108 research outputs found
Calidad educativa y evaluación en clave comparada : Rupturas y continuidades entre dos períodos
No full textFil: Menozzi, Daniela. Universidad Nacional de Tres de Febrero.Fil: Gómez, Julieta Clara. Universidad Nacional de Tres de Febrero
A Rotaxane-Like Supramolecular Assembly Featuring Orthogonal Recognition Modes
No full textA party of four: This Communication describes the complete noncovalent self-assembly of a four-component rotaxane-like structure, where two orthogonal molecular recognition modes are used to thread the crown ether into the axle and to insert the cavitand end-capping groups
The Effect of Number and Position of P=O/P=S Bridging Units on Cavitand Selectivity toward Methyl Ammonium Salts
No full textThe present work reports the synthesis and complexation properties of five mixed bridge P=O/P=S cavitands toward N,N-methyl butyl ammonium chloride (1) as prototype guest. The influence of number and position of P=O and P=S groups on the affinity of phosphonate cavitands toward 1 is assessed via ITC titrations in DCE as solvent. Comparison of the resulting Kass values, the enthalpic and entropic contributions to the overall binding with those of the parent tetraphosphonate Tiiii and tetrathiophosphonate TSiiii cavitands allows one to single out the simultaneous dual H-bond between the cavitand and the salt as the major player in complexation
Food labeling : analysis, understanding, and perception
No full textFood labels are the first informative tool found by the customers during shopping, and are informative in terms of ingredients, nutrient content, and the presence of allergens of the selected product [...]
Antiplatelet therapy in acute coronary syndromes
No full textIntroduction: Antiplatelet therapy is the cornerstone of treatment for patients with acute coronary syndromes in the acute phase and in long-term management. Over the last few years, new antiplatelet drugs have been developed and the therapeutic landscape has rapidly evolved.
Areas covered: We review the available evidence and most recent data concerning all of the principal classes of antiplatelet agents, including aspirin, thienopyridines and glycoprotein IIb/IIIa inhibitors, as well the impact of the new drugs prasugrel and ticagrelor and the available data concerning cangrelor, elinogrel and PAR-1 inhibitors (still under development).
Expert opinion: This review considers the management of antiplatelet therapy in the light of recent advances, highlighting how to identify patients who will receive the greatest benefit from the older and newer agents, and underscoring the importance of carefully balancing the risks of ischaemia and bleeding in order to improve clinical outcomes. Finally, the paper discusses the potential role of functional and genetic tests in guiding the choice of antiplatelet therapy in a future perspective of 'personalised medicine'
A stakeholder engagement approach for identifying future research directions in the evaluation of current and emerging applications of GMOs
No full textThe yield of several commodity crops is provided in large part by genetically modified crops in North and South America. However, reservations exist in Europe due to possible negative effects on human health or environment. This paper aims to analyse the current research priorities identified in EU countries and to engage European stakeholders into the formulation of future common research needs regarding the effects of the possible adoption of commercially available and forthcoming genetically modified organisms (GMOs) in the areas of socio-economics, human and animal health, and environment. Additionally, it aims to identify the requirements for sharing available research capacities and existing infrastructures. First a mapping exercise of existing research activities in Europe was performed. A questionnaire was developed on a web-based platform and submitted to national focal points to collect information from EU Member States. Information was collected from 320 research projects conducted in the last 10 years in Europe. To refine results of the surveys, twenty invited experts and stakeholders from the public funding agencies of different EU Member States participated in an international workshop. This paper reports the main findings of these activities
Studio della tradizione dei Miracles de Nostre Dame di Gautier de Coinci, con edizione critica dei miracoli di Laon
