13 research outputs found
Software de simulação gráfica para análise de processos elétricos em tecidos biológicos em nível celular
Get PDFDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Este estudo trata do desenvolvimento de um programa de simulação que contém apresentações gráficas e interações claras com o usuário, facilitando a entrada de dados e o entendimento dos resultados apresentados na simulação de sistemas biológicos sobre influência de campos eletromagnéticos. Foi utilizado o modelo desenvolvido por Ramos et al. (2000, 2001) de análise numérica da distribuição espacial de campo elétrico e densidade de cargas iônicas em materiais biológicos, baseado no Método do Circuito Equivalente (MCE). Este modelo se apresenta como uma ferramenta versátil para investigar meios não homogêneos e anisotrópicos, e foi criado com duas abordagens complementares: análise em nível celular e de tecido. Neste trabalho é apresentado o modelo do circuito equivalente em escala celular. O conhecimento de soluções numéricas que resolvam as implicações dos efeitos dos campos magnéticos em sistemas biológicos pode elucidar os fenômenos envolvidos nos resultados experimentais, reduzindo os riscos envolvidos em pesquisas com seres vivos, uma vez que se pode, através do programa, ter um planejamento dos estudos experimentais e terapêuticos
Desenvolvimento do método do circuito equivalente para análise numérica de processos elétricos em tecidos biológicos
Get PDFTese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.: O interesse nas propriedades elétricas de materiais biológicos data de mais de um século. Contudo, a análise teórica de grandezas e propriedades em tecidos biológicos por métodos analíticos somente é possível em modelos muito simplificados. Esta tese baseia-se no desenvolvimento de um método numérico especialmente projetado para permitir a modelagem de agregados de células e tecidos, representando com fidelidade as características elétricas do meio em dimensões celulares e descrevendo com precisão as propriedades macroscópicas em grandes volumes de tecido. A técnica baseia-se na solução da equação de continuidade, em um espaço discretizado com elementos de volume retangulares, e modela o transporte elétrico no meio através de um circuito equivalente constituído de elementos concentrados, como capacitâncias, condutâncias e fontes de corrente. Esta técnica é denominada de Método do Circuito Equivalente (MCE), e foi concebida como tendo duas abordagens que se complementam: o modelo em escala celular e o modelo em escala de tecido. Esta tese demonstra a versatilidade e potencialidade do método para analisar diferentes aspectos do comportamento elétrico de tecidos. Com base nos resultados obtidos propomos que o MCE deve se tornar uma importante ferramenta na pesquisa em bioeletromagnetismo, bem como no planejamento de terapias baseadas na eletro-estimulação biológica
Efeito da planta vitex montevidensis na aterosclerose experimental : uma abordagem sobre o desenvolvimento de um medicamento fitoterápico na indústria brasileira
Get PDFTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014As plantas Vitex montevidensis, Campomanesia xantocarpa e Allophylus edulis são espécies nativas presentes na região Sul do Brasil. Atualmente sua utilização e conhecimento vem quase que inteiramente da cultura popular, que utiliza a infusão de suas folhas para diminuição dos níveis lipídicos. Sendo assim, este estudo teve como objetivo investigar os efeitos anticolesterêmicos e antiaterogênico dos extratos e frações das plantas em camundongos geneticamente modificados tratados com dieta rica em gordura. Após realização das etapas botânica e fitoquímica, as três plantas foram submetidas a realização de testes farmacológicos onde foi possível observar que os extratos e as frações residual e n-butanol da planta Vitex montevidensis foram capazes de reduzir os níveis de colesterol total, triglicéridos e LDL-C além de diminuir a área da lesão aterosclerótica e o índice aterogênico. Além disso, o tratamento não mostrou nenhum indício de toxicidade aguda, evidenciado pela ausência de sinais clínicos relevantes, bem como ausência de morte em todo o período de observação. Através de análises fitoquímicas foi possível identificar que a planta é rica em glicoflavonóides sendo a vitexina, isovitexina, orientina e isoorientina, flavonóides presentes em grande quantidade na planta, podendo ser responsáveis pelos efeitos farmacologicos encontrados. Estes resultados suportam o potencial terapêutico do extrato da planta Vitex montevidensis para o tratamento de doenças cardiovasculares.Abstracts: The plants Vitex montevidensis, Campomanesia Xantocarpa and Allophylus edulis species are present in Southern Brazil. Currently their use and knowledge come almost entirely from popular culture, which uses the infusion of its leaves to decrease lipid levels. Therefore, this study aimed to investigate the anticholesteremic and antiatherogenic effects of the plant extract and fractions in genetically modified mice treated with high fat diet. After performing the botanical and phytochemical steps, the three plants were submitted to the pharmacological tests where it was observed that the extracts and fractions of Vitex montevidensis were able to reduce levels of total cholesterol, triglycerides and LDL besides reducing the area of atherosclerotic lesion and the atherogenic index. Moreover, this treatment showed no sign of acute toxicity, as evidenced by the absence of relevant clinical signs as well as the absence of death throughout the observation period. Through the phytochemical analysis was possible to identify that the plant is rich in glicoflavonoids being vitexin, isovitexin, orientin and isoorientin flavonoids present in large quantities in the plant, and these flavonoids may be responsible for the pharmacological effects here found. These results support the therapeutic potential of the extract of the plant Vitex montevidensis for the treatment of cardiovascular diseases
Ovarian cancer screening in the general population.
