108 research outputs found
Loss of efficacy during long-term infliximab therapy for sight-threatening childhood uveitis
No full textObjective. To describe efficacy and safety of infliximab in the treatment of childhood chronic uveitis during a long-term follow-up. Methods. Fifteen patients (median age 12 yrs, range 5-21 yrs) with chronic uveitis were enrolled. Before infliximab treatment, children had presented active uveitis despite treatment with MTX and/or CSA. All were also receiving oral prednisone (1-2 mg/kg/day) for at least 1 month. Infliximab (5 mg/kg) was administered at weeks 0, 2, 6 and then every 6-8 weeks. Later on, in patients enrolled in Florence the administration interval was progressively increased up to 10 weeks if uveitis did not flare, whilst in children from Padua the scheduled infusion rate was maintained every 6 weeks. Absence or recurrence rate of uveitis up to the last visit was recorded. Results. Median follow-up on treatment was 30 months (range 16-38 months), median number of infusions 22 (range 11-30). During the first year, 13/15 children achieved a complete remission over a median period of 10 weeks, but all relapsed thereafter. The probability of a first relapse was correlated to length of treatment, once remission was achieved (P < 0.03). The total number of relapses correlated with the duration of treatment (rs = 0.81; P < 0.002) and with the total number of infusions (rs = 0.83; P = 0.001). The total number of relapses on treatment at last follow-up was not significantly different between the two centres. Conclusions. Even if limited to a small group, infliximab appears to be an effective treatment for uveitis in children, but its efficacy seems to wane over time. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved
A new computerized method for the assessment of skin lesions in localized scleroderma
No full textObjective. Up to now, no validated tools are in use for the assessment of the skin lesions in localized scleroderma (LS). The aim of this study is to evaluate the performance of a new computerized skin score (CSS) method for the measurement of circumscribed lesions in LS. Methods. The study consisted of three phases: see up of the CSS technique, measurement of target lesions of LS patients, assessment of intra- and inter-rater reliability. The CSS technique consists in delimitating the indurate lesion on an adhesive transparent film, transferring it over a cardboard and then calculating the affected area with a specifically created software. The technique was explained to a panel of 10 physicians with different expertise in LS (three paediatric rheumatologists, two dermatologists, five paediatric residents). All participants, singularly and blindly to the others, examined 10 consecutive atients twice after a time interval of at least 6 h. The intra-observer variability was evaluated by the repeatability coefficient and the inter-rater reliability by the intra-class correlation oefficient (ICC). Results. The repeatability coefficients were good, ranging between 1.90 and 7.03. The mean values of skin scores were not significantly different among the examiners. The ICC for indurate area calculation were high in both the experts (0.97) and the residents (0.91-0.94). Conclusions. CSS has shown to be a reliable method to assess the skin lesions in patients with LS. It is reproducible, easy to use and, with the support of the CSS software, applicable worldwide. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved
Urban heat island mitigation by green infrastructure in European Functional Urban Areas
Get PDFThe Urban Heat Island (UHI) effect is one of the most harmful environmental hazards for urban dwellers. Climate change is expected to increase the intensity of the UHI effect. In this context, the implementation of Urban Green Infrastructure (UGI) can partially reduce UHI intensity, promoting a resilient urban environment and contributing to climate change adaptation and mitigation. In order to achieve this result, there is a need to systematically integrate UGI into urban planning and legislation, but this process is subject to the availability of widely applicable, easily accessible and quantitative evidence. To offer a big picture of urban heat intensity and opportunities to mitigate high temperatures, we developed a model that reports the Ecosystem Service (ES) of microclimate regulation of UGI in 601 European cities. The model simulates the temperature difference between a baseline and a no-vegetation scenario, extrapolating the role of UGI in mitigating UHI in different urban contexts. Finally, a practical, quantitative indicator that can be applied by policymakers and city administrations has been elaborated, allowing to estimate the amount of urban vegetation that is needed to cool summer temperatures by a certain degree. UGI is found to cool European cities by 1.07 °C on average, and up to 2.9 °C, but in order to achieve a 1 °C drop in urban temperatures, a tree cover of at least 16% is required. The microclimate regulation ES is mostly dependent on the amount of vegetation inside a city and by transpiration and canopy evaporation. Furthermore, in almost 40% of the countries, more than half of the residing population does not benefit from the microclimate regulation service provided by urban vegetation. Widespread implementation of UGI, in particular in arid regions and cities with insufficient tree cover, is key to ensure healthy urban living conditions for citizens
