37 research outputs found
Impact of educational intervention on knowledge, attitude and awareness of good clinical practice among health care providers
No full textImpact of educational intervention on knowledge, attitude and awareness of good clinical practice among health care providers
No full textBackground: Clinical trials play an important role in the generation of evidence-based data in health care practices. To ensure the credibility of data and the safety and well-being of the patients Good clinical practice (GCP) guidelines play an important role. At present, we have little knowledge about awareness of GCP guidelines among health care providers in India.
Aim: To assess the level of awareness, and perception of the health care providers toward GCP and subsequent change in these after a dayer training session on GCP guidelines.
Settings and Design: A cross-sectional descriptive questionnaire-based study was conducted amongst health care providers, that is, doctors, dentists, nurses of a Tertiary Health Care and Teaching Institute.
Materials and Methods: Participants were given descriptive questionnaire; they completed the questionnaire before and after undergoing a day training program in GCP guidelines.
Statistical Analysis Used: The impact of the effectiveness of educational intervention among healthcare professionals was evaluated by two-tailed Z-test.
Results: Out of 120 participants, 80 were medical doctors, 20 dental doctors, and 20 nurses. A dayse training program on GCP guidelines was found to increase positive attitudes toward various aspects of clinical trials.
Conclusion: A day's training program on GCP guidelines may help to increase the knowledge as well as awareness about principles and techniques of clinical research, which will increase the credibility of clinical research in the country
Extrato de semente de Mucuna pruriens (feijão aveludado) melhora a epilepsia e a ansiedade contra modelos experimentais in vivo: uma análise histopatológica
No full textIntroduction: the plant Mucuna pruriens is traditionally used in Indian system ofmedicine for the therapy of several neurological disorders. Chemical investigationson the plant have established the presence of levodopa and tryptamine which areresponsible for treating the neurological disorders like Parkinsonism. Objective:the objective of this research was to scientifically explore and ascertain its antiepilepticand anxiolytic activity in preclinical studies on Swiss albino mice. Materialand Method: the antiepileptic and anxiolytic effect of ethanolic extract of Mucunapruriens (EEMP) tested against maximal electroshock (MES) pentylenetetrazol(PTZ)-induced convulsions, Elevated Plus Maze, and light and dark arena. Actophotometertest performed to evaluate its potential locomotor activity deficitinducing action. Result: treatment of mice with EEMP significantly upturned theMES-induced convulsions, which was reflected by diminution in the time interval(sec) of entire phases of MES-induced convulsions, with an improvement in GABAlevels. In the PTZ model, pretreatment with EEMP delayed the latency and reducedthe intensity to clonic convulsions (p< 0.0001), and also delayed the latency oftonic convulsions as well as decrease the mortality mice in the treated groups ina dose-dependent manner. EEMP intervention dose dependently restored brainGABA levels. Assessment of GABA in mice’s brain after administration of EEMPexhibits significant modulation of GABA levels. Conclusion: overall, the findingssuggest that Mucuna pruriens has anticonvulsant and anxiolytic properties that aremediated by positive GABAergic neurotransmission hence could be used to treatepileptic seizures, petitmal and grandmal epilepsy.Introducción: la planta Mucuna pruriens se utiliza tradicionalmente en el sistemaindio de medicina para la terapia de varios trastornos neurológicos. Las investigacionesquímicas en la planta han establecido la presencia de levodopa y triptamina,que son responsables del tratamiento de trastornos neurológicos como el parkinsonismo.Objetivo: el objetivo de esta investigación fue explorar y determinar científicamentesu actividad antiepiléptica y ansiolítica en estudios preclínicos en ratonesalbinos suizos. Material y método: el efecto antiepiléptico y ansiolítico del extractoetanólico de Mucuna pruriens (EMPE) se ensayó frente a convulsiones inducidaspor electrochoque máximo (MES) pentilentetrazol (PTZ), Laberinto Elevado Plusy arena clara y oscura. Prueba de actofotómetro realizada para evaluar su potencialacción inductora de déficit de actividad locomotora. Resultado: el tratamiento deratones con EEMP aumentó significativamente las convulsiones inducidas por MES,lo que se reflejó por la disminución en el intervalo de tiempo (s) de fases completasde convulsiones inducidas por MES, con una mejora en los niveles de GABA. Enel modelo PTZ, el pretratamiento con EEMP retrasó la latencia y redujo la intensidadde las convulsiones clónicas (p< 0,0001), y también retrasó la latencia de lasconvulsiones tónicas, así como disminuyó la mortalidad de los ratones en los grupostratados de una manera dependiente de la dosis. La intervención de EMPE restauróde forma dependiente de la dosis los niveles de GABA en el cerebro. La evaluaciónde GABA en el cerebro de ratones después de la administración de EEMP muestrauna modulación significativa de los niveles de GABA. Conclusión: en general, loshallazgos sugieren que Mucuna pruriens tiene propiedades anticonvulsivas y ansiolíticas que están mediadas por neurotransmisión GABAérgica positiva, por lo quepodría usarse para tratar convulsiones epilépticas, epilepsia pequeña y granular.Introdução: a planta Mucuna pruriens é tradicionalmente