No full textDespite significant improvements in therapy, ovarian cancer continues to be a leading cause of death amongst women with gynaecological malignancies. Advanced stage at diagnosis is thought to be a major contributor to mortality. Hence, there is considerable interest in early detection through screening. In the 1990s, Professor Jacobs pioneered the development of a multimodal ovarian cancer screening (OCS) strategy using serum CA125 as the first line screen and pelvic ultrasound as the second line test. This thesis summarises the next steps in the journey with refining of the screening algorithm, feasibility testing in a pilot randomised control trial (RCT) and finally setting up and recruiting 200,000 women into the largest ever RCT . The risk of ovarian cancer in postmenopausal women with elevated CA125 levels was established through a detailed analysis of 1219 pelvic scans from 741 women with raised CA125 levels in the completed trial of 22,000 women. Based on this, the multimodal 'Risk of Ovarian Cancer' (ROC) algorithm was refined and morphology instead of volume was used to interpret the ovarian scans. The refined ROC algorithm was then prospectively evaluated in a pilot RCT of 13,582 postmenopausal women. The trial established that screening using the ROC algorithm was feasible and could achieve high specificity and positive predictive value. The improved performance characteristics of the screening strategy and the experience accumulated in running and organising the pilot trial led to the design and successful implementation of a RCT - the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) - to assess the impact of early detection on disease mortality. The trial commenced in 2001 with recruitment of 202,638 postmenopausal women by September 2005. The issues involved in setting up the trial, recruitment of 202,000 women and the baseline characteristics of this population are described
Centro de Ciências da Saúde da Universidade Federal do Rio de Janeiro: 50 anos junto com a sociedade e a comunidade acadêmica
No full textO movimento pós reforma universitária de 1968, foi um dos marcos políticos que transferiu o ensino do ciclo básico da Faculdade de Medicina para os recém-criados: Instituto de Ciências Biomédicas, Instituto de Biofísica Carlos Chagas Filho e o Instituto de Microbiologia. A partir daí, em 1969, é criado e implantado o Centro de Ciências Médicas, na Praia Vermelha, e nomeado seu primeiro decano, o professor Carlos Cruz Lima, no dia 04 de setembro. Em 1973, começou a transferência das instalações da Praia Vermelha para a Cidade Universitária (FÁVERO; LIMA, 2011). O Centro de Ciências da Saúde (CCS) agrega suas respectivas Unidades Acadêmicas, Unidades Hospitalares e Órgãos Suplementares. É com essa data que o Centro de Ciências da Saúde comemorou seus 50 anos em 2019. O atual decano do Centro, professor Luiz Eurico Nasciutti, instituiu uma comissão composta por técnicos, docentes e discentes para organizar a celebração desse Jubileu de Ouro. Foi criada uma logomarca especial para a data, com estímulo de utilização pelos eventos das Unidades vinculadas ao CCS interessadas em se coadunar com a proposta. Na sessão solene comemorativa do dia 16 de setembro de 2019, muitos foram os momentos de grande emoção do corpo social e convidados com homenagens e premiações a pessoas que foram os destaques que fizeram com que o trabalho realizado ao longo desses 50 anos fosse rememorado e celebrado com grande júbilo. Parte desta história foi contada por meio de vídeos com narrativas de dirigentes, docentes e eméritos. Esse trabalho pretende mostrar as articulações e o alcance do envolvimento do corpo funcional do CCS nessa comemoração que não foi só sobre o passado, mas se utilizou de suas realizações para fortalecer laços que mantém as perspectivas de um futuro vanguardista. Foram analisadas as atividades aderentes ao projeto e montado um quadro quantitativo e qualitativo. Nele puderam ser reveladas áreas de interesse focal das atividades e outras menos exploradas e que tem grande poder de envolvimento. O CCS não é só o maior Centro Universitário da Universidade Federal do Rio de Janeiro, que produz ensino, pesquisa, extensão/assistência, cumprindo sua missão institucional com responsabilidade social. No momento, o CCS, também vem somando esforços com a UFRJ no combate à pandemia da COVID-19, com sua imperiosa contribuição para a sociedade brasileira através de suas pesquisas científicas e produção de insumos
insights from the international multicenter ISACS-STEMI registry
Get PDFPublisher Copyright: © 2022. The Author(s).BACKGROUND: Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. METHODS: In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. RESULTS: A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dissimilarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. CONCLUSION: This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline characteristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. TRIAL REGISTRATION NUMBER: NCT04412655 (2nd June 2020).publishersversionpublishe
Education Research Gender, Education and Development - A Partially Annotated and Selective Bibliography
