100,804 research outputs found
Corrigendum: Platinated Nucleotides are Substrates for the Human Mitochondrial Deoxynucleotide Carrier (DNC) and DNA Polymerase γ: Relevance for the Development of New Platinum-Based Drugs (ChemistrySelect, (2016), 1, (4633-4637), 10.1002/slct.201600961)
No full textIn agreement with all authors of this paper the order of the authors and the contribution “Paola Lunetti[+], Alessandro Romano[+], Chiara Carrisi, Daniela Antonucci, Tiziano Verri, Giuseppe E. De Benedetto, Vincenza Dolce, Francesco P. Fanizzi, Michele Benedetti,* and Loredana Capobianco.* [+] These authors contributed equally to this paper. * Corresponding authors: Michele Benedetti and Loredana Capobianco, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce.” is corrected to read the original order of the first submitted version of the paper: “Chiara Carrisi[+], Alessandro Romano[+], Paola Lunetti, Daniela Antonucci, Tiziano Verri, Giuseppe E. De Benedetto, Vincenza Dolce, Francesco P. Fanizzi, Michele Benedetti,* and Loredana Capobianco.* [+] These authors contributed equally to this paper. * Corresponding authors: Loredana Capobianco and Michele Benedetti, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce.” For completeness the following individual contributions of the authors were added in the Supporting Information: “Author contributions: L.C., M.B., C.C., A.R. designed research; C.C., A.R., P.L. and D.A. performed research; L.C., M.B., C.C., A.R., V.D. and P.L. analysed data; F.P.F., A.R., L.C. and M.B. wrote the paper; L.C., M.B., T.V., G.D.B. and F.P.F. active discussion paper revision.”
Duet (O Dolce Concento)
No full textDuet for Two Performers on One Piano Forte in which is introduced the admired Air O Dolce Concento with Variations. Bates catalog record.
Circa 1838-1839https://scarab.bates.edu/hbvlh/1026/thumbnail.jp
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
A Formal Ontology of Sequences
No full textThe Sequence Ontology is an OBO Foundry ontology that provides categories of sequences and sequence features that are applied to the annotation of genomes. To facilitate interoperability with other domain ontologies and to provide a foundation for automated inference, we provide here an axiom system for the Sequence and Junction categories in first- and second-order predicate logics
A Multipurpose Method for Seismic Vulnerability Assesment of Urban Areas
No full textThe present work
outlines
a methodological framework
for
“ordering”
through progressive levels of analyses
different evaluation models concerning
the seismic vulnerability at urban scale,
with respect to the possibl
e final
objectives:
seismic scenarios, emergency or
urban planning
,
as far as
seismic mitigation
or economical
estimates.
The research work has been developed within the URBISIT Project, funded by Italian Civil Department
(DPC).
The paper illustrates t
he general framework governing each
assessment
level and the
mutual relation between
each of them.
Following, e
ach level of analyses is
systematically
described also through some recent
applications
,
carried out
o
n
some representative Italian urban centres
.
In the end, a
correlation
among
different
assessment levels is carried out
in order to better fo
cus the usability of
each model as well as
its reliability with respect to the possible objectives
. Finally some conclusions are drawn
and possible developmen
t of the research outlined
Exploring sex-specific hematological changes and their impact on quality of life in patients with prolactinoma
No full textContext: Despite prolactin ́s (PRL) role in stimulating hematopoiesis, anemia is commonly observed in men with macroprolactinomas. However, hematological changes in men with microprolactinomas and women with prolactinomas remain unexplored, and the impact of erythropoietic alterations on quality of life (QoL) is still unclear. Objective: To explore sex-related changes in red blood cell (RBC) parameters and their potential impact on QoL at initial diagnosis of prolactinoma and after normalization of PRL under dopamine agonists. Design: Retrospective, monocentric study involving 205 patients with prolactinoma (127 women, 62%). The SF-36 QoL questionnaire was administered to 57 women and 34 men. Results: In women, no significant changes in RBC parameters were observed at diagnosis or after PRL normalization, regardless the adenoma size. Conversely, men with microprolactinoma showed a significant increase in hematocrit (HCT) and hemoglobin (Hb) levels after PRL normalization (median HCT 42.3 vs.44.0%; Hb 14.5 vs. 15.1 g/dL; both p < 0.005). Men with macroprolactinoma exhibited similar improvements (HCT 40.2 vs. 43.9%; Hb 14.0 vs. 15.1 g/dL; both p < 0.0001). In men, hypogonadism was observed in 73% of patients at baseline, and in 11% after PRL normalization. In male patients where SF-36 was administered at diagnosis and after PRL normalization, energy improvement was observed (median 50 vs. 60, p < 0.05). While changes in Hb and HCT were not significantly impacting the QoL of women and men, persistence of hypogonadism after PRL normalization, negatively impacted all the QoL scores of men. Conclusion: Patients with prolactinoma show sex-dependent changes in RBC parameters. Unlike women, men exhibit decreased HCT and Hb levels irrespective of adenoma size. Of note, the failure to recover from hypogonadism significantly affected the QoL of men
Taming the Sea of Errors: An Ontological Study of Biases in DOLCE
No full textIn this paper, we present a preliminary ontology of bias based on the
DOLCE foundational ontology. The main reason for devising such an endeavour
is to make explicit the ontological assumptions behind the use of terms indicating
the elements composing a biased outcome. Firstly, we discuss what the object of a
bias is —namely, the entity that might be deemed biased, which we identify with
situated inferences, i.e. propositional contents that can be asserted by some (human
or artificial) agent from other propositional contents. We will thus categorise in
DOLCE various types of biases as concepts that classify situated inferences. The
content of such inferences is then associated with the following elements: i) the
agent responsible for drawing the conclusion, ii) the objects and iii) the concepts
used in the premises and in the conclusion of the inference, iv) the time when the
inference takes place. These ingredients will serve to trace the origin of what we
shall call a biased inference back to any of the above elements, relating some of the
biases present in the literature to these ontologically founded elements
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