No full textInsieme alle Cantigas de Santa Maria di Alfonso X, i Miracles de Nostre Dame di Gautier de Coinci sono uno dei capolavori della miracolistica mariana medievale. Scritti nella regione di Soissons tra il 1215 e il 1230, i Miracles sono una raccolta organizzata simmetricamente in due libri che include anche canzoni, preghiere e due trattati in versi. Nell’introduzione, che propone un profilo biografico aggiornato dell’autore, tra le altre cose, ci si sofferma sulla supposta influenza dei Miracles sulle Cantigas di Alfonso X. Il secondo capitolo, con l’obiettivo di aggiornare il quadro della tradizione manoscritta tracciato da A. Ducrot-Granderye nel 1932, fornisce un catalogo dei 40 mss. della tradizione organica dei Miracles, dove si trova descritto analiticamente il contenuto testuale di ogni singolo manoscritto e sono discusse tutte le proposte di datazione e di localizzazione finora avanzate (con particolare attenzione anche ai possessori antichi). Il catalogo dei manoscritti è implementato anche da una serie di sussidi che costituiscono l’Appendice I: si tratta di tavole e schede che forniscono la trascrizione di tutte le rubriche e di tutte le glosse latine della raccolta. Il Catalogo (e la sua estensione dell’Appendice I) sono alla base del terzo capitolo dedicato alla tradizione di tutta la raccolta, dove è posta particolare attenzione alle fasi redazionali dei Miracles, proponendone una nuova (testimoniata dai manoscritti D e I), e prestando particolare attenzione alla datazione delle varie tappe di formazione della raccolta. La seconda parte della tesi consiste invece nell’edizione critica dei miracoli di Laon (II Mir 14-17 e II Mir 26), condotta su tutti i manoscritti disponibili. L’edizione è aperta da uno studio comparatistico di tutte le versioni mediolatine e romanze dei miracoli pubblicati, ed è seguita da note filologiche e di commento. Chiude la tesi l’Appendice II, che offre l’edizione di due testi inediti scoperti durante l’allestimento del Catalogo.Gautier de Coinci’s Miracles de Nostre Dame are one of the masterpieces of the genre of the miracles of the Virgin in medieval literature. Written between 1215 and 1230 by Gautier de Coinci, a monk from Saint-Médard in Soissons, the Miracles form a symmetrically-organised two-book collection which also includes songs, prayers and two treatises in verse. This thesis opens with an introduction primarily focused at creating a fresh biographical portrait of the author and exploring the connections between the Miracles and the Cantigas of Alfonso X. Nearly a century after A. Ducrot-Granderye’s 1932 book centred on the manuscripts of the Miracles, this dissertation provides a catalogue of the 40 complete manuscripts of the Miracles, including an analytical description of their textual content and a re-assessment of their dating, location, and early owners. The manuscript catalogue is supplemented by tables (Appendix I) containing information (headings, Latin glosses, illustrations) for each text in the collection. This section devoted to the Miracles manuscripts serves as a basis for chapter 3, which revolves around the tradition of the collection. The main contributions of this chapter concern the multiple redactions of the Miracles (with the identification of a new redactional phase attested by manuscripts D and I). The second part of the thesis presents the critical edition of the miracles of Laon (II Mir 14-17 and II Mir 26). It is introduced by a chapter aimed at study all the Latin and Romance versions of the miracles of Laon and is accompanied by a discussion of the relationships between the manuscripts and philological notes. Finally, Appendix II presents the edition of two previously unpublished texts discovered during the preparation of the manuscript catalogue.À côté des Cantigas de Santa Maria d’Alphonse X, les Miracles de Nostre Dame de Gautier de Coinci sont l’un des chefs-d’oeuvre du genre des miracles de la Vierge dans les littératures romanes du Moyen Âge. Écrits entre 1215 et 1230 par un moine de Saint-Médard de Soissons, Gautier de Coinci, les Miracles forment un recueil en deux livres organisé de manière symétrique, qui présente également des chansons, des prières et deux traités en vers. L’introduction est principalement consacrée à établir un nouveau profil biographique de l’auteur et à étudier les liens entre les Miracles et les Cantigas d’Alphonse X. Près d’un siècle après le livre dédié à la tradition manuscrite des Miracles par A. Ducrot-Granderye en 1932, cette thèse propose une nouvelle analyse des principaux manuscrits de l’oeuvre. Le chapitre 2 présente ainsi un catalogue des 40 manuscrits de la tradition organique du recueil, comprenant une description analytique de leur contenu textuel, ainsi qu’une réévaluation de leur datation, de leur localisation et de leurs possesseurs anciens. Des nouveautés sont présentées dans la thèse, notamment l’hypothèse selon laquelle le manuscrit L des Miracles (Paris, BnF, fr. 22928) aurait été réalisé pour Blanche de France ou Jeanne de Dammartin ; la localisation du ms. D (Paris, Ars. 3517-18) dans la région de Cambrai ; et de nouvelles preuves inédites confirmant la localisation des manuscrits N (Paris, BnF, fr. 25532) et x (Paris, BnF, fr. 15110), respectivement à l’abbaye de Saint-Médard de Soissons et dans la région de Dijon. Le catalogue des manuscrits est complété par des tableaux (Appendice I) regroupant plusieurs informations (rubriques, gloses