460 research outputs found
Perspectives on Policy Analysis: A Framework for Understanding and Design
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Policy Analysi
Kirtland Temple: The Biography of a Shared Mormon Sacred Space
No full textDavid J. Howlett, a professor and member of the Community of Christ, opens up a view of the Kirtland Temple that is not often considered by members of The Church of Jesus Christ of Latter-day Saints. Howlett chronicles the various ways that the Kirtland Temple has been a point of conflict and confluence, influencing the interaction between faith traditions stemming from Joseph Smith’s religious experiences
How to involve inhabitants in urban design planning by using digital tools?: An overview on a state of the art, key challenges and promising approaches
No full textDifferent cases of public disagreement in different European countries have shown recently that perusing a thorough planning process is by no means a guarantee for a broad public acceptance of an envisioned urban project. Consequently, the employment of digital media and tools to enable participation of inhabitants in urban planning processes on a massive scale is a promising, but currently not comprehensively analyzed approach. Our research activities are intended to gain an overview on a state of the art of research on communication channels, methods and best practices as well as to identify key challenges and promising strategies and tools to overcome these challenges with specific regards to large numbers of users and digital supported approaches. The latter aspects comprise the investigation of phenomena like participant selection, framing effects and gamified approaches for digital-mediated participatory processes as well as native language processing techniques to examine opinions as well as ideas of relevance from massive public feedback. To examine, we performed literature reviews of several hundred research articles, investigated cases in Germany, France and the Netherlands by interviews and workshops with stakeholders and employed methods of prototyping to conceptualize, develop and assess some promising approaches such as sentiment analysis in detail.OLD Management and Organisatio
Goodbye to projects? The institutional impact of sustainable livelihoods approaches on development interventions
No full textThe research goodbye to projects grew out of the increasing interest in sustainable livelihoods approaches (SLA) and growing disillusion with projects as mechanisms for addressing the development needs of the poor. Its aim was to investigate the implication of the adoption of SLA on the management of development interventions and in particular of the future of development projects. The underlying research questions were: a) How are elements of the sustainable livelihoods principles being applied in practice b) What are the problems and challenges for managing livelihoods-oriented development interventions? c) What is the future for development projects, given the increase in direct budget and sectoral assistance?Livelihoods, Projects, Economic development, EPRC, Muhumuza, Sustainable development, Financial Economics, Institutional and Behavioral Economics, International Relations/Trade, Labor and Human Capital, Livestock Production/Industries, Political Economy,
Government Communication as a Policy Tool: A Framework for Analysis
No full textGovernment communication is now a large growth industry in many countries. Exactly what is meant by the term, however, varies from author to author. In this paper government communication is conceived as a policy tool or instrument, that is, as a means to give effect to policy goals. Three key policy-relevant aspects of the term are examined: (1) the link between government communications and the ‘nodality’ or information resource set out by Hood in his study of policy instruments; (2) the role of government communications in the ‘front-end’ of the public policy and production processes related to agenda-setting, policy formulation and producer activities as opposed to the ‘back-end’ of policy implementation, policy evaluation,, consumption and distribution and (3) the general aims of network management and overcoming information asymmetries which help explain the range of procedural and substantive policy tools used in government communication efforts. A model of four basic types of government communications is developed and examples provided of each general category. The implications of this analysis for cross-national comparative policy analyses of government communication activities and the evaluation of accountability and policy efficacy in contemporary governance are then discussed
Abstract 08: Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas
No full textAbstract
Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs) are deadly and common cancers. Recent genomic studies implicate multiple genetic pathways, including cell signaling, cell cycle and immune evasion, in their development. Here we analyze public data sets and uncover a previously unappreciated role of epigenome deregulation in the genesis of 13% of HPV-negative HNSCCs. Specifically, we identify novel recurrent mutations encoding p.Lys36Met (K36M) alterations in multiple H3 histone genes. We further validate the presence of these alterations in multiple independent HNSCC data sets and show that, along with previously described NSD1 mutations, they correspond to a specific DNA methylation cluster. The K36M substitution and NSD1 defects converge on altering methylation of histone H3 at K36 (H3K36), subsequently blocking cellular differentiation and promoting oncogenesis. Our data further indicate limited redundancy for NSD family members in HPV-negative HNSCCs and suggest a potential role for impaired H3K36 methylation in their development. Further investigation of drugs targeting chromatin regulators is warranted in HPV-negative HNSCCs driven by aberrant H3K36 methylation.
Citation Format: Chao Lu, Simon Papillon-Cavanagh, Tenzin Gayden, Leonie G. Mikael, Denise Bechet, Christina Karamboulas, Laurie Ailles, Jason Karamchandani, Dylan M. Marchione, Benjamin A. Garcia, Ilan Weinreb, David Goldstein, Peter W. Lewis, Octavia-Maria Dancu, Sandeep Dhaliwal, William Stecho, Christopher J. Howlett, Joe S. Mymryk, John W. Barrett, Anthony C. Nichols, C David Allis, Jacek Majewski, Nada Jabado. Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr 08.</jats:p
Strengthening the bound on the mass of the lightest neutrino with terrestrial and cosmological experiments
No full textWe determine the upper limit on the mass of the lightest neutrino from the most robust recent cosmological and terrestrial data. Marginalizing over possible effective relativistic degrees of freedom at early times ((N)(eff)) and assuming normal mass ordering, the mass of the lightest neutrino is less than 0.037 eV at 95% confidence; with inverted ordering, the bound is 0.042 eV. These results improve upon the strength and robustness of other recent limits and constrain the mass of the lightest neutrino to be barely larger than the largest mass splitting. We show the impacts of realistic mass models and different sources of (N)(eff).Patrick Stöcker, Csaba Balázs, Sanjay Bloor, Torsten Bringmann, Tomás E. Gonzalo, Will Handley, Selim Hotinli, Cullan Howlett, Felix Kahlhoefer, Janina J. Renk, Pat Scott, Aaron C. Vincent, and Martin White (The GAMBIT Cosmology Workgroup)
Validating and designing a service centric view for C2TP:Cloud computing tipping point model
No full textThis paper attempts to extend current research efforts in cloud computing by creating a value model for ICT organisations to objectively determine to invest in either cloud computing or continue investing with on premise hosting options. The model will attempt to factor ICT organisations' business attributes, financial attributes and technical attributes to provide a balanced view. Previously the authors of this paper have proposed a Cloud Computing Tipping Point model to address these gaps in research. The author also attempts to enable the model with package of services to exchange information with 3rd parties and agents that consumes the model. This paper attempts to validate the Cloud Computing Tipping Point model by leveraging surveys. The paper also attempts to validate the model by creating an artifact to demonstrate the model's capability. It continues to discusses the authors attempt to enable service centric capability by leveraging service oriented architecture (SOA) concepts. This paper concludes by introducing a standard based XML taxonomy to exchange information between the model and its clients or agents.</p
- …