Get PDFCommunity/Rural/Urban Development,
Cocristais farmacêuticos de furosemida: obtenção, caracterização e estudos de estabilidade
Get PDFDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013A Furosemida é um potente diurético de alça indicado para o tratamento de edema associado à insuficiência cardíaca. Ela compreende um fármaco-modelo para aplicação em sistemas tecnológicos que aprimorem suas características de labilidade química e baixa solubilidade. Dentre as ferramentas utilizadas no melhoramento de sistemas farmacêuticos, as técnicas de modelagem cristalina vem ganhando destaque pelo impacto que exercem sobre as características biofarmacêuticas de um produto. Neste contexto, o presente trabalho objetivou realizar o screening de formas cocristalinas de furosemida e determinar suas propriedades fisicoquímicas em comparação com o fármaco puro. O desenvolvimento e a validação de metodologias analíticas para determinação de furosemida em estudos de estabilidade e dissolução foram realizados tendo por base a cromatografia líquida de alta eficiência. Os ensaios de design supramolecular foram iniciados por estudos de cristalização da furosemida pura em solução e resultaram em materiais cristalinos puros e misturas de fases. Dependendo do método de cristalização escolhido, os sistemas demonstraram partículas marcantemente diferentes para amostras descritas como isomórficas e que apresentaram desempenho variável frente os ensaios de dissolução. Já as tentativas de cocristalização da furosemida empregaram a moagem como ferramenta principal. O processamento de furosemida com outros compostos em moinho de bolas a seco e com solventes resultou basicamente na obtenção de três situações diferentes: sistemas amorfos, sistemas cristalinos compreendendo novas modificações sólidas e sistemas cristalinos compreendendo os insumos de partida segregados. Observou-se que a presença de fase amorfa levou à formação de cocristais sob condições em que a mobilidade e a energia das moléculas encontraram-se aumentadas e havia complementaridade entre os insumos. Destacam-se os exemplos dos sistemas cocristalinos furosemida:cafeína e furosemida:nicotinamida, para os quais foram obtidas uma e cinco modificações cristalinas inéditas, respectivamente. Evidenciou-se experimentalmente que a utilização de técnicas de mecanossíntese e cristalização são efetivas no que se refere ao screening e à análise de novas formas sólidas em insumos farmacêuticos ativos. Estas são importantes ferramentas de desenho e controle de qualidade de fármacos e podem influenciar no desempenho dos mesmos e na sua produção, <br
Multimedia and the Hybrid City: Geographies of Techno cultural Spaces in South Korea
Get PDFThe purpose of this research is to explore how multimedia technologies such as the Internet, satellite TV, cable TV and mobile phones, combined with people's everyday practices, produce the hybrid city where the boundaries between binary territories are blurred; and to offer implications for understanding our everyday lives and cities. Here, multimedia technologies are crucial triggers by which the boundaries between binary categories such as time/space, actual/virtual, human/machine and so on are blurred. And, cities, where urban locales are connected to electronic networks and human bodies are wired to electronic machines, are locations where such boundary-blurring processes occur intensively. I call such a city the 'hybrid city' where we can observe various geographies of technocultural spaces formed by multimedia technologies. In this epistemological context, I investigate cities in South Korea, a country that is one of the most 'wired' to electronic networks in the world. My argument is that the hybrid city, composed of global-local networks, actual- virtual circuits, centripetal-centrifugal vectors and human-machine hybrids, cannot be explained as a singular and consistent space, but rather as multiple and complex spaces. This is because the hybrid city itself exists in between different categories or territories. That is, the hybrid city does not exist as A or B, but instead in between A and в which are deterritorialised towards each other through a-parallel evolution or co-evolution, and thus it can be seen as fractal and fluid. In this sense, the hybrid city can be defined as not a 'being', but 'becomings' always in motion through the continuous 'dis/appearances' or 'dis/connections' of heterogeneous networks. In Latour's, Deleuze and Guattari's and Haraway's terms, the hybrid city is not only composed of a number of actor-networks, rhizomes or cyborgs, but also a kind of actor-network, rhizome or cyborg itself. That is, the hybrid city is the 'middle kingdom' in Latour's terms
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PALO ALTO TIMES.
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VOL. 3.
PALO ALTO, SANTA CLARA COUNTY, CAL., FRIDAY, SEPTEMBER 27, 18! tt.
NO, 39.
ALBINOS AT CAPE COD
Tbey am illiterate, and oooonnt for
tbelr pbyaioal peouliariUee by lha
theory that on* of their ancestor* bad
bi* boir turn whito after a fright, and
£ FOR TUFFiRMER.
Haired People.
THESE ARE OVEI A til. tWED-
| . ol liable Hint* Taken Prom Our
Agricultural Eichatifc*.