utilizada na medicinaindiana para o tratamento de diversas desordens neurológicas. Investigaçõesquímicas na planta estabeleceram a presença de levodopa e triptamina, responsáveispelo tratamento de distúrbios neurológicos como o parkinsonismo. Objetivo: oobjetivo desta pesquisa foi explorar cientificamente e verificar sua atividade antiepilépticae ansiolítica em estudos pré-clínicos em camundongos albinos suíços. Materiale Método: o efeito antiepiléptico e ansiolítico do extrato etanólico de Mucunapruriens (EEMP) testado contra convulsões induzidas por eletrochoque máximo(MES), pentilenotetrazol (PTZ), labirinto em cruz elevado e arena clara e escura.Teste de actofotômetro realizado para avaliar sua potencial ação indutora de déficitde atividade locomotora. Resultado: o tratamento de camundongos com EEMPaumentou significativamente as convulsões induzidas por MES, o que se refletiu nadiminuição do intervalo de tempo (seg) de fases inteiras das convulsões induzidas porMES, com uma melhora nos níveis de GABA. No modelo PTZ, o pré-tratamentocom EEMP retardou a latência e reduziu a intensidade das convulsões clônicas (p<0,0001), e também retardou a latência das convulsões tônicas, bem como diminuiu amortalidade dos camundongos nos grupos tratados de maneira dose-dependente. Aintervenção do EEMP restaurou os níveis cerebrais de GABA dependentes da dose.A avaliação de GABA no cérebro de camundongos após a administração de EEMPexibe modulação significativa dos níveis de GABA. Conclusão: no geral, os achadossugerem que Mucuna pruriens tem propriedades anticonvulsivantes e ansiolíticasque são mediadas por neurotransmissão GABAérgica positiva, portanto, pode serusado para tratar crises epilépticas, epilepsia petitmal e grandmal
Multifaceted Responses to Heat Stress in Plants: A Review of the Morpho-physiological, Biochemical and Anatomical Changes
No full textHeat stress, a significant abiotic factor, adversely affects plant growth and productivity by disrupting various physiological and biochemical processes. Plants, being immobile, respond to environmental changes through alterations in gene expression, metabolism, and growth dynamics. Elevated temperatures, exceeding the threshold for heat tolerance, negatively influence critical functions such as photosynthesis, respiration, water balance, and membrane stability. Root development is particularly sensitive to heat stress, resulting in reduced root mass and impaired water and nutrient uptake. Photosynthetic capacity diminishes due to decreased chlorophyll content and impaired photochemical reactions, leading to reduced biomass and yield. Heat stress impacts plant water status by disturbing hydraulic conductivity and increasing membrane permeability, leading to dehydration and a decline in water potential. This stress reduces membrane stability, resulting in electrolyte leakage and cellular damage. It also induces the production of reactive oxygen species (ROS), which requires the activation of antioxidant enzymes to minimize oxidative stress. Also, to maintain osmotic balance and enhance stress tolerance, plants accumulate osmolytes such as proline. Additionally, anatomical adaptations in leaves, stems, and roots, such as changes in stomatal density, xylem vessel size, and gas exchange patterns, highlight the plant\u27s strategies to cope with heat stress. Understanding these varied responses is crucial for developing strategies to enhance crop resilience in the face of increasing global temperatures and climate change
The Effectiveness of Different Revision Approaches in Science on Achievement and Retention of Learners Having Different Learning Styles
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Interaction of Twisted Light with Metal Tips
No full textA study of the interaction of Laguerre-Gaussian (LG) beams with Tungsten tips. A change in the order of the interaction for LG beams compared to Gaussian beams is reported. © Optica Publishing Group 2021, © 2021 The Author(s
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No full textNot AvailableRECYCLING OF COMMERCIAL PIGGERY WASTES INSEMI-INTENSIVE CARP POLYCULTURE UNDER RAIN-FED PONDENVIRONMENT IN ASSAM: AN ECONOMIC ANALYSISB. K. BHATTACHARJYA*, K. BARMAN1, S. YENGKOKPAM, D. DEBNATH, P. DAS, N.SHARMA, S. R. PEGU1, A. K. YADAV, S. BORAH, K. K. SARMA, P. GOGOI, A. KAKATI, D. K.SARMA1, B. P. MOHANTY2 AND B. K. DAS2ICAR-Central Inland Fisheries Research Institute, Regional Centre, HOUSEFED Complex, Dispur,Guwahati - 781 006, Assam, India1ICAR-National Research Centre on Pig, Rani, Guwahati - 781 131, Assam, India2ICAR-Central Inland Fisheries Research Institute, Barrackpore, Kolkata - 700 120, West Bengal, IndiaEmail of corresponding author: [email protected] (B. K. Bhattacharjya)(Received : 25.08.2017; Accepted : 25.10.2017)Not Availabl
A Prospective Randomised Trial to Study the Efficacy of Vitamin B6 (Pyridoxine) and Vitamin E in Patients of Premenstrual Syndrome
No full textRevolutionizing Dentistry: The Applications of Artificial Intelligence in Dental Health Care
No full textArtificial intelligence (AI) is transforming the landscape of health care, and dentistry is no exception. This article explores the various applications of AI in dentistry, showcasing how this advanced technology is revolutionizing diagnosis, treatment, and patient care. From enabling early detection of oral diseases to enhancing the precision of dental procedures, AI is driving the industry toward more efficient and effective dental healthcare services. This article delves into the specific ways in which AI is being integrated into dental practices, highlighting its potential to improve patient outcomes and advance the field of dentistry
