confluence of minds who engage not only with the base text, which acts as its focal point, but also with each other – creating a virtual large-scale and long-term republic of letters.
The Risāla Commentary Corpus (RCC) is the first project that aims to explore the accumulation of commentaries of Ibn Abī Zayd al-Qayrawānī’s (386/996) Risāla quantitatively. The Risāla is an influential early legal digest of the Mālikī school of law, which contains a renowned chapter on the Sunnī creed (ʿaqīda). It has attracted more than 200 commentaries over the last millennium penned by scholars from al-Andalus, North Africa (including Mauritania and Sudan), the Arabian Peninsula and Iraq. The data set gathers key information about the commentaries, the commentators and the manuscript record of the corpus, which will allow researchers to analyse its regional hubs, to compare and contrast their development over time and to pursue other avenues. This material carries the potential to advance our understanding of the Mālikī school of law, the genre of (legal) commentaries and its contribution to the historical development of the textual universe of the Sharīʿa as a whole.
Version 1.0 (uploaded 25.03.2025) contains 217 Risāla commentaries, written by 186 commentators, materialised in 831 manuscripts (alongside countless print copies)
Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming
No full textLow nephron endowment constitutes a risk factor for hypertension and renal disease. Epigenetic regulation is crucial for nephron progenitor cell differentiation, impacting nephron number and renal function. The role of many epigenetic modulators, such as Lysine-specific histone demethylase 1a (LSD1), remains unclear. We used Lsd1 knockout mice to demonstrate that Lsd1 depletion in nephron progenitor cells results in reduced kidney size in neonates and leads to glomerulosclerosis, proteinuria, and renal cysts in adults. Notably, LSD1 deletion in podocytes or tubular cells did not replicate these effects. CRISPR/Cas9-mediated LSD1 deletion in human kidney organoids caused cyst formation and altered gene expression, with snRNA-seq revealing downregulation of podocyte genes and upregulation of metabolic genes. The presence of non-coding RNAs indicates roles in cell proliferation. Our study reveals the critical role of LSD1 function in nephron development and highlights its impact on transcriptional programming for long-term renal function and susceptibility to cyst formation
When consumers evaluate the remuneration policies of content providers: The influence of digital subscription platform remuneration models on consumers' decision-making and market outcomes
No full textPaper "When consumers evaluate the remuneration policies of content providers: The influence of digital subscription platform remuneration models on consumers’ decision-making and market outcomes"
- Data sets
- Experiment and figure files
- SPSS & R scripts
- Manuscript version
Multispectral Imaging Data from London, Royal Asiatic Society (RAS), Ms Hodgson 34 and Ms Hodgson 35
No full textMultispectral imaging data. Imaging was performed to recover damaged writing at the Royal Asiatic Society in London
XRF Measurements (ARTAX) and reflectography (DInoLite) for ink composition analysis was performed. Link to dataset is included in related identifier
Album of Louis Brassin, Stadtgeschichtliches Museum Leipzig, A/2013/392 (1852–1895)
No full textThe album is kept in the Stadtgeschichtliches Museum Leipzig (accession number A/2013/392). It has been digitised at the CSMC as part of the project ‘Creating Music Albums as Originals Made of Originals’. It measures 29 × 22,5 cm (landscape) and belonged to the Belgian singer, pianist and composer Louis Brassin (* 24 June 1840 in Aachen, † 17 May 1884 in St. Petersburg). Brown leather binding with blind embossing, title “Album” in golden letters on the front cover. Gilt edges, white moiré endpapers. Pencil pagination in top outer corner, which does not include the portrait inserted in front of the first entry (Henriette Sontag) and has a gap between pp. 6 and 9, possibly indicating the later removal of an album leaf. The pagination of the facsimile starts with the pagination in the album, but includes the portrait (pp. 3–4) and does not account for the gap, and is thus identical to the pencil pagination on the pages 1–2 and 9–98
Supporting Information Data for the Publication "Predicting Ligand Binding Modes by Scaffold-Guided Structure Refinement"
No full textThis dataset is part of the supporting information for the publication "Predicting Ligand Binding Modes by Scaffold-Guided Structure Refinement" by Pletzer-Zelgert et.al.
It contains a directory for each of the three protein targets discussed in the publication FABP4, ADCY10 and PDE10. These directories will contain the following files:
• Initial models used as input (One for FABP4 and ADCY10, Five for PDE10).