Entre o aggiornamento e a solidão: práticas discursivas de D. Antônio Mazzarotto, primeiro bispo diocesano de Ponta Grossa - PR (1930-1965)
Get PDFTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-graduação em HistóriaAnálise das práticas discursivas de D. Antonio Mazzarotto, primeiro bispo da Diocese de Ponta Grossa PR (1930-1965). D. Antonio nasceu em 1890, em Santa Felicidade (PR), e foi ordenado em 1914. Ainda um jovem sacerdote, angariou fama de erudição, eloqüência na pregação e empenho na direção espiritual da juventude. Desde a época do seminário até 1965, quando renunciou, sua produção escrita foi incessante. Voltou-se especialmente para a escrita de cartas pastorais, publicadas todo dia 23 de fevereiro e nelas veiculou o programa da Restauração Católica para a diocese. Em Ponta Grossa, locus de disputa de projetos múltiplos e desiguais, D. Antonio representou o esforço unificador e normatizador da instituição católica. Bispo exemplar e inserido numa determinada tradição espiritual suas representações discursivas explicitam simultaneamente a influência da formação e os sentidos singulares da mensagem anunciad
Pengembangan Modul Digital Pada Mata Pelajaran Komputer Dan Jaringan Dasar Program Keahlian TKJ Di SMKN 2 Malang
No full textRINGKASAN Pada pembelajaran di Kelas X Program Keahlian TKJ SMKN 2 Malang pada mata pelajaran Komputer dan Jaringan Dasar belum ada bahan ajar yang sesuai sebagai acuan belajar siswa. Selama ini guru mencari materi dari berbagai sumber yang disesuaikan dengan silabus yang ada. Siswa Kelas X Program Keahlian TKJ SMKN 2 Malang pada mata pelajaran Komputer dan Jaringan Dasar kurang termotivasi dalam pembelajaran sehingga kurang aktif dalam pembelajaran. Hal tersebut menyebabkan pembelajaran kurang maksimal sehingga membutuhkan bahan ajar mandiri yang dapat digunakan oleh siswa yang memiliki bermacam-macam gaya belajar. Salah satu alternatif adalah dengan pembuatan modul digital dengan format e-pub. Model pengembangan yang digunakan adalah model pengembangan R&D menurut Sugiyono, langkah-langkahnya adalah ; (1) Potensi dan masalah, (2) Pengumpulan data, (3) Desain produk, (4) Validasi desain, (5) Revisi desain, (6) Uji coba produk, (7) Revisi produk, (8) Uji coba pemakaian, (9) Revisi produk, dan (10) Produksi massal. Tingkat kelayakan modul digital Komputer dan Jaringan Dasar yang diperoleh dari hasil validasi para ahli dan siswa antara lain: (1) ahli media menyatakan produk ini layak digunakan dengan perolehan persentase 92%. (2) ahli materi menyatakan produk ini layak digunakan dengan perolehan persentase 91%. (3) responden pada uji coba kelompok kecil dan uji coba lapangan menyatakan produk ini layak digunakan dengan perolehan masing-masing 76% dan 81%. Berdasarkan hasil yang telah dipaparkan di atas, menunjukkan bahwa perolehan persentase minimal 76% sehingga modul digital dinyatakan sangat layak digunakan dengan mempertimbangkan komentar, kritik, dan saran
Para além das instituições: Veblen e um sistema de tecnologias
No full textAlthough Veblen is recognized for the theme of institutions, there are substantial contributions from the author on technology and its importance in the process of institutional change. Considering that Veblen gained notoriety for his institution-centered approach, the problem that motivated this research arises from the following question: what are Veblen's contributions to technologies? Based on a theoretical-argumentative discussion, with authentic interpretations of the author's main ideas, this article aims to structure Veblen's contributions on technologies. Technology is considered by Veblen as an element immersed in economic and social relations and that goes beyond its physical and material aspect. Both machines and equipment (physical technology) and knowledge accumulated in individuals (social technology) are part of what is called Veblen's “system of technologies” and is related to the “system of institutions”.Apesar de Veblen ser reconhecido pela temática das instituições, existem contribuições substanciais do autor sobre a tecnologia e a sua importância no processo de mudança institucional. Tendo em vista que Veblen ganhou notoriedade pela abordagem centrada nas instituições, o problema que motivou essa pesquisa decorre do seguinte questionamento: quais as contribuições de Veblen sobre as tecnologias? A partir de uma discussão teórica-argumentativa, com interpretações autênticas das principais ideias do autor, este artigo objetiva estruturar as contribuições de Veblen sobre as tecnologias. A tecnologia é considerada por Veblen como um elemento imerso nas relações econômicas e sociais e que vai além do seu aspecto físico e material. Tanto as máquinas e os equipamentos (tecnologia física) quanto os conhecimentos acumulados nos indivíduos (tecnologia social) fazem parte do que é chamado de “sistema de tecnologias” de Veblen e se relaciona com o “sistema de instituições”
