13 research outputs found
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
No full textThe poly(ADP-ribose) polymerases (PARPs) participate in various processes. Here, we report that the PARP-13/ZAP shorter isoform (hereafter called ZAPS), rather than the full length protein, is selectively induced by 3pRNA, and functions as a potent stimulator of retinoic acid-inducible gene-I (RIG-I)-mediated interferon (IFN) responses in human cells. ZAPS associates with RIG-I to promote the oligomerization and ATPase activity of RIG-I, leading to robust activation of IRF3 and NF-κB pathways. Disruption of the PARP-13/ZAP gene, ZC3HAV1, severely abrogated the induction of IFN-α, IFN-β and other cytokines upon viral infection. These results indicate that ZAPS is a key regulator of RIG-I signaling during the innate antiviral immune response, suggesting its possible use as a therapeutic target for viral control
Elektro-physiologische Untersuchungen über den Einfluss chirurgischer Eingriffe auf den elektrischen Hautwiderstand im Bereich von Akupunkturpunkten
No full textCognition : exploring the science of the mind /
No full textOne of the most successful texts ever published on its subject, the new Seventh Edition focuses on the insights and ideas that drive the field and supports student learning. Three exciting features-a new pedagogical programme based on the "testing effect", a comprehensive, author-created instructor's guide, and ZAPS Cognition Labs-deliver a dynamic, interactive introduction to cognitive psychology today.Previous edition: 2016.Includes bibliographical references and indexes.The foundations of cognitive psychology -- The science of the mind -- The neural basis for cognition -- Learning about the world around us -- Visual perception -- Recognizing objects -- Paying attention -- Memory -- The acquisition of memories and the working-memory system -- Interconnections between acquisition and retrieval -- Remembering complex events -- Knowledge -- Concepts and generic knowledge -- Language -- Visual knowledge -- Thinking -- Judgment and reasoning -- Problem solving and intelligence -- Conscious thought, unconscious thought -- Appendix: research methods -- Glossary -- References.One of the most successful texts ever published on its subject, the new Seventh Edition focuses on the insights and ideas that drive the field and supports student learning. Three exciting features-a new pedagogical programme based on the "testing effect", a comprehensive, author-created instructor's guide, and ZAPS Cognition Labs-deliver a dynamic, interactive introduction to cognitive psychology today.Vakgroep Experimentele Psychologi
Changes in Electrical Skin Resistance at Gallbladder 34 (GB34)
No full textAbstractObjectiveElectrodermal screening is widely used in the acupuncture community for point location, diagnosis and therapy. However the underlying theory that electrical skin resistance (ESR) of an area corresponding to an acupuncture point (AP) is lower than ESR of the surrounding areas is yet to be proven. The objective of this study was to evaluate and quantify the phenomenon of ESR changes at the Gallbladder 34 (GB34) Acupuncture Point (AP).Materials and MethodsIn this single-blinded study GB34 was measured bilaterally in 43 healthy volunteers. Electrical skin resistance measurements (ESRMs) were performed with a specially designed array consisting of 64 (8 × 8) electrodes on an area of 6 × 6 cm. Then the electrodes corresponding to the AP were identified and compared with those of the surrounding electrodes with Wilcoxon rank sum test. Values for p of less than 0.05 were considered statistically significant.ResultsEighty-one ESRMs were evaluated. ESR was significantly different from the surrounding skin area in 27 (33.3%) cases with 15 (18.5%) points showing a lower and 12 (14.1%) points showing a higher ESR.ConclusionThis shows that ESR changes at APs exist in one third of the measured points, a very low rate for a postulation that forms the basis of various diagnosis and therapy systems
Hip arthrodesis in the pediatric population: where do we stand?
No full textReconstructive and salvage procedures have continued to evolve in orthopedic surgery with changing functional demands of the population as well as advances in implants and surgical techniques. What used to be popular or traditional care at some point may eventually become a thing of the past, and this is true as far as many orthopedic surgical procedures are concerned. Understanding the etiology, pathogenesis, and managing and postponing the destructive pathway of osteoarthritis (OA) has been the goal of orthopedists since the specialty began in the early part of 18th century. Options of treating the severe sequelae of an arthritic joint have varied in different treatment eras. Management options have changed from a spectrum of non-treatment and slow suffering to muscle and soft-tissue releases, interposition arthroplasty and eventual extreme options like joint fusion or arthrodesis. The concept and advent of joint replacement surgery started a new era in the management of OA and was a dream come true in many ways. Mobility and stability are achieved together during the arthroplasty (joint replacement) that allowes the patient to maintain a good level of function. Arthroplasty certainly has its pros and cons as we have discovered in the past six decades. Pushing the envelope to younger population has its limitation in terms of longevity of the prosthesis, early loosening, need for repeated revisions that at some point may not be technically possible and risk of infection and disastrous consequences like PE and death associated with the gravity of the procedure. As infrequent as it is in today’s clinical practice, arthrodesis of the hip joint has a role and remains a solid option for a well selected case. The purpose of this review is to discuss the current indications in the pediatric population and outline surgical techniques for hip arthrodesis while pointing out limitations and shortcomings
Surgical and nonsurgical treatment of total rupture of the pectoralis major muscle in athletes: update and critical appraisal
No full textJörn Kircher, Christoph Ziskoven, Thilo Patzer, Daniela Zaps, Bernd Bittersohl, Rüdiger KrauspeUniversity Hospital, Orthopaedic Department, Heinrich-Heine University Düsseldorf, Düsseldorf, GermanyAbstract: The complete rupture of the pectoralis major tendon is an uncommon injury but has become increasingly common among athletes in recent years. This may be due to a higher number of individuals taking part in high-impact sports and weightlifting as well as the use of anabolic substances, which can make muscles and tendons vulnerable to injury. In recent literature, there are only few recommendations to rely on conservative treatment alone, but there are a number of reports and case series recommending early surgical intervention. Comparing the results of the two treatment regimens, there is clear evidence for a superior outcome after surgical repair with better cosmesis, better functional results, regaining of muscle power, and return to sports compared with the conservative treatment. In summary, anatomic surgical repair is the treatment of choice for complete acute ruptures of the pectoralis major tendon or muscle in athletes.Keywords: pectoralis major, rupture, athlete, conservative treatment, surgical treatment, steroid, tendon, sports injur
Discrepancy between prevalence and perceived effectiveness of treatment methods in myofascial pain syndrome: Results of a cross-sectional, nationwide survey
No full textBackground: Myofascial pain is a common dysfunction with a lifetime prevalence affecting up to 85% of the general population. Current guidelines for the management of myofascial pain are not available. In this study we investigated how physicians on the basis of prescription behaviour evaluate the effectiveness of treatment options in their management of myofascial pain. Methods: We conducted a cross-sectional, nationwide survey with a standardized questionnaire among 332 physicians (79.8% male, 25.6% female, 47.5 +/- 9.6 years) experienced in treating patients with myofascial pain. Recruitment of physicians took place at three German meetings of pain therapists, rheumatologists and orthopaedists, respectively. Physicians estimated the prevalence of myofascial pain amongst patients in their practices, stated what treatments they used routinely and then rated the perceived treatment effectiveness on a six-point scale (with 1 being excellent). Data are expressed as mean +/- standard deviation. Results: The estimated overall prevalence of active myofascial trigger points is 46.1 +/- 27.4%. Frequently prescribed treatments are analgesics, mainly metamizol/paracetamol (91.6%), non-steroidal anti-inflammatory drugs/coxibs (87.0%) or weak opioids (81.8%), and physical therapies, mainly manual therapy (81.1%), TENS (72.9%) or acupuncture (60.2%). Overall effectiveness ratings for analgesics (2.9 +/- 0.7) and physical therapies were moderate (2.5 +/- 0.8). Effectiveness ratings of the various treatment options between specialities were widely variant. 54.3% of all physicians characterized the available treatment options as insufficient. Conclusions: Myofascial pain was estimated a prevalent condition. Despite a variety of commonly prescribed treatments, the moderate effectiveness ratings and the frequent characterizations of the available treatments as insufficient suggest an urgent need for clinical research to establish evidence-based guidelines for the treatment of myofascial pain syndrome
The Hip Antero-Superior Labral Tear with Avulsion of Rectus Femoris (Haltar) Lesion: Does the Slap Equivalent in the Hip Exist?
No full textCelluloid Activist
No full textCelluloid Activist is the biography of gay-rights giant Vito Russo, the man who wrote The Celluloid Closet: Homosexuality in the Movies, commonly regarded as the foundational text of gay and lesbian film studies and one of the first to be widely read. But Russo was much more than a pioneering journalist and author. A founding member of the Gay and Lesbian Alliance Against Defamation (GLAAD) and cofounder of the AIDS Coalition to Unleash Power (ACT UP), Russo lived at the center of the most important gay cultural turning points in the 1960s, 1970s, and 1980s. His life as a cultural Zelig intersects a crucial period of social change, and in some ways his story becomes the story of a developing gay revolution in America. A frequent participant at “zaps” and an organizer of Gay Activists Alliance (GAA) cabarets and dances—which gave the New York gay and lesbian community its first social alternative to Mafia-owned bars—Russo made his most enduring contribution to the GAA with his marshaling of “Movie Nights,” the forerunners to his worldwide Celluloid Closet lecture tours that gave gay audiences their first community forum for the dissection of gay imagery in mainstream film
Assessment and management of chronic pain in patients with stable total hip arthroplasty
No full textClassen T, Bittersohl D, Landgraeber S, Li X, Jäger M. Assessment and management of chronic pain in patients with stable total hip arthroplasty. International Orthopaedics. 2013;37(1):1-7.Total hip arthroplasty (THA) is one of the most successful operations that can restore function and relieve pain. Although a majority of the patients achieve significant pain relief after THA, there are a number of patients that develop chronic pain for unknown reasons. A literature search was performed looking for chronic pain after total hip arthroplasty and stable THA. Major causes of chronic pain include aseptic loosening or infection. However, there is a subset of patients with a stable THA that present with chronic pain which can have several aetiologies. These include soft tissue, bony, neurological, vascular and psychological causes. Essential for successful treatment is the ability to make the correct diagnosis. Thus therapy may be either non-operative or operative. In addition, diagnosis and management often may require multidisciplinary approaches to successfully alleviate chronic pain in these patients with a stable prosthesis
