50 research outputs found
THE SHARP EDGES OF CONTEMPORARY WORLD POLITICS
No full textBook Review: Bulavin A.V., Karpovich O.G., Manoilo A.V., Mantusov V. B. World politics. Advanced lines and red lines. Moscow: RIO Russian customs Academy, 2018. 456 p.The article presents a detailed review of the monograph “World politics. Front lines and red lines”. The author assesses the nature and content of the influence of the main participants in the system of international relations, both individual States and non-state actors, including transnational corporations on the state and prospects of development of world politics. Directions of adjustment of the foreign policy strategy of Russia in the conditions of aggravation of a situation and reanimation of hostile anti-Russian course from a number of participants of world political process are defined
Чтение в системе советской антирелигиозной пропаганды 1920-х - первой половины 1930-х гг. (на примере Среднего Урала)
No full textThe researches in the history of religiousness and atheism of the soviet society demand the analysis of the methods used in the atheistic propaganda. The author of the article assesses the role of reading of antireligious literature in the system of atheistic propaganda in the Middle Ural in 1920-1930s and shows the factors strengthening or weakening its impact on the population.Исследование религиозности и атеизма советского общества требует анализа методик, применявшихся в ходе атеистической пропаганды. В статье дана оценка роли, которую играло чтение антирелигиозной литературы на Среднем Урале в 1920-1930 е гг., а также показаны факторы, усиливавшие и ослаблявшие его воздействие на население
Wip1 Controls Global Heterochromatin Silencing via ATM/BRCA1-Dependent DNA Methylation
No full textSummaryWip1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mechanistic network has been proposed. We found that Wip1 plays a key role in the transcriptional regulation of heterochromatin-associated DNA sequences. Wip1 was required for epigenetic remodeling of repetitive DNA elements through regulation of BRCA1 interaction with HP1, the recruitment of DNA methyltransferases, and subsequent DNA methylation. Attenuation of ATM, in turn, reversed heterochromatin methylation. This mechanism was critical for the recruitment of the AID cytidine deaminase, and Wip1 levels strongly correlated with C-to-T substitutions and a total mutation load in primary breast cancers. We propose that Wip1 plays an important role in the regulation of global heterochromatin silencing and thus is critical in maintaining genome integrity
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
No full textInternational audienceThe accumulation of senescent cells can drive many age-associated phenotypes and pathologies. Consequently, it has been proposed that removing senescent cells might extend lifespan. Here, we generated two knockin mouse models targeting the best-characterized marker of senescence, p16Ink4a. Using a genetic lineage tracing approach, we found that age-induced p16High senescence is a slow process that manifests around 10-12 months of age. The majority of p16High cells were vascular endothelial cells mostly in liver sinusoids (LSECs), and to lesser extent macrophages and adipocytes. In turn, continuous or acute elimination of p16High senescent cells disrupted blood-tissue barriers with subsequent liver and perivascular tissue fibrosis and health deterioration. Our data show that senescent LSECs are not replaced after removal and have important structural and functional roles in the aging organism. In turn, delaying senescence or replacement of senescent LSECs could represent a powerful tool in slowing down aging