Mycophenolate mofetil for the treatment of juvenile onset SLE: A multicenter study
No full textMycophenolate mofetil (MMF) has proved to be an efficacious and safe therapy in adult lupus nephritis. Recently, this drug has been suggested as a possible new alternative treatment also for juvenile-onset SLE (juvenile-SLE). A multicenter study has been performed to evaluate the efficacy and safety of MMF in controlling the disease activity in children and adolescents with juvenile-SLE. Our results show that MMF was effective in reducing the disease activity or as a steroidsparing agent in 14 of 26 patients (54%), stabilised the disease in 8 (31%) and was ineffective in 4 (15%). In particular, in patients without renal involvement, a good response was registered in 9 of 13 patients (69%). Among those patients with renal involvement, MMF was effective in 5 of 13 patients (38%), partially effective in 4 (31%) and ineffective in 4 (31%). No severe side effects have been observed; only two patients stopped the drug because of severe diarrhoea and abdominal pain. With the limits of a retrospective study, MMF seems to be effective and safe for the treatment of juvenile-SLE, especially in patients with no renal involvement. Copyright © The Author(s), 2009
Juvenile and young adult-onset systemic sclerosis share the same organ involvement in adulthood: Data from the Eustar database
No full textObjective. The aim of the present study was to explore the long-term outcome and clinical characteristics of adult patients with juvenile onset in the EULAR Scleroderma Trials and Research (EUSTAR) cohort and compare them with adult patients with onset between 20 and 40 years of age.Methods. From the EUSTAR SSc cohort two patient groups were analysed: patients with juvenile SSc (jSSc) who are adults at present, and patients diagnosed between the age of 20 and 40 years (aSSc). Demographic data of the patients, organ involvement and outcome of the disease were examined using the Minimal Essential Data Set database system.Results. From 5000 patients in the EUSTAR cohort, 60 patients (1.2%) with jSSc and 910 patients (18%) with aSSc were selected according the inclusion criteria. In the jSSc group, the mean age of disease onset was 12.4 years (range 2-15.9 years), and in the aSSc group, the mean age was 32 years (range 20-40 years). Disease subsets were similar. The antibody profile was also comparable except for ACAs, which were positive in 5% of the jSSc group and 26.9% of the aSSc group (P < 0.005). Organ involvement (lung, kidney, joint, muscle and heart) was similar in the two groups of patients at the time of the last follow-up.Conclusion. The subset distribution in the jSSc and aSSc cohorts was found to be similar. Only the frequency of ACAs was significantly lower in the jSSc, which supports the hypothesis that the SSc patients with paediatric onset in the adult cohort may represent a distinct subgroup of the complete cohort of paediatric patients. © The Author 2012. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved
MANAJEMEN PEMBINAAN SPIRITUAL WARGA BINAAN DI LEMBAGA PEMBINAAN KHUSUS ANAK KELAS II BANDAR LAMPUNG
Get PDFABSTRAK
Pembinaan spiritual adalah suatu proses bimbingan untuk
memperbaiki tingkah laku narapidana atau warga binaan agar
memiliki kepribadian baik, akhlak yang terpuji dan bertanggung
jawab, agar pembinaan itu berjalan dengan baik diperlukan
manajemen pembinaan spiritual yang tepat. Lembaga LPKA kelas II
Bandar Lampung dalam membina spiritual warga binaan sudah
menerapkan prinsip-prinsip manajemen, namun dalam penerapan
fungsi pelaksanaan tidak terimplementasikan dengan baik. Karena itu
maka penelitian berusaha mengungkapkan proses pembinaan spiritual
warga binaan klas II bandar lampung.
Penilitian ini menggunakan penelitian kualitatif. sumber data
pada penelitian ini yaitu Staff Lapas, Ustadz atau pembina spritual dan
Warga binaan. Metode pengumpulan data yang digunakan dalam
penelitian ini yaitu wawancara (interview) berupa wawancara non
struktur, Observasi dan Dokumentasi. Setelah data terkumpul
kemudian penulis melakukan analisis data dengan melakukan reduksi
data dan display data, untuk menarik kesimpulan menggunakan teknik
deduktif yaitu dengan melakukan penarikan kesimpulan yang
berangkat dari fakta-fakta khusus dan ditarik kesimpulan secara
umum.