THE CHARACTERISTICS OF CVPS1ES., Victor llstll,.t. born In l?M. U tbe
*w„. ; oldest ot tbe three aorvlving French-
i men wbo war* nnder Ore al Waterloo.
For GensraUoas a Family Has Hatatnsd g^. A\\„ Thompeon. of Borden
tb* Pa.uiian,)- Wblch Hade lu Ap. tJ,vtt_. K.J., 100 yeat* old. t* oald to be
pearsn<t m ibe i f ih CeaMiy. tbe oldest clergyman In tb* world.
Frederic-: Polk.an old alaroof James
] K. Folk's fatnllr,now living at Bridge-
A Boatou dispatch to the Fblladel* \ vlllc. Del., baa pauied hli lOfitb birth-
pbla Timea aay* tbat since thu appear*! day.
once of albino girls in side show* and William .-.plow aged 103. recently
"7 ...... eonguover*] songs tn IMWl tr> \lel-
dim* mnnom* tto g.neral public haa XXtgtmt Eng„ beedde- eondncting a
indulged in _o„iiderable apeonlatiou aa oharus and ploying a piano,
to whom tb* manager* of tbese freak : alllo. El.nun. de Veraigne, of Herf-
aggrevatlooa prooure tbelr _rls_y*balred'eourt, In Ibo Deportment of Haute
specimens. Although seldom met with tioone. Franca, at the recent celebrant otber planes tbere la at Cepe Cod * tlon _( ber In lit birthday recited a
t it 1, .m m ..( tbeee pink-eyed and long poem trom a public platform,
white-haired people. For generationi Mra. Lucy Alexander, a colored
tbe Pitlaley family, known lit the sec. woman from Virgin lar'now living in
tlon aa tbo "wbIto-haired Plltaley*," Keokuk, Iowa, ia 1 IB year* old. She
bare been albino. They have fnler- con thread a needle without glome*
married, and aiibotrgb clannish in tbe and ber bearing il still perfect.
extreme, ytara ago took Into tbe faml- Mm*. Cbevlllard. ot lllegarden.
ly fold a man name.. Reynold a, in France, 1*100 year* old, and has never
wbosn chll.lrnti the pucultorliy crapped eaten meat. Sho has subsisted on
ont and mlded lint "wbito-haired Hoy- bread, frait, milk, add vegetable*,
uolds" to tho little army uf Cape drinking cider wsll diluted with water.
Cod's human oortosille*. Mm., Baetowka. who aerved aa a
Until quite reac-atly a dcaen or flf- vivandiere at lb« batll* of Waterloo,
toen Pitlaley albinos might have been tella ber stories of the great Napoleon
found within balf oa many mile* of to Ihe fourth generation uf llnstowkas
each other ami somctim.a under the nt Anlche, Franco, .lie In 113 year*
same roof. Bnt tho families In wbich old.
there on albluaa have •ottered lately Mr* Lucy Evans, of Independence,
and spread over tbe moat lonely part* Mo., baa poand ber tilth birthday,
of tbe country from Freetown to Ware- and still aaeirta witb tbe houoowork.
Iism. at tb.' entrance tn Capo Cod. tibo is full of stories of Indian adv_n-
The mtueum albino and the albino tore In ihe early settlement of the Celt*.
In real life have little in cum in no. Tbe Ira I West.
albinoathoaiBlsdUappmnttng. Hlsor Near Qnantieo, M.l . lives Mrs.
ber hair i-ta't ell roped to in* mnnom Habre Wright, wbo ba* passed ber
hum lt doesn't stand out a la Cir- lOTlb birthday and haa only recently
oaaman. In tho natural Fittaley state became blind, Wbon Washington
tlin alhiun balr Is dingy, because they died alio woro a block rlbbou around
don't know any better, andjt tbey did her arm for thirty dayi ia hnutir of thu
Ihey probably wouldn't adopt .Ibe deceased President,
modern methods of washing hair. "Grandma" Nancy Borger. of Belle-
Tbe eye* of tbe albinoa in tbisregion font*. Pa., who raw tbe first iron fur-
prove their albinism beyond flneMlou. naoe bnllt in that plane and ha* talked
They are usually described aa pink, with ono of (.on. Washinginii'a staff
IQta rabbits'eye*. They ore extreme officer*, bear* her 10. year* wilh cbeer-
ly weak and almost closed, *o tbat it ia fnlneea and rigor, and still iloe* sumo
dim cult to get a square look into tbe housework evety day.
or* it*.-.. Wben tbe eye ii opened Mr. and Mrs. Monoel.both 110 years
the lid is lifted only for • ■■ run< . and old, celebrated their diamond wedding
it take* a qnlck look to dlaourer that moeuily, at Kenneboubuort. Me. '
thj popll la dark red and aurrnnndod Tbeir chlldreu, grandchildren and
with a hj.il,. . nd ring, while the ball great-grandchildren Joined In Ihe wed-
• ■'. tbe ay* ia pale pink and surrounded ding march, and an old colonial dance
with the plnklsb rim of Ibe eyelid, on Ibe green followed.