• One file containing all series ligands in the SDF format.
• One txt file containing ligand names, ligand SMILES and measured activities.
• One csv file containing all information from the evaluation.
• One subdirectory containing the successfully identified model as a pdb file containing
the protein, an SD file containing the docked ligand poses, as well as one Mol2 file
containing the representative scaffold for the cluster
MSI data of Tibetan initiation cards from the Zhangzhung Nyengyu tsakali collection
No full textThe object of study is the set of 65 Tibetan initiation cards (tsakali) belonging to the Bon religion. The cards are made of paper, each measuring 9.4 cm in width × 20.2 cm in height. On the recto side they bear the polychrome image of a divinity, a saint, or a sacred object, and on the verso a passage of text of varying length citing a scripture related to the corresponding image. These tsakalis are used in initiation rituals to empower neophytes into the particular domain of religion they represent.
The MSI data:
Images in preview are compressed and of lower quality. They are mainly intended to serve as thumbnails. Original hiqh quality TIF images can be found in the Color and PROCESSED folder below (zip file). For information about filenames and folderstructure as well as MSI system related info, please read the "Brief Description of Datasets for Multispectral Imaging"
Supporting Information for the StrAcTable publication
No full textAll supporting data files for the StrAcTable publication and the StrAcTable datasets are given here.
Following is a short description of each file:
parsed_ligand_data.csv - parsed data of LigandExtactor
parsed_structuere_data.csv - parsed data of StructureProfiler
parsed_activity_data_raw.csv - parsed activity data of ActivityFinder (activity mode)
active_site_data.csv - parsed active site mutation data of ActivityFinder (activity mode)
parsed_activity_data_raw_enriched.csv - parsed activity data of ActivityFinder with additional annotated data (activtiy mode)
filtered_activites.csv - filtered version of parsed_activity_data_raw_enriched (activity mode)
chembl_target_dict_activities.json - json of all chembl targets for each entry (activity mode)
refined_active_site_data.json - refined active site data for each entry (activity mode)
discarded_target_data_automated_activities.csv - target filtering cascade results (activity mode)
parsed_target_data_raw - parsed activity data of ActivityFinder (target mode)
parsed_target_data_enriched_raw.csv - parsed activity data of ActivityFinder with additional annotated data (target mode)
parsed_target_data_filtered.csv - filtered version of parsed_target_data_enriched_raw (target mode)
StrAcTable.csv - merge of ligand data, structure data and enriched activity data (activity mode)
StrAcTable_filtered.csv - merge of ligand data, structure data and filtered activity data (activity mode)
StrAcTableT.csv - merge of ligand data, structure data and enriched activity data (target mode)
StrAcTableT_filtered.csv - merge of ligand data, structure data and filtered activity data (target mode)
StrAcTable_comments.json - csvw explanation for all columns in StrAcTable
Sunburst_plot_pdb.html - sunburst plot of the target hierarchy for all pdb entries in StrAcTable
For further details please consult the publication
Bulk RNA-sequencing of murine bone marrow-derived macrophages upon treatment with live or apoptotic thymocyte-derived extracellular vesicles
No full textTo investigate the differential effects of extracellular vesicles (EVs) derived from live versus apoptotic cells on macrophage function, we performed bulk RNA sequencing on murine bone marrow-derived macrophages (BMDMs) treated with EVs isolated from live thymocytes (liveT-EVs) or apoptotic thymocytes (aT-EVs). BMDMs were generated from C57BL/6J mice and differentiated over seven days. On day 7, cells were treated for 24 hours with either liveT-EVs or aT-EVs. Apoptosis in donor thymocytes was induced by 24-hour culture following initial harvest, and EVs were isolated via differential ultracentrifugation. RNA was extracted using QIAshredder columns and the RNeasy mini Kit (Qiagen), with three biological replicates per condition.
Library preparation and transcriptome sequencing were performed by BGI using 100 bp paired-end reads on the DNBSEQ platform. Reads were aligned to the mouse reference genome GRCm39 using STAR aligner (version 2.7.10b). Differential gene expression analysis was performed using DESeq2 (version 1.40.2), and pathway analysis was conducted using clusterProfiler (version 4.8.3) and enrichR (version 3.4). This dataset reveals distinct transcriptomic signatures induced by EVs depending on the viability status of their donor cells, with apoptotic cell-derived EVs notably activating nitric oxide-related pathways in target macrophages