Hasil penelitian ini menunjukan bahwa manajemen pembinaan
spiritual warga binaan di LPKA kelas II Bandar Lampung ,yang
diawali proses perencanaan meliputi pembinaan spiritual dengan
program-program mingguan, bulanan dan tahunan. Lalu proses
pengorganisasian pembinaan spiritual yang meliputi pembagian tugas
serta hal-hal yang akan dilakukan dengan orang yang akan
melaksanakan. Selanjutnya yaitu pelaksanaan pembinaan spiritual
dapat dikatakan belum maksimal karena kegiatan pembinaan spiritual
di Lembaga belum terimplementasikan dengan baik yang pertama
pada pelaksanaan pembinaan spiritual yang monoton terkait program�program yang Lembaga buat. Terakhir, dilakukan proses pengawasan
atau evaluasi oleh petugas terkait bagaimana sistem kegiatan yang
telah dilakukan menggunakan metode instrumen.
Kata Kunci : Lembaga pembinaan khusus anak, Manajemen
pembinaan spiritual
iii
ABSTRACT
Spiritual formation is a process of guidance to improve the
behavior of prisoners or fostered citizens so that they have good
personalities, commendable and responsible morals, so that the
formation runs well, proper spiritual formation management is
needed. LPKA class II Bandar Lampung institution in fostering the
spirituality of fostered residents has applied management principles,
but in the implementation of the implementation function is not
implemented properly. Therefore, the research seeks to reveal the
process of spiritual formation of class II assisted citizens of Bandar
Lampung.
This research uses qualitative research. The sources of data in
this study are Lapas Staff, Ustadz or spiritual coaches and fostered
citizens. The data collection method used in this study is interviews in
the form of non-structured interviews, observation and
documentation. After the data is collected, the author analyzes the
data by reducing data and displaying data, to draw conclusions using
deductive techniques, namely by drawing conclusions that depart from
specific facts and draw conclusions in general.
The results of this study show that the management of spiritual
formation of fostered residents in LPKA class II Bandar Lampung,
which begins the planning process includes spiritual formation with
weekly, monthly and annual programs. Then the process of organizing
spiritual formation which includes the division of tasks and things to
be done with the person who will carry out. Furthermore, the
implementation of spiritual formation can be said to have not been
optimal because spiritual formation activities in the institution have
not been implemented properly, the first is the implementation of
monotonous spiritual formation related to the programs that the
institution makes. Finally, a process of supervision or evaluation is
carried out by officers related to how the system of activities that have
been carried out using the instrument method.
Keywords: Special child formation institution, Spiritual formation
managemen
ANALISIS BATASAN PEMBERIAN INFORMASI SAHAM KEPADA PUBLIK OLEH INFLUENCER SAHAM BERDASARKAN UNDANGUNDANG NOMOR 8 TAHUN 1995 TENTANG PASAR MODAL
Get PDFIndonesia Stock Exchange (IDX) recorded, in total of 10.3 million investors
on December 28, 2022, marking a 37.5% increase from 7.48 million investors. The
majority of these investors, approximately 81%, are domestic investors. As the
number of retail investors continues to rise, stock influencers are considered to
influence stock market participation. Therefore, it is necessary to establish a legal
framework for stock influencers when providing information to the public, with the
intention of preventing any potential losses to followers or capital market investors.
The issues raised are the limitations of stock influencers in providing information
to the public and the legal consequences of violations in conjuction with
government's efforts to overcome the practice of stock pom-poms.
With this interest in mind, the author has chosen to address this issue in the
form of a thesis titled "Analysis of Limits on Stock Information Dissemination to the
Public by Stock Influencers Based on Law Number 8 of 1995 on the Capital
Market." The research methodology will involve a normative juridical legal study
and literature review (library research). The normative legal research aims to
identify legal rules that address legal issues or reveal scientific truths. It utilizes a
statutory approach, focusing on legal provisions and regulations.
The findings of this study reveal that the Capital Market Law (UUPM)
prohibits stock recommendation actions by stock influencers who do not possess
authorization from the Financial Services Authority (OJK). Moreover, in the
dissemination of public information, stock influencers are prohibited from
providing misleading material facts, or engaging in fraud or market manipulation,
which may create misleading perceptions about an issuer. On top of that, stock
influencers are forbid for being affiliated with an issuer, which includes insider
trading activities. The OJK, as the regulatory body, and the Indonesia Stock
Exchange (IDX), as the facilitator of the capital market, provide legal protection
efforts that are both preventive and punitive. The preventive legal protection effort
includes updates to capital market regulations, social education through webinars
such as the School of Capital Market, Investor Protection Fund by Indonesia SIPF,
and consumer services provided by the Financial Services Authority (OJK). The
punitive effort includes administrative, criminal, and civil sanctions along the
disgorgement funds as a form of a legal protection
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