Tbe effect wonld be thoroughly pink If Mr*. Mary Oorham, a ocutennarian
ihe eye remained at reel. It la almost of Lynn, Mobs., has just had Iho buuur
impoeeibln tu obtain a direct look Into of presiding over five generations of
the eye. because frt.m Ibo eyu of the iur descen.lauia. who number 120.
bealtby albino red light* stem b> dart. This remarkable woman distinctly re-
while the pupil quiver* and diUtr* and member* the execution of Robert Em-
seema to move nnoeadngy. met in ISO0. She still rata witb ber
ll I* over a oratory and a balf since uwn teeth, and has never bad a tooth-
tho appearance uf the m-i albino was aeba In ber life.
neenrded in the Fittaley tribe, tilnee Mr*. Anno Mario Phieeter.ouo of tho
tbat time pnibably mere tban one bun- earliest white aettler* In tbe titato^-af
died have been born bearing thi* name Ohio, passed ber lOOtb birthday oo>
or baring mother* from tbia family. May 31 in good health and strength,
At one time it is estimslel that only and is living with ber cbllldren or
a few lm than fifty nlblppa were Hv- Pot a ska la, Ohio, She celobraled ber
lug within a radio* of twenty-live centennial liy a public reception, Jat
mill*- i: I'liniii might here have held .which 5,OOO .people were present,
an albino congress if ha bed been able Home months ago, in (ilaasbcro, N.
to engage all of tbeee people witb tbe J. Mr*. Hannah Chard ■.< ',.'-,■ t.., ber
wonderfnl wine red pupils. Il haa lOdlh birthday. At her rcqngat, devo-
a I way* torn among the 1 .grada uf ihe' tlimal exerclsea wore belSiiiiid *he!
country that the great ali.iwinon did Joined In tho alnging of her favorite
recurit hU collection from tbla locality, bymn, "I've Anchored My Soul."
'bot today tbe premd Pitlaley deny in- Sb* i< * fluent talker, and enlrrtaiotd
dlnganily tbat Barnum ever bod tbe company with many a war story,
enongb money lo engage even one of tieveu miles ninth of Jeffersuurille,
tbem to poor In pnbllr. lnd, live* Daniel I-au_.ii. Ho ho* Jnil
Tbe origin of lhn family ta connected celnhrnted his lOflth birthday, aud
wllb oue of lho wicbedcet upland.*"of still help* plant tho corn, enjoy* a
tbe early hiatcey of tbe New World. Ashing or banting excursion end faan-
T-MT* i* even a chance tbat perhaps die* a title iu true frotltietuman Olyle.
•ome Pittsley was * relative of Ihe Contrary to moat aged people, he
sweet and pious Evangeline Wben prldco himself in never having seen
tbo English deported fhmi Iho vale* of Waahlngton. Boono or otbor early
Aoadia tbe lamiHc. of tbo French notable*, and !,.,« never klltwcl an In-
neutrols and scattered tbem ln almost dlan.
evety fettlemrnt from ibe mouth of Mr*. Harriet McMurray an old ool-
the Penobecot aroand to Louisiana, orvd auntie, living In Wichita, Kan..
Freetown, wblob wo* near tho colony 1* 115 year* old. Her greatest delight
nf Plymouth, had not been ahlo to aend la mixing witb "quality," and almost
Ita full quota uf men Into the army.. »'*..' day aome ono take* ber ont for '
s.i In tbe distribution of tho Freocb Vcpin. She i* in full pom melon of
from Acadia fifteen men. with some her faculties, end renumbers seeing
woxntn and children, wer* left in Washington "tdttin* on tbe porch *t
Freetown. Alexandry. with ruffle* all np and
Tbo bitterest of ail wu tba sopors- down his shirt front and silk slocking*
tlon and splitting up of families. The and powerful while hair." Hhewo.
people were filled with dejection, and Col. Ridley's wife's housekeeper dor-
tbe poorest ot tbem appaTcnitv bol It; ing the war of tfilt.
some rude lodge In ibe forests and took Noah Baby, an inmate of tb* !_«_.*
no care how tbey lived. None spoko tawny poor farm, at New Branswick'.
tbelr language. Tbey were stranger*! N. J., 1* 1!_ y.ar* of ago. Ho waa I
In hablli and maimers. Men had been born at Eaton town, dates county,
Mparated from wtvea and daughter*. North Carolina, and served In the
and wive* left wllboot Ibeir husband*. United Stat** navy before the begin.
Joat what tbe name of the French nlng of Ibe present century. He was
neutral anoeator of the albino Pirtslrys a sailor on th* historic frigate Const! ■
may havo been no rcaearc). ba* ever .tutlon, and remember* bearing (.eoTge
revealed, tin the lown reourds, on nl' Washington make a speech ..tic. at
within fifty year*, tbe name boa been Norfolk. Baby now weight lex than
Flggsley. In many eaae* tb* *ame 100 pound*, and la vary weak, bnt In
I .Si**'. *y bo* been corrvpted into the foil pcaocaioo of bi* faculties. He
"Hoggaley." takes hia bitter* regularly, and ba*
Tbo first appearance of pink eye* bean an babllnal user of tobaoOn,
and wbllo hair waa Inn Hubert Pitta-; Richard lleddick*. colon.!, who
ley, somewhere lu Ihe first balf of tbe - claims to be ISO yeara af age, and Ibo
eighteenth century. Some plan It o* oldest man In tb* world. Uvea at Pitts.
•arly a* 1T3I. From" that time down berg. He is tbe only living rarvivor
tbe albino character.sties have been of Ihe revolutionary war,having served
oantinnatly reproduced. It la believed In Ibe camp of Ibo Continental army,
that contluual Intermarriogn has been Koddlak lay* (hat for lervloa* ren-
largely Instrumental ia banding down dared Ibe potriotlo can** by his people.'
Ibe pink eye* and white hair. Tbe his grandfOther aud father and Ibeir
PittBleyawm clannish. Tbfy wouldn't famlllee were freed em condition tb*t
mingle with otber famlUe*. much leas they would remove to a free State
take wive* from tbem.' Theyolnbbed wltblu twulve month*. Heddlok* la
by tbemjelvca, bol olteuer one family apparently clear-headed, and la air-
made* home for Itoelf inaomedeitTted anmstontlal In alt bla ilatemcnta.
house or Jnck*4 bonae (n a lonely port In proof of tbeee fact* be r*f*_* to lb*
...a ._■., -,..!>.. ■ i. ,afjhj.wjtr mtLof ntsord\j£ ,bl*.suuiBB_iaiion in tbe
a t-iwn-hip. Tb.v mrrlx rare* t. V*. eooniv reoord* *t Richmond, dated
taltve. In their ways anil their lore ■**■>'! *■ 1777.
of outdx* life tbeae people abow many; ■ •*« -——
of tb* cbaractorlstloa of gypxim, and: llanks— Let's go. Hirers. Four acta
another point wMcb allies Ibem to-of tbt* ia abont all I can eland,
the -rendering elan* it tbelr ability to Hit rt a—Let's .tt It out. Hank,
"nrap" bor***. a ba*t___a at which ■ Seven ot tto character*are killed off
mo« all of tbe males ar* expert*, j In the next act—Indlooapolli Journal.
SOMCTHINO- FOR AU RURAUSTS.
; latereatlng TeplMfortb* ggrtauiturtit,
Hortisuii .Htl an* flaaeral
.arai**.
Tbs Aalstlc T-.1-.
Probably no other fowls havo done
more to stimulate tbe tat*r**t In highbred poultry than bar* the Asiatic
race*. Tbey are the largest and moat
Impootngbreeda extant, and always
attract much attention at poultry exhibitions far tln'ir magnificent oarriaga
and form. Th«lr rich and lotmoa*
coloring and beautiful panelling are
■In strong point* in their favor. It
waa tbe Brahma and Coobln wbich
uindo such a fnrore fur largo fowls in
i the "hen fever days." These birdi
wem ram tbon, and faboluua pricea
were given for Inem; not exceeding.
bowev«r. many price* of -ibe present
day rvalixed i... tbe bt___l_ra of prlxe
aot-cininna at the largest nxhlbitlona.
i Thn Brabtua* are probably tha bent
known uf any thoroughbred .fowl
among American poultry keeper*, lt
Is tb* largeet af all, 12 poande bring
attained by many matured male*. Tbe
earrlago of a line old Brum ha oook a*
bn more* abont bl* Bock la truly a
noble sight. Tho prodacllou of perfectly patterned penciling, with tbe
coveted hU. r grotmd color on tbe female* of tbe Dark Brahma luxe* tbe
study of tbe moat oklllful fonder*: >
und thn clearly-I need hackle* and tail
.-.iv.-r i.-i of tbo Light showing strong .
1 black points, wllb * pure white surface, have been point* witb which few
have snoeeeded. As to economic value,
iho Brabmai rank high. Tbnro are
many good layers among tbem, ao lhat
If one keeps them fur eggs, bteoding '
from among the beat Layer* among
Ibem, he wlll eooa bava a very productive strain. Their egga are very
largo, and of rich color. Tb* Brahma
is .-.I.n-ivi-iy u: 4 in croase* to obtain
broiler* and fowls fur tbe fattening
pen, both In this coantry and Europe.
Tbere ore now being bred pur* white
Brobmat, claimed to to ^rurta from
the light.
