1,720,992 research outputs found

    Mediation analysis with case–control sampling : identification and estimation in the presence of a binary mediator

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    With reference to a stratified case–control (CC) procedure based on a binary variable of primary interest, we derive the expression of the distortion induced by the sampling design on the parameters of the logistic model of a secondary variable. This is particularly relevant when performing mediation analysis (possibly in a causal framework) with stratified case–control (SCC) data in settings where both the outcome and the mediator are binary. Despite being designed for parametric identification, our strategy is general and can be used also in a nonparametric context. With reference to parametric estimation, we derive the maximum likelihood (ML) estimator and the M-estimator of the joint outcome–mediator parameter vector. We then conduct a simulation study focusing on the main causal mediation quantities (i.e., natural effects) and comparing M- and ML estimation to existing methods, based on weighting. As an illustrative example, we reanalyze a German CC data set in order to investigate whether the effect of reduced immunocompetency on listeriosis onset is mediated by the intake of gastric acid suppressors

    Statistical assessment of public health care services: a multilevel Markov model

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    In this work, a multilevel Latent Markov model is proposed to study the evolution of the health status of elderly patients hosted in different nursing homes. A dataset is considered which is gathered from the Long Term Care Facilities programme, a longitudinal study carried on in Umbria (Italy). The data at hand cover the years 2012 and 2013. The final goal of our analysis is to rank the nursing homes according to their performance in retaining patients in the best health conditions. Our results show significantly different nursing home performances

    Estimation of the treatment effect variance in a difference-in-differences framework

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    We compare two regression-based estimators of treatment/policy effects in a standard difference-in-differences setting without additional covariates. These two estimators, deriving from what we term the piled and unpiled regression models, produce identical finite-sample estimates, thus sharing the same theoretical variance. However, they are not equivalent with regard to the estimation of such a variance. We show that under the assumed model the piled approach should be preferred since it results in a more efficient variance estimator, thereby returning more reliable standard errors for the treatment effect. We further show that this result holds even when the normality assumption for the regression error terms is violated

    Missing Data: A Unified Taxonomy Guided by Conditional Independence

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    Recent work (Seaman et al., 2013; Mealli & Rubin, 2015) attempts to clarify the not always well-understood difference between realised and everywhere definitions of missing at random (MAR) and missing completely at random. Another branch of the literature (Mohan et al., 2013; Pearl & Mohan, 2013) exploits always-observed covariates to give variable-based definitions of MAR and missing completely at random. In this paper, we develop a unified taxonomy encompassing all approaches. In this taxonomy, the new concept of ‘complementary MAR’ is introduced, and its relationship with the concept of data observed at random is discussed. All relationships among these definitions are analysed and represented graphically. Conditional independence, both at the random variable and at the event level, is the formal language we adopt to connect all these definitions. Our paper covers both the univariate and the multivariate case, where attention is paid to monotone missingness and to the concept of sequential MAR. Specifically, for monotone missingness, we propose a sequential MAR definition that might be more appropriate than both everywhere and variable-based MAR to model dropout in certain contexts

    Tackling Non-Ignorable Dropout in the Presence of Time Varying Confounding

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    We explore the sensitivity of time varying confounding adjusted estimates to different dropout mechanisms. We extend the Heckman correction to two time points and explore selection models to investigate situations where the dropout process is driven by unobserved variables and the outcome respectively. The analysis is embedded in a Bayesian framework which provides several advantages. These include fitting a hierarchical structure to processes that repeat over time and avoiding exclusion restrictions in the case of the Heckman correction. We adopt the decision theoretic approach to causal inference which makes explicit the no-regime-dropout dependence assumption. We apply our methods to data from the ‘Counterweight programme’ pilot: a UK protocol to address obesity in primary care. A simulation study is also implemented

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods
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