2,067 research outputs found
P. Stanislaus De Backer, S. J., Institutiones Metaphysicae specialis, t. II et III : Psychologia
No full textFaelens Gaston. P. Stanislaus De Backer, S. J., Institutiones Metaphysicae specialis, t. II et III : Psychologia. In: Revue néo-scolastique. 12ᵉ année, n°46, 1905. pp. 279-280
P. Stanislaus De Backer, S. J., Institutiones Metaphysicae specialis, t. II et III : Psychologia
No full textFaelens Gaston. P. Stanislaus De Backer, S. J., Institutiones Metaphysicae specialis, t. II et III : Psychologia. In: Revue néo-scolastique. 12ᵉ année, n°46, 1905. pp. 279-280
't Hollandts Venezoen in Engelandt gebacken Wederleyt door d'Amsterdamse Pastey-Backer Tegen sijn Buyrman Brandt
No full textTiele: "Gesprek tussen Pasteybacker en (Geeraert) Brandt. Van den Venezoen zegt de eerste: "Sy seggen datse op de Singel gemengt, en op de Keysersgracht by de Heere straet gekneet, en in de Dirck-van-assens-steegh gebacken is".Knuttel, W.P.C. Catalogus van de pamfletten-verzameling berustende in de Koninklijke Bibliotheek, 10618Toegeschreven aan Joachim Oudaan of Pieter de GrootKolumnentitel: Buur-Praetjen Tusschen een Pastey-Backer,en sijn Buyrman Brandt, Klagende aen de selve over 't Bederf van sijn NeeringeKnuttel 10618Tiele, P. A. Bibliotheek van Nederlandsche pamfletten 1,3,6533STCN 86315726
Music Therapy Training:a Process to Develop the Musical and Therapeutic Identity of the Music Therapist
No full textKonsthistoriepodden, avsnitt 35: Harriet Backer, Barndop i Tanum kyrka
No full textI detta poddavsnitt förenar vi våra forskningsintressen, 1800-talsmåleri och medeltida kyrkor: vi pratar om den norska konstnären Harriet Backers målning ”Barndop i Tanum Kyrka” från 1892. Vanligtvis finns konstverket att beskåda på Nasjonalmuseet i Oslo, men just nu kan man se det på den stora Harriet Backer-utställningen på Nationalmuseum i Stockholm. Harriet Backer är en av de mest kända norska konstnärerna. Hennes yrkeskarriär spänner över 50 år och en tid då konstvärlden ändrade sig radikalt för kvinnor. När Harriet Backer började sina konstnärliga studier på 1870-talet var det ett mansdominerat fält. Hon blev framgångsrik och erkänd, men hon var likväl “bara” en kvinna. Jens Thiis, som var direktör för Nasjonalgalleriet i Oslo från 1908-1941, skrev om henne i sin bok om norska målare och bildhuggare 1907: “Fröken Backer är i själva verket den av alla norska målarinnor som är mest née peintre [alltså: född till målare] och även i sina manliga kollegors lag intar hon en hög ställning som målare.” I poddavsnittet berättar vi mer om Harriet Backers karaktäristiska intima och självupplevda sätt att skildra norska kyrkorum som är unikt i den norska konsthistorien. Vi berättar hur interiörsgenren blev populär på 1800-talet och hur Backer anknöt till 1800-talets olika nationalromantiska skildringar av kyrkorummet eller psykologiserande närstudier av kyrkobesökare, men också den hårda kritiken hon mötte. Samspelet av färgerna, ljus och skuggan som skapar den stämningsfulla atmosfären i hennes målningar åstadkom hon genom sitt noggranna arbete på plats, t ex i den iskalla kyrkan i Tanum. Eftersom hon antog sig sina motiv på samma sätt som en friluftsmålare, kan man med all rätt kalla hennes målningar för ett “inomhus-friluftsmåleri”. Avsnittet handlar också om Harriet Backers konstnärliga utveckling från hennes tidiga måleri i Düsseldorfsskolans anda tills friluftsmåleriet och impressionismen satte sina spår på hennes naturalistiska färgmåleri under hennes år i Paris
Involvement of two Ets binding sites in the transcriptional activation of the MAGE1 gene
No full textThe MAGE1 gene codes for an antigen recognized on melanoma cell line MZ2-MEL by autologous cytolytic T lymphocytes. It is expressed in a number of tumors of different histological origins, but not in normal tissues except in testis. The MAGE1 promoter region was analyzed by performing transient transfections in MZ2-MEL cells with luciferase reporter plasmids. A fragment extending from nucleotide -792 to +118 exhibited high transcriptional activity. By deletional analysis of this fragment, we identified five activating regions designated C, A, B', B, and D. The activity of region A depends on the presence of region B' and vice versa. Two inverted Ets motifs contained in regions B' and B were found to drive 90% of the activity of the MAGE1 promoter in MZ2-MEL cells. Electrophoretic mobility shift assays performed with a nuclear extract from MZ2-MEL cells and with competitor oligonucleotides containing an Ets consensus site showed that nuclear proteins bind to the Ets motif of regions B' and B. Similar experiments suggested that region A binds transcription factors of the Sp1 family. The MAGE1 promoter was found to exert transcriptional activity in tumor cells where the MAGE1 gene is not expressed, suggesting that other mechanisms, such as demethylation, may contribute to the tumor-specific expression of the gene
Averting a pandemic health crisis in Europe by 2020: what physicians need to know regarding cholesterol management
No full textBACKGROUND: Cardiovascular disease (CVD) represents a major cause of premature death, disability, and escalating healthcare costs throughout Europe. According to a recent report by the Stockholm Network (an independent European 'think tank'), major political, economic, social, and medical changes are urgently needed with respect to cholesterol management to help prevent CVD. METHODS: To identify key cholesterol management issues that practitioners should consider to help prevent an impending European health crisis, our collective experience of policies and practices relating to CVD and cholesterol management in our respective countries was consolidated and used to develop this commentary. RESULTS: Physicians and healthcare workers are uniquely positioned to make immediate and meaningful improvements in preventing and treating CVD if they recognize and address a handful of key clinical issues pertaining to cholesterol management. These issues include utilizing newer combination therapies and realizing the limitations of statins, improving compliance with cholesterol-lowering therapies, promoting a healthy lifestyle and diet, making treatment decisions based on patients' total CVD risk, fostering communication between primary and secondary providers, and soliciting governmental funding to implement disease management programmes. CONCLUSIONS: By promptly and effectively addressing these cholesterol management issues, physicians and other healthcare professionals have an unprecedented opportunity to help reduce CVD in Europe to lessen the personal, social, and economic impact of this devastating disease
Peer Networking and Community Change: Improving Foundation Practice
No full text· This article brings together the Annie E. Casey Foundation’s 15 years of experience with peer networking— examining through two research studies the process of peer networking and its impact, both with community-based and funder groups.
· Peer networking helps people with common interests to exchange information, disseminate good practices, and build a leadership structure for work they do together, such as a community change initiative.
· Casey’s research identified 10 good practices for effective peer networking, as well as 10 challenges that can affect its success; a four-level model was created to provide context for these findings.
· The research indicates that peer networking can have significant impact for communities and in meeting philanthropic goals, but it is costly and must be carefully structured if it is to be successful.
· Casey is working to synthesize its peer networking practices into a more strategic framework, and other foundations might use some of its lessons learned to enhance their own practices in this area
How sample handling distorts telomere studies
No full textTelomere length (TL) is investigated as a biomarker for aging and disease-susceptibility, but
measurement using quantitative polymerase chain reaction (qPCR) faces challenges in accuracy
and reproducibility. The potential impact of pre-analytical factors on TL measurements remains
underexplored. We evaluated the impact of delayed blood processing, a typical feature in population
studies. Blood samples from 35 adults were processed for buffy coat extraction either immediately or
kept at 4 °C and processed after three and seven days (total n=105). After processing, samples were
stored at -80 °C. Relative TL was measured via qPCR and expressed as T/S ratio. Strikingly, delayed
blood processing led to a significant increase in TL: the mean T/S ratio was 0.886±0.205 at day 0, rising
to 1.022±0.240 at day 3 (p=0.03) and to 1.190±0.205 at day 7 (p<0.001), corresponding to increases
of 15% and 34%, respectively. Notably, TL correlated inversely with DNA integrity. These findings
underscore the critical impact of delayed sample processing on TL measurements, emphasizing the
need for consistent pre-analytical protocols to ensure accurate and reliable research outcomes. The
impact of our findings is considerable as it may overshadow not only previously reported results but
also real biological differences in TL between studied groups of patients.This work is funded in part by the Research Foundation Flanders (grant number G072022N to JDB and grant
number 12X9623N to DSM)
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.
No full textOBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock.
METHODS: The European Society of Intensive Care Medicine invited 12 experts to form a Task Force to update a previous consensus (Antonelli et al.: Intensive Care Med 33:575-590, 2007). The same five questions addressed in the earlier consensus were used as the outline for the literature search and review, with the aim of the Task Force to produce statements based on the available literature and evidence. These questions were: (1) What are the epidemiologic and pathophysiologic features of shock in the intensive care unit ? (2) Should we monitor preload and fluid responsiveness in shock ? (3) How and when should we monitor stroke volume or cardiac output in shock ? (4) What markers of the regional and microcirculation can be monitored, and how can cellular function be assessed in shock ? (5) What is the evidence for using hemodynamic monitoring to direct therapy in shock ? Four types of statements were used: definition, recommendation, best practice and statement of fact.
RESULTS: Forty-four statements were made. The main new statements include: (1) statements on individualizing blood pressure targets; (2) statements on the assessment and prediction of fluid responsiveness; (3) statements on the use of echocardiography and hemodynamic monitoring.
CONCLUSIONS: This consensus provides 44 statements that can be used at the bedside to diagnose, treat and monitor patients with shock
- …