Tbe Cochin traora to -tbat well-
knowu Shanghai "that grow ao tall,"
although careful aelecttv* brooding baa
made a greet change. And now we
lee In Jhe Cocbln lines of harmony
scarcely excelled ,,. any type, when
In tbe old Shanghai ihey were angular and nngraoefnl. Tbo Coebln* present to the eye a superb fowl. They'
appear, through their wonderful development of feather. larger even tbon
tbe Rrabmas, elibougfa in weight they
are bardly their equal. Tbe elan-fard
color* of tbe Coohin *re white, blaok,
luitt and partridge, tbo latter preeent-
Ing nearly tbe *«,„.• dtefirlullle* tn pro-'
4jncin^,tbe color a* tbe dark Brahma.
the pattern of tbe peadllng on the
females being alike. Tbe ground
color, however, la a golden mahogany
ma., .ni i -:i..T Tho dirt rib. tlon of
Ihe [colors an rbe partridge cock ia tbe
same a* nn tbe Dark Brahma, only
being rich gold and mahogany
where tbo Daik Brahma la silvery
wiiii.- It 1* Improbable that Ibli bird
has been used In strengthening tbe
pnwlilen of penciling on Ihe Dark
Brahma. In tbe "Lordly Ball" we
bare tbe truest Ideal Cochin form, the
longct-t feather and moot abundant
fluff, which gnea largely to making ap
tli„ <.-.tin's round appearanoo. Tho ■
Coobln Is bardly an economic bird,
being bred mostly for tbe fancy. It
i* fairly prodoctiee, bowevi-'. and
quite hardy.
Tbe Langahan Is tbe latest arrival
among the Ails tics, bnt it baa already
gained tbe reputation of being tbe
most productive. It is tbe smallett;
and moat active of tbem all Cock*
erelo. however, bare attained ten
I im ml-, at nine months, although that
ii abont a pound or two more than
i,-i,i.il. Tbe Blaoba were Ibe first color'
broogbt from Cblna. I heir native
couotiy. and have proven tbe most
hardy. The White* are albino sport*
from tbe Blacks, and not generally
considered quite as strong aa the latter. Ae egg produoom the Longshans
ore esteemed very hlgbly, and aa birds
foe tbe table tbey ai*e exoellenl.
ti.. Klafet-rrams in.*. it,lar...i.
In a recent gleaning Id Bee Cult un-,
C. Davenport saya be prefer* the eight-
frame rise biv* becaooe be it a _peda|.
lit, making bi* living by produdng
honey, and bis experience tells him
Ibat be can make mata money with a
Urge nnmber nf frame* Id eight-frame
!>!.■>■» (ban bo cod wllb the some nnm-,
ber In ten or twelve-frame bive*.
though iu *om* eraeona be find* it
necessary to feed tn order to keep
brood-rearing np.
He aaya: I ... not i .ink the locality I
makes in,;-!, difference to tho specialist
about Ihe right stve of^ive. Of course
II might moke a diffrrvnc*. aa to tb*
time, and amount to be fed. t believe
I can make mnre In any l.x_allty witb
frames in tbo elgbt-fra.ua hive than I,
eon with the same nnmber of frames
In larger ones, for my experience boo'
been that, ai a general thing, eight
r.. i ■ ■ are enough for tbe best queen*
w* mm get at the present time. In
raying "thr bett queens," I dn not
mean the*, that are tba mo*t prollfio. |
I hove bod queeoa Ibat would kaop'
ten. and. In a faw ■_..-•. eves twelve
frames fall ot brood, bot tbese qn*___a
needed to be, prolific, for tbelr beea
ware so abort-lived tbat then* onlonlea
ooold not stare a* much aurplua tu
otbefb win...- ijucfii. did not kaop
•Igbt fr-tne* fait.
Again. I bav* bad very prolific
qowvua wboie tot* lived long enongb;
but tbey wer* worthiest *o far aa nu- j
pin* boney waa couc«o*d. for their
entire time and atiin^-.a.. seamed lo be
devoted to rearing bee* and swarming.
Sometime* we aue reports uf queens
j Ibat will keep twlevo. <* oven fourteen
i frame* full of brood, ami tbelr beea
atom a large surplus. I bava had two
J or three *_cb ijiihiii. bat they or* very
tat* and bard to get: and If w* ooold.
get tbem. woold tbay be any bettor? |
Huppow. we bad queen* that wonld lay
I a* much aa two of the very beet onee
we now have, ooold w* get any more
. surplaa for tbe same number ol weak*.
. • ra. or per troa*. than w* now Ao? I,
i do not believe we eoold from my ox- \
1 perlunoe. I believe that, after a oolony
got* to a oertaln *t_engtb—a'atrengtb^
with Ibe right kind of a queen --the
: eight-frame hlv* given ample room to
' develop, and tbey will tton aa much
or more for tbe same number of work-;
| or* a* one muoh larger; and I bod !
;ninob rather produon 300 ponnda at.
'. honey in two eight-frame blvaa tban I
' would In one all lean -frame biva.