latines, illustrations) pour chaque texte du recueil. Cette section dédiée aux manuscrits des Miracles sert de base pour le chapitre 3 consacré à la tradition du recueil. Les principaux apports de ce chapitre concernent le cadre rédactionnel de l’oeuvre (avec l’identification d’unephase rédactionnelle inédite attestée par les manuscrits D et I) et la mise au jour des dates de composition des différentes parties. Le chapitre propose également un examen critique des rapports entre les manuscrits du point de vue philologique, évaluant à la fois les données fournies par la bibliographie antérieure et celles découlant de l’examen des manuscrits ainsi que du travail sur l’édition critique des miracles de Laon. Laseconde partie de la thèse présente d’ailleurs l’édition critique des miracles de Laon (II Mir 14-17 et II Mir 26), préparée sur tous les manuscrits disponibles. Elle est introduite par un chapitre qui vise à étudier toutes les versions latines et romanes des miracles de Laon et est accompagnée par une discussion sur les rapports entre les manuscrits et par des notes philologiques. Enfin, l’Appendice II présente l’édition de deux textes inédits découverts lors de la préparation du catalogue des manuscrits : une version précédemment inconnue d’un miracle de la Vierge en vers, et deux textes en prose (une version de la Vie des Pères et un miracle de Saint Basile)
Thermodynamics of Host-guest Interactions between Methylpyridinium Salts and Phosphonate Cavitands
No full textIn this work, the properties of complexation of tetraphosphonate cavitands towards methylpyridinium guests were investigated via isothermal titration calorimetry (ITC). For this purpose, Tiiii[C3H7, CH3 , Ph], Tiiii[C3H7, H, Ph], TSiiii[C3H7, H, Ph] hosts and three different methylpyridinium guests were synthesised. The role of the following parameters in the host–guest complexation was investigated: (i) solvation, (ii) nature of the guest counterion, (iii) presence of substituents in the apical positions of the receptor, and (iv) P=O versus P=S bridging units. The results showed that (i) switching from dichloroethane to methanol leads to a decrease of the association constant due to the competitive nature of the solvent, (ii) the guest counterion does not affect the thermodynamics of the process, (iii) the apical methyl groups enhance the binding affinity of the receptor and (iv) the comparison between phosphonate and thiophosphonate hosts clearly demonstrates that cation–dipole interactions are necessary for binding
Process for the preparation of oxygen barrier film
No full textThe invention relates to a process for the preparation of an oxygen barrier film having an oxygen barrier layer and a treated substrate, comprising the steps of:
a) subjecting a polyolefin substrate to a surface treatment to 5 obtain the treated substrate wherein the surface under the parts of the curves corresponding to the C-O, C-N and C=O groups is at least 10% based on the total surface under the curve as obtained by X-ray photoelectron spectroscopy (XPS),
b) applying an aqueous or hydroalcoholic coating composition comprising 0.1 to 25 10 wt% of polyvinyl alcohol and 0.1 to 30 wt% of a metal alkoxide on the treated substrate
obtained by step a) and
c) drying the coating composition to obtain the oxygen barrier layer resulting in the oxygen barrier film
Knowledge gaps and research needs in the evaluation of the effects of GMOs
No full textThe main purpose of this paper is to define a comprehensive picture of transnational research needs regarding the effects of genetically modified organisms (GMOs) in the areas of human and animal health, environment, and techno-economics and societies, as well as requirements for sharing available research capacities and existing infrastructures. First a mapping exercise of existing research activities and knowledge regarding the health, environmental and socio-economic effects of GMOs in Europe was performed. A questionnaire has been developed on a web-based platform (the CADIMA database) and submitted to national focal points to collect information from Member States. Information was collected from 320 projects. Then, twenty-three invited experts and stakeholders participated in a workshop. The focus of the workshop was on GM crops or other applications on the marketplace or near to be commercialized, not necessarily in the EU, but that may have effects in the EU. Applications intentionally released into the environment and/or used immediately in feed and food applications were considered. Starting from a long list of research needs covering a number of 40 issues in the area of human and animal health, 67 research needs in the area of environment, and 70 items in the area of techno-economics, a synthesis of the main research needs and gaps, as well as requirements for sharing available research capacities and existing infrastructures was identified by the experts
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