162,508 research outputs found
La Belgique et la Première Guerre mondiale. Bibliographie I België en de Eerste Wereldoorlog. Bibliografie, sous la direction de P. Lefèvre et J. Lorette, par P. Philippe, L. Sieben, C. Van Tuijcom et E. Meuwissen
No full textDecock Pierre. La Belgique et la Première Guerre mondiale. Bibliographie I België en de Eerste Wereldoorlog. Bibliografie, sous la direction de P. Lefèvre et J. Lorette, par P. Philippe, L. Sieben, C. Van Tuijcom et E. Meuwissen. In: Revue belge de philologie et d'histoire, tome 68, fasc. 4, 1990. Histoire - Geschiedenis. pp. 1038-1039
La Belgique et la Première Guerre mondiale. Bibliographie I België en de Eerste Wereldoorlog. Bibliografie, sous la direction de P. Lefèvre et J. Lorette, par P. Philippe, L. Sieben, C. Van Tuijcom et E. Meuwissen
No full textDecock Pierre. La Belgique et la Première Guerre mondiale. Bibliographie I België en de Eerste Wereldoorlog. Bibliografie, sous la direction de P. Lefèvre et J. Lorette, par P. Philippe, L. Sieben, C. Van Tuijcom et E. Meuwissen. In: Revue belge de philologie et d'histoire, tome 68, fasc. 4, 1990. Histoire - Geschiedenis. pp. 1038-1039
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
The MAPK hypothesis: immune-regulatory effects of MAPK-pathway genetic dysregulations and implications for breast cancer immunotherapy
No full textWith the advent of checkpoint inhibition, immunotherapy has revolutionized the clinical management of several cancers, but has demonstrated limited efficacy in mammary carcinoma. Transcriptomic profiling of cancer samples defined distinct immunophenotypic categories characterized by different prognostic and predictive connotations. In breast cancer, genomic alterations leading to the dysregulation of mitogen-activated protein kinase (MAPK) pathways have been linked to an immune-silent phenotype associated with poor outcome and treatment resistance. These aberrations include mutations of MAP3K1 and MAP2K4, amplification of KRAS, BRAF, and RAF1, and truncations of NF1. Anticancer therapies targeting MAPK signaling by BRAF and MEK inhibitors have demonstrated clear immunologic effects. These off-target properties could be exploited to convert the immune-silent tumor phenotype into an immune-active one. Preclinical evidence supports that MAPK-pathway inhibition can dramatically increase the efficacy of immunotherapy. In this review, we provide a detailed overview of the immunomodulatory impact of MAPK-pathway blockade through BRAF and MEK inhibitions. While BRAF inhibition might be relevant in melanoma only, MEK inhibition is potentially applicable to a wide range of tumors. Context-dependent similarities and differences of MAPK modulation will be dissected, in light of the complexity of the MAPK pathways. Therapeutic strategies combining the favorable effects of MAPK-oriented interventions on the tumor microenvironment while maintaining T-cell function will be presented. Finally, we will discuss recent studies highlighting the rationale for the implementation of MAPK-interference approaches in combination with checkpoint inhibitors and immune agonists in breast cancer
Proposal to conserve the name Perenniporia against Physisporus with a conserved type (Basidiomycota)
No full textDecock & Stalpers discuss the current
taxonomic situation in Perenniporia and the subsequent
nomenclatural problems in detail. The current lectotype
of Perenniporia, Polyporus unitus Pers., long considered
to be identical with Boletus medulla-panis Jacq., is neither
conspecific nor congeneric with the latter. Hence the
current, well-known concept of Perenniporia, developed
around Perenniporia medulla-panis (Jacq. : Fr.) Donk, does
not include the actual type of the generic name
Improving nomenclatural consistency: a decade of experience in the World Register of Marine Species
Full text linkHorton, Tammy, Gofas, Serge, Kroh, Andreas, Poore, Gary C.B., Read, Geoffrey, Rosenberg, Gary, Stöhr, Sabine, Bailly, Nicolas, Boury-Esnault, Nicole, Brandão, Simone N., Costello, Mark J., Decock, Wim, Dekeyzer, Stefanie, Hernandez, Francisco, Mees, Jan, Paulay, Gustav, Vandepitte, Leen, Vanhoorne, Bart, Vranken, Sofie (2017): Improving nomenclatural consistency: a decade of experience in the World Register of Marine Species. European Journal of Taxonomy 389: 1-24, DOI: https://doi.org/10.5852/ejt.2017.38
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
COPPER(II) COMPLEXES OF LACTOBIONIC ACID - LACTONE-ACID EQUILIBRIUM AND PROTON DISSOCIATION
No full textPotentiometric, polarographic, and spectroscopic data allowed us to establish the coordination equilibria in the Cu(II) lactobionic acid system. At lower pH regions the equilibrium between acid and lacton forms is also described. The stability constants of the cupric species are about a hundred or more times higher when compared to the galacturonic acid complexes, although the coordination modes in both systems are exactly the same. The obtained results clearly indicate that lactobionic acid is a very efficient chelating agent for metal ions most likely due to secondary interactions between protonated hydroxyl groups and metal ions, as well as possible interligand interactions. These interactions are likely to favor lactobionic acid rather than uronic acids, due to its higher flexibility
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