Some of the advocatea . . targe hive*
telli oi tbat bee* ln aaeh blvsa will'
roar a good many more beea daring
tbn lotler part of theaeaaun, and thus
have mora bee* for winter, and tbat,,
such being tbe oom, tb*y will winter
batter and build np faster In the,
spring. I will admit tbat oolonlea in
larger bivi* of twelve or fourteen
frame* will rear more beea ot a time,
when then. Is nothing for thorn lo do. '.
This i* wby colonise in big htr** do
not star* a* much surplus. lb take* a
good deal of bou*y lo rear *nd keep
tbeee extra bee* over winter— enough
ao tbat, ln largo aplarlea. It woald
amount to $100 or mure; and with ma
tbey BMMtaUj die uff in tbe apring before tbey have dona mnch If any good.
Bnt 1 winter in cellars altogether. In
onl-door wintering it may bo quite.
different, and the eanio may bn true of -
deep frame*. I imva belter su-cent:
In wintering wilh bee* on tbe Hondard
frames than J do On nn.— .1. ,i an
deeper.
Walaul Urasan.
The walnut grnwer* of Southern
California mot In oenventlon August
aotb in tb* asaembly room of the
Chamber of Commerce- life attendance woe quite Urge, tbere being
nearly eighty peeent at tbe afternoon
mmsIod, comprising delegate* frnnf
Bonto Barbara, Voutnra, Urango, San.
Diego and Loa Angele* cooolie*- Today'* boaine** waa largely coaBned to
odd res ws by som* of ibaee present on
the soils best adapted to tbe saoou-inl
gruwlboftbe walnut. Tbla convention fa tbe first of lu kind over held
In any part "(.ohc world) and aeveral
of the addreoM* toad* embody information Wblcb will prove moat valuable
walnut growers in otber parte of
TEEGRAPHIC NEWS.
Condensed Telegraphic Reports of
I-_.tr .-.vents.
tbat
mtry.
The aubjec. la o very lmpcnt*nt one
to South-en California, as by for tbe
greater bulk of the walnuts shipped
bona tbe Pacific Coact to tbe t_*stem
market* are grown In Southern California. In 1.. I tbe export* from hero
were H.I4B..0. pounds, and In t.n.
:...'.(.'.,Him pounds Tbe quantity of
walnuts imported doling tboee two
vr ar.. as nearly a* can be a-- it»,n. ..
waa about lfi.000,000 poundo. By
tbl* it.- seen thai tbere is still considerable margin for tbo SoDlboni California grower to wurk on, provided
always tbat tb* dnty nn the foreigp
article is not pot _■> low at to give tbe
foreign grower the advantage over the
S: ii,t in rt, Calif amis um,. The foreigner hoi tbe advantago already, aod
a very big one. In tbo matter nf
freight. It Is. therefore, perhaps not
too much to expect tbat tbe Uovara*
ment will protect Ita own against ibe
powers of otbor oaantrie*. Tbe former
duly waa 3 ceota a ponad on waliiuto,
but tho present (tovernment. In Its
rigb leonine**, saw fit to reduce it to _
cent* a pound.—Log Aogelea Ttmeai
A .,..1,11.-; «-.,,.
We not,i- that tn aome Btxtn tbere
ia muoh talk of un active, stringent
weed low and Ita atrlot enforcement.
Tbere ia mocb need of eoeh o low
and It* active operation in California.
and ll would afford a partial relief at
There I* no greater peat of this „ .-
tore in any coantry than tba wild
morning glory convolvulus avensis and
there is no weed mote difficult of extermination. It aeema to bav* been
seeded over tbe lower land* of Santa
Clara valley. Dan . oaqnin and Sacramento valleys by tho overflow of tbe
streams in the winter and spring, and
I* still further mattered by ordinary
.•-llltalH-a.
Ita disastrous effecti on orabarda
bavo been repeatedly noticed.
Marnlog glory can be completely
eradicated from any soil fay thorough
cultivation, and by thorough evltiva-
tion we mean that tbe plant meet not
b* allowed to show a green leaf above
tho aurfooe of tbo ground at any time.
One year will generally du tha work,
bat to be sure Ibe cultivation must go
well i,,i" the - :.- u.s ysar.
Land* ibat overflow will to **edcd
again unlcaa every farmer on tbe
airI-urns worka as well aa tbe muot vtg.
IlonL— Pacific Tree and Vine.
I-I..III. ■.' rrult.tit-oaalnc.
J. M. Main, a-boee place la about
•even mllea ont on tbe Laa Oato* rad,
think* be ho* no rraaon to complain of
bla oondltlun thia season.
Ho bas fifteen acre*, on wblch he
baa 7000 v|n*e. while tha remainder I*
planted lo prunes, reaches, and apri-
oota. Fn.ra sixty apricof treea be got
hi tone of fruit, being an avaroge of
300 -Kiunils lo the tree. Ho aold them
for |30 o ton, which hrongbt blm t)180
from a little more than balf an oero.
He aold hi* prunv* for f _o par Ion and
Is drying bi* p*n*-_besL Kt. -*£x*m it
one cf tbe many wbo